Reham Muhammad Amin Srour Sewilam, MSc

Affiliate Member

Research Program:

Cancer Biology

Faculty Rank:

Graduate assistant

Campus:

University of Arkansas for Medical Sciences

College:

College of Medicine

Department:

Biochemistry & Molecular Biology

Cancer Research Interest

Disease Site Focus: Brain, Pediatric Oncology
Research Focus Area: Diagnosis/ Prognosis, Carcinogenesis, Prevention, Treatment
Type of Research: Basic, Translational
Research Keywords: DNA replication, Replication stress, DNA damage tolerance and Transletion synthesis
Research Interest Statement: We are studying mechanisms that allow replication of endogenous fork barriers, including those imposed by oncogenic sources in cancer. My team and I have uncovered a role for pol kappa in governing fork speed and ssDNA gap formation in GBM-derived cells. Without pol kappa, the pace of replication exceeds its ability to fill in ssDNA gaps, leaving the genome in GBM cells vulnerable to further damage. I am exploring the mechanistic features involved in these processes and the potential implications for therapy resistance in these deadly tumors.

Ketkar A, Sewilam RS, McCrury MJ, [et al.]. Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis. RSC chemical biology. 2023 4(7):466-485. PMID: 37415867. PMCID: PMC10320842.