Ashim Kumar Bagchi, PhD

Research Program: Cancer Biology Faculty Rank: Instructor Campus: University of Arkansas for Medical Sciences College: College of Pharmacy Department: Pharmaceutical Sciences

Cancer Research Interest

• Disease Site Focus: Breast
• Research Focus Area: Treatment, Prevention, Informatics
• Type of Research: Basic, Translational
• Research Keywords: Doxorubicin, Cancer, Lymphedema, Cardiovascular Diseases
• Research Interest Statement: Over the past few years, my research has focused on elucidating mechanisms of chemotherapy-driven cardiotoxicity, especially with anthracyclines such as doxorubicin. This led to multiple publications in top peer-reviewed journals in our field, including BBA-Molecular Cell Research, AJP-Heart and Circulatory Physiology, Scientific Reports, Heart Failure Reviews, and others. In my current position, my research efforts are focused on determining the potential involvement of lymphatic vasculature and its cellular contents that may contribute to cardiomyopathy using in vitro and preclinical rodent model systems. This will allow us to find ways to mitigate the adverse effects of doxorubicin treatment in cancer patients.

Contact Information

• Email Address: ABAGCHI@UAMS.EDU
• Profiles Research Networking Software: View Profile

Publications

• Cheng W, Cui C, Liu G, [et al., including Bagchi AK]. NF-κB, A Potential Therapeutic Target in Cardiovascular Diseases. Cardiovascular drugs and therapy. 2023 37(3):571-584. PMID: 35796905.
• Al-Shudiefat AA, Ludke A, Malik A, [et al., including Bagchi AK]. Olive oil protects against progression of heart failure by inhibiting remodeling of heart subsequent to myocardial infarction in rats. Physiological reports. 2022 10(15):e15379. PMID: 35938295. PMCID: PMC9358399.
• Kore RA, Bagchi AK, Varughese KI, Mehta JL. The structural basis of effective LOX-1 inhibition. Future medicinal chemistry. 2022 14(10):731-743. PMID: 35466695.
• Malik A, Bagchi AK, Jassal DS, Singal PK. Interleukin-10 Mitigates Doxorubicin-Induced Endoplasmic Reticulum Stress as Well as Cardiomyopathy. Biomedicines. 2022 10(4). PMID: 35453640. PMCID: PMC9027958.
• Bagchi AK, Malik A, Akolkar G, [et al.]. Endoplasmic Reticulum Stress Promotes iNOS/NO and Influences Inflammation in the Development of Doxorubicin-Induced Cardiomyopathy. Antioxidants (Basel, Switzerland). 2021 10(12). PMID: 34943000. PMCID: PMC8750247.
• Farahmand F, Malik A, Sharma A, [et al., including Bagchi AK]. Role of oxidative stress versus lipids in monocrotaline-induced pulmonary hypertension and right heart failure. Physiological reports. 2021 9(22):e15090. PMID: 34816616. PMCID: PMC8611258.
• Bagchi AK, Malik A, Akolkar G, [et al.]. Study of ER stress and apoptotic proteins in the heart and tumor exposed to doxorubicin. Biochimica et biophysica acta. Molecular cell research. 2021 1868(7):119039. PMID: 33857568.
• Malik A, Bagchi AK, Vinayak K, [et al.]. Vitamin C: historical perspectives and heart failure. Heart failure reviews. 2021 26(3):699-709. PMID: 33033908.
• Bagchi AK, Surendran A, Malik A, [et al.]. IL-10 attenuates OxPCs-mediated lipid metabolic responses in ischemia reperfusion injury. Scientific reports. 2020 10(1):12120. PMID: 32694752. PMCID: PMC7374703.