Samuel G Mackintosh, PhD

Associate Member

Research Program:

Cancer Biology

Faculty Rank:

Assistant Professor

Campus:

University of Arkansas for Medical Sciences

College:

College of Medicine

Department:

Biochemistry & Molecular Biology

Cancer Research Interest

Disease Site Focus: No Specific Disease Site
Research Focus Area: Detection
Type of Research: Basic
Research Interest Statement: My research interests focus on proteomics and mass spectrometry. I oversee the day-to-day operations of the IDeA National Resource for Quantitative Proteomics (UAMS/WPRCI Proteomics Shared Resource), which serves a nationwide user base and comprehensively supports proteomics research at UAMS and within the Cancer Institute.

Contact Information

Email Address: MACKINTOSHSAMUELG@UAMS.EDU
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Publications

Garg S, Morehead LC, Bird JT, [et al., including Mackintosh SG]. Characterization of methionine dependence in melanoma cells. bioRxiv : the preprint server for biology. 2023. PMID: 37066392. PMCID: PMC10104025.
Pei J, Xiao Y, Liu X, [et al., including Mackintosh SG]. Piperlongumine conjugates induce targeted protein degradation. Cell chemical biology. 2023. PMID: 36750097. PMCID: PMC10074544.
Hashimi M, Sebrell T, Hedges J, [et al., including Mackintosh SG]. Antiviral response mechanisms in a Jamaican Fruit Bat intestinal organoid model of SARS-CoV-2 infection. Research square. 2022. PMID: 36561186. PMCID: PMC9774215.
Scieszka D, Byrum SD, Mackintosh SG, [et al.]. Subchronic Electronic Cigarette Exposures Have Overlapping Protein Biomarkers with Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis. American journal of respiratory cell and molecular biology. 2022 67(4):503-506. PMID: 36178855. PMCID: PMC9564931.
Das BK, Wang L, Fujiwara T, [et al., including Mackintosh SG]. Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton. eLife. 2022 11. PMID: 35758636. PMCID: PMC9352353.
Li D, Yu X, Kottur J, [et al., including Mackintosh SG]. Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic. Oncogene. 2022. PMID: 35525905. PMCID: PMC9189076.
Vazquez JH, Kennon-McGill S, Byrum SD, [et al., including Mackintosh SG]. Proteomics Indicates Lactate Dehydrogenase is Prognostic in Acetaminophen-induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways. Toxicological sciences : an official journal of the Society of Toxicology. 2022. PMID: 35172013. PMCID: PMC9216044.
Chau MJ, Quintero JE, Blalock E, [et al., including Mackintosh SG]. Transection injury differentially alters the proteome of the human sural nerve. PloS one. 2022 17(11):e0260998. PMID: 36417411. PMCID: PMC9683555.
Rosa F, Zybailov BL, Glazko GV, [et al., including Mackintosh SG]. Milk Formula Diet Alters Bacterial and Host Protein Profile in Comparison to Human Milk Diet in Neonatal Piglet Model. Nutrients. 2021 13(11). PMID: 34835974. PMCID: PMC8618976.
Delgado M, Washam CL, Urbaniak A, [et al., including Mackintosh SG]. Phosphoproteomics Provides Novel Insights into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle. ACS omega. 2021 6(38):24949-24959. PMID: 34604676. PMCID: PMC8482483.
Waldrip ZJ, Burdine L, Harrison DK, [et al., including Mackintosh SG]. DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells. The Journal of biological chemistry. 2021:101209. PMID: 34562454. PMCID: PMC8551498.
Xu C, Meng F, Park KS, [et al., including Mackintosh SG]. A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells. Cell chemical biology. 2021. PMID: 34469831. PMCID: PMC8882712.
Ahn JH, Davis ES, Daugird TA, [et al., including Mackintosh SG]. Phase separation drives aberrant chromatin looping and cancer development. Nature. 2021. PMID: 34163069. PMCID: PMC8647409.
Wang Y, Zhou J, Mackintosh SG, Du Y. RuvB-Like Protein 2 Interacts with the NS1 Protein of Influenza A Virus and Affects Apoptosis That Is Counterbalanced by Type I Interferons. Viruses. 2021 13(6). PMID: 34072766. PMCID: PMC8229658.
Fan H, Guo Y, Tsai YH, [et al., including Mackintosh SG]. A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing. Nucleic acids research. 2021 49(8):4441-4455. PMID: 33823544. PMCID: PMC8096256.
Schinke CD, Boerma M, Bird JT, [et al., including Mackintosh S]. PHF19 inhibition as a therapeutic target in multiple myeloma. Current research in translational medicine. 2021 69(3):103290. PMID: 33894670. PMCID: PMC8316274.
Xu C, Tsai YH, Galbo PM, [et al., including Mackintosh SG]. Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer. Nucleic acids research. 2021. PMID: 33849067. PMCID: PMC8136773.
Li J, Galbo PM Jr, Gong W, [et al., including Mackintosh SG]. ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism. Nature communications. 2021 12(1):1045. PMID: 33594072. PMCID: PMC7886901.
Garcia M, Salazar R, Wilson T, [et al., including Mackintosh S]. Early Gestational Exposure to Inhaled Ozone Impairs Maternal Uterine Artery and Cardiac Function. Toxicological sciences : an official journal of the Society of Toxicology. 2020. PMID: 33146391. PMCID: PMC8453811.
Koss B, Boerma M, Shields BD, [et al., including Mackintosh SG]. Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion. Cancer research. 2020. PMID: 33004350. PMCID: PMC7642172.
Karaduta O, Glazko G, Dvanajscak Z, [et al., including Mackintosh S]. Resistant starch slows the progression of CKD in the 5/6 nephrectomy mouse model. Physiological reports. 2020 8(19):e14610. PMID: 33038060. PMCID: PMC7547583.
Storey AJ, Naceanceno KS, Lan RS, [et al., including Mackintosh SG]. ProteoViz: a tool for the analysis and interactive visualization of phosphoproteomics data. Molecular omics. 2020. PMID: 32347222. PMCID: PMC7423749.
Dimori M, Heard-Lipsmeyer ME, Byrum SD, [et al., including Mackintosh SG]. Respiratory defects in the CrtapKO mouse model of osteogenesis imperfecta. American journal of physiology. Lung cellular and molecular physiology. 2020 318(4):L592-L605. PMID: 32022592. PMCID: PMC7191481.
Chua XY, Mensah T, Aballo T, [et al., including Mackintosh SG]. Tandem Mass Tag Approach Utilizing Pervanadate BOOST Channels Delivers Deeper Quantitative Characterization of the Tyrosine Phosphoproteome. Molecular & cellular proteomics : MCP. 2020 19(4):730-743. PMID: 32071147. PMCID: PMC7124467.
Storey AJ, Hardman RE, Byrum SD, [et al., including Mackintosh SG]. Accurate and Sensitive Quantitation of the Dynamic Heat Shock Proteome Using Tandem Mass Tags. Journal of proteome research. 2020 19(3):1183-1195. PMID: 32027144. PMCID: PMC7241437.
Ramirez AM, Byrum SD, Beenken KE, [et al., including Mackintosh SG]. Exploiting Correlations between Protein Abundance and the Functional Status of saeRS and sarA To Identify Virulence Factors of Potential Importance in the Pathogenesis of Staphylococcus aureus Osteomyelitis. ACS infectious diseases. 2020 6(2):237-249. PMID: 31722523. PMCID: PMC7294808.
Vazquez JH, Clemens MM, Allard FD, [et al., including Mackintosh SG]. Identification of Serum Biomarkers to Distinguish Hazardous and Benign Aminotransferase Elevations. Toxicological sciences : an official journal of the Society of Toxicology. 2020 173(2):244-254. PMID: 31651977. PMCID: PMC8445655.
Martinez Barrera S, Byrum S, Mackintosh SG, Kozubowski L. Registered report protocol: Quantitative analysis of septin Cdc10-associated proteome in Cryptococcus neoformans. PloS one. 2020 15(12):e0242381. PMID: 33315917. PMCID: PMC7735571.
Ren Z, Ahn JH, Liu H, [et al., including Mackintosh SG]. PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation. Blood. 2019 134(14):1176-1189. PMID: 31383640. PMCID: PMC6776795.
Cragle CE, MacNicol MC, Byrum SD, [et al., including Mackintosh SG]. Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation. The Journal of biological chemistry. 2019 294(28):10969-10986. PMID: 31152063. PMCID: PMC6635449.
Zhang L, Yao Y, Zhang S, [et al., including Mackintosh SG]. Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma. Science translational medicine. 2019 11(491). PMID: 31068440.
Gao J, Byrd AK, Zybailov BL, [et al., including Mackintosh SG]. DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA. Chemical communications (Cambridge, England). 2019 55(31):4467-4470. PMID: 30855040. PMCID: PMC6459694.
Garcia-Rill E, Tackett AJ, Byrum SD, [et al., including Mackintosh SG]. Local and Relayed Effects of Deep Brain Stimulation of the Pedunculopontine Nucleus. Brain sciences. 2019 9(3). PMID: 30889866. PMCID: PMC6468768.
Shields BD, Koss B, Taylor EM, [et al., including Mackintosh SG]. Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma. Cancer research. 2019 79(6):1113-1123. PMID: 30674537. PMCID: PMC6420873.
West KL, Byrum SD, Mackintosh SG, [et al.]. Proteomic characterization of the arsenic response locus in S. cerevisiae. Epigenetics. 2019 14(2):130-145. PMID: 30739529. PMCID: PMC6557609.
Zybailov BL, Glazko GV, Rahmatallah Y, [et al., including Mackintosh SG]. Metaproteomics reveals potential mechanisms by which dietary resistant starch supplementation attenuates chronic kidney disease progression in rats. PloS one. 2019 14(1):e0199274. PMID: 30699108. PMCID: PMC6353070.
Byrum SD, Loughran AJ, Beenken KE, [et al., including Mackintosh SG]. Label-Free Proteomic Approach to Characterize Protease-Dependent and -Independent Effects of sarA Inactivation on the Staphylococcus aureus Exoproteome. Journal of proteome research. 2018 17(10):3384-3395. PMID: 30209945. PMCID: PMC6209314.
Zhang X, Zhang S, Liu X, [et al., including Mackintosh SG]. Oxidation resistance 1 is a novel senolytic target. Aging cell. 2018 17(4):e12780. PMID: 29766639. PMCID: PMC6052462.
Abdallah AO, Coleman H, Kamel M, [et al., including Mackintosh S]. A novel prostate cancer immunotherapy using prostate-specific antigen peptides and Candida skin test reagent as an adjuvant. SAGE open medicine. 2018 6:2050312118800202. PMID: 30245818. PMCID: PMC6144584.
Shields BD, Mahmoud F, Taylor EM, [et al., including Mackintosh SG]. Indicators of responsiveness to immune checkpoint inhibitors. Scientific reports. 2017 7(1):807. PMID: 28400597. PMCID: PMC5429745.
Hartman JH, Miller GP, Caro AA, [et al., including Mackintosh SG]. 1,3-Butadiene-induced mitochondrial dysfunction is correlated with mitochondrial CYP2E1 activity in Collaborative Cross mice. Toxicology. 2017 378:114-124. PMID: 28082109. PMCID: PMC5319481.
Byrum SD, Burdine MS, Orr L, [et al., including Mackintosh SG]. Time- and radiation-dose dependent changes in the plasma proteome after total body irradiation of non-human primates: Implications for biomarker selection. PloS one. 2017 12(3):e0174771. PMID: 28350824. PMCID: PMC5370149.
Holthoff ER, Byrum SD, Mackintosh SG, [et al.]. Vulvar squamous cell carcinoma aggressiveness is associated with differential expression of collagen and STAT1. Clinical proteomics. 2017 14:40. PMID: 29225558. PMCID: PMC5717999.
Ayyadevara S, Balasubramaniam M, Suri P, [et al., including Mackintosh SG]. Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans. Aging. 2016 8(12):3486-3497. PMID: 27992858. PMCID: PMC5270681.
Chu R, Alford SE, Hart K, [et al., including Mackintosh SG]. Mitotic arrest-induced phosphorylation of Mcl-1 revisited using two-dimensional gel electrophoresis and phosphoproteomics: nine phosphorylation sites identified. Oncotarget. 2016 7(48):78958-78970. PMID: 27738316. PMCID: PMC5346690.
Blair LP, Liu Z, Labitigan RL, [et al., including Mackintosh SG]. KDM5 lysine demethylases are involved in maintenance of 3'UTR length. Science advances. 2016 2(11):e1501662. PMID: 28138513. PMCID: PMC5262454.
Fujiwara T, Ye S, Castro-Gomes T, [et al., including Mackintosh SG]. PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis. JCI insight. 2016 1(17):e86330. PMID: 27777970. PMCID: PMC5070964.
Ayyadevara S, Balasubramaniam M, Parcon PA, [et al., including Mackintosh SG]. Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls. Aging cell. 2016 15(5):924-39. PMID: 27448508. PMCID: PMC5013017.
Byrd AK, Zybailov BL, Maddukuri L, [et al., including Mackintosh SG]. Evidence That G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress. The Journal of biological chemistry. 2016 291(34):18041-57. PMID: 27369081. PMCID: PMC5016190.
Ayyadevara S, Balasubramaniam M, Johnson J, [et al., including Mackintosh SG]. PIP3-binding proteins promote age-dependent protein aggregation and limit survival in C. elegans. Oncotarget. 2016 7(31):48870-48886. PMID: 27429199. PMCID: PMC5226477.