Jessica Lynn Kelliher, PhD
Affiliate Member
|
| Research Program:
Cancer Biology
Faculty Rank:
Postdoctoral Fellow
Campus:
University of Arkansas for Medical Sciences
College:
College of Medicine
Department:
Biochemistry & Molecular Biology
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Cancer Research Interest
- Disease Site Focus: No Specific Disease Site
- Research Focus Area: Treatment, Prevention, Carcinogenesis
- Type of Research: Basic, Translational
- Research Keywords: DNA damage, H2AX, 53BP1, DNA damage response
- Research Interest Statement: My research interests include the DNA damage response and its modulation in cancer cells. I study the molecular mechanisms of DNA repair in order to discover new targets for cancer therapies and understand the mechanisms behind the current therapeutic strategies used in cancer treatments. I hope to be able to leverage the altered DNA damage response in cancer cells to selectively inhibit cancer cell growth while leaving healthy cells intact.
Contact Information
- Email Address: JKELLIHER@UAMS.EDU
Recent Publications
- Kelliher JL, Folkerts ML, Shen KV, [et al.]. Evolved histone tail regulates 53BP1 recruitment at damaged chromatin. Nature communications. 2024 15(1):4634. PMID: 38821984. PMCID: PMC11143218.
- Lee SO, Kelliher JL, Song W, [et al.]. UBA80 and UBA52 fine-tune RNF168-dependent histone ubiquitination and DNA repair. The Journal of biological chemistry. 2023 299(8):105043. PMID: 37451480. PMCID: PMC10413357.
- Kelliher J, Tackett A, Ghosal G, Leung JWC. New answers to the old RIDDLE: RNF168 and the DNA damage response pathway. The FEBS journal. 2021. PMID: 33797206. PMCID: PMC8486888.
- Kelliher JL, West KL, Gong Q, Leung JWC. Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination. Nature communications. 2020 11(1):2462. PMID: 32424115. PMCID: PMC7235047.