Samuel G Mackintosh, PhD

Research Program: Cancer Biology Faculty Rank: Professor Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Biochem & Molecular Histone Epigenet

Cancer Research Interest

• Disease Site Focus: No Specific Disease Site
• Research Focus Area: Detection
• Type of Research: Basic
• Research Interest Statement: My research interests focus on proteomics and mass spectrometry. I oversee the day-to-day operations of the IDeA National Resource for Quantitative Proteomics (UAMS/WPRCI Proteomics Shared Resource), which serves a nationwide user base and comprehensively supports proteomics research at UAMS and within the Cancer Institute.

Contact Information

• Email Address: MACKINTOSHSAMUELG@UAMS.EDU
• Profiles Research Networking Software: View Profile

Recent Publications

• Ahn JH, Guo Y, Lyons H, [et al., including Mackintosh SG]. The phenylalanine-and-glycine repeats of NUP98 oncofusions form condensates that selectively partition transcriptional coactivators. Molecular cell. 2025 85(4):708-725.e9. PMID: 39922194.
• Beenken KE, Campbell MJ, Byrum SD, [et al., including Mackintosh SG]. Staphylococcus aureus Proteins Implicated in the Reduced Virulence of sarA and sarA/agr Mutants in Osteomyelitis. Microorganisms. 2025 13(1). PMID: 39858949. PMCID: PMC11767506.
• Sharma A, Jun SR, Bhattarai D, [et al., including Mackintosh S]. Cold Storage Disrupts the Proteome and Phosphoproteome Landscape in Rat Kidney Transplants. Transplantation. 2024. PMID: 39716351.
• Zhao S, Lu J, Pan B, [et al., including Mackintosh SG]. TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons. Nature. 2023 623(7987):633-642. PMID: 37938770. PMCID: PMC11000523.
• Garg S, Morehead LC, Bird JT, [et al., including Mackintosh SG]. Characterization of methionine dependence in melanoma cells. Molecular omics. 2023. PMID: 37782107. PMCID: PMC10903584.
• Todorova VK, Byrum SD, Mackintosh SG, [et al.]. Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells. International journal of molecular sciences. 2023 24(17). PMID: 37685904. PMCID: PMC10487651.
• Chen M, Li J, Zhang L, [et al., including Mackintosh SG]. CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins. Nucleic acids research. 2023 51(14):7288-7313. PMID: 37378433. PMCID: PMC10415139.
• Seman A, Chandra PK, Byrum SD, [et al., including Mackintosh SG]. Targeting mitochondria in the aged cerebral vasculature with SS-31, a proteomic study of brain microvessels. GeroScience. 2023. PMID: 37458933. PMCID: PMC10643806.
• Pei J, Xiao Y, Liu X, [et al., including Mackintosh SG]. Piperlongumine conjugates induce targeted protein degradation. Cell chemical biology. 2023. PMID: 36750097. PMCID: PMC10074544.
• Scieszka D, Byrum SD, Mackintosh SG, [et al.]. Subchronic Electronic Cigarette Exposures Have Overlapping Protein Biomarkers with Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis. American journal of respiratory cell and molecular biology. 2022 67(4):503-506. PMID: 36178855. PMCID: PMC9564931.
• Das BK, Wang L, Fujiwara T, [et al., including Mackintosh SG]. Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton. eLife. 2022 11. PMID: 35758636. PMCID: PMC9352353.
• Li D, Yu X, Kottur J, [et al., including Mackintosh SG]. Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic. Oncogene. 2022. PMID: 35525905. PMCID: PMC9189076.
• Vazquez JH, Kennon-McGill S, Byrum SD, [et al., including Mackintosh SG]. Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways. Toxicological sciences : an official journal of the Society of Toxicology. 2022. PMID: 35172013. PMCID: PMC9216044.
• Chau MJ, Quintero JE, Blalock E, [et al., including Mackintosh SG]. Transection injury differentially alters the proteome of the human sural nerve. PloS one. 2022 17(11):e0260998. PMID: 36417411. PMCID: PMC9683555.
• Rosa F, Zybailov BL, Glazko GV, [et al., including Mackintosh SG]. Milk Formula Diet Alters Bacterial and Host Protein Profile in Comparison to Human Milk Diet in Neonatal Piglet Model. Nutrients. 2021 13(11). PMID: 34835974. PMCID: PMC8618976.
• Delgado M, Washam CL, Urbaniak A, [et al., including Mackintosh SG]. Phosphoproteomics Provides Novel Insights into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle. ACS omega. 2021 6(38):24949-24959. PMID: 34604676. PMCID: PMC8482483.
• Waldrip ZJ, Burdine L, Harrison DK, [et al., including Mackintosh SG]. DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells. The Journal of biological chemistry. 2021:101209. PMID: 34562454. PMCID: PMC8551498.
• Xu C, Meng F, Park KS, [et al., including Mackintosh SG]. A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells. Cell chemical biology. 2021. PMID: 34469831. PMCID: PMC8882712.
• Ahn JH, Davis ES, Daugird TA, [et al., including Mackintosh SG]. Phase separation drives aberrant chromatin looping and cancer development. Nature. 2021. PMID: 34163069. PMCID: PMC8647409.
• Wang Y, Zhou J, Mackintosh SG, Du Y. RuvB-Like Protein 2 Interacts with the NS1 Protein of Influenza A Virus and Affects Apoptosis That Is Counterbalanced by Type I Interferons. Viruses. 2021 13(6). PMID: 34072766. PMCID: PMC8229658.
• Fan H, Guo Y, Tsai YH, [et al., including Mackintosh SG]. A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing. Nucleic acids research. 2021 49(8):4441-4455. PMID: 33823544. PMCID: PMC8096256.
• Schinke CD, Boerma M, Bird JT, [et al., including Mackintosh S]. PHF19 inhibition as a therapeutic target in multiple myeloma. Current research in translational medicine. 2021 69(3):103290. PMID: 33894670. PMCID: PMC8316274.
• Xu C, Tsai YH, Galbo PM, [et al., including Mackintosh SG]. Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer. Nucleic acids research. 2021. PMID: 33849067. PMCID: PMC8136773.
• Li J, Galbo PM Jr, Gong W, [et al., including Mackintosh SG]. ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism. Nature communications. 2021 12(1):1045. PMID: 33594072. PMCID: PMC7886901.
• Garcia M, Salazar R, Wilson T, [et al., including Mackintosh S]. Early Gestational Exposure to Inhaled Ozone Impairs Maternal Uterine Artery and Cardiac Function. Toxicological sciences : an official journal of the Society of Toxicology. 2020. PMID: 33146391. PMCID: PMC8453811.
• Koss B, Boerma M, Shields BD, [et al., including Mackintosh SG]. Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion. Cancer research. 2020. PMID: 33004350. PMCID: PMC7642172.
• Karaduta O, Glazko G, Dvanajscak Z, [et al., including Mackintosh S]. Resistant starch slows the progression of CKD in the 5/6 nephrectomy mouse model. Physiological reports. 2020 8(19):e14610. PMID: 33038060. PMCID: PMC7547583.