Kalyani Dhusia, PhD

Research Program: Cancer Biology Faculty Rank: Assistant Staff Scientist Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Biochemistry & Molecular Biology

Cancer Research Interest

• Disease Site Focus: No Specific Disease Site
• Research Focus Area: Informatics
• Type of Research: Translational
• Research Keywords: genomics, proteomics, multiomics
• Research Interest Statement: Accomplished bioinformatics researcher with extensive experience in leading data analysis and computational biology projects focused on cancer genomics, multi-omics data integration, and machine learning. Expert in developing and optimizing scalable bioinformatics pipelines, performing statistical analysis, and applying advanced computational methods to solve complex biological problems. Proficient in Python, R, SQL, and cloud platforms (GCP), with a strong background in analyzing large genomic datasets, including NGS, transcriptomics, proteomics data (including DIA, DDA and TMT) and single-cell genomics. Passionate about translating data-driven insights into meaningful contributions to healthcare and therapeutic advancements.

Contact Information

• Email Address: KDHUSIA@UAMS.EDU

Recent Publications

• Su Z, Dhusia K, Wu Y. Encoding the space of protein-protein binding interfaces by artificial intelligence. Computational biology and chemistry. 2024 110:108080. PMID: 38643609.
• Dhusia K, Rizvi AZ, Rai S, Ramteke PW. Withdrawal notice to "Structural and functional characterization for interaction of silver nanoparticles with ergostrol in Trichoderma harzianum" [Microb. Pathog. 125 (2018) 318-324]. Microbial pathogenesis. 2023 178:106052. PMID: 36906439.
• Dhusia K, Su Z, Wu Y. Computational analyses of the interactome between TNF and TNFR superfamilies. Computational biology and chemistry. 2023 103:107823. PMID: 36682326.
• Su Z, Dhusia K, Wu Y. Understanding the functional role of membrane confinements in TNF-mediated signaling by multiscale simulations. Communications biology. 2022 5(1):228. PMID: 35277586. PMCID: PMC8917213.
• Dhusia K, Madrid C, Su Z, Wu Y. EXCESP: A Structure-Based Online Database for Extracellular Interactome of Cell Surface Proteins in Humans. Journal of proteome research. 2022 21(2):349-359. PMID: 34978816.
• Dhusia K, Su Z, Wu Y. A structural-based machine learning method to classify binding affinities between TCR and peptide-MHC complexes. Molecular immunology. 2021 139:76-86. PMID: 34455212. PMCID: PMC10811653.
• Su Z, Dhusia K, Wu Y. Coarse-grained simulations of phase separation driven by DNA and its sensor protein cGAS. Archives of biochemistry and biophysics. 2021 710:109001. PMID: 34352244.
• Dhusia K, Wu Y. Classification of protein-protein association rates based on biophysical informatics. BMC bioinformatics. 2021 22(1):408. PMID: 34404340. PMCID: PMC8371850.
• Wu Y, Dhusia K, Su Z. Mechanistic dissection of spatial organization in NF-κB signaling pathways by hybrid simulations. Integrative biology : quantitative biosciences from nano to macro. 2021 13(5):109-120. PMID: 33893499. PMCID: PMC8129552.
• Desmet NM, Dhusia K, Qi W, [et al.]. Bioengineering of Genetically Encoded Gene Promoter Repressed by the Flavonoid Apigenin for Constructing Intracellular Sensor for Molecular Events. Biosensors. 2021 11(5). PMID: 33924783. PMCID: PMC8147076.
• Su Z, Dhusia K, Wu Y. A computational study of co-inhibitory immune complex assembly at the interface between T cells and antigen presenting cells. PLoS computational biology. 2021 17(3):e1008825. PMID: 33684103. PMCID: PMC7971848.
• Su Z, Dhusia K, Wu Y. Understanding the impacts of cellular environments on ligand binding of membrane receptors by computational simulations. The Journal of chemical physics. 2021 154(5):055101. PMID: 33557556.
• Su Z, Dhusia K, Wu Y. A multiscale study on the mechanisms of spatial organization in ligand-receptor interactions on cell surfaces. Computational and structural biotechnology journal. 2021 19:1620-1634. PMID: 33868599. PMCID: PMC8026753.
• Su Z, Dhusia K, Wu Y. Understand the Functions of Scaffold Proteins in Cell Signaling by a Mesoscopic Simulation Method. Biophysical journal. 2020 119(10):2116-2126. PMID: 33113350. PMCID: PMC7732726.
• Pandey S, Dhusia K, Katara P, [et al.]. An in silico analysis of deleterious single nucleotide polymorphisms and molecular dynamics simulation of disease linked mutations in genes responsible for neurodegenerative disorder. Journal of biomolecular structure & dynamics. 2020 38(14):4259-4272. PMID: 31630641.
• Dhusia K, Su Z, Wu Y. Understanding the Impacts of Conformational Dynamics on the Regulation of Protein-Protein Association by a Multiscale Simulation Method. Journal of chemical theory and computation. 2020 16(8):5323-5333. PMID: 32667783. PMCID: PMC10829009.
• Dhusia K, Su Z, Wu Y. Using Coarse-Grained Simulations to Characterize the Mechanisms of Protein-Protein Association. Biomolecules. 2020 10(7). PMID: 32679892. PMCID: PMC7407674.