Samuel G Mackintosh, PhD

Research Program: Cancer Biology Faculty Rank: Assistant Professor Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Biochem & Molecular Histone Epigenet

Cancer Research Interest

• Disease Site Focus: No Specific Disease Site
• Research Focus Area: Detection
• Type of Research: Basic
• Research Interest Statement: My research interests focus on proteomics and mass spectrometry. I oversee the day-to-day operations of the IDeA National Resource for Quantitative Proteomics (UAMS/WPRCI Proteomics Shared Resource), which serves a nationwide user base and comprehensively supports proteomics research at UAMS and within the Cancer Institute.

Contact Information

• Email Address: MACKINTOSHSAMUELG@UAMS.EDU
• Profiles Research Networking Software: View Profile

Recent Publications

• Zhao S, Lu J, Pan B, [et al., including Mackintosh SG]. TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons. Nature. 2023 623(7987):633-642. PMID: 37938770. PMCID: PMC11000523.
• Garg S, Morehead LC, Bird JT, [et al., including Mackintosh SG]. Characterization of methionine dependence in melanoma cells. Molecular omics. 2023. PMID: 37782107. PMCID: PMC10903584.
• Todorova VK, Byrum SD, Mackintosh SG, [et al.]. Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells. International journal of molecular sciences. 2023 24(17). PMID: 37685904. PMCID: PMC10487651.
• Chen M, Li J, Zhang L, [et al., including Mackintosh SG]. CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins. Nucleic acids research. 2023 51(14):7288-7313. PMID: 37378433. PMCID: PMC10415139.
• Seman A, Chandra PK, Byrum SD, [et al., including Mackintosh SG]. Targeting mitochondria in the aged cerebral vasculature with SS-31, a proteomic study of brain microvessels. GeroScience. 2023. PMID: 37458933. PMCID: PMC10643806.
• Pei J, Xiao Y, Liu X, [et al., including Mackintosh SG]. Piperlongumine conjugates induce targeted protein degradation. Cell chemical biology. 2023. PMID: 36750097. PMCID: PMC10074544.
• Scieszka D, Byrum SD, Mackintosh SG, [et al.]. Subchronic Electronic Cigarette Exposures Have Overlapping Protein Biomarkers with Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis. American journal of respiratory cell and molecular biology. 2022 67(4):503-506. PMID: 36178855. PMCID: PMC9564931.
• Das BK, Wang L, Fujiwara T, [et al., including Mackintosh SG]. Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton. eLife. 2022 11. PMID: 35758636. PMCID: PMC9352353.
• Li D, Yu X, Kottur J, [et al., including Mackintosh SG]. Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic. Oncogene. 2022. PMID: 35525905. PMCID: PMC9189076.
• Vazquez JH, Kennon-McGill S, Byrum SD, [et al., including Mackintosh SG]. Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways. Toxicological sciences : an official journal of the Society of Toxicology. 2022. PMID: 35172013. PMCID: PMC9216044.
• Chau MJ, Quintero JE, Blalock E, [et al., including Mackintosh SG]. Transection injury differentially alters the proteome of the human sural nerve. PloS one. 2022 17(11):e0260998. PMID: 36417411. PMCID: PMC9683555.
• Rosa F, Zybailov BL, Glazko GV, [et al., including Mackintosh SG]. Milk Formula Diet Alters Bacterial and Host Protein Profile in Comparison to Human Milk Diet in Neonatal Piglet Model. Nutrients. 2021 13(11). PMID: 34835974. PMCID: PMC8618976.
• Delgado M, Washam CL, Urbaniak A, [et al., including Mackintosh SG]. Phosphoproteomics Provides Novel Insights into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle. ACS omega. 2021 6(38):24949-24959. PMID: 34604676. PMCID: PMC8482483.
• Waldrip ZJ, Burdine L, Harrison DK, [et al., including Mackintosh SG]. DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells. The Journal of biological chemistry. 2021:101209. PMID: 34562454. PMCID: PMC8551498.
• Xu C, Meng F, Park KS, [et al., including Mackintosh SG]. A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells. Cell chemical biology. 2021. PMID: 34469831. PMCID: PMC8882712.
• Ahn JH, Davis ES, Daugird TA, [et al., including Mackintosh SG]. Phase separation drives aberrant chromatin looping and cancer development. Nature. 2021. PMID: 34163069. PMCID: PMC8647409.
• Wang Y, Zhou J, Mackintosh SG, Du Y. RuvB-Like Protein 2 Interacts with the NS1 Protein of Influenza A Virus and Affects Apoptosis That Is Counterbalanced by Type I Interferons. Viruses. 2021 13(6). PMID: 34072766. PMCID: PMC8229658.
• Fan H, Guo Y, Tsai YH, [et al., including Mackintosh SG]. A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing. Nucleic acids research. 2021 49(8):4441-4455. PMID: 33823544. PMCID: PMC8096256.
• Schinke CD, Boerma M, Bird JT, [et al., including Mackintosh S]. PHF19 inhibition as a therapeutic target in multiple myeloma. Current research in translational medicine. 2021 69(3):103290. PMID: 33894670. PMCID: PMC8316274.
• Xu C, Tsai YH, Galbo PM, [et al., including Mackintosh SG]. Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer. Nucleic acids research. 2021. PMID: 33849067. PMCID: PMC8136773.
• Li J, Galbo PM Jr, Gong W, [et al., including Mackintosh SG]. ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism. Nature communications. 2021 12(1):1045. PMID: 33594072. PMCID: PMC7886901.
• Garcia M, Salazar R, Wilson T, [et al., including Mackintosh S]. Early Gestational Exposure to Inhaled Ozone Impairs Maternal Uterine Artery and Cardiac Function. Toxicological sciences : an official journal of the Society of Toxicology. 2020. PMID: 33146391. PMCID: PMC8453811.
• Koss B, Boerma M, Shields BD, [et al., including Mackintosh SG]. Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion. Cancer research. 2020. PMID: 33004350. PMCID: PMC7642172.
• Karaduta O, Glazko G, Dvanajscak Z, [et al., including Mackintosh S]. Resistant starch slows the progression of CKD in the 5/6 nephrectomy mouse model. Physiological reports. 2020 8(19):e14610. PMID: 33038060. PMCID: PMC7547583.
• Storey AJ, Naceanceno KS, Lan RS, [et al., including Mackintosh SG]. ProteoViz: a tool for the analysis and interactive visualization of phosphoproteomics data. Molecular omics. 2020. PMID: 32347222. PMCID: PMC7423749.
• Dimori M, Heard-Lipsmeyer ME, Byrum SD, [et al., including Mackintosh SG]. Respiratory defects in the CrtapKO mouse model of osteogenesis imperfecta. American journal of physiology. Lung cellular and molecular physiology. 2020 318(4):L592-L605. PMID: 32022592. PMCID: PMC7191481.
• Chua XY, Mensah T, Aballo T, [et al., including Mackintosh SG]. Tandem Mass Tag Approach Utilizing Pervanadate BOOST Channels Delivers Deeper Quantitative Characterization of the Tyrosine Phosphoproteome. Molecular & cellular proteomics : MCP. 2020 19(4):730-743. PMID: 32071147. PMCID: PMC7124467.
• Storey AJ, Hardman RE, Byrum SD, [et al., including Mackintosh SG]. Accurate and Sensitive Quantitation of the Dynamic Heat Shock Proteome Using Tandem Mass Tags. Journal of proteome research. 2020 19(3):1183-1195. PMID: 32027144. PMCID: PMC7241437.
• Ramirez AM, Byrum SD, Beenken KE, [et al., including Mackintosh SG]. Exploiting Correlations between Protein Abundance and the Functional Status of saeRS and sarA To Identify Virulence Factors of Potential Importance in the Pathogenesis of Staphylococcus aureus Osteomyelitis. ACS infectious diseases. 2020 6(2):237-249. PMID: 31722523. PMCID: PMC7294808.
• Vazquez JH, Clemens MM, Allard FD, [et al., including Mackintosh SG]. Identification of Serum Biomarkers to Distinguish Hazardous and Benign Aminotransferase Elevations. Toxicological sciences : an official journal of the Society of Toxicology. 2020 173(2):244-254. PMID: 31651977. PMCID: PMC8445655.
• Martinez Barrera S, Byrum S, Mackintosh SG, Kozubowski L. Registered report protocol: Quantitative analysis of septin Cdc10-associated proteome in Cryptococcus neoformans. PloS one. 2020 15(12):e0242381. PMID: 33315917. PMCID: PMC7735571.