Mamatha Gaddam, MD, MBBS

Full Member

Research Program:

Cancer Therapeutics

Faculty Rank:

Assistant professor

Campus:

University of Arkansas for Medical Sciences

College:

College of Medicine

Department:

Hematology & Oncology

Cancer Research Interest

Disease Site Focus: Leukemia/ Lymphoma, Hematologic Malignancies
Research Focus Area: Treatment, Detection, Diagnosis/ Prognosis
Type of Research: Clinical
Research Interest Statement: My research primarily focuses on clinical studies in lymphoma, with a particular emphasis on adverse effects and long-term outcomes of CAR T-cell therapy. I am interested in identifying, characterizing, and managing immune effector cell-associated toxicities, such as HLH-like syndromes, in patients with B-cell lymphomas treated with CAR T therapy. My work also explores the long-term side effects and survivorship issues following CAR T-cell treatment. In addition, I am involved in research focused on the treatment of T-cell lymphomas, a challenging and heterogeneous group of hematologic malignancies. I conduct quality improvement studies aimed at optimizing care delivery and treatment outcomes in lymphoma patients. These efforts include improving diagnostic workflows, enhancing supportive care practices, and reducing variability in clinical management. Through a combination of clinical and translational research, I aim to improve both short- and long-term outcomes for patients with lymphoid malignancies.

“A051902 A Randomized Phase II Study of CHO(E)P vs CC-486-CHO(E)P vs Duvelisib-CHO(E)P in Previously Untreated CD30 Negative Peripheral T-cell Lymphomas” (NCT04803201)

Thalambedu N, Mohan Lal B, Harbaugh B, [et al., including Gaddam M]. Unveiling Myelodysplastic Syndromes: Exploring Pathogenic Mechanisms and Therapeutic Advances. Cancers. 2025 17(3). PMID: 39941875. PMCID: PMC11816122.
Fugere T, Baltz A, Mukherjee A, [et al., including Gaddam M]. Immune Effector Cell-Associated HLH-like Syndrome: A Review of the Literature of an Increasingly Recognized Entity. Cancers. 2023 15(21). PMID: 37958323. PMCID: PMC10647774.