Duah H Alkam, PhD, MSc

Research Program: Cancer Biology Faculty Rank: Biostatistician Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Biochemistry & Molecular Biology

Cancer Research Interest

• Disease Site Focus: Melanoma
• Research Focus Area: Informatics
• Type of Research: Translational
• Research Keywords: proteogenomics, multiomics integration, WES, transcriptomics, proteomics
• Research Interest Statement: Our goal is to identify novel cancer/melanoma specific driver proteins using novel proteogenomics pipelines. The nationally-renowned UAMS proteomics core positions us to lead in developing proteogenomic workflows that incorporate genomics and/or transcriptomic signatures into proteomic databases. This will enhance our detection of key cancer/melanoma proteins as we consider multiple omics levels in target identification and prioritization.

Contact Information

• Email Address: DAlkam@uams.edu

Recent Publications

• Osei B, May BH, Beard JS, [et al., including Alkam D]. Rare SNP in the HELB gene interferes with RPA interaction and cellular function of HELB. NAR molecular medicine. 2025 2(2):ugaf019. PMID: 40496644. PMCID: PMC12147029.
• Biedka S, Yablonska S, Peng X, [et al., including Alkam D]. IP-to-MS: An Unbiased Workflow for Antigen Profiling. Journal of proteome research. 2025 24(2):795-812. PMID: 39814365. PMCID: PMC11812086.
• Tesfay MZ, Zhang Y, Ferdous KU, [et al., including Alkam D]. Enhancing immune response and survival in hepatocellular carcinoma with novel oncolytic Jurona virus and immune checkpoint blockade. Molecular therapy. Oncology. 2024 32(4):200913. PMID: 39758249. PMCID: PMC11697550.
• Pechous RD, Malaviarachchi PA, Banerjee SK, [et al., including Alkam DH]. An ex vivo human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy. Journal of virology. 2024:e0079424. PMID: 38940558. PMCID: PMC11265413.
• Biedka S, Alkam D, Washam CL, [et al.]. One-pot method for preparing DNA, RNA, and protein for multiomics analysis. Communications biology. 2024 7(1):324. PMID: 38485785. PMCID: PMC10940598.
• Choudhury S, Byrum SD, Alkam D, [et al.]. Expression of integrin β-7 is epigenetically enhanced in multiple myeloma subgroups with high-risk cytogenetics. Clinical epigenetics. 2023 15(1):18. PMID: 36737807. PMCID: PMC9898982.
• Zhang Y, Gabere M, Taylor MA, [et al., including Alkam D]. Repurposing live attenuated trivalent MMR vaccine as cost-effective cancer immunotherapy. Frontiers in oncology. 2022 12:1042250. PMID: 36457491. PMCID: PMC9706410.
• Alkam D, Wongsurawat T, Nookaew I, [et al.]. Is amplification bias consequential in transposon sequencing (TnSeq) assays? A case study with a Staphylococcus aureus TnSeq library subjected to PCR-based and amplification-free enrichment methods. Microbial genomics. 2021 7(10). PMID: 34596508. PMCID: PMC8627206.
• Chappell K, Tackett A, Manna K, [et al., including Alkam D]. Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer. Molecular omics. 2021. PMID: 34142686. PMCID: PMC8504614.
• Alkam D, Jenjaroenpun P, Ramirez AM, [et al.]. The Increased Accumulation of Staphylococcus aureus Virulence Factors Is Maximized in a purR Mutant by the Increased Production of SarA and Decreased Production of Extracellular Proteases. Infection and immunity. 2021 89(4). PMID: 33468580. PMCID: PMC8090970.