Japneet Kaur, PhD

Associate Member

Research Program:

Cancer Biology

Faculty Rank:

Postdoctoral Fellow

Campus:

University of Arkansas for Medical Sciences

College:

College of Medicine

Department:

Physiology & Cell Biology BoneCancer

Cancer Research Interest

Disease Site Focus: Breast
Research Focus Area: Carcinogenesis
Type of Research: Translational
Research Keywords: Breast cancer, Bone, Cellular senescence
Research Interest Statement: My research focusses on understanding the molecular and cellular mechanisms by which bone metastatic breast cancer (BCa) modulates the tumor microenvironment (TME), with particular emphasis on cellular senescence. The overarching goal of my work is to identify and characterize modifiable molecular factors within the TME, which could serve as therapeutic targets to prevent or delay the progression of BCa metastases and associated bone disease. Currently, I am investigating the pathways through which BCa-derived factors induce senescence in the bone TME, thereby facilitating BCa growth and the concomitant skeletal disease. The ultimate goal is to discover novel methods to inhibit these pathways, providing innovative therapeutic options for metastatic BCa and improve clinical outcomes in patients.

Kaur J, Adhikari M, Sabol HM, [et al.]. Single-cell Transcriptomic Analysis Identifies Senescent Osteocytes that Trigger Bone Destruction in Breast Cancer Metastasis. Cancer research. 2024. PMID: 39312185.
Sabol HM, Ashby C, Adhikari M, [et al., including Kaur J]. A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma. Haematologica. 2024. PMID: 38385272. PMCID: PMC11290536.