Vy Nguyen
Affiliate Member
|
| Research Program:
Cancer Biology
Faculty Rank:
Graduate Assistant
Campus:
University of Arkansas for Medical Sciences
Department:
Biochemistry & Molecular Biology
|
Cancer Research Interest
- Disease Site Focus: Thoracic/ Lung
- Research Focus Area: Carcinogenesis, Treatment
- Type of Research: Basic
- Research Keywords: Metastasis, Cell-adhesion
- Research Interest Statement: My research focuses on Rnd3, an atypical Rho GTPase, and its role in lung cancer progression. Lung adenocarcinomca patient with low level of Rnd3 exhibits a significantly higher chance of survival. Our lab preliminary data suggests that Rnd3 regulate metastatic hallmarks independently from the canonical RhoA-ROCK1 pathway. My project involving characterizing this novel pathway by using site-directed mutagenesis on Rnd3 fusion constructs and accessing the effect of Rnd3 loss on cancer progression with in vivo mouse model.
Contact Information
- Email Address: VNguyen@uams.edu
Recent Publications
- West KL, Nguyen TTN, Tengler KA, [et al.]. Autophosphorylation of the Tousled-like kinases TLK1 and TLK2 regulates recruitment to damaged chromatin via PCNA interaction. Nucleic acids research. 2024. PMID: 39727191. PMCID: PMC11879137.