Peter A Crooks, PhD, MSc, DSc

Research Program: Cancer Therapeutics Faculty Rank: Professor Campus: University of Arkansas for Medical Sciences College: College of Pharmacy Department: Pharmaceutical Sciences

Cancer Research Interest

• Disease Site Focus: Brain, Breast, Cutaneous/Melanoma, GI, Leukemia/ Lymphoma
• Research Focus Area: Prevention, Treatment
• Type of Research: Basic

Contact Information

• Email Address: PACROOKS@UAMS.EDU
• Profiles Research Networking Software: View Profile

Active Grants

• NIH/Nat. Inst. on Aging – 1R01AG084473
  “Role of glucose transport in Alzheimer?s disease p”
  Co-Investigator
  04/15/23 – 03/31/28

Publications

• LoBianco FV, Krager KJ, Johnson E, [et al., including Crooks PA]. Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells. Frontiers in toxicology. 2022 4:936149. PMID: 36591540. PMCID: PMC9795200.
• Darrigues E, Zhao EH, De Loose A, [et al., including Crooks PA]. Biobanked Glioblastoma Patient-Derived Organoids as a Precision Medicine Model to Study Inhibition of Invasion. International journal of molecular sciences. 2021 22(19). PMID: 34639060. PMCID: PMC8509225.
• Bowroju SK, Penthala NR, Lakkaniga NR, [et al., including Crooks PA]. Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer's disease. Bioorganic & medicinal chemistry. 2021 45:116311. PMID: 34304133. PMCID: PMC8405574.
• Penthala NR, Balasubramaniam M, Dachavaram SS, [et al., including Crooks PA]. Antitumor properties of novel sesquiterpene lactone analogs as NF?B inhibitors that bind to the IKK? ubiquitin-like domain (ULD). European journal of medicinal chemistry. 2021 224:113675. PMID: 34229108. PMCID: PMC8511328.
• Adeneye AA, Olorundare OE, Omobowale TO, [et al., including Crooks PA]. Selected Antihypertensive Agents and Their Fixed-Dose Combinations Effectively Ameliorate Trastuzumab-Mediated Cardiac Dysfunction In Rats. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. 2021 36(1):57-65. PMID: 34987247.
• Traver G, Sekhar KR, Crooks PA, [et al.]. Targeting NPM1 in irradiated cells inhibits NPM1 binding to RAD51, RAD51 foci formation and radiosensitizes NSCLC. Cancer letters. 2021 500:220-227. PMID: 33358698. PMCID: PMC7822076.
• Yadlapalli JSK, Albayati ZAF, Breen PJ, [et al., including Crooks PA]. A pharmacokinetic study of morphine-6-O-sulfate in rat plasma and brain. Drug development research. 2021. PMID: 33427316.
• Albayati ZAF, Penthala NR, Bommagani S, [et al., including Crooks PA]. Evaluation of bone and kidney toxicity of BT2-peg2, a potential carrier for the targeted delivery of antibiotics to bone. Toxicology reports. 2021 8:359-364. PMID: 33665133. PMCID: PMC7898066.
• Lee C, Sinha AK, Henry K, [et al., including Crooks PA]. Characterizing the Access of Cholinergic Antagonists to Efferent Synapses in the Inner Ear. Frontiers in neuroscience. 2021 15:754585. PMID: 34970112. PMCID: PMC8712681.
• Wang R, Kumar B, Bhat-Nakshatri P, [et al., including Crooks PA]. Aging-associated skeletal muscle defects in HER2/Neu transgenic mammary tumor model. JCSM rapid communications. 2021 4(1):24-39. PMID: 33842876. PMCID: PMC8028024.
• Balasubramaniam M, Mainali N, Bowroju SK, [et al., including Crooks PA]. Structural modeling of GSK3? implicates the inactive (DFG-out) conformation as the target bound by TDZD analogs. Scientific reports. 2020 10(1):18326. PMID: 33110096. PMCID: PMC7591898.
• Yang JF, Williams AH, Penthala NR, [et al., including Crooks PA]. Binding Modes and Selectivity of Cannabinoid 1 (CB1) and Cannabinoid 2 (CB2) Receptor Ligands. ACS chemical neuroscience. 2020. PMID: 32997485. PMCID: PMC7756905.
• Penthala NR, Shoeib A, Dachavaram SS, [et al., including Crooks PA]. 7-Azaindolequinuclidinones (7-AIQD): A novel class of cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor ligands. Bioorganic & medicinal chemistry letters. 2020 30(22):127501. PMID: 32882418. PMCID: PMC7686103.
• Bowroju SK, Mainali N, Ayyadevara S, [et al., including Crooks PA]. Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of A? Self-Aggregation and Metal Chelation-Induced A? Aggregation. Molecules (Basel, Switzerland). 2020 25(16). PMID: 32784464. PMCID: PMC7463714.
• Moore JP 2nd, Robling K, Romero C, [et al., including Crooks PA]. Oxone®-Mediated TEMPO-Oxidized Cellulose Nanomaterial Ultrafiltration and Dialysis Mixed-Matrix Hollow Fiber Membranes. Polymers. 2020 12(6). PMID: 32549325. PMCID: PMC7361684.
• Moore Ii JP, Dachavaram SS, Bommagani S, [et al., including Crooks PA]. Oxone®-Mediated TEMPO-Oxidized Cellulose Nanomaterials form I and form II. Molecules (Basel, Switzerland). 2020 25(8). PMID: 32316421. PMCID: PMC7221945.
• Olorundare OE, Adeneye AA, Akinsola AO, [et al., including Crooks PA]. Therapeutic Potentials of Selected Antihypertensive Agents and Their Fixed-Dose Combinations Against Trastuzumab-Mediated Cardiotoxicity. Frontiers in pharmacology. 2020 11:610331. PMID: 33897413. PMCID: PMC8058606.
• Lee NR, Zheng G, Leggas M, [et al., including Crooks PA]. GZ-11608, a Vesicular Monoamine Transporter-2 Inhibitor, Decreases the Neurochemical and Behavioral Effects of Methamphetamine. The Journal of pharmacology and experimental therapeutics. 2019 371(2):526-543. PMID: 31413138. PMCID: PMC6863457.
• Balasubramaniam M, Ayyadevara S, Ganne A, [et al., including Crooks PA]. Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases. iScience. 2019 20:248-264. PMID: 31593839. PMCID: PMC6817627.
• Ketkar A, Maddukuri L, Penthala NR, [et al., including Crooks PA]. Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms. ACS chemical biology. 2019 14(6):1337-1351. PMID: 31082191. PMCID: PMC7357868.
• Ford BM, Cabanlong CV, Tai S, [et al., including Crooks PA]. Reduced Tolerance and Asymmetrical Crosstolerance to Effects of the Indole Quinuclidinone Analog PNR-4-20, a G Protein-Biased Cannabinoid 1 Receptor Agonist in Mice: Comparisons with ?9-Tetrahydrocannabinol and JWH-018. The Journal of pharmacology and experimental therapeutics. 2019 369(2):259-269. PMID: 30833484. PMCID: PMC6447997.
• Marecki JC, Aarattuthodiyil S, Byrd AK, [et al., including Crooks PA]. N-Naphthoyl-substituted indole thio-barbituric acid analogs inhibit the helicase activity of the hepatitis C virus NS3. Bioorganic & medicinal chemistry letters. 2019 29(3):430-434. PMID: 30578035. PMCID: PMC6377802.
• Bommagani S, Penthala NR, Balasubramaniam M, [et al., including Crooks PA]. A novel tetrazole analogue of resveratrol is a potent anticancer agent. Bioorganic & medicinal chemistry letters. 2019 29(2):172-178. PMID: 30528695. PMCID: PMC6497071.
• Kakraba S, Ayyadevara S, Penthala NR, [et al., including Crooks PA]. A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer's Disease. Frontiers in molecular neuroscience. 2019 12:310. PMID: 31920540. PMCID: PMC6920216.
• Kearney SE, Zahoránszky-K?halmi G, Brimacombe KR, [et al., including Crooks PA]. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. ACS central science. 2018 4(12):1727-1741. PMID: 30648156. PMCID: PMC6311695.
• Maggio SE, Saunders MA, Nixon K, [et al., including Crooks PA]. An improved model of ethanol and nicotine co-use in female P rats: Effects of naltrexone, varenicline, and the selective nicotinic ?6?2* antagonist r-bPiDI. Drug and alcohol dependence. 2018 193:154-161. PMID: 30384323. PMCID: PMC6239925.
• Bommagani S, Penthala NR, Parkin S, Crooks PA. Crystal structure of 13-(E)-(2-amino-benzyl-idene)parthenolide. Acta crystallographica. Section E, Crystallographic communications. 2018 74(Pt 11):1543-1546. PMID: 30443377. PMCID: PMC6218918.
• Flores-Lopez G, Moreno-Lorenzana D, Ayala-Sanchez M, [et al., including Crooks PA]. Parthenolide and DMAPT induce cell death in primitive CML cells through reactive oxygen species. Journal of cellular and molecular medicine. 2018 22(10):4899-4912. PMID: 30079458. PMCID: PMC6156390.
• Janganati V, Ponder J, Balasubramaniam M, [et al., including Crooks PA]. MMB triazole analogs are potent NF-?B inhibitors and anti-cancer agents against both hematological and solid tumor cells. European journal of medicinal chemistry. 2018 157:562-581. PMID: 30121494. PMCID: PMC6281399.
• Lamture G, Crooks PA, Borrelli MJ. Actinomycin-D and dimethylamino-parthenolide synergism in treating human pancreatic cancer cells. Drug development research. 2018 79(6):287-294. PMID: 30295945. PMCID: PMC6193836.
• Dachavaram SS, Penthala NR, Calahan JL, [et al., including Crooks PA]. Highly sulphated cellulose: a versatile, reusable and selective desilylating agent for deprotection of alcoholic TBDMS ethers. Organic & biomolecular chemistry. 2018 16(33):6057-6062. PMID: 30090907.
• Yadlapalli JSK, Bommagani SB, Mahelona RD, [et al., including Crooks PA]. Evaluation of morphine-like effects of the mixed mu/delta agonist morphine-6-O-sulfate in rats: Drug discrimination and physical dependence. Pharmacology research & perspectives. 2018 6(4):e00403. PMID: 29930811. PMCID: PMC6009770.
• Maggio SE, Saunders MA, Baxter TA, [et al., including Crooks P]. Effects of the nicotinic agonist varenicline, nicotinic antagonist r-bPiDI, and DAT inhibitor (R)-modafinil on co-use of ethanol and nicotine in female P rats. Psychopharmacology. 2018 235(5):1439-1453. PMID: 29455292. PMCID: PMC6058964.
• Yadlapalli JSK, Dogra N, Walbaum AW, [et al., including Crooks PA]. Pinprick hypo- and hyperalgesia in diabetic rats: Can diet content affect experimental outcome?. Neuroscience letters. 2018 673:24-27. PMID: 29490230. PMCID: PMC5889730.
• Zafar MK, Maddukuri L, Ketkar A, [et al., including Crooks PA]. A Small-Molecule Inhibitor of Human DNA Polymerase ? Potentiates the Effects of Cisplatin in Tumor Cells. Biochemistry. 2018 57(7):1262-1273. PMID: 29345908. PMCID: PMC7312786.
• Lee NR, Zheng G, Crooks PA, [et al.]. New Scaffold for Lead Compounds to Treat Methamphetamine Use Disorders. The AAPS journal. 2018 20(2):29. PMID: 29427069. PMCID: PMC7047575.
• Kangiser MM, Dwoskin LP, Zheng G, [et al., including Crooks PA]. Varenicline and GZ-793A differentially decrease methamphetamine self-administration under a multiple schedule of reinforcement in rats. Behavioural pharmacology. 2018 29(1):87-97. PMID: 28863003. PMCID: PMC5760454.
• Yadlapalli JSK, Dogra N, Walbaum AW, [et al., including Crooks PA]. Preclinical assessment of utility of M6S for multimodal acute and chronic pain treatment in diabetic neuropathy. Life sciences. 2018 192:151-159. PMID: 29191644.
• Madadi NR, Penthala NR, Ketkar A, [et al., including Crooks PA]. Synthesis and Evaluation of 2-Naphthaleno trans-Stilbenes and Cyanostilbenes as Anticancer Agents. Anti-cancer agents in medicinal chemistry. 2018 18(4):556-564. PMID: 28403783. PMCID: PMC7584397.
• Hankosky ER, Joolakanti SR, Nickell JR, [et al., including Crooks PA]. Fluoroethoxy-1,4-diphenethylpiperidine and piperazine derivatives: Potent and selective inhibitors of [3H]dopamine uptake at the vesicular monoamine transporter-2. Bioorganic & medicinal chemistry letters. 2017 27(24):5467-5472. PMID: 29153425. PMCID: PMC5782818.
• Wang R, Bhat-Nakshatri P, Padua MB, [et al., including Crooks PA]. Pharmacological Dual Inhibition of Tumor and Tumor-Induced Functional Limitations in a Transgenic Model of Breast Cancer. Molecular cancer therapeutics. 2017 16(12):2747-2758. PMID: 28978719. PMCID: PMC5716864.
• Ford BM, Franks LN, Tai S, [et al., including Crooks PA]. Characterization of structurally novel G protein biased CB1 agonists: Implications for drug development. Pharmacological research. 2017 125(Pt B):161-177. PMID: 28838808. PMCID: PMC5849406.
• Mendonca MS, Turchan WT, Alpuche ME, [et al., including Crooks PA]. DMAPT inhibits NF-?B activity and increases sensitivity of prostate cancer cells to X-rays in vitro and in tumor xenografts in vivo. Free radical biology & medicine. 2017 112:318-326. PMID: 28782644. PMCID: PMC6322835.
• Yadlapalli JSK, Dogra N, Walbaum AW, [et al., including Crooks PA]. Evaluation of Analgesia, Tolerance, and the Mechanism of Action of Morphine-6-O-Sulfate Across Multiple Pain Modalities in Sprague-Dawley Rats. Anesthesia and analgesia. 2017 125(3):1021-1031. PMID: 28489639. PMCID: PMC5561516.
• Yadlapalli JSK, Albayati ZAF, Penthala NR, [et al., including Crooks PA]. Stability studies of potent opioid analgesic, morphine-6-O-sulfate in various buffers and biological matrices by HPLC-DAD analysis. Biomedical chromatography : BMC. 2017 31(9). PMID: 28205234.
• Bommagani S, Ponder J, Penthala NR, [et al., including Crooks PA]. Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells. European journal of medicinal chemistry. 2017 136:393-405. PMID: 28525840. PMCID: PMC5531865.
• Janganati V, Ponder J, Thakkar S, [et al., including Crooks PA]. Succinamide derivatives of melampomagnolide B and their anti-cancer activities. Bioorganic & medicinal chemistry. 2017 25(14):3694-3705. PMID: 28545815. PMCID: PMC5531864.
• Walbaum A, Fifer EK, Parkin S, Crooks PA. Crystal structure of 4,4'-bis-[3-(piperidin-1-yl)prop-1-yn-1-yl]-1,1'-biphen-yl. Acta crystallographica. Section E, Crystallographic communications. 2017 73(Pt 6):864-866. PMID: 28638646. PMCID: PMC5458311.
• Han YS, Penthala NR, Oliveira M, [et al., including Crooks PA]. Identification of resveratrol analogs as potent anti-dengue agents using a cell-based assay. Journal of medical virology. 2017 89(3):397-407. PMID: 27509184.
• Albayati ZAF, Janganati V, Chen Z, [et al., including Crooks PA]. Identification of a melampomagnolide B analog as a potential lead molecule for treatment of acute myelogenous leukemia. Bioorganic & medicinal chemistry. 2017 25(3):1235-1241. PMID: 28049618. PMCID: PMC5291787.
• Nickell JR, Siripurapu KB, Horton DB, [et al., including Crooks PA]. GZ-793A inhibits the neurochemical effects of methamphetamine via a selective interaction with the vesicular monoamine transporter-2. European journal of pharmacology. 2017 795:143-149. PMID: 27986625. PMCID: PMC7050634.
• Penthala NR, Janganati V, Alpe TL, [et al., including Crooks PA]. N-[11CH3]Dimethylaminoparthenolide (DMAPT) uptake into orthotopic 9LSF glioblastoma tumors in the rat. Bioorganic & medicinal chemistry letters. 2016 26(24):5883-5886. PMID: 27866815. PMCID: PMC5154296.
• Pei S, Minhajuddin M, D'Alessandro A, [et al., including Crooks PA]. Rational design of a parthenolide-based drug regimen that selectively eradicates acute myelogenous leukemia stem cells. The Journal of biological chemistry. 2016 291(48):25280. PMID: 27888238. PMCID: PMC5122795.
• Smith CA, Mont S, Traver G, [et al., including Crooks PA]. Targeting Enox1 in tumor stroma increases the efficacy of fractionated radiotherapy. Oncotarget. 2016 7(47):77926-77936. PMID: 27788492. PMCID: PMC5363632.
• Yadlapalli JSK, Ford BM, Ketkar A, [et al., including Crooks PA]. Antinociceptive effects of the 6-O-sulfate ester of morphine in normal and diabetic rats: Comparative role of mu- and delta-opioid receptors. Pharmacological research. 2016 113(Pt A):335-347. PMID: 27637375. PMCID: PMC5107169.
• Pei S, Minhajuddin M, D'Alessandro A, [et al., including Crooks PA]. Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells. The Journal of biological chemistry. 2016 291(42):21984-22000. PMID: 27573247. PMCID: PMC5063982.
• Laxmi SV, Anil P, Rajitha G, [et al., including Crooks PA]. Synthesis of thiazolidine-2,4-dione derivatives: anticancer, antimicrobial and DNA cleavage studies. Journal of chemical biology. 2016 9(4):97-106. PMID: 27698947. PMCID: PMC5026645.
• Nickell JR, Culver JP, Janganati V, [et al., including Crooks PA]. Synthesis and in vitro evaluation of water-soluble 1,4-diphenethylpiperazine analogs as novel inhibitors of the vesicular monoamine transporter-2. Bioorganic & medicinal chemistry letters. 2016 26(18):4441-4445. PMID: 27524311. PMCID: PMC5002989.
• Sau A, Lau R, Cabrita MA, [et al., including Crooks PA]. Persistent Activation of NF-?B in BRCA1-Deficient Mammary Progenitors Drives Aberrant Proliferation and Accumulation of DNA Damage. Cell stem cell. 2016 19(1):52-65. PMID: 27292187. PMCID: PMC6850408.
• Liu X, Gujarathi S, Zhang X, [et al., including Crooks PA]. Synthesis of (2R,8' S,3' E)-?-tocodienol, a tocoflexol family member designed to have a superior pharmacokinetic profile compared to ?-tocotrienol. Tetrahedron. 2016 72(27-28):4001-4006. PMID: 27773949. PMCID: PMC5070675.
• Zong H, Sen S, Zhang G, [et al., including Crooks PA]. In vivo targeting of leukemia stem cells by directing parthenolide-loaded nanoparticles to the bone marrow niche. Leukemia. 2016 30(7):1582-6. PMID: 26669973. PMCID: PMC4911325.
• Nickell JR, Culver JP, Janganati V, [et al., including Crooks PA]. 1,4-Diphenalkylpiperidines: A new scaffold for the design of potent inhibitors of the vesicular monoamine transporter-2. Bioorganic & medicinal chemistry letters. 2016 26(13):2997-3000. PMID: 27212067. PMCID: PMC4946565.