Somaya Ibrahim

Affiliate Member

Research Program:

Cancer Therapeutics

Faculty Rank:

Graduate Student

Campus:

University of Arkansas for Medical Sciences

Department:

Physiology & Cell Biology

Cancer Research Interest

Disease Site Focus: Breast, Pediatric Oncology
Research Focus Area: Treatment, Carcinogenesis
Type of Research: Translational, Basic
Research Keywords: Pathophysiology, Molecular Metabolism, Cell differentiation, Pluripotent stem cells, Tissue fibrosis, Chemotherapy induced heart failure
Research Interest Statement: My research integrates cutting-edge technologies like 3D bioprinting, human iPSCs, and organoid models to explore the systemic and organ-specific effects of cancer therapeutics, particularly chemotherapy, in cancer survivors. Aiming to bridge the gap between scientific discovery and clinical application, my current work focuses on understanding the short- and long-term impact of chemotherapy on the heart and other vital organs, using advanced models to simulate disease progression and therapeutic responses. By leveraging these innovative platforms, my goal is to unravel the mechanistic consequences of cancer treatments and contribute to the development of more effective and targeted therapies for cancer patients. Through my research, I hope to drive meaningful improvements in drug development, optimize treatment protocols, and advance patient-centered healthcare solutions for cancer survivors.

Ibrahim SY, Holdiness R, Thadisena A, [et al.]. 3-D biomechanics and epigenomics reveal atypical fibroblast responses in cardiometabolic disease. American journal of physiology. Heart and circulatory physiology. 2025 329(5):H1267-H1277. PMID: 41071684.
Meshrkey F, Ibrahim SY, Bagchi RA, Richardson WJ. Temporal Dynamics of Extracellular Matrix Remodeling in Anthracycline-Induced Cardiotoxicity. Cells. 2025 14(18). PMID: 41002436.
Ibrahim SY, Bagchi RA. Interplay between stress, chloride homeostasis, and cardiovascular regulation. American journal of physiology. Heart and circulatory physiology. 2025. PMID: 40953130.
Ibrahim SY, Carter J, Bagchi RA. Histone Deacetylases in Metabolism: the Known and the Unexplored. Physiology (Bethesda, Md.). 2025 40(3). PMID: 39470602.
Makhoul I, Ibrahim SM, Abu-Rmaileh M, [et al.]. P10s-PADRE vaccine combined with neoadjuvant chemotherapy in ER-positive breast cancer patients induces humoral and cellular immune responses. Oncotarget. 2021 12(22):2252-2265. PMID: 34733416. PMCID: PMC8555684.