Jagadeesh Narasimhappagari, PhD

Affiliate Member

Research Program:

Cancer Biology

Faculty Rank:

Assistant Staff Scientist

Campus:

University of Arkansas for Medical Sciences

College:

College of Medicine

Department:

Geriatrics

Cancer Research Interest

Disease Site Focus: Brain, Breast, Melanoma
Research Focus Area: Prevention, Carcinogenesis, Treatment
Type of Research: Translational
Research Keywords: Neuroinflammation, Interleukin-1Beta, Glioblastoma, Neuroblastoma, Breast cancer
Research Interest Statement: IL-1β is produced and secreted by various cell types, such as immune cells, fibroblasts, or cancer cells. IL-1β and its downstream signaling has been reported to facilitate cancer metastasis in various types of cancers including Breast, liver, colon and Glioblastoma cancer conditions. Understanding its mechanism of action and its downstream events can open a gateway for new therapeutic interventions. Immunotherapy and its anticancer mechanisms have been reported to be successful strategies in the drug development. So regulating IL-1β and its receptor through targeted drugs can be the promising anti cancer therapy.

Narasimhappagari J, Liu L, Balasubramaniam M, [et al.]. When Two Worlds Collide: The Contribution and Association Between Genetics (APOEε4) and Neuroinflammation (IL-1β) in Alzheimer's Neuropathogenesis. Cells. 2025 14(15). PMID: 40801649.
Balasubramaniam M, Narasimhappagari J, Liu L, [et al.]. Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer's disease by targeted small molecules. Communications biology. 2024 7(1):60. PMID: 38191671. PMCID: PMC10774381.
Jagadeesh N, Kulkani SS, Chachadi VB, [et al.]. Purification, characterization of an entomopathogenic fungal lectin from Purpureocillium lilacinum and its involvement in pathogenesis leading to mycotic keratitis. Archives of microbiology. 2022 204(11):673. PMID: 36255493.
Jagadeesh N, Belur S, Ballal S, [et al.]. Cephalosporium curvulum lectin causes mycotic keratitis by initiating infection through MyD88 dependent cellular proliferation and apoptosis in human corneal epithelial cells. Glycoconjugate journal. 2021 38(4):509-516. PMID: 34146213.