Wayne P Wahls, PhD
Associate Member
Research Program:
Cancer Biology
Faculty Rank:
Professor
Campus:
University of Arkansas for Medical Sciences
College:
College of Medicine
Department:
Biochemistry & Molecular Biology
|
Cancer Research Interest
- Disease Site Focus: No Specific Disease Site
- Research Focus Area: Carcinogenesis
- Type of Research: Basic
- Research Keywords: Genome dynamics, Homologous recombination, DNA damage response
- Research Interest Statement: Research in my laboratory encompasses chromosome dynamics, epigenetics, stress responsive signaling pathways, and homologous recombination. We use a powerful model organism, the fission yeast S. pombe, to define molecular mechanisms of fundamental biological processes used by all eukaryotes, including humans. Our work has provided important insight into genome dynamics and instability, cellular growth controls, and the formation and repair of double-strand DNA breaks, each of which is germane to the causes and consequences of cancer. I have a secondary interest in science funding policy, focused on the sources, impacts and remediation of vast disparities in NIH funding among institutions and states. I have been funded consistently through my career by agencies such as the Damon Runyan Cancer Research Foundation, the Leukemia Society of America, the NIH, and the Human Frontier Science Program. I currently have an active NIH R01 grant (GM145834) for the systematic elucidation of DNA sequence codes that regulate homologous recombination.
Contact Information
- Email Address: WAHLSWAYNEP@UAMS.EDU
- Profiles Research Networking Software: View Profile
Active Grants
- NIH/Nat. Inst. of General Medical Sciences – 1R01GM145834“Systematic elucidation of DNA sequence codes that regulate meiotic recombination”Principal Investigator05/10/22 – 03/31/26
Publications
- Protacio RU, Malone EG, Wahls WP. DNA sequences and distinct mechanisms for ura4-595 and ura4-294 alleles of S. pombe. microPublication biology. 2024 2024. PMID: 38440330. PMCID: PMC10910285.
- Protacio RU, Mukiza TO, Davidson MK, Wahls WP. Molecular mechanisms for environmentally induced and evolutionarily rapid redistribution (plasticity) of meiotic recombination. Genetics. 2022 220(2). PMID: 34888655. PMCID: PMC9097252.
- Protacio RU, Davidson MK, Wahls WP. Adaptive Control of the Meiotic Recombination Landscape by DNA Site-dependent Hotspots With Implications for Evolution. Frontiers in genetics. 2022 13:947572. PMID: 35812747. PMCID: PMC9257126.
- Storey AJ, Hardman RE, Byrum SD, [et al., including Wahls WP]. Accurate and Sensitive Quantitation of the Dynamic Heat Shock Proteome Using Tandem Mass Tags. Journal of proteome research. 2020 19(3):1183-1195. PMID: 32027144. PMCID: PMC7241437.
- Storey AJ, Wang HP, Protacio RU, [et al., including Wahls WP]. Targeted Forward Genetics: Population-Scale Analyses of Allele Replacements Spanning Thousands of Base Pairs in Fission Yeast. G3 (Bethesda, Md.). 2019 9(12):4097-4106. PMID: 31597677. PMCID: PMC6893178.
- Mukiza TO, Protacio RU, Davidson MK, [et al., including Wahls WP]. Diverse DNA Sequence Motifs Activate Meiotic Recombination Hotspots Through a Common Chromatin Remodeling Pathway. Genetics. 2019 213(3):789-803. PMID: 31511300. PMCID: PMC6827382.
- Wahls WP. Opinion: The National Institutes of Health needs to better balance funding distributions among US institutions. Proceedings of the National Academy of Sciences of the United States of America. 2019 116(27):13150-13154. PMID: 31266906. PMCID: PMC6613164.