Monique Ann Spillman, MD, PhD

Research Program: Cancer Therapeutics Faculty Rank: Professor, Clinical Educator Track Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Obstetrics & Gynecology

Cancer Research Interest

• Disease Site Focus: Gynecology
• Research Focus Area: Treatment
• Type of Research: Translational
• Research Keywords: estrogen, ovarian cancer, hereditary cancer, ethics, clinical trials
• Research Interest Statement: I am a Professor and Division Chief of Gynecologic Oncology at the University of Arkansas for Medical Sciences. My lab research included investigation of the connection between estrogen and the BRCA double strand break DNA repair pathway, as well as the role of estrogen in the growth and metastasis of ovarian cancer. This line of investigation was augmented by our development of a fluorescent intraabdominal mouse model of ovarian cancer. Extended family obligations directed my career away from bench science and towards more clinical investigation. My clinical practice as a gynecologic oncologist includes the treatment of women with gynecologic malignancies and genetic predisposition to cancer. I perform surgery, both traditional and minimally invasive; administer chemotherapy, immunotherapy and small molecule inhibitors; as well as contribute to the clinical trial enterprise as a Principal Investigator and Sub-Investigator in our Division portfolio. As my career path has matured into more administrative roles, I continue to serve as a content consultant for gynecologic cancers, steroid hormone interactions, menopause and development of early detection testing for ovarian cancer. I currently am the PI on the OvaPrint trial, which is a prospective validation of our early serum cell free DNA ovarian cancer detection trial. In addition, I am the site PI for the Giredestrant endometrial cancer trial, which is a phase II trial of a novel estrogen antagonist in low grade endometrial cancer.

Contact Information

• Email Address: MSpillman@uams.edu
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Recent Publications

• Buckley DN, Lewinger JP, Gooden G, [et al., including Spillman M]. OvaPrint-A Cell-free DNA Methylation Liquid Biopsy for the Risk Assessment of High-grade Serous Ovarian Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2023 29(24):5196-5206. PMID: 37812492. PMCID: PMC10722131.
• Brown AJ, duPont N, Alvarez RD, [et al., including Spillman MA]. MAID ready for primetime?: A survey of SGO members regarding medical aid in dying (MAID). Gynecologic oncology reports. 2021 37:100829. PMID: 34277920. PMCID: PMC8271105.
• Kandimalla R, Wang W, Yu F, [et al., including Spillman M]. OCaMIR-A Noninvasive, Diagnostic Signature for Early-Stage Ovarian Cancer: A Multi-cohort Retrospective and Prospective Study. Clinical cancer research : an official journal of the American Association for Cancer Research. 2021 27(15):4277-4286. PMID: 34035068. PMCID: PMC10327469.
• Shalowitz DI, Lefkowits C, Landrum LM, [et al., including Spillman MA]. Principles of ethics and critical communication during the COVID-19 pandemic. Gynecologic oncology. 2020 158(3):526-530. PMID: 32622474. PMCID: PMC7315948.