Gunnar Boysen, PhD

Research Program: Cancer Prevention and Population Sciences Faculty Rank: Associate Professor Campus: University of Arkansas for Medical Sciences College: College of Public Health Department: Environmental & Occupational Health

Cancer Research Interest

• Disease Site Focus: Breast, Head and Neck, Thoracic/ Lung
• Research Focus Area: Prevention, Treatment, Detection, Carcinogenesis, Diagnosis/ Prognosis
• Type of Research: Basic
• Research Interest Statement: Dr. Boysen is associate professor of Environmental and Occupational Health at the University of Arkansas for Medical Sciences. His research interest is in lifestyle-exposure-gene-interactions (LEGI) and how these affect carcinogenesis. He has been studying DNA and protein adducts to understand the internal dose exposures and metabolism, as well as how this is determined by genetic background and modified by nutritional components. Dr. Boysen received his PhD in chemistry from University of Kaiserslautern Germany in 2002 in collaboration with the University of Minnesota Cancer Center in Minneapolis, MN, for work on DNA and protein adducts derived from PAH and tobacco-specific nitrosamines. He then pursued a post-doctoral fellowship at the University of North Carolina using several protein adducts to study species differences in biotransformation of 1,3-butadiene. During this time, he became interested in compound-compound interactions and the effects of co-exposures on carcinogen metabolism. He developed an adductomics tool to enable comprehensive profiling of reactive compounds in mixtures. More recently he develops personalize therapy, targeting metabolic reprogramming of metastases.

Contact Information

• Email Address: GBoysen@uams.edu
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Publications

• Boysen G, Rusyn I, Chiu WA, Wright FA. Characterization of population variability of 1,3-butadiene derived protein adducts in humans and mice. Regulatory toxicology and pharmacology : RTP. 2022 132:105171. PMID: 35469930.
• Boysen G, Nookaew I. Current and Future Methodology for Quantitation and Site-Specific Mapping the Location of DNA Adducts. Toxics. 2022 10(2). PMID: 35202232. PMCID: PMC8876591.
• Wadley T, Moon SH, DeMott MS, [et al., including Boysen G]. Nanopore Sequencing for Detection and Characterization of Phosphorothioate Modifications in Native DNA Sequences. Frontiers in microbiology. 2022 13:871937. PMID: 35531280. PMCID: PMC9069010.
• Schleiff MA, Crosby S, Blue M, [et al., including Boysen G]. CYP2C9 and 3A4 play opposing roles in bioactivation and detoxification of diphenylamine NSAIDs. Biochemical pharmacology. 2021 194:114824. PMID: 34748821.
• Pujari SS, Jokipii Krueger CC, Chao C, [et al., including Boysen G]. DEB-FAPy-dG Adducts of 1,3-Butadiene: Synthesis, Structural Characterization, and Formation in 1,2,3,4-Diepoxybutane Treated DNA*. Chemistry (Weinheim an der Bergstrasse, Germany). 2021. PMID: 34767297.
• Nellis M, Caperton CO, Liu K, [et al., including Boysen G]. Lung metabolome of 1,3-butadiene exposed Collaborative Cross mice reflects metabolic phenotype of human lung cancer. Toxicology. 2021 463:152987. PMID: 34648870.
• Flynn NR, Ward MD, Schleiff MA, [et al., including Boysen G]. Bioactivation of Isoxazole-Containing Bromodomain and Extra-Terminal Domain (BET) Inhibitors. Metabolites. 2021 11(6). PMID: 34203690. PMCID: PMC8232216.
• Schleiff MA, Payakachat S, Schleiff BM, [et al., including Boysen G]. Impacts of diphenylamine NSAID halogenation on bioactivation risks. Toxicology. 2021:152832. PMID: 34107285.
• Boysen G, Arora R, Degner A, [et al.]. Effects of GSTT1 Genotype on the Detoxification of 1,3-Butadiene Derived Diepoxide and Formation of Promutagenic DNA-DNA Cross-Links in Human Hapmap Cell Lines. Chemical research in toxicology. 2020. PMID: 33381973.
• Schleiff MA, Flynn NR, Payakachat S, [et al., including Boysen G]. Significance of Multiple Bioactivation Pathways for Meclofenamate as Revealed through Modeling and Reaction Kinetics. Drug metabolism and disposition: the biological fate of chemicals. 2020. PMID: 33239334.
• Pinson AO, Pouncey DL, Schleiff MA, [et al., including Boysen G]. Significance of Competing Metabolic Pathways for 5F-APINACA Based on Quantitative Kinetics. Molecules (Basel, Switzerland). 2020 25(20). PMID: 33092129. PMCID: PMC7587938.
• Nookaew I, Jenjaroenpun P, Du H, [et al., including Boysen G]. Detection and discrimination of DNA adducts differing in size, regiochemistry and functional group by nanopore sequencing. Chemical research in toxicology. 2020. PMID: 32799528.
• Jenjaroenpun P, Wongsurawat T, Wadley TD, [et al., including Boysen G]. Decoding the epitranscriptional landscape from native RNA sequences. Nucleic acids research. 2020. PMID: 32710622.
• Trentzsch M, Nyamugenda E, Miles TK, [et al., including Boysen G]. Delivery of phosphatidylethanolamine blunts stress in hepatoma cells exposed to elevated palmitate by targeting the endoplasmic reticulum. Cell death discovery. 2020 6:8. PMID: 32123584. PMCID: PMC7028721.
• Boysen G, Shimoni A, Danylesko I, [et al.]. A simplified method for detection of N-terminal valine adducts in patients receiving treosulfan. Rapid communications in mass spectrometry : RCM. 2019 33(21):1635-1642. PMID: 31240802. PMCID: PMC6817381.
• Davis MA, Barnette DA, Flynn NR, [et al., including Boysen G]. CYP2C19 and 3A4 Dominate Metabolic Clearance and Bioactivation of Terbinafine Based on Computational and Experimental Approaches. Chemical research in toxicology. 2019 32(6):1151-1164. PMID: 30925039. PMCID: PMC6692898.
• Nyamugenda E, Trentzsch M, Russell S, [et al., including Boysen G]. Injury to hypothalamic Sim1 neurons is a common feature of obesity by exposure to high-fat diet in male and female mice. Journal of neurochemistry. 2019 149(1):73-97. PMID: 30615192. PMCID: PMC6438752.
• Boysen G, Jamshidi-Parsian A, Davis MA, [et al.]. Glutaminase inhibitor CB-839 increases radiation sensitivity of lung tumor cells and human lung tumor xenografts in mice. International journal of radiation biology. 2019 95(4):436-442. PMID: 30557074. PMCID: PMC6622448.
• Pottenger LH, Boysen G, Brown K, [et al.]. Understanding the importance of low-molecular weight (ethylene oxide- and propylene oxide-induced) DNA adducts and mutations in risk assessment: Insights from 15 years of research and collaborative discussions. Environmental and molecular mutagenesis. 2019 60(2):100-121. PMID: 30536466. PMCID: PMC6590209.
• Cardenas VM, Cen R, Clemens MM, [et al., including Boysen G]. Use of Electronic Nicotine Delivery Systems (ENDS) by pregnant women I: Risk of small-for-gestational-age birth. Tobacco induced diseases. 2019 17:44. PMID: 31516487. PMCID: PMC6662791.
• Clemens MM, Cardenas VM, Fischbach LA, [et al., including Boysen G]. Use of electronic nicotine delivery systems by pregnant women II: Hair biomarkers for exposures to nicotine and tobacco-specific nitrosamines. Tobacco induced diseases. 2019 17:50. PMID: 31516493. PMCID: PMC6662780.
• Boysen G. Response to Interpretation of Mass Spectral Data for the Cisplatin 1,2 Intrastrand Guanine-Guanine Adduct. Chemical research in toxicology. 2018 31(11):1108. PMID: 30215251.
• Pouncey DL, Hartman JH, Moore PC, [et al., including Boysen G]. Novel isomeric metabolite profiles correlate with warfarin metabolism phenotype during maintenance dosing in a pilot study of 29 patients. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 2018 29(7):602-612. PMID: 30334816.
• Barnette DA, Davis MA, Dang NL, [et al., including Boysen G]. Lamisil (terbinafine) toxicity: Determining pathways to bioactivation through computational and experimental approaches. Biochemical pharmacology. 2018 156:10-21. PMID: 30076845. PMCID: PMC6188815.
• Sappington D, Helms S, Siegel E, [et al., including Boysen G]. Diagnosis of lung tumor types based on metabolomic profiles in lymph node aspirates. Cancer treatment and research communications. 2018 14:1-6. PMID: 30104001.
• Apopa PL, Alley L, Penney RB, [et al., including Boysen G]. PARP1 Is Up-Regulated in Non-small Cell Lung Cancer Tissues in the Presence of the Cyanobacterial Toxin Microcystin. Frontiers in microbiology. 2018 9:1757. PMID: 30127774. PMCID: PMC6087756.
• Boysen G. The Glutathione Conundrum: Stoichiometric Disconnect between Its Formation and Oxidative Stress. Chemical research in toxicology. 2017 30(5):1113-1116. PMID: 28426193.
• Hartman JH, Miller GP, Caro AA, [et al., including Boysen G]. 1,3-Butadiene-induced mitochondrial dysfunction is correlated with mitochondrial CYP2E1 activity in Collaborative Cross mice. Toxicology. 2017 378:114-124. PMID: 28082109. PMCID: PMC5319481.
• Sappington DR, Siegel ER, Hiatt G, [et al., including Boysen G]. Glutamine drives glutathione synthesis and contributes to radiation sensitivity of A549 and H460 lung cancer cell lines. Biochimica et biophysica acta. 2016 1860(4):836-43. PMID: 26825773. PMCID: PMC4768472.