Bethany Paxton

Affiliate- Trainee Member

Research Program:

Cancer Biology

Faculty Rank:

PhD Student

Campus:

University of Arkansas for Medical Sciences

Department:

Physiology & Cell Biology

Cancer Research Interest

Disease Site Focus: Multiple Myeloma
Research Focus Area: Treatment
Type of Research: Translational
Research Interest Statement: I am a second-year PhD student in the Graduate Program in Interdisciplinary Biomedical Sciences (GPIBS) in the lab of Dr. Jesus Delgado-Calle. My research focuses on understanding the cellular and molecular interactions that occur between multiple myeloma (MM) cells and cells of the tumor microenvironment (TME) that induce dormancy in MM cells. Dormant MM cells are resistant to several frontline chemotherapies and can contribute to patient relapse upon reawakening. Using a combination of in vitro, ex vivo, and in vivo approaches, I aim to learn more about the regulation of MM dormancy by the TME and use bone-targeted therapeutic approaches to eliminate dormant cells to delay or prevent relapse.

Ketkar A, Sewilam RS, McCrury MJ, [et al., including Paxton BC]. Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis. RSC chemical biology. 2023 4(7):466-485. PMID: 37415867. PMCID: PMC10320842.