Amit K. Tiwari, MS, PhD

Full Member

Research Program:

Cancer Therapeutics

Faculty Rank:

Associate Dean of Research and Graduate Studies Professor

Campus:

University of Arkansas for Medical Sciences

College:

College of Pharmacy

Department:

Pharmaceutical Sciences

Cancer Research Interest

Disease Site Focus: Breast, GI, Prostate, Melanoma, Pediatric Oncology
Research Focus Area: Treatment, Carcinogenesis, Health Disparities, Informatics
Type of Research: Basic, Translational
Research Keywords: Multidrug resistant Cancer, Drug Discovery, Drug Delivery, Drug Design and Development, Cell Death Mechanisms, ABC Transporters, Apoptosis Resistance, PK/PD, Toxicology
Research Interest Statement: Dr. Tiwari a seasoned pharmacologist and a board-certified toxicologist directs the Cancer & Systems Therapeutics (CAST) research group. The CAST team focuses primarily on improving drug design, discovery, development and delivery using tumor- directed pharmacokinetic/ pharmacodynamic (PK/PD) investigations, as well as exploring novel approaches to molecular determinants of drug resistance, tumorigenesis, and drug disposition. The goal is to develop novel, safe and targeted therapeutics for drug resistant cancers. The CAST is a multidisciplinary research group that also focuses on innovative drug delivery systems, natural products drug discovery, and chemical toxicity. Most recently, CAST has been engaged in drug discovery efforts i.e., developing novel cancer cell death inducers that modulate necroptosis, methuosis, and autophagy among others.

Contact Information

Email Address: ATiwari@uams.edu
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Recent Publications

Zhang W, Lee A, Tiwari AK, Yang MQ. Characterizing the Tumor Microenvironment and Its Prognostic Impact in Breast Cancer. Cells. 2024 13(18). PMID: 39329702. PMCID: PMC11429566.
Singh V, Shirbhate E, Kore R, [et al., including Tiwari AK]. Microbial Metabolites-Induced Epigenetic Modifications for Inhibition of Colorectal Cancer: Current Status and Future Perspectives. Mini reviews in medicinal chemistry. 2024. PMID: 38982701.
Ranch K, Chawnani D, Jani H, [et al., including Tiwari AK]. An update on the latest strategies in retinal drug delivery. Expert opinion on drug delivery. 2024 21(5):695-712. PMID: 38787783.
Stouffer M, Wandling E, Dickson L, [et al., including Tiwari AK]. Gedunin modulates cellular growth and apoptosis in glioblastoma cell lines. Cancer reports (Hoboken, N.J.). 2024 7(5):e2051. PMID: 38702989. PMCID: PMC11069102.
Robey RW, Fitzsimmons CM, Guiblet WM, [et al., including Tiwari AK]. The Methyltransferases METTL7A and METTL7B Confer Resistance to Thiol-Based Histone Deacetylase Inhibitors. Molecular cancer therapeutics. 2024 23(4):464-477. PMID: 38151817. PMCID: PMC11223745.
Desai D, Majrashi M, Pathak S, [et al., including Tiwari AK]. Evaluate the in vitro effect of anthracycline and alkylating cytophosphane chemotherapeutics on dopaminergic neurons. Cancer reports (Hoboken, N.J.). 2024 7(4):e2074. PMID: 38627904. PMCID: PMC11021631.
Alrbyawi H, Annaji M, Fasina O, [et al., including Tiwari AK]. Rapidly Dissolving Trans-scleral Microneedles for Intraocular Delivery of Cyclosporine A. AAPS PharmSciTech. 2024 25(2):28. PMID: 38302687.
Shirbhate E, Singh V, Jahoriya V, [et al., including Tiwari AK]. Dual inhibitors of HDAC and other epigenetic regulators: A novel strategy for cancer treatment. European journal of medicinal chemistry. 2024 263:115938. PMID: 37989059.
Singh V, Shirbhate E, Kore R, [et al., including Tiwari AK]. Dietary Plant Metabolites Induced Epigenetic Modification as a Novel Strategy for the Management of Prostate Cancer. Mini reviews in medicinal chemistry. 2024 24(15):1409-1426. PMID: 38385496.
Paudel D, Nair DVT, Joseph G, [et al., including Tiwari AK]. Gastrointestinal microbiota-directed nutritional and therapeutic interventions for inflammatory bowel disease: opportunities and challenges. Gastroenterology report. 2024 12:goae033. PMID: 38690290. PMCID: PMC11057942.
Annaji M, Mita N, Heard J, [et al., including Tiwari AK]. Long-Acting Drug Delivery Technologies for Meloxicam as a Pain Medicine. Critical reviews in therapeutic drug carrier systems. 2024 41(5):111-150. PMID: 38608134.
Shirbhate E, Singh V, Kore R, [et al., including Tiwari AK]. The Role of Cytokines in Activation of Tumour-promoting Pathways and Emergence of Cancer Drug Resistance. Current topics in medicinal chemistry. 2024 24(6):523-540. PMID: 38258788.
Shirbhate E, Singh V, Mishra A, [et al., including Tiwari AK]. Targeting Lysosomes: A Strategy Against Chemoresistance in Cancer. Mini reviews in medicinal chemistry. 2024 24(15):1449-1468. PMID: 38343053.
Tripathi PN, Lodhi A, Rai SN, [et al., including Tiwari AK]. Review of Pharmacotherapeutic Targets in Alzheimer's Disease and Its Management Using Traditional Medicinal Plants. Degenerative neurological and neuromuscular disease. 2024 14:47-74. PMID: 38784601. PMCID: PMC11114142.
Le J, Pan G, Zhang C, [et al., including Tiwari AK]. Targeting ferroptosis in gastric cancer: Strategies and opportunities. Immunological reviews. 2024 321(1):228-245. PMID: 37903748.
Kang X, Huang Y, Wang H, [et al., including Tiwari AK]. Tumor-Associated Macrophage Targeting of Nanomedicines in Cancer Therapy. Pharmaceutics. 2023 16(1). PMID: 38258072. PMCID: PMC10819517.
Annaji M, Mita N, Heard J, [et al., including Tiwari AK]. 3D-Printed Capsaicin-Loaded Injectable Implants for Targeted Delivery in Obese Patients. AAPS PharmSciTech. 2023 24(7):200. PMID: 37783858.
Neupane R, Boddu SHS, Al-Tabakha MM, [et al., including Tiwari AK]. Percutaneous absorption and Skin accumulation of Lorazepam-Diphenhydramine- Haloperidol Carbopol gel in Porcine Ear Skin. AAPS PharmSciTech. 2023 24(7):183. PMID: 37700110.
Zajac KK, Malla S, Babu RJ, [et al., including Tiwari AK]. Ethnic disparities in the immune microenvironment of triple negative breast cancer and its role in therapeutic outcomes. Cancer reports (Hoboken, N.J.). 2023 6 Suppl 1(Suppl 1):e1779. PMID: 36632988. PMCID: PMC10440847.
Sharma R, Tiwari AK. Bridging racial and ethnic disparities in cancer research. Cancer reports (Hoboken, N.J.). 2023 6 Suppl 1(Suppl 1):e1871. PMID: 37528671. PMCID: PMC10440838.
Chavda V, Zajac KK, Gunn JL, [et al., including Tiwari AK]. Ethnic differences in hepatocellular carcinoma prevalence and therapeutic outcomes. Cancer reports (Hoboken, N.J.). 2023 6 Suppl 1(Suppl 1):e1821. PMID: 37344125. PMCID: PMC10440848.
Tian S, Paudel D, Hao F, [et al., including Tiwari AK]. Refined fiber inulin promotes inflammation-associated colon tumorigenesis by modulating microbial succinate production. Cancer reports (Hoboken, N.J.). 2023:e1863. PMID: 37489647. PMCID: PMC10644334.
Ji N, Tiwari AK, Yang DH. Unraveling immunotherapy's role in propelling cancer outcomes. Cancer reports (Hoboken, N.J.). 2023 6(7):e1862. PMID: 37409510. PMCID: PMC10363831.
Golonka RM, Yeoh BS, Saha P, [et al., including Tiwari AK]. Loss of toll-like receptor 5 potentiates spontaneous hepatocarcinogenesis in farnesoid X receptor-deficient mice. Hepatology communications. 2023 7(6). PMID: 37219858. PMCID: PMC10208708.
Chandra Mouli HM, Vinod A, Kumari S, [et al., including Tiwari AK]. Deuterated driven new chemical entities: An optimistic way to improve therapeutic efficacy. Bioorganic chemistry. 2023 135:106490. PMID: 37001472.
Kang X, Jadhav S, Annaji M, [et al., including Tiwari AK]. Advancing Cancer Therapy with Copper/Disulfiram Nanomedicines and Drug Delivery Systems. Pharmaceutics. 2023 15(6). PMID: 37376016. PMCID: PMC10302862.
Dulal D, Boring A, Terrero D, [et al., including Tiwari AK]. Tackling of Immunorefractory Tumors by Targeting Alternative Immune Checkpoints. Cancers. 2023 15(10). PMID: 37345111. PMCID: PMC10216651.
Wang Q, Atluri K, Tiwari AK, Babu RJ. Exploring the Application of Micellar Drug Delivery Systems in Cancer Nanomedicine. Pharmaceuticals (Basel, Switzerland). 2023 16(3). PMID: 36986532. PMCID: PMC10052155.
Al Saqr A, Annaji M, Poudel I, [et al., including Tiwari AK]. Topical Delivery of Diacetyl Boldine in a Microemulsion Formulation for Chemoprotection against Melanoma. Pharmaceutics. 2023 15(3). PMID: 36986762. PMCID: PMC10054442.
Hammad AM, Naser A, Amawi H, [et al., including Tiwari AK]. Effect of amoxicillin/clavulanic acid in attenuating pregabalin-induced condition place preference. Behavioural brain research. 2023 439:114244. PMID: 36470419.
Pal DB, Tiwari AK, Prasad N, [et al.]. Sustainable valorization of water hyacinth waste pollutant via pyrolysis for advance microbial fuel investigation. Chemosphere. 2023 314:137602. PMID: 36563719.
Thakur CK, Karthikeyan C, Abou-Dahech MS, [et al., including Tiwari AK]. Microwave-Assisted Functionalization of Multi-Walled Carbon Nanotubes for Biosensor and Drug Delivery Applications. Pharmaceutics. 2023 15(2). PMID: 36839659. PMCID: PMC9962829.
Sigdel I, Ofori-Kwafo A, Heizelman RJ 3rd, [et al., including Tiwari AK]. Biomimetic on-chip assay reveals the anti-metastatic potential of a novel thienopyrimidine compound in triple-negative breast cancer cell lines. Frontiers in bioengineering and biotechnology. 2023 11:1227119. PMID: 37840664. PMCID: PMC10569307.
Raman D, Tiwari AK. Role of eIF4A1 in triple-negative breast cancer stem-like cell-mediated drug resistance. Cancer reports (Hoboken, N.J.). 2022 5(12):e1299. PMID: 33053607. PMCID: PMC9780423.
Poudel I, Annaji M, Wibowo FS, [et al., including Tiwari AK]. Hispolon Cyclodextrin Complexes and Their Inclusion in Liposomes for Enhanced Delivery in Melanoma Cell Lines. International journal of molecular sciences. 2022 23(22). PMID: 36430965. PMCID: PMC9695989.
Balaji S, Neupane R, Malla S, [et al., including Tiwari AK]. IND-2, a Quinoline Derivative, Inhibits the Proliferation of Prostate Cancer Cells by Inducing Oxidative Stress, Apoptosis and Inhibiting Topoisomerase II. Life (Basel, Switzerland). 2022 12(11). PMID: 36431014. PMCID: PMC9693996.
Thakur CK, Neupane R, Karthikeyan C, [et al., including Tiwari AK]. Lysinated Multiwalled Carbon Nanotubes with Carbohydrate Ligands as an Effective Nanocarrier for Targeted Doxorubicin Delivery to Breast Cancer Cells. Molecules (Basel, Switzerland). 2022 27(21). PMID: 36364286. PMCID: PMC9657689.
Bachu RD, Abou-Dahech M, Balaji S, [et al., including Tiwari AK]. Oncology biosimilars: New developments and future directions. Cancer reports (Hoboken, N.J.). 2022 5(11):e1720. PMID: 36195576. PMCID: PMC9675387.
Pal DB, Tiwari AK, Srivastava N, [et al.]. Biomass valorization of Eichhornia crassipes root using thermogravimetric analysis. Environmental research. 2022 214(Pt 4):114046. PMID: 35998700.
Alrbyawi H, Boddu SHS, Poudel I, [et al., including Tiwari AK]. Cardiolipin for Enhanced Cellular Uptake and Cytotoxicity of Thermosensitive Liposome-Encapsulated Daunorubicin toward Breast Cancer Cell Lines. International journal of molecular sciences. 2022 23(19). PMID: 36233061. PMCID: PMC9569717.
Kumari S, Maddeboina K, Bachu RD, [et al., including Tiwari AK]. Pivotal role of nitrogen heterocycles in Alzheimer's disease drug discovery. Drug discovery today. 2022 27(10):103322. PMID: 35868626.
Abbott KL, Salamat JM, Flannery PC, [et al., including Tiwari AK]. Gefitinib Inhibits Rifampicin-Induced CYP3A4 Gene Expression in Human Hepatocytes. ACS omega. 2022 7(38):34034-34044. PMID: 36188260. PMCID: PMC9520547.
McGowan J, Borucki M, Omairi H, [et al., including Tiwari AK]. SARS-CoV-2 Monitoring in Wastewater Reveals Novel Variants and Biomarkers of Infection. Viruses. 2022 14(9). PMID: 36146835. PMCID: PMC9503862.
Shirbhate E, Veerasamy R, Boddu SHS, [et al., including Tiwari AK]. Histone deacetylase inhibitor-based oncolytic virotherapy: A promising strategy for cancer treatment. Drug discovery today. 2022 27(6):1689-1697. PMID: 35183793.
Alrbyawi H, Poudel I, Annaji M, [et al., including Tiwari AK]. pH-Sensitive Liposomes for Enhanced Cellular Uptake and Cytotoxicity of Daunorubicin in Melanoma (B16-BL6) Cell Lines. Pharmaceutics. 2022 14(6). PMID: 35745701. PMCID: PMC9228428.
Kabir MA, Kharel A, Malla S, [et al., including Tiwari AK]. Automated detection of apoptotic versus nonapoptotic cell death using label-free computational microscopy. Journal of biophotonics. 2022 15(4):e202100310. PMID: 34936215.
Deng LJ, Deng WQ, Fan SR, [et al., including Tiwari AK]. m6A modification: recent advances, anticancer targeted drug discovery and beyond. Molecular cancer. 2022 21(1):52. PMID: 35164788. PMCID: PMC8842557.
Al Saqr A, Annaji M, Poudel I, [et al., including Tiwari AK]. Niosomal formulation of hydroxytyrosol, a polyphenolic antioxidant, for enhancing transdermal delivery across human cadaver skin. Pharmaceutical development and technology. 2022 27(2):155-163. PMID: 34978253.
Khare VM, Saxena VK, Pasternak MA, [et al., including Tiwari AK]. The expression profiles of chemokines, innate immune and apoptotic genes in tumors caused by Rous Sarcoma Virus (RSV-A) in chickens. Genes and immunity. 2022 23(1):12-22. PMID: 34934184.
Powe E, Parschauer D, Istifan J, [et al., including Tiwari AK]. Luteolin enhances erlotinib's cell proliferation inhibitory and apoptotic effects in glioblastoma cell lines. Frontiers in pharmacology. 2022 13:952169. PMID: 36199696. PMCID: PMC9527275.
Alrbyawi H, Poudel I, Annaji M, [et al., including Tiwari AK]. Recent Advancements of Stimuli-Responsive Targeted Liposomal Formulations for Cancer Drug Delivery. Pharmaceutical nanotechnology. 2022 10(1):3-23. PMID: 35156590.
Amawi H, Al-Azzam S, Alzanati T, [et al., including Tiwari AK]. The Validity of Mobile Applications to Facilitate Patient Care Provided to Cancer Patients: Opportunities and Limitations. Recent patents on anti-cancer drug discovery. 2022 17(2):204-213. PMID: 34323199.
Boddu SHS, Bhagav P, Karla PK, [et al., including Tiwari AK]. Polyamide/Poly(Amino Acid) Polymers for Drug Delivery. Journal of functional biomaterials. 2021 12(4). PMID: 34698184. PMCID: PMC8544418.
Neupane R, Malla S, Abou-Dahech MS, [et al., including Tiwari AK]. Antiproliferative Efficacy of N-(3-chloro-4-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine, DW-8, in Colon Cancer Cells Is Mediated by Intrinsic Apoptosis. Molecules (Basel, Switzerland). 2021 26(15). PMID: 34361570. PMCID: PMC8347809.
Len JM, Hussein N, Malla S, [et al., including Tiwari AK]. A Novel Dialkylamino-Functionalized Chalcone, DML6, Inhibits Cervical Cancer Cell Proliferation, In Vitro, via Induction of Oxidative Stress, Intrinsic Apoptosis and Mitotic Catastrophe. Molecules (Basel, Switzerland). 2021 26(14). PMID: 34299490. PMCID: PMC8306139.
Hussein NA, Malla S, Pasternak MA, [et al., including Tiwari AK]. The role of endolysosomal trafficking in anticancer drug resistance. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. 2021 57:100769. PMID: 34217999.
Mishra GP, Bhadane RN, Panigrahi D, [et al., including Tiwari AK]. The interaction of the bioflavonoids with five SARS-CoV-2 proteins targets: An in silico study. Computers in biology and medicine. 2021 134:104464. PMID: 34020130. PMCID: PMC8108478.
Neupane R, Boddu SHS, Abou-Dahech MS, [et al., including Tiwari AK]. Transdermal Delivery of Chemotherapeutics: Strategies, Requirements, and Opportunities. Pharmaceutics. 2021 13(7). PMID: 34206728. PMCID: PMC8308987.
Annaji M, Poudel I, Boddu SHS, [et al., including Tiwari AK]. Resveratrol-loaded nanomedicines for cancer applications. Cancer reports (Hoboken, N.J.). 2021 4(3):e1353. PMID: 33655717. PMCID: PMC8222557.
Von Suskil M, Sultana KN, Elbezanti WO, [et al., including Tiwari AK]. Bruton's Tyrosine Kinase Targeting in Multiple Myeloma. International journal of molecular sciences. 2021 22(11). PMID: 34071917. PMCID: PMC8198777.
Palliyage GH, Hussein N, Mimlitz M, [et al., including Tiwari AK]. Novel Curcumin-Resveratrol Solid Nanoparticles Synergistically Inhibit Proliferation of Melanoma Cells. Pharmaceutical research. 2021 38(5):851-871. PMID: 33982225.
Tukaramrao DB, Malla S, Saraiya S, [et al., including Tiwari AK]. A Novel Thienopyrimidine Analog, TPH104, Mediates Immunogenic Cell Death in Triple-Negative Breast Cancer Cells. Cancers. 2021 13(8). PMID: 33919653. PMCID: PMC8074041.
Amawi H, Aljabali AAA, Boddu SHS, [et al., including Tiwari AK]. The use of zebrafish model in prostate cancer therapeutic development and discovery. Cancer chemotherapy and pharmacology. 2021 87(3):311-325. PMID: 33392639.
Kurakula M, Chen L, Tiwari AK, [et al.]. Recent Advances in Lipid-Based Nanovesicular Delivery Systems for Melanoma Therapy. Critical reviews in therapeutic drug carrier systems. 2021 38(4):1-38. PMID: 34369738.
Tiwari AK. Transformative Approaches to Improve Chemotherapy for Difficult to Treat Solid Tumors. Current pharmaceutical design. 2021 27(46):4649. PMID: 34875985.
Balaji S, Terrero D, Tiwari AK, [et al.]. Alternative approaches to overcome chemoresistance to apoptosis in cancer. Advances in protein chemistry and structural biology. 2021 126:91-122. PMID: 34090621.
Sigdel I, Gupta N, Faizee F, [et al., including Tiwari AK]. Biomimetic Microfluidic Platforms for the Assessment of Breast Cancer Metastasis. Frontiers in bioengineering and biotechnology. 2021 9:633671. PMID: 33777909. PMCID: PMC7992012.
Verma S, Singh A, Varshney A, [et al., including Tiwari A]. Infectious Keratitis: An Update on Role of Epigenetics. Frontiers in immunology. 2021 12:765890. PMID: 34917084. PMCID: PMC8669721.
Kumari S, Carmona AV, Tiwari AK, Trippier PC. Amide Bond Bioisosteres: Strategies, Synthesis, and Successes. Journal of medicinal chemistry. 2020 63(21):12290-12358. PMID: 32686940. PMCID: PMC7666045.
Al Saqr A, Aldawsari MF, Alrbyawi H, [et al., including Tiwari AK]. Co-Delivery of Hispolon and Doxorubicin Liposomes Improves Efficacy Against Melanoma Cells. AAPS PharmSciTech. 2020 21(8):304. PMID: 33150503.
Boddu SHS, Tukaramrao DB, Al-Tabakha MM, [et al., including Tiwari AK]. Evaluation of Cytotoxicity and Taste-Masking Effect of Selected Flavors on Dental Lidocaine HCl Injection. Pharmaceuticals (Basel, Switzerland). 2020 13(11). PMID: 33138130. PMCID: PMC7693877.
Reznik SE, Tiwari AK, Ashby CR Jr. Edaravone: A potential treatment for the COVID-19-induced inflammatory syndrome?. Pharmacological research. 2020 160:105055. PMID: 32619723. PMCID: PMC7326414.
Howard CM, Estrada M, Terrero D, [et al., including Tiwari AK]. Identification of Cardiac Glycosides as Novel Inhibitors of eIF4A1-Mediated Translation in Triple-Negative Breast Cancer Cells. Cancers. 2020 12(8). PMID: 32759815. PMCID: PMC7465665.
Al-Oudat BA, Ramapuram H, Malla S, [et al., including Tiwari AK]. Novel Chrysin-De-Allyl PAC-1 Hybrid Analogues as Anticancer Compounds: Design, Synthesis, and Biological Evaluation. Molecules (Basel, Switzerland). 2020 25(13). PMID: 32635530. PMCID: PMC7412250.