Charles M Quick, MD

Research Program: Cancer Therapeutics Faculty Rank: Associate Professor Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Pathology

Cancer Research Interest

• Research Interest Statement: I am a surgical pathologist that specializes in gynecologic and perinatal surgical pathology. My research focuses on precancerous lesions and tumor microenvironment of the gynecologic tract.

Contact Information

• Email Address: QUICKCHARLESM@UAMS.EDU
• Profiles Research Networking Software: View Profile

Active Grants

• NIH/Nat. Cancer Institute – 2R01CA143130
  “Understanding and Enhancing T-Cell Responses to High Risk Human Papillomaviruses-Renewal”
  Co-Investigator
  07/01/21 – 06/30/26

Publications

• Alhallak I, Quick CM, Graham GL, Simmen RCM. A Pilot Study on the Co-existence of Diabetes and Endometriosis in Reproductive-Age Women: Potential for Endometriosis Progression. Reproductive sciences (Thousand Oaks, Calif.). 2023. PMID: 36788175.
• Lennerz JK, Pantanowitz L, Amin MB, [et al., including Quick CM]. Ensuring remote diagnostics for pathologists: an open letter to the US Congress. Nature medicine. 2022 28(12):2453-2455. PMID: 36266514.
• Hamza MA, Quick CM, Williams HR, [et al.]. HPV-associated Vulvar Intraepithelial Carcinoma With Sebaceous Differentiation: Report of 2 Cases. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 2022. PMID: 36383010.
• Paidi SK, Troncoso JR, Raj P, [et al., including Quick CM]. Raman spectroscopy and machine learning reveals early tumor microenvironmental changes induced by immunotherapy. Cancer research. 2021. PMID: 34645610. PMCID: PMC8841097.
• Racher ML, Morris M, Scott AP, [et al., including Quick CM]. Placental location site and adverse antepartum pregnancy complications: a meta-analysis and review of the literature. Archives of gynecology and obstetrics. 2021. PMID: 34590170.
• Mercier AM, Zorn KK, Quick CM, Huffman LB. Recurrent gynandroblastoma of the ovary with germline DICER1 mutation: A case report and review of the literature. Gynecologic oncology reports. 2021 37:100806. PMID: 34169133. PMCID: PMC8207187.
• Troncoso JR, Diaz PM, Lee DE, [et al., including Quick CM]. Longitudinal monitoring of tumor response to immune checkpoint inhibitors using noninvasive diffuse reflectance spectroscopy. Biomedical optics express. 2021 12(7):3982-3991. PMID: 34457393. PMCID: PMC8367250.
• Choi J, Manzano A, Dong W, [et al., including Quick CM]. Integrated mutational landscape analysis of uterine leiomyosarcomas. Proceedings of the National Academy of Sciences of the United States of America. 2021 118(15). PMID: 33876771. PMCID: PMC8053980.
• Shibata T, Shah S, Evans T, [et al., including Quick CM]. Expansion of Human Papillomavirus-Specific T Cells in Periphery and Cervix in a Therapeutic Vaccine Recipient Whose Cervical High-Grade Squamous Intraepithelial Lesion Regressed. Frontiers in immunology. 2021 12:645299. PMID: 34659195. PMCID: PMC8515132.
• Johnsrud AJ, Jenkins SV, Jamshidi-Parsian A, [et al., including Quick CM]. Evidence for Early Stage Anti-Tumor Immunity Elicited by Spatially Fractionated Radiotherapy-Immunotherapy Combinations. Radiation research. 2020 194(6):688-697. PMID: 33348372. PMCID: PMC8008989.
• Jeffus SK, Quick CM, Chen C, [et al.]. Prospective Consensus Reporting by Gynecologic Pathology and Dermatopathology Improves Diagnosis of Vulvar Biopsies. Archives of pathology & laboratory medicine. 2020 144(12). PMID: 33212498.
• Kutanzi KR, Ewing LE, Skinner CM, [et al., including Quick CM]. Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration. International journal of molecular sciences. 2020 21(20). PMID: 33096940. PMCID: PMC7656295.
• Wright MF, Fitzlaff S, Wyeth A, [et al., including Quick CM]. Nuclear Beta-Catenin Expression in Endometrioid Intraepithelial Neoplasia (Atypical Hyperplasia) Does Not Predict Carcinoma on Subsequent Hysterectomy. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 2020. PMID: 32897964.
• Sandlin AT, Magann EF, Ounpraseuth ST, [et al., including Quick CM]. A comparison of placental pathology between small for gestational age infants at < 5 % versus 5-9. European journal of obstetrics, gynecology, and reproductive biology. 2020 252:483-489. PMID: 32758859.
• Sangoi AR, Cox RM, Higgins JP, [et al., including Quick CM]. Non-Invasive Papillary Urothelial Carcinoma with "Micropapillary" Architecture: Clinicopathologic Study of 18 Patients Emphasizing Clinical Outcomes. Histopathology. 2020. PMID: 32443178.
• Miousse IR, Tobacyk J, Quick CM, [et al.]. Reply to Flugge: the anti-metastatic potential of methionine restriction in melanoma. Carcinogenesis. 2020 41(3):390-391. PMID: 31140558. PMCID: PMC7221500.
• Whittington JR, Cummings KF, Ounpraseuth ST, [et al., including Quick CM]. Placental changes in diabetic pregnancies and the contribution of hypertension. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2020:1-9. PMID: 32075455.
• Kolin DL, Quick CM, Dong F, [et al.]. SMARCA4-deficient Uterine Sarcoma and Undifferentiated Endometrial Carcinoma Are Distinct Clinicopathologic Entities. The American journal of surgical pathology. 2020 44(2):263-270. PMID: 31567195.
• Skinner CM, Nookaew I, Ewing LE, [et al., including Quick CM]. Potential Probiotic or Trigger of Gut Inflammation - The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract. Journal of dietary supplements. 2020 17(5):543-560. PMID: 32400224. PMCID: PMC7470626.
• Pabona JMP, Burnett AF, Brown DM, [et al., including Quick CM]. Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells. Reproductive sciences (Thousand Oaks, Calif.). 2020 27(1):267-277. PMID: 32046384. PMCID: PMC7077930.
• Whittington JR, Whitcombe DD, Eads LE, [et al., including Quick CM]. Signet Ring Cell Carcinoma with Lymphangitic Carcinomatosis in Pregnancy: A Case Report of an Unexpected Maternal Death and Review of the Literature. The American journal of case reports. 2019 20:1888-1891. PMID: 31844036. PMCID: PMC6930696.
• Jenkins SV, Robeson MS 2nd, Griffin RJ, [et al., including Quick CM]. Gastrointestinal Tract Dysbiosis Enhances Distal Tumor Progression through Suppression of Leukocyte Trafficking. Cancer research. 2019 79(23):5999-6009. PMID: 31591154. PMCID: PMC6891208.
• Ellis SK, Quick CM, Graham J. Faculty Peer Review as a Strategy to Assure Quality in a New Team-Based Learning Curriculum-a Single Institution Experience. Medical science educator. 2019 29(4):1089-1094. PMID: 34457587. PMCID: PMC8368823.
• Colpaert RM, Ramseyer AM, Luu T, [et al., including Quick CM]. Diagnosis and Management of Placental Mesenchymal Disease. A Review of the Literature. Obstetrical & gynecological survey. 2019 74(10):611-622. PMID: 31670834.
• Simmen RCM, Brown DM, Quick CM, [et al.]. Co-morbidity of type 1 diabetes and endometriosis: bringing a new paradigm into focus. The Journal of endocrinology. 2019. PMID: 31472479.
• Ewing LE, McGill MR, Yee EU, [et al., including Quick CM]. Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration. Molecules (Basel, Switzerland). 2019 24(12). PMID: 31212965. PMCID: PMC6630875.
• Mallinger WD, Quick CM. Benign and Premalignant Lesions of the Endometrium. Surgical pathology clinics. 2019 12(2):315-328. PMID: 31097106.
• Ewing LE, Skinner CM, Quick CM, [et al.]. Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model. Molecules (Basel, Switzerland). 2019 24(9). PMID: 31052254. PMCID: PMC6539990.
• Paidi SK, Diaz PM, Dadgar S, [et al., including Quick CM]. Label-Free Raman Spectroscopy Reveals Signatures of Radiation Resistance in the Tumor Microenvironment. Cancer research. 2019 79(8):2054-2064. PMID: 30819665. PMCID: PMC6467810.
• Baniak N, Fadare O, Köbel M, [et al., including Quick CM]. Targeted Molecular and Immunohistochemical Analyses of Endometrial Clear Cell Carcinoma Show that POLE Mutations and DNA Mismatch Repair Protein Deficiencies Are Uncommon. The American journal of surgical pathology. 2019 43(4):531-537. PMID: 30585826.
• Singh N, Hirschowitz L, Zaino R, [et al., including Quick CM]. Pathologic Prognostic Factors in Endometrial Carcinoma (Other Than Tumor Type and Grade). International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 2019 38 Suppl 1:S93-S113. PMID: 30550486. PMCID: PMC6296841.
• Malpica A, Euscher ED, Hecht JL, [et al., including Quick CM]. Endometrial Carcinoma, Grossing and Processing Issues: Recommendations of the International Society of Gynecologic Pathologists. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 2019 38 Suppl 1:S9-S24. PMID: 30550481. PMCID: PMC6296844.
• Post GR, Yuan Y, Holthoff ER, [et al., including Quick CM]. Identification of a novel monocytic phenotype in Classic Hodgkin Lymphoma tumor microenvironment. PloS one. 2019 14(11):e0224621. PMID: 31714922. PMCID: PMC6850552.
• Fadare O, Desouki MM, Gwin K, [et al., including Quick CM]. Clear Cell Renal Cell Carcinoma Metastatic to the Gynecologic Tract: A Clinicopathologic Analysis of 17 Cases. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 2018 37(6):525-535. PMID: 29140878.
• Miousse IR, Tobacyk J, Quick CM, [et al.]. Modulation of dietary methionine intake elicits potent, yet distinct, anticancer effects on primary versus metastatic tumors. Carcinogenesis. 2018 39(9):1117-1126. PMID: 29939201. PMCID: PMC6148987.
• Brown DM, Lee HC, Liu S, [et al., including Quick CM]. Notch-1 Signaling Activation and Progesterone Receptor Expression in Ectopic Lesions of Women With Endometriosis. Journal of the Endocrine Society. 2018 2(7):765-778. PMID: 30151432. PMCID: PMC6106104.
• Herfs M, Roncarati P, Koopmansch B, [et al., including Quick C]. A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine. British journal of cancer. 2018 118(10):1302-1312. PMID: 29700411. PMCID: PMC5959925.
• Pinto A, Kahn RM, Rosenberg AE, [et al., including Quick C]. Uterine rhabdomyosarcoma in adults. Human pathology. 2018 74:122-128. PMID: 29320751.
• Mirkovic J, McFarland M, Garcia E, [et al., including Quick C]. Targeted Genomic Profiling Reveals Recurrent KRAS Mutations in Mesonephric-like Adenocarcinomas of the Female Genital Tract. The American journal of surgical pathology. 2018 42(2):227-233. PMID: 28984674.
• Fadare O, Roma AA, Desouki MM, [et al., including Quick C]. The significance of L1CAM expression in clear cell carcinoma of the endometrium. Histopathology. 2018 72(3):532-538. PMID: 28941294.
• Jeffreys M, Jeffus SK, Herfs M, Quick C. Accentuated p53 staining in usual type vulvar dysplasia-A potential diagnostic pitfall. Pathology, research and practice. 2018 214(1):76-79. PMID: 29254796.
• Koonce NA, Juratli MA, Cai C, [et al., including Quick C]. Real-time monitoring of circulating tumor cell (CTC) release after nanodrug or tumor radiotherapy using in vivo flow cytometry. Biochemical and biophysical research communications. 2017 492(3):507-512. PMID: 28822765. PMCID: PMC5743220.
• Sangoi AR, Kshirsagar M, Roma AA, [et al., including Quick C]. Interobserver Reproducibility Among Gynecologic Pathologists in Diagnosing Heterologous Osteosarcomatous Component in Gynecologic Tract Carcinosarcomas. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 2017 36(4):386-392. PMID: 28221217.
• Herfs M, Longuespée R, Quick CM, [et al.]. Proteomic signatures reveal a dualistic and clinically relevant classification of anal canal carcinoma. The Journal of pathology. 2017 241(4):522-533. PMID: 27976366.
• Holthoff ER, Byrum SD, Mackintosh SG, [et al., including Quick CM]. Vulvar squamous cell carcinoma aggressiveness is associated with differential expression of collagen and STAT1. Clinical proteomics. 2017 14:40. PMID: 29225558. PMCID: PMC5717999.
• Zhao S, Bellone S, Lopez S, [et al., including Quick CM]. Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial-mesenchymal transition. Proceedings of the National Academy of Sciences of the United States of America. 2016 113(43):12238-12243. PMID: 27791010. PMCID: PMC5087050.
• Holthoff ER, Spencer H, Kelly T, [et al., including Quick CM]. Pathologic features of aggressive vulvar carcinoma are associated with epithelial-mesenchymal transition. Human pathology. 2016 56:22-30. PMID: 27327194. PMCID: PMC5021565.
• Levy RA, Kumarapeli AR, Spencer HJ, Quick CM. Cervical polyps: Is histologic evaluation necessary?. Pathology, research and practice. 2016 212(9):800-3. PMID: 27465834.
• Parra-Herran C, Taljaard M, Djordjevic B, [et al., including Quick CM]. Pattern-based classification of invasive endocervical adenocarcinoma, depth of invasion measurement and distinction from adenocarcinoma in situ: interobserver variation among gynecologic pathologists. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2016 29(8):879-92. PMID: 27174588.