Rushita Bagchi, PhD

Research Program: Cancer Therapeutics Faculty Rank: Assistant Professor Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Physiology & Cell Biology

Cancer Research Interest

• Disease Site Focus: Breast, Pediatric Oncology
• Research Focus Area: Treatment, Carcinogenesis
• Type of Research: Basic, Translational
• Research Keywords: Pathophysiology, Molecular Metabolism, Cell differentiation, Pluripotent stem cells, Tissue fibrosis, Chemotherapy induced heart failure
• Research Interest Statement: Cancer and its treatment are closely related to cardiovascular disease and metabolic syndrome. My acquired training in these fields has allowed me to establish a research program that evaluates and dissects underlying causes of these conditions in healthy and cancer patients. The MREA award for my lab provided the foundation for us to delve into chemotherapy-induced heart failure studies directly. We use state of the art 3D bioprinting and human iPSC-differentiated cells to answer our research questions.

Contact Information

• Email Address: RBAGCHI@UAMS.EDU
• Profiles Research Networking Software: View Profile

Recent Publications

• Meshrkey F, Ibrahim SY, Bagchi RA, Richardson WJ. Temporal Dynamics of Extracellular Matrix Remodeling in Anthracycline-Induced Cardiotoxicity. Cells. 2025 14(18). PMID: 41002436.
• Ibrahim SY, Bagchi RA. Interplay between stress, chloride homeostasis, and cardiovascular regulation. American journal of physiology. Heart and circulatory physiology. 2025. PMID: 40953130.
• Ibrahim SY, Carter J, Bagchi RA. Histone Deacetylases in Metabolism: the Known and the Unexplored. Physiology (Bethesda, Md.). 2025 40(3). PMID: 39470602.
• Schuetze KB, Stratton MS, Bagchi RA, [et al.]. BRD4 inhibition rewires cardiac macrophages toward a protective phenotype marked by low MHC class II expression. American journal of physiology. Heart and circulatory physiology. 2025 328(2):H294-H309. PMID: 39716819.
• Robinson EL, Tharp CA, Bagchi RA, McKinsey TA. Gravi-D peptide disrupts HDAC11 association with an AKAP to stimulate adipocyte thermogenic signaling. The Journal of clinical investigation. 2024 134(9). PMID: 38690735.
• Robinson EL, Bagchi RA, Major JL, [et al.]. HDAC11 inhibition triggers bimodal thermogenic pathways to circumvent adipocyte catecholamine resistance. The Journal of clinical investigation. 2023 133(19). PMID: 37607030.
• Nagalingam RS, Chattopadhyaya S, Al-Hattab DS, [et al., including Bagchi RA]. Scleraxis and fibrosis in the pressure-overloaded heart. European heart journal. 2022 43(45):4739-4750. PMID: 36200607.
• Rangarajan S, Locy ML, Chanda D, [et al., including Bagchi RA]. Mitochondrial uncoupling protein-2 reprograms metabolism to induce oxidative stress and myofibroblast senescence in age-associated lung fibrosis. Aging cell. 2022 21(9):e13674. PMID: 35934931.
• Bagchi RA, Robinson EL, Hu T, [et al.]. Reversible lysine fatty acylation of an anchoring protein mediates adipocyte adrenergic signaling. Proceedings of the National Academy of Sciences of the United States of America. 2022 119(7). PMID: 35149557.
• Soranno DE, Baker P 2nd, Kirkbride-Romeo L, [et al., including Bagchi RA]. Female and male mice have differential longterm cardiorenal outcomes following a matched degree of ischemia-reperfusion acute kidney injury. Scientific reports. 2022 12(1):643. PMID: 35022484.
• Çakır I, Hadley CK, Pan PL, [et al., including Bagchi RA]. Histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesity. Nature metabolism. 2022 4(1):44-59. PMID: 35039672.
• Ambruso SL, Gil HW, Fox B, [et al., including Bagchi RA]. Lung metabolomics after ischemic acute kidney injury reveals increased oxidative stress, altered energy production, and ATP depletion. American journal of physiology. Lung cellular and molecular physiology. 2021 321(1):L50-L64. PMID: 33949208.
• Travers JG, Wennersten SA, Peña B, [et al., including Bagchi RA]. HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling. Circulation. 2021 143(19):1874-1890. PMID: 33682427.
• Riching AS, Danis E, Zhao Y, [et al., including Bagchi RA]. Suppression of canonical TGF-β signaling enables GATA4 to interact with H3K27me3 demethylase JMJD3 to promote cardiomyogenesis. Journal of molecular and cellular cardiology. 2021 153:44-59. PMID: 33359755.
• Soranno DE, Kirkbride-Romeo L, Wennersten SA, [et al., including Bagchi RA]. Acute Kidney Injury Results in Long-Term Diastolic Dysfunction That Is Prevented by Histone Deacetylase Inhibition. JACC. Basic to translational science. 2021 6(2):119-133. PMID: 33665513.
• Jahan F, Bagchi RA. Enhancing NAD(+) Metabolome in Cardiovascular Diseases: Promises and Considerations. Frontiers in cardiovascular medicine. 2021 8:716989. PMID: 34513955.
• Major JL, Bagchi RA, Pires da Silva J. Application of microRNA Database Mining in Biomarker Discovery and Identification of Therapeutic Targets for Complex Disease. Methods and protocols. 2020 4(1). PMID: 33396619.