Vy Nguyen

Affiliate Member

Research Program:

Cancer Biology

Faculty Rank:

Graduate Assistant

Campus:

University of Arkansas for Medical Sciences

College:

College of Medicine

Department:

Biochemistry & Molecular Biology

Cancer Research Interest

Disease Site Focus: Thoracic/ Lung
Research Focus Area: Carcinogenesis, Treatment
Type of Research: Basic
Research Keywords: Metastasis, Cell-adhesion
Research Interest Statement: My research focuses on Rnd3, an atypical Rho GTPase, and its role in lung cancer progression. Lung adenocarcinomca patient with low level of Rnd3 exhibits a significantly higher chance of survival. Our lab preliminary data suggests that Rnd3 regulate metastatic hallmarks independently from the canonical RhoA-ROCK1 pathway. My project involving characterizing this novel pathway by using site-directed mutagenesis on Rnd3 fusion constructs and accessing the effect of Rnd3 loss on cancer progression with in vivo mouse model.

Garcia Garcia N, Nguyen THV, Richey D, [et al.]. Rnd3 regulates lung cancer cell invasion and migration independently of ROCK1 signaling via alpha 5 integrin modulation. Life science alliance. 2026 9(5). PMID: 41735013.
West KL, Nguyen TTN, Tengler KA, [et al.]. Autophosphorylation of the Tousled-like kinases TLK1 and TLK2 regulates recruitment to damaged chromatin via PCNA interaction. Nucleic acids research. 2025 53(4). PMID: 39727191. PMCID: PMC11879137.