Research Focus Area:
Treatment, Diagnosis/ Prognosis, Carcinogenesis
DNase, deoxyribonuclease, endonuclease, DNA fragmentation, cell death, apoptosis
Type of Research:
Research Interest Statement:
Every mammalian cell contains several endogenous DNases aimed to protect itself from foreign DNA. Same DNases fragment host DNA after cell injury, prior, during and after cell death. Normal cells have high total activity of DNases, which makes them vulnerable to any cytotoxic insults, including chemo- and radiotherapy. Cancer cells, instead, have low activity of DNases, which promotes their survival in a hostile environment. We develop therapies to increase activity of DNases in cancer cells, and inhibit those in normal cells, therefore changing the balance toward better therapeutic efficacy of anticancer agents.
NIH/Nat. Inst. of General Medical Sciences – 2P20GM109005
“Basnakian Subproject-CELLULAR AND MOLECULAR TOXICOLOGY CORE”
08/17/20 – 05/31/25
Garg S, Garg TK, Wise SY, [et al., including Basnakian AG]. Effects of Gamma-Tocotrienol on Intestinal Injury in a GI-Specific Acute Radiation Syndrome Model in Nonhuman Primate. International journal of molecular sciences. 2022 23(9). PMID: 35563033. PMCID: PMC9100017.
Chambers SA, Newman M, Frangie MM, [et al., including Basnakian AG]. Antimelanoma activities of chimeric thiazole-androstenone derivatives. Royal Society open science. 2021 8(8):210395. PMID: 34430045. PMCID: PMC8355692.
Hansa RK, Khan MMK, Frangie MM, [et al., including Basnakian AG]. 4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents. European journal of medicinal chemistry. 2021 219:113402. PMID: 33845234. PMCID: PMC8165011.
Basnakian AG, Moore CL. Apoptotic DNase network: Mutual induction and cooperation among apoptotic endonucleases. Journal of cellular and molecular medicine. 2021 25(14):6496-6499. PMID: 34085765. PMCID: PMC8278086.
Moore CL, Savenka AV, Basnakian AG. TUNEL Assay: A Powerful Tool for Kidney Injury Evaluation. International journal of molecular sciences. 2021 22(1). PMID: 33401733. PMCID: PMC7795088.
Fahmi T, Wang X, Zhdanov DD, [et al., including Basnakian AG]. DNase I Induces Other Endonucleases in Kidney Tubular Epithelial Cells by Its DNA-Degrading Activity. International journal of molecular sciences. 2020 21(22). PMID: 33212932. PMCID: PMC7698339.
Delancey E, Allison D, Kc HR, [et al., including Basnakian AG]. Synthesis of 4,4'-(4-Formyl-1H-pyrazole-1,3-diyl)dibenzoic Acid Derivatives as Narrow Spectrum Antibiotics for the Potential Treatment of Acinetobacter Baumannii Infections. Antibiotics (Basel, Switzerland). 2020 9(10). PMID: 32998384. PMCID: PMC7601628.
Sadhukhan R, Leung JWC, Garg S, [et al., including Basnakian AG]. Fractionated radiation suppresses Kruppel-like factor 2 pathway to a greater extent than by single exposure to the same total dose. Scientific reports. 2020 10(1):7734. PMID: 32382091. PMCID: PMC7206069.
Whitt J, Duke C, Sumlin A, [et al., including Basnakian AG]. Synthesis of Hydrazone Derivatives of 4-[4-Formyl-3-(2-oxochromen-3-yl)pyrazol-1-yl]benzoic acid as Potent Growth Inhibitors of Antibiotic-resistant Staphylococcus aureus and Acinetobacter baumannii. Molecules (Basel, Switzerland). 2019 24(11). PMID: 31146470. PMCID: PMC6600224.
Garg S, Boerma M, Sadhukhan R, [et al., including Basnakian AG]. Gamma-Tocotrienol Protects the Intestine from Radiation Potentially by Accelerating Mesenchymal Immune Cell Recovery. Antioxidants (Basel, Switzerland). 2019 8(3). PMID: 30845647. PMCID: PMC6466604.
Fahmi T, Branch D, Nima ZA, [et al., including Basnakian AG]. Mechanism of graphene-induced cytotoxicity: Role of endonucleases. Journal of applied toxicology : JAT. 2017 37(11):1325-1332. PMID: 28543094.
Nedosekin DA, Fahmi T, Nima ZA, [et al., including Basnakian A]. Photoacoustic in vitro flow cytometry for nanomaterial research. Photoacoustics. 2017 6:16-25. PMID: 28417068. PMCID: PMC5387917.
Fil D, DeLoach A, Yadav S, [et al., including Basnakian AG]. Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease. Human molecular genetics. 2017 26(4):686-701. PMID: 28040732. PMCID: PMC5968635.
Rogers LJ, Basnakian AG, Orloff MS, [et al.]. 2-amino-1-methyl-6-phenylimidazo(4,5-b) pyridine (PhIP) induces gene expression changes in JAK/STAT and MAPK pathways related to inflammation, diabetes and cancer. Nutrition & metabolism. 2016 13:54. PMID: 27547236. PMCID: PMC4992261.