Kirk L West, PhD

Affiliate Member

Research Program:

Cancer Biology

Faculty Rank:

Assistant Professor

Campus:

University of Arkansas for Medical Sciences

College:

College of Medicine

Department:

Biochemistry & Molecular DNA & RNA

Cancer Research Interest

Disease Site Focus: No Specific Disease Site
Research Focus Area: Carcinogenesis, Treatment
Type of Research: Basic
Research Keywords: DNA damage repair, Post-translation modification, Kinases, Mass spectrometry
Research Interest Statement: My research interests including using proteomics and biochemical techniques to understand the role of the understudied kinases, TLK1 and TLK2, in the DNA damage response. The goal of this work is to better understand how the cell regulates DNA damage repair pathway choice and hopefully lead to more effective cancer therapies.

West KL, Nguyen TTN, Tengler KA, [et al.]. Autophosphorylation of the Tousled-like kinases TLK1 and TLK2 regulates recruitment to damaged chromatin via PCNA interaction. Nucleic acids research. 2024. PMID: 39727191. PMCID: PMC11879137.
Li J, Xiong N, West KL, [et al.]. Nuclear F-actin assembly on damaged chromatin is regulated by DYRK1A and Spir1 phosphorylation. Nucleic acids research. 2024. PMID: 38966995. PMCID: PMC11347173.
Dong C, West KL, Tan XY, [et al.]. Screen identifies DYRK1B network as mediator of transcription repression on damaged chromatin. Proceedings of the National Academy of Sciences of the United States of America. 2020 117(29):17019-17030. PMID: 32611815. PMCID: PMC7382216.
Kelliher JL, West KL, Gong Q, Leung JWC. Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination. Nature communications. 2020 11(1):2462. PMID: 32424115. PMCID: PMC7235047.