James Craig Forrest, PhD

Research Program: Cancer Biology Faculty Rank: Associate Professor Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Microbiology & Immunology

Cancer Research Interest

• Disease Site Focus: Leukemia/ Lymphoma
• Research Focus Area: Prevention, Carcinogenesis
• Type of Research: Basic

Contact Information

• Email Address: JCFORREST@UAMS.EDU
• Profiles Research Networking Software: View Profile

Active Grants

• NIH/Nat. Inst. of General Medical Sciences – 1P30GM145393
  “COBRE - Phase III Center for Microbial Pathogenesi”
  Co-Investigator
  05/05/22 – 04/30/27
• NIH/Nat. Inst. of General Medical Sciences – 1P30GM145393
  “COBRE - Phase III”
  Co-Investigator
  05/05/22 – 04/30/27
• NIH/Nat. Inst. of Dental & Craniofacial Research – 1R03DE031978
  “Targeting ILlRAP in virus-associated malignancies”
  Co-Investigator
  05/01/22 – 04/30/24
• NIH/Nat. Cancer Institute – 2R01CA167065
  “Defining mechanisms of gammaherpesvirus-driven gen”
  Principal Investigator
  03/11/22 – 02/28/27
• NIH/Nat. Inst. of Nursing Research – 5R42NR017124
  “A Transparent Surgical Mask to Improve Patient/Car”
  Co-Investigator
  03/01/22 – 02/29/24
• NIH/Nat. Inst. of Allergy & Infectious Diseases – 1R56AI150911
  “Defining mechanisms of KSHV pathogenesis using MHV68-KSHV chimeric viruses- Resubmission”
  Principal Investigator
  09/14/20 – 08/31/23

Publications

• Karger AB, Brien JD, Christen JM, [et al., including Forrest JC]. The Serological Sciences Network (SeroNet) for COVID-19: Depth and Breadth of Serology Assays and Plans for Assay Harmonization. mSphere. 2022:e0019322. PMID: 35703544. PMCID: PMC9429934.
• Wilkins H, Jastaniah E, Spray B, [et al., including Forrest JC]. Seroprevalence of SARS-CoV-2 antibodies in front-line pediatric health care workers. Journal of the American College of Emergency Physicians open. 2022 3(3):e12743. PMID: 35601650. PMCID: PMC9110875.
• Gupta A, Owens SM, Oldenburg DG, [et al., including Forrest JC]. Lytic Replication and Reactivation from B Cells Is Not Required for Establishing or Maintaining Gammaherpesvirus Latency In Vivo. Journal of virology. 2022:e0069022. PMID: 35647668. PMCID: PMC9215232.
• Kennedy JL, Forrest JC, Young SG, [et al.]. Temporal Variations in Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Infections by Race and Ethnicity in Arkansas. Open forum infectious diseases. 2022 9(5):ofac154. PMID: 35493126. PMCID: PMC9045955.
• Karger AB, Brien JD, Christen JM, [et al., including Forrest JC]. The Serological Sciences Network (SeroNet) for COVID-19: Depth and Breadth of Serology Assays and Plans for Assay Harmonization. medRxiv : the preprint server for health sciences. 2022. PMID: 35262095. PMCID: PMC8902887.
• Dai L, Lu YC, Chen J, [et al., including Forrest JC]. Oral Shedding of an Oncogenic Virus Alters the Oral Microbiome in HIV+ Patients. Frontiers in microbiology. 2022 13:882520. PMID: 35516440. PMCID: PMC9063630.
• Cardenas VM, Kennedy JL, Williams M, [et al., including Forrest JC]. State-wide random seroprevalence survey of SARS-CoV-2 past infection in a southern US State, 2020. PloS one. 2022 17(4):e0267322. PMID: 35476717. PMCID: PMC9045671.
• Arthur JM, Forrest JC, Boehme KW, [et al.]. Development of ACE2 autoantibodies after SARS-CoV-2 infection. PloS one. 2021 16(9):e0257016. PMID: 34478478. PMCID: PMC8415618.
• Owens SM, Oldenburg DG, White DW, Forrest JC. Deletion of Murine Gammaherpesvirus Gene M2 in AID-Expressing B Cells Impairs Host Colonization and Viral Reactivation. Journal of virology. 2020. PMID: 33028711. PMCID: PMC7737732.
• Wongsurawat T, Gupta A, Jenjaroenpun P, [et al., including Forrest JC]. Author Correction: R-loop-forming Sequences Analysis in Thousands of Viral Genomes Identify A New Common Element in Herpesviruses. Scientific reports. 2020 10(1):12173. PMID: 32678142. PMCID: PMC7368006.
• Dai L, Jung BG, Chen J, [et al., including Forrest JC]. The potential impacts of early secreted antigenic target of 6 kDa (ESAT-6) of Mycobacterium tuberculosis on KSHV-infected cells. Journal of medical virology. 2020. PMID: 32648938. PMCID: PMC7796979.
• Chen J, Goyal N, Dai L, [et al., including Forrest J]. Developing new ceramide analogs and identifying novel sphingolipid controlled genes against a virus-associated lymphoma. Blood. 2020. PMID: 32518949. PMCID: PMC7645984.
• Dai L, Forrest J, Barrett L, [et al.]. Porphyromonas gingivalis coinfects with KSHV in oral cavities of HIV+ patients and induces viral lytic reactivation. Journal of medical virology. 2020. PMID: 32436999. PMCID: PMC7679274.
• Wongsurawat T, Gupta A, Jenjaroenpun P, [et al., including Forrest JC]. R-loop-forming Sequences Analysis in Thousands of Viral Genomes Identify A New Common Element in Herpesviruses. Scientific reports. 2020 10(1):6389. PMID: 32286400. PMCID: PMC7156643.
• Dai L, Forrest J, Qiao J, [et al.]. Kaposi Sarcoma-Associated Herpesvirus and Staphylococcus aureus Coinfection in Oral Cavities of HIV-Positive Patients: A Unique Niche for Oncogenic Virus Lytic Reactivation. The Journal of infectious diseases. 2020 221(8):1331-1341. PMID: 31111897. PMCID: PMC7325796.
• Chen J, Forrest J, post s, [et al.]. Mechanistic Insights into Chemoresistance Mediated by Oncogenic Viruses in Lymphomas. Viruses. 2019 11(12). PMID: 31888174. PMCID: PMC6950054.
• Chen J, Dai L, Goldstein A, [et al., including Forrest JC]. Identification of new antiviral agents against Kaposi's sarcoma-associated herpesvirus (KSHV) by high-throughput drug screening reveals the role of histamine-related signaling in promoting viral lytic reactivation. PLoS pathogens. 2019 15(12):e1008156. PMID: 31790497. PMCID: PMC6907871.
• Chen J, Del Valle L, Lin HY, [et al., including Forrest JC]. Expression of PD-1 and PD-Ls in Kaposi's sarcoma and regulation by oncogenic herpesvirus lytic reactivation. Virology. 2019 536:16-19. PMID: 31394407. PMCID: PMC6733645.
• Gao Y, Wang L, Lei Z, [et al., including Forrest JC]. IRF4 promotes Epstein-Barr virus activation in Burkitt's lymphoma cells. The Journal of general virology. 2019 100(5):851-862. PMID: 30907723.
• Chen J, Forrest J, post s, [et al.]. Transactivation of human endogenous retroviruses by tumor viruses and their functions in virus-associated malignancies. Oncogenesis. 2019 8(1):6. PMID: 30643113. PMCID: PMC6331641.
• Xu W, Forrest J, post s, [et al.]. Distinct systemic microbiome and microbial translocation are associated with plasma level of anti-CD4 autoantibody in HIV infection. Scientific reports. 2018 8(1):12863. PMID: 30150778. PMCID: PMC6110826.
• Knowlton JJ, Fernández de Castro I, Ashbrook AW, [et al., including Forrest JC]. The TRiC chaperonin controls reovirus replication through outer-capsid folding. Nature microbiology. 2018 3(4):481-493. PMID: 29531365. PMCID: PMC5874176.
• Salinas E, Gupta A, Sifford JM, [et al., including Forrest JC]. Conditional mutagenesis in vivo reveals cell type- and infection stage-specific requirements for LANA in chronic MHV68 infection. PLoS pathogens. 2018 14(1):e1006865. PMID: 29364981. PMCID: PMC5798852.
• Gupta A, Oldenburg DG, Salinas E, [et al., including Forrest JC]. Murine Gammaherpesvirus 68 Expressing Kaposi Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen (LANA) Reveals both Functional Conservation and Divergence in LANA Homologs. Journal of virology. 2017 91(19). PMID: 28747501. PMCID: PMC5599733.
• Li G, Ward C, Yeasmin R, [et al., including Forrest JC]. A codon-shuffling method to prevent reversion during production of replication-defective herpesvirus stocks: Implications for herpesvirus vaccines. Scientific reports. 2017 7:44404. PMID: 28287622. PMCID: PMC5347388.
• Dong S, Forrest JC, Liang X. Murine Gammaherpesvirus 68: A Small Animal Model for Gammaherpesvirus-Associated Diseases. Advances in experimental medicine and biology. 2017 1018:225-236. PMID: 29052141.