Sara C Shalin, MD, PhD

Research Program: Cancer Biology Faculty Rank: Professor Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: COM Pathology (and Chair of Dermatology)

Cancer Research Interest

• Disease Site Focus: Melanoma
• Research Focus Area: Diagnosis/ Prognosis
• Type of Research: Translational
• Research Keywords: melanoma, skin, inflammatory
• Research Interest Statement: I am a board-certified pathologist with special expertise in dermatopathology. In addition to my clinical efforts, I have protected time for my research interests, which include studies on melanoma prevention, detection, diagnosis, staging and treatment. My studies have been predominantly studies of archival patient samples of diseases or entities of interest and funded by institutional/departmental funding or collaborative efforts with other Cancer center researchers.

Contact Information

• Email Address: SCSHALIN@UAMS.EDU
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Publications

• Cornejo KM, Hutchinson L, O'Donnell P, [et al., including Shalin SC]. Molecular Profiling of Syringocystadenocarcinoma Papilliferum Reveals RAS-Activating Mutations. Archives of pathology & laboratory medicine. 2023. PMID: 37074845.
• Drolshagen H, Zoumberos N, Shalin S. Bullous Tinea. Archives of pathology & laboratory medicine. 2023. PMID: 36602892.
• Ly S, Rick J, Goff R, [et al., including Shalin S]. Cutaneous Oxalosis Due to Primary Hyperoxaluria. The American Journal of dermatopathology. 2022 44(12):981-983. PMID: 36395453.
• McKinnon AT, Shalin SC, Evans MS. Bilateral eyelid swelling as the presenting sign of subcutaneous sarcoidosis. Pediatric dermatology. 2022. PMID: 36443578.
• Hamza MA, Quick CM, Williams HR, [et al., including Shalin SC]. HPV-associated Vulvar Intraepithelial Carcinoma With Sebaceous Differentiation: Report of 2 Cases. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 2022. PMID: 36383010.
• Ahmed A, Gittens BE, Stewart SA, Shalin SC. Demographics and perceptions of diversity in dermatopathology workforce and training environments in the United States. Journal of cutaneous pathology. 2022. PMID: 36308409. PMCID: PMC10023271.
• Dreher K, Lindsey M, Shalin S, Evans MS. A Pink Pedal Plaque in an 8-Year-Old Boy. Clinical pediatrics. 2022:99228221106623. PMID: 35746872.
• Draper E, Rollins B, Matlock S, [et al., including Shalin S]. Milia en plaque manifesting as a post-herpetic isotopic response. Dermatology online journal. 2022 28(3). PMID: 36259804.
• Campbell K, Bridge JA, DiMaio D, [et al., including Shalin SC]. Dermatofibrosarcoma protuberans with platelet-derived growth factor-D rearrangement; two cases with morphologically distinct presentations. Journal of cutaneous pathology. 2022 49(3):274-277. PMID: 34628665.
• Higgins AD, Shalin SC. Blue nevus with smooth muscle hyperplasia: A rare hamartoma. Journal of cutaneous pathology. 2022 49(3):310-313. PMID: 34716951.
• Lindsey MS, Bridge JA, Douglas DS, [et al., including Shalin SC]. Primary Cutaneous Alveolar Rhabdomyosarcoma in an Elderly Adult: A Rare Potential Mimic of Merkel Cell Carcinoma. The American Journal of dermatopathology. 2022 44(3):218-222. PMID: 34991098.
• Fung MA, Vidal CI, Armbrecht EA, [et al., including Shalin SC]. Appropriate use criteria for ancillary diagnostic testing in dermatopathology: New recommendations for 11 tests and 220 clinical scenarios from the American Society of Dermatopathology Appropriate Use Criteria Committee. Journal of cutaneous pathology. 2022 49(3):231-245. PMID: 34536035.
• Lindsey M, Vishal S, Gardner JM, Shalin SC. Characterization of Morphologic and Cytochemical Staining Properties of Exogenous Materials Mimicking Fungal Organisms Encountered in Skin Biopsies. The American Journal of dermatopathology. 2021 43(10):679-687. PMID: 34546986.
• Krystel-Whittemore M, Chan MP, Shalin SC, [et al.]. Deep Herpes. The American journal of surgical pathology. 2021 45(10):1357-1363. PMID: 34324455.
• Morgan AG, Rush JL, Shalin SC, Kincannon JM. Hyperkeratotic Plaques of Distal Extremities as a Presenting Sign of Autoimmune Hepatitis: Answer. The American Journal of dermatopathology. 2021 43(9):672-673. PMID: 34411021.
• Morgan AG, Rush JL, Shalin SC, Kincannon JM. Hyperkeratotic Plaques of Distal Extremities as a Presenting Sign of Autoimmune Hepatitis: Challenge. The American Journal of dermatopathology. 2021 43(9):e101. PMID: 34411025.
• Parra O, Bridge JA, Busam KJ, [et al., including Shalin SC]. Dermal melanocytic tumor with CRTC1-TRIM11 fusion: Report of two additional cases with review of the literature of an emerging entity. Journal of cutaneous pathology. 2021 48(7):915-924. PMID: 33586183.
• Singh AP, Jeffus SK, Shalin SC. Cervical dysplasia in a patient with inherited epidermodysplasia verruciformis-A mere coincidence?. Journal of cutaneous pathology. 2021 48(6):763-770. PMID: 33319409.
• Nedosekin D, Wilson KD, Campbell K, [et al., including Shalin S]. Immunologic overlap in a case of linear IgG/IgA bullous dermatosis responsive to rituximab. JAAD case reports. 2021 9:57-60. PMID: 33665277. PMCID: PMC7898068.
• Shalin SC, Racher LM, Campbell KK. Lichenoid dermatoses involving the vulva: A clinical-pathologic correlation?. Seminars in diagnostic pathology. 2021 38(1):3-18. PMID: 32951943.
• Jeffus SK, Quick CM, Chen C, [et al., including Shalin SC]. Prospective Consensus Reporting by Gynecologic Pathology and Dermatopathology Improves Diagnosis of Vulvar Biopsies. Archives of pathology & laboratory medicine. 2020 144(12). PMID: 33212498.
• Shalin SC, Ferringer T, Cassarino DS. PAS and GMS utility in dermatopathology: Review of the current medical literature. Journal of cutaneous pathology. 2020 47(11):1096-1102. PMID: 32515092.
• Dawson K, Bridge JA, Sumegi J, [et al., including Shalin SC]. Epithelioid Fibrous Histiocytoma With Dot-Like Perinuclear ALK Expression and PRKAR2A-ALK Fusion. The American Journal of dermatopathology. 2020 42(11):861-864. PMID: 32379091.
• Fancher K, Gardner JM, Shalin SC. Elastophagocytosis and interstitial granulomatous infiltrate are more common in extragenital vs genital lichen sclerosus. Journal of cutaneous pathology. 2020 47(10):903-912. PMID: 32399972.
• Carlock S, Fulton EH, Rosenbaum E, [et al., including Shalin SC]. Hansen Disease (Leprosy) and Armadillo Exposure in Arkansas: A Case Series. The American Journal of dermatopathology. 2020 42(10):769-773. PMID: 32379089.
• Campbell KK, Gardner JM, Hall K, [et al., including Shalin SC]. Consecutive Immunohistochemical Staining on a Single Slide is Effective in Confirming Melanocytic Derivation. Applied immunohistochemistry & molecular morphology : AIMM. 2020 28(9):e76-e81. PMID: 30499815.
• Taylor EM, Byrum SD, Edmondson JL, [et al., including Shalin SC]. Proteogenomic analysis of melanoma brain metastases from distinct anatomical sites identifies pathways of metastatic progression. Acta neuropathologica communications. 2020 8(1):157. PMID: 32891176. PMCID: PMC7487560.
• Harrison DK, Tackett A, Waldrip ZJ, [et al., including Shalin SC]. DNA-PKcs Inhibition Extends Allogeneic Skin Graft Survival. Transplantation. 2020. PMID: 32890138. PMCID: PMC7902289.
• Cloutier JM, Shalin SC, Lindberg M, [et al.]. Cutaneous pleomorphic fibromas arising in patients with germline TP53 mutations. Journal of cutaneous pathology. 2020 47(8):734-741. PMID: 32187703.
• Donizy P, Wu CL, Mull J, [et al., including Shalin SC]. Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas. Cells. 2020 9(5). PMID: 32380691. PMCID: PMC7290913.
• Davis LE, Shalin SC, Tackett AJ. Utility of histone H3K27me3 and H4K20me as diagnostic indicators of melanoma. Melanoma research. 2020 30(2):159-165. PMID: 32142497. PMCID: PMC7080300.
• Wei T, Shalin S, Draper E, [et al.]. Abnormal elastin and collagen deposition is present in extracranial arteriovenous malformations: A comparison to intracranial disease. Histology and histopathology. 2019 34(12):1355-1363. PMID: 31119718.
• Abate MS, Battle LR, Emerson AN, [et al., including Shalin SC]. Dermatologic Urgencies and Emergencies: What Every Pathologist Should Know. Archives of pathology & laboratory medicine. 2019 143(8):919-942. PMID: 30785787.
• Lora Gonzalez M, Webb M, Shalin S. Periumbilical Papule: Challenge. The American Journal of dermatopathology. 2019 41(7):e71-e72. PMID: 29505474.
• Shalin SC, Gardner JM, Kaley JR. Pearls and Updates in Dermatopathology for the General Surgical Pathologist: Experts Weigh In on What You Need to Know. Archives of pathology & laboratory medicine. 2019 143(7):786-788. PMID: 31225990.
• Lora Gonzalez M, Webb M, Shalin S. Periumbilical Papule: Answer. The American Journal of dermatopathology. 2019 41(7):531-532. PMID: 31232737.
• Shields BD, Koss B, Taylor EM, [et al., including Shalin SC]. Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma. Cancer research. 2019 79(6):1113-1123. PMID: 30674537. PMCID: PMC6420873.
• Davis LE, Shalin SC, Tackett AJ. Current state of melanoma diagnosis and treatment. Cancer biology & therapy. 2019 20(11):1366-1379. PMID: 31366280. PMCID: PMC6804807.
• Haller J, David MP, Lee NE, [et al., including Shalin SC]. Impact of Pathologist Involvement in Sarcoma and Rare Tumor Patient Support Groups on Facebook: A Survey of 542 Patients and Family Members. Archives of pathology & laboratory medicine. 2018 142(9):1113-1119. PMID: 29377717.
• Dunn ALJ, Gardner JM, Kaley JR, [et al., including Shalin SC]. ALK Rearrangements Are Infrequent in Cellular Blue Nevus and Deep Penetrating Nevus. The American Journal of dermatopathology. 2018 40(7):469-478. PMID: 29923908.
• Durvasula VSPB, Shalin SC, Tulunay-Ugur OE, [et al.]. Effects of supramaximal balloon dilatation pressures on adult cricoid and tracheal cartilage: A cadaveric study. The Laryngoscope. 2018 128(6):1304-1309. PMID: 28988443.
• Dinehart M, Abate MS, Jennings T, [et al., including Shalin SC]. Colliding, colonizing or combining? Four cases illustrating the unique challenges presented by melanoma arising in conjunction with basal cell carcinoma. Journal of cutaneous pathology. 2018 45(6):443-452. PMID: 29484694.
• Abate MS, Shalin S. Progressive widespread telangiectasias. Cutis. 2018 101(5):E1-E3. PMID: 29894536.
• Dunn A, Broadfoot BG, Hunt J, [et al., including Shalin SC]. Metastatic laryngeal large cell neuroendocrine carcinoma: A rare case of presentation and extreme tumor burden. Journal of cutaneous pathology. 2018 45(3):229-233. PMID: 29194700.
• Purnell JC, Gardner JM, Brown JA, Shalin SC. Conventional Versus Giant Basal Cell Carcinoma, a Review of 57 Cases: Histologic Differences Contributing to Excessive Growth. Indian journal of dermatology. 2018 63(2):147-154. PMID: 29692457. PMCID: PMC5903045.
• Ch?opik A, Selim MA, Peng Y, [et al., including Shalin SC]. Prognostic role of tumoral PDL1 expression and peritumoral FoxP3+ lymphocytes in vulvar melanomas. Human pathology. 2018 73:176-183. PMID: 29307625.
• Carlquist E, Lee NE, Shalin SC, [et al.]. Dermatopathology and Social Media: A Survey of 131 Medical Professionals From 29 Countries. Archives of pathology & laboratory medicine. 2018 142(2):184-190. PMID: 28657771.
• Carlquist E, Lee NE, Shalin SC, [et al.]. Dermatopathology and Social Media: Improving Participation by Increasing Clarity. Archives of pathology & laboratory medicine. 2018 142(1):11. PMID: 29257927.
• Dias-Santagata D, Selim MA, Su Y, [et al., including Shalin SC]. KIT mutations and CD117 overexpression are markers of better progression-free survival in vulvar melanomas. The British journal of dermatology. 2017 177(5):1376-1384. PMID: 28734009.
• Kaur V, Swami A, Shebli A, [et al., including Shalin S]. A rare case of blastic plasmacytoid dendritic cell neoplasm with deletion 7q.31, in the setting of heavy pre-treatment with alkylating chemotherapy. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners. 2017 23(7):552-556. PMID: 27559020.
• Johnson G, Gardner JM, Shalin SC. Polarizable crystals in apocrine sweat gland tumors: A series of 3 cases. Journal of cutaneous pathology. 2017 44(8):698-702. PMID: 28497640.
• Mahmoud F, Shields B, Makhoul I, [et al., including Shalin S]. Immune surveillance in melanoma: From immune attack to melanoma escape and even counterattack. Cancer biology & therapy. 2017 18(7):451-469. PMID: 28513269. PMCID: PMC5639850.
• Liles JE, Shalin SC, White BA, [et al.]. Parvovirus B19 infection in an adult presenting with connective tissue disease-like symptoms: a report of the clinical and histological findings. Dermatology online journal. 2017 23(6). PMID: 28633740.
• Shields BD, Mahmoud F, Taylor EM, [et al., including Shalin S]. Indicators of responsiveness to immune checkpoint inhibitors. Scientific reports. 2017 7(1):807. PMID: 28400597. PMCID: PMC5429745.
• Kothari A, Shalin SC, Crescencio JC, Burgess MJ. Skin lesion in a patient with acute myeloid leukemia. Transplant infectious disease : an official journal of the Transplantation Society. 2017 19(1). PMID: 27862750.
• Shalin SC. A review of kinase fusions in melanocytic tumors. Laboratory investigation; a journal of technical methods and pathology. 2017 97(2):158-165. PMID: 27892929.
• Kaliki V, Shalin SC, Edgar-Zarate C. A Rare Rash in a Pediatric Patient Due to a Very Common Medication. Clinical pediatrics. 2017 56(1):97-99. PMID: 27029819.
• Kothari A, Shalin SC, Rico Crescencio JC, Burgess MJ. Skin Lesion with Splenic Microabscesses in a Patient with Acute Myeloid Leukemia. The American journal of medicine. 2016 129(12):e325-e327. PMID: 27637597.
• Romano RC, Gardner JM, Shalin SC, [et al.]. High Relative Expression of Pannexin 3 (PANX3) in an Axillary Sweat Gland Carcinoma With Osteosarcomatous Transformation. The American Journal of dermatopathology. 2016 38(11):846-851. PMID: 27391460.
• Mohan M, Shalin SC, Kothari A, [et al.]. Lasiodiplodia species fungal osteomyelitis in a multiple myeloma patient. Transplant infectious disease : an official journal of the Transplantation Society. 2016 18(5):761-764. PMID: 27391908.
• Jones C, Shalin SC, Gardner JM. Incidence of mature adipocytic component within cutaneous smooth muscle neoplasms. Journal of cutaneous pathology. 2016 43(10):866-71. PMID: 27404774.
• Erstine EM, Elwood HR, Westbrook KC, [et al., including Shalin SC]. Desmoplastic melanoma presenting as primary alopecia neoplastica: a report of two cases. Journal of cutaneous pathology. 2016 43(10):872-9. PMID: 27272456.
• Shields BD, Tackett AJ, Shalin SC. Proteomics and melanoma: a current perspective. Global dermatology. 2016 3(4):366-370. PMID: 30214824. PMCID: PMC6133306.
• Uhlenhake EE, Clark LN, Smoller BR, [et al., including Shalin SC]. Nuclear factor XIIIa staining (clone AC-1A1 mouse monoclonal) is a sensitive and specific marker to discriminate sebaceous proliferations from other cutaneous clear cell neoplasms. Journal of cutaneous pathology. 2016 43(8):649-56. PMID: 27153339.
• Clark LN, Elwood HR, Uhlenhake EE, [et al., including Shalin SC]. Nuclear factor XIIIa staining (clone AC-1A1 mouse monoclonal) is a highly sensitive marker of sebaceous differentiation in normal and neoplastic sebocytes. Journal of cutaneous pathology. 2016 43(8):657-62. PMID: 27153463.
• Fulton E, Alapat D, Mabry A, [et al., including Shalin SC]. CLL/SLL with initial presentation as a longstanding cutaneous plaque: a rare case. Journal of cutaneous pathology. 2016 43(8):717-21. PMID: 27147484.
• Schnebelen AM, Gardner JM, Shalin SC. Margin Status in Shave Biopsies of Nonmelanoma Skin Cancers: Is It Worth Reporting?. Archives of pathology & laboratory medicine. 2016 140(7):678-81. PMID: 27116089.