Ahmed Ghareeb, BPharm, MSc, MS

Affiliate Member

Research Program:

Cancer Therapeutics

Faculty Rank:

Graduate Assistant

Campus:

University of Arkansas for Medical Sciences

Department:

Pharmacology & Toxicology

Cancer Research Interest

Disease Site Focus: Breast
Research Focus Area: Treatment
Type of Research: Translational
Research Keywords: Targeted protein degradation (TPD), PROTACs, molecular glues, AUTACs, SNIPERs, degron-based therapeutics, cancer pharmacology, drug discovery and development, medicinal chemistry, chemical biology, molecular pharmacology, protein homeostasis, ubiquitin–proteasome system, endoplasmic reticulum stress, GRP78 signaling, immunogenic cell death (ICD), necroptosis, triple-negative breast cancer (TNBC), small-molecule therapeutics, and translational cancer research.
Research Interest Statement: My research focuses on developing next-generation targeted protein degradation (TPD) platforms for cancer therapy by overcoming the limitations of current technologies, including PROTACs, AUTACs, SNIPERs, and molecular glues. By designing degraders that mimic endogenous protein degradation signals, I aim to establish novel strategies for the selective degradation of disease-associated proteins. My work combines medicinal chemistry, chemical biology, and molecular pharmacology to discover and optimize small-molecule therapeutics for cancer. My long-term research goal is to translate innovative protein degradation technologies into precision cancer therapeutics with improved efficacy and safety.