Samuel G Mackintosh, PhD

Research Program: Cancer Biology Faculty Rank: Professor Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Biochem & Molecular Histone Epigenet

Cancer Research Interest

• Disease Site Focus: No Specific Disease Site
• Research Focus Area: Detection
• Type of Research: Basic
• Research Interest Statement: My research interests focus on proteomics and mass spectrometry. I oversee the day-to-day operations of the IDeA National Resource for Quantitative Proteomics (UAMS/WPRCI Proteomics Shared Resource), which serves a nationwide user base and comprehensively supports proteomics research at UAMS and within the Cancer Institute.

Contact Information

• Email Address: MACKINTOSHSAMUELG@UAMS.EDU
• Profiles Research Networking Software: View Profile

Active Grants

• NIH/Nat. Inst. of General Medical Sciences – 2R24GM137786
  “Renewal IDeA National Resource for Quantitative Proteomics”
  Co-Investigator
  9/1/2025 – 7/31/2030

Recent Publications

• Silasi R, Keshari RS, Abe T, [et al., including Mackintosh SG]. Protective effects of factor XI inhibition by abelacimab in a baboon model of live Staphylococcus aureus sepsis. Journal of thrombosis and haemostasis : JTH. 2025 23(10):3370-3385. PMID: 40582699.
• Upreti M, Petrosyan A, Thornton ME, [et al., including Mackintosh SG]. Multicellular tumor-stromal interactions recapitulate aspects of therapeutic response and human oncogenic signaling in a 3D disease model for H3K27M-altered DIPG. Oncogene. 2025 44(39):3694-3712. PMID: 40914769.
• Li D, Zhang ZM, Mei L, [et al., including Mackintosh SG]. BAHCC1 binds H4K20me1 to facilitate the MCM complex loading and DNA replication. Nature communications. 2025 16(1):5502. PMID: 40592879.
• Hembruff S, Dekonenko A, Thyfault J, [et al., including Mackintosh SG]. BRCA1 influences whole-body metabolism in humanized mice. American journal of physiology. Endocrinology and metabolism. 2025. PMID: 40353614. PMCID: PMC12167638.
• Ahn JH, Guo Y, Lyons H, [et al., including Mackintosh SG]. The phenylalanine-and-glycine repeats of NUP98 oncofusions form condensates that selectively partition transcriptional coactivators. Molecular cell. 2025 85(4):708-725.e9. PMID: 39922194. PMCID: PMC12224276.
• Beenken KE, Campbell MJ, Byrum SD, [et al., including Mackintosh SG]. Staphylococcus aureus Proteins Implicated in the Reduced Virulence of sarA and sarA/agr Mutants in Osteomyelitis. Microorganisms. 2025 13(1). PMID: 39858949. PMCID: PMC11767506.
• Sharma A, Jun SR, Bhattarai D, [et al., including Mackintosh S]. Cold Storage Disrupts the Proteome and Phosphoproteome Landscape in Rat Kidney Transplants. Transplantation. 2024. PMID: 39716351.
• Bolin EH, Mourani PM, Byrum SD, [et al., including Mackintosh SG]. Quantitative plasma proteomic analysis in children after superior cavopulmonary anastomosis with pulmonary arteriovenous malformations. Pediatric research. 2024. PMID: 39134758.
• Daneshgar N, Lan R, Regnier M, [et al., including Mackintosh SG]. Klotho enhances diastolic function in aged hearts through Sirt1-mediated pathways. GeroScience. 2024. PMID: 38976132. PMCID: PMC11336011.
• Espejo-Serrano C, Aitken C, Tan BF, [et al., including Mackintosh SG]. Chromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses. Life science alliance. 2024 7(3). PMID: 38199845. PMCID: PMC10781586.
• Martinez Barrera S, Hatchell E, Byrum SD, [et al., including Mackintosh SG]. Quantitative analysis of septin Cdc10 & Cdc3-associated proteome during stress response in the fungal pathogen Cryptococcus neoformans. PloS one. 2024 19(12):e0313444. PMID: 39689097. PMCID: PMC11651612.
• Zhao S, Lu J, Pan B, [et al., including Mackintosh SG]. TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons. Nature. 2023 623(7987):633-642. PMID: 37938770. PMCID: PMC11000523.
• Hashimi M, Sebrell TA, Hedges JF, [et al., including Mackintosh SG]. Antiviral responses in a Jamaican fruit bat intestinal organoid model of SARS-CoV-2 infection. Nature communications. 2023 14(1):6882. PMID: 37898615. PMCID: PMC10613288.
• Garg S, Morehead LC, Bird JT, [et al., including Mackintosh SG]. Characterization of methionine dependence in melanoma cells. Molecular omics. 2023. PMID: 37782107. PMCID: PMC10903584.
• Todorova VK, Byrum SD, Mackintosh SG, [et al.]. Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells. International journal of molecular sciences. 2023 24(17). PMID: 37685904. PMCID: PMC10487651.
• Chen M, Li J, Zhang L, [et al., including Mackintosh SG]. CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins. Nucleic acids research. 2023 51(14):7288-7313. PMID: 37378433. PMCID: PMC10415139.
• Seman A, Chandra PK, Byrum SD, [et al., including Mackintosh SG]. Targeting mitochondria in the aged cerebral vasculature with SS-31, a proteomic study of brain microvessels. GeroScience. 2023. PMID: 37458933. PMCID: PMC10643806.
• Pei J, Xiao Y, Liu X, [et al., including Mackintosh SG]. Piperlongumine conjugates induce targeted protein degradation. Cell chemical biology. 2023. PMID: 36750097. PMCID: PMC10074544.
• Scieszka D, Byrum SD, Mackintosh SG, [et al.]. Subchronic Electronic Cigarette Exposures Have Overlapping Protein Biomarkers with Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis. American journal of respiratory cell and molecular biology. 2022 67(4):503-506. PMID: 36178855. PMCID: PMC9564931.
• Das BK, Wang L, Fujiwara T, [et al., including Mackintosh SG]. Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton. eLife. 2022 11. PMID: 35758636. PMCID: PMC9352353.
• Li D, Yu X, Kottur J, [et al., including Mackintosh SG]. Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic. Oncogene. 2022. PMID: 35525905. PMCID: PMC9189076.
• Vazquez JH, Kennon-McGill S, Byrum SD, [et al., including Mackintosh SG]. Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways. Toxicological sciences : an official journal of the Society of Toxicology. 2022. PMID: 35172013. PMCID: PMC9216044.
• Chau MJ, Quintero JE, Blalock E, [et al., including Mackintosh SG]. Transection injury differentially alters the proteome of the human sural nerve. PloS one. 2022 17(11):e0260998. PMID: 36417411. PMCID: PMC9683555.
• Rosa F, Zybailov BL, Glazko GV, [et al., including Mackintosh SG]. Milk Formula Diet Alters Bacterial and Host Protein Profile in Comparison to Human Milk Diet in Neonatal Piglet Model. Nutrients. 2021 13(11). PMID: 34835974. PMCID: PMC8618976.
• Delgado M, Washam CL, Urbaniak A, [et al., including Mackintosh SG]. Phosphoproteomics Provides Novel Insights into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle. ACS omega. 2021 6(38):24949-24959. PMID: 34604676. PMCID: PMC8482483.
• Waldrip ZJ, Burdine L, Harrison DK, [et al., including Mackintosh SG]. DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells. The Journal of biological chemistry. 2021:101209. PMID: 34562454. PMCID: PMC8551498.
• Xu C, Meng F, Park KS, [et al., including Mackintosh SG]. A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells. Cell chemical biology. 2021. PMID: 34469831. PMCID: PMC8882712.
• Ahn JH, Davis ES, Daugird TA, [et al., including Mackintosh SG]. Phase separation drives aberrant chromatin looping and cancer development. Nature. 2021. PMID: 34163069. PMCID: PMC8647409.
• Wang Y, Zhou J, Mackintosh SG, Du Y. RuvB-Like Protein 2 Interacts with the NS1 Protein of Influenza A Virus and Affects Apoptosis That Is Counterbalanced by Type I Interferons. Viruses. 2021 13(6). PMID: 34072766. PMCID: PMC8229658.
• Fan H, Guo Y, Tsai YH, [et al., including Mackintosh SG]. A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing. Nucleic acids research. 2021 49(8):4441-4455. PMID: 33823544. PMCID: PMC8096256.
• Schinke CD, Boerma M, Bird JT, [et al., including Mackintosh S]. PHF19 inhibition as a therapeutic target in multiple myeloma. Current research in translational medicine. 2021 69(3):103290. PMID: 33894670. PMCID: PMC8316274.
• Xu C, Tsai YH, Galbo PM, [et al., including Mackintosh SG]. Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer. Nucleic acids research. 2021. PMID: 33849067. PMCID: PMC8136773.
• Li J, Galbo PM Jr, Gong W, [et al., including Mackintosh SG]. ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism. Nature communications. 2021 12(1):1045. PMID: 33594072. PMCID: PMC7886901.
• Garcia M, Salazar R, Wilson T, [et al., including Mackintosh S]. Early Gestational Exposure to Inhaled Ozone Impairs Maternal Uterine Artery and Cardiac Function. Toxicological sciences : an official journal of the Society of Toxicology. 2020. PMID: 33146391. PMCID: PMC8453811.