Samaneh Goorani, PhD

Research Program: Cancer Therapeutics Faculty Rank: Assistant Research Professor Campus: University of Arkansas for Medical Sciences College: College of Pharmacy Department: Pharmaceutical Science

Cancer Research Interest

• Disease Site Focus: Breast, Hematologic Malignancies, GI
• Research Focus Area: Prevention, Treatment
• Type of Research: Translational
• Research Keywords: Malignant, Metastasis, Taxicology, prevention
• Research Interest Statement: My research focuses on exploring medicinal plants and nanotechnology-based approaches for cancer prevention and therapy, with an emphasis on triple-negative breast cancer. I have investigated the bioactive properties of plants such as Allium eriophyllum, Gundelia tournefortii, and Falcaria vulgaris, demonstrating their antioxidant, anti-inflammatory, and anticancer potential. Recent work includes the green synthesis of nickel nanoparticles from Alhagi sparsifolia with anti-breast carcinoma activity, as well as studies on plant-based extracts that promote wound healing and exhibit cytotoxic effects against cancer cells. This integrated approach aims to identify and develop plant-derived compounds as affordable, effective, and accessible cancer therapeutics.

Contact Information

• Email Address: SGoorani@uams.edu
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Recent Publications

• Hye Khan MA, Goorani S, Atamanchuk A, [et al.]. Dual acting inhibitor of soluble epoxide hydrolase and Cyclooxygenase-2, attenuates glomerular injury in renal hypoplasia mice. European journal of pharmacology. 2025 1006:178132. PMID: 40946955.
• Palfrey HA, Goorani S, Mishra A, [et al.]. Transforming growth factor β receptor 1 and mitogen-activated protein 4 kinase 4 dual inhibitor, TK-850, reduces renal fibrosis in unilateral ureteral-obstructed mice. The Journal of pharmacology and experimental therapeutics. 2025 392(8):103644. PMID: 40706137.
• Zangene S, Goorani S, Morovvati H, Anbara H. Effects of polystyrene microplastics on mice cardiac tissue structure: Protective role of resveratrol. Chemosphere. 2025 379:144406. PMID: 40262232.
• Khan MAH, Ameer OZ, Goorani S, Salman IM. Editorial: Debates in experimental pharmacology and drug discovery 2023: innovative approaches to chronic kidney disease drug discovery, identification of targets and safety assessment. Frontiers in pharmacology. 2025 16:1588367. PMID: 40201689.
• Miller B, Imig J, Goorani S, [et al.]. Targeting p66Shc to restore K(ATP) channel and renal microvascular responses in a preclinical model of diabetic nephropathy. Frontiers in physiology. 2025 16:1620591. PMID: 40837098.
• Goorani S, Zangene S, Imig JD. Hypertension: A Continuing Public Healthcare Issue. International journal of molecular sciences. 2024 26(1). PMID: 39795981. PMCID: PMC11720251.
• Zangene S, Morovvati H, Anbara H, [et al., including Goorani S]. Polystyrene microplastics cause reproductive toxicity in male mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024 194:115083. PMID: 39521238.
• Goorani S, Khan AH, Mishra A, [et al.]. Kidney Injury by Unilateral Ureteral Obstruction in Mice Lacks Sex Differences. Kidney & blood pressure research. 2024. PMID: 38185105. PMCID: PMC10877550.
• Imig JD, Abdul Hye Khan M, Stavniichuk A, [et al., including Goorani S]. Salt-sensitive hypertension after reversal of unilateral ureteral obstruction. Biochemical pharmacology. 2023:115438. PMID: 36716827. PMCID: PMC10107073.