Lyle J Burdine, MD, PhD

Research Program: Cancer Therapeutics Faculty Rank: Associate Professor Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Surgery Leadership

Cancer Research Interest

• Disease Site Focus: GI
• Research Focus Area: Treatment, Diagnosis/ Prognosis, Detection
• Type of Research: Translational, Basic
• Research Keywords: Liver Cancer, Liver Transplant, DNA-PK, Cell Based Therapy, Cellular Engineering
• Research Interest Statement: Research efforts are currently focused within three areas. 1. Immunology 2. Cancer Biology 3. Clinical outcomes and trends within hepatobiliary/transplant surgery. The basic science efforts have centered on transplant immunology, cancer immunology, and hepatobiliary cancer. We are interested in a particular enzyme, DNA-PKcs, and the role of that enzyme in peripheral lymphocyte development. Additional basic science projects involve collaborations with Dr. William Lu in the cancer center collaborating on synthetic T-cell biology projects and Dr. James Meek in Interventional radiology on investigating the role of Y90 in local tumor control, reshaping the tumor microenvironment, and liver augmentation prior to resection.My clinical research efforts are mostly done to help foster and develop medical student/resident research interest in all areas of surgery including cancer. To date this has resulted in 6 student presentations at national conferences and 2 student papers. With the low entry barriers, clinical research provides a good opportunity to help develop students that have an interest in academic medicine.

Contact Information

• Email Address: LBURDINE@UAMS.EDU
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Recent Publications

• Eigbire-Molen OJ, Cassol CA, Kenan DJ, [et al., including Burdine LJ]. Smartphone-based machine learning model for real-time assessment of medical kidney biopsy. Journal of pathology informatics. 2024 15:100385. PMID: 39071542. PMCID: PMC11283020.
• Hardgrave H, Jeon H, Wells A, [et al., including Burdine LJ]. Kidney Utilization in the Context of a Shifting Donor Landscape in the United States. Transplantation. 2024. PMID: 40101109.
• Ahangaran M, Sun E, Le K, [et al., including Burdine LJ]. Pilot Study of a Web-Based Tool for Real-Time Adequacy Assessment of Kidney Biopsies. Kidney international reports. 2024 9(9):2809-2813. PMID: 39291211. PMCID: PMC11403039.
• Waldrip ZJ, Acharya B, Armstrong D, [et al., including Burdine L]. Discovery of the DNA-PKcs inhibitor DA-143 which exhibits enhanced solubility relative to NU7441. Scientific reports. 2024 14(1):19999. PMID: 39198533. PMCID: PMC11358143.
• Lynch JM, Batiste D, Burdine L, Meek J. Hepatic Artery Thrombectomy after Orthotopic Liver Transplantation: A Stent Retriever and/or Aspiration-Guided Catheter Approach. Journal of vascular and interventional radiology : JVIR. 2024. PMID: 38945294.
• Sanikommu S, Lusardi K, Burdine L, Dare RK. Development of VRE meningitis due to haematogenous spread while on high-dose daptomycin therapy. JAC-antimicrobial resistance. 2023 5(6):dlad118. PMID: 38021040. PMCID: PMC10654863.
• Azevedo-Pouly AC, Appell LE, Burdine L, [et al.]. Chemical inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4(+) helper and CD8(+) effector T cells. Immunology and cell biology. 2023. PMID: 37149747. PMCID: PMC10527493.
• Giorgakis E, Ivanics T, Wallace D, [et al., including Burdine L]. Acuity circles allocation policy impact on waitlist mortality and donation after circulatory death liver transplantation: A nationwide retrospective analysis. Health science reports. 2023 6(2):e1066. PMID: 36751274. PMCID: PMC9892027.
• Gottsponer JA, Baker DL, Osborn T, [et al., including Burdine LJ]. Non-insulinoma pancreatogenous hypoglycemia syndrome due to nesidioblastosis following bariatric Roux-en-Y gastric bypass. Journal of surgical case reports. 2023 2023(2):rjad050. PMID: 36811071. PMCID: PMC9939044.
• Giorgakis E, Estrada MM, Wells A, [et al., including Burdine L]. Women Referred for Liver Transplant Are Less Likely to Be Transplanted Irrespective of Socioeconomic Status. Transplant international : official journal of the European Society for Organ Transplantation. 2023 36:11667. PMID: 38020747. PMCID: PMC10651715.
• Hardgrave H, Wells A, Nigh J, [et al., including Burdine L]. COVID-19 Mortality in Vaccinated vs. Unvaccinated Liver & Kidney Transplant Recipients: A Single-Center United States Propensity Score Matching Study on Historical Data. Vaccines. 2022 10(11). PMID: 36423017. PMCID: PMC9694459.
• Fletchinger T, Jensen HK, Wells A, [et al., including Burdine L]. Impact of Prolonged Cold Ischemia Time on One Year Kidney Transplant Outcomes. Transplantation proceedings. 2022 54(8):2170-2173. PMID: 36180253.
• Hairston HC, Ipe TS, Burdine L, [et al.]. Incidence of Red Cell Antibody Formation Following Massive Transfusion Protocol: Experience of a Single Institution. The American surgeon. 2022:31348221129500. PMID: 36169356.
• Hardgrave H, Burdine L, Patel R, Giorgakis E. Negative COVID-19 Plasma PCR Following COVID-19+ Donor Kidney Transplant. Transplantation. 2022. PMID: 35642956.
• Giorgakis E, Ivanics T, Khorsandi SE, [et al., including Burdine L]. Disparities in the Use of Older Donation After Circulatory Death Liver Allografts in the United States Versus the United Kingdom. Transplantation. 2022. PMID: 35642976.
• Giorgakis E, Khorsandi SE, Burdine L, [et al.]. Corrigendum to: Center volume impact on graft survival and waitlist time in donation after circulatory death (DCD) liver transplantation in the United States. The British journal of surgery. 2021 109(1):e20. PMID: 34878524.
• Hill SEM, Jensen HK, Reif R, [et al., including Burdine L]. National Readmissions Database characterization of post-cholecystectomy care for inpatients: Readmissions and bile duct repair. American journal of surgery. 2021 222(6):1186-1188. PMID: 34176599.
• Giorgakis E, Khorsandi SE, Burdine L, [et al.]. Centre volume impact on graft survival and waiting list time in donation after circulatory death liver transplantation in the USA. The British journal of surgery. 2021 108(12):e404-e406. PMID: 34672324.
• Cook MD, Karim SA, Jensen HK, [et al., including Burdine LJ]. Percutaneous Cholecystostomy Tubes versus Medical Management for Acute Cholecystitis. The American surgeon. 2021:31348211054567. PMID: 34747221.
• Waldrip ZJ, Burdine L, Harrison DK, [et al.]. DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells. The Journal of biological chemistry. 2021:101209. PMID: 34562454. PMCID: PMC8551498.
• Abu-Rmaileh M, Ramseyer AM, Burdine L, Dajani NK. Fetal intracranial hemorrhage associated with maternal coagulopathy and vitamin K deficiency after biliary drain placement: A case report and literature review. Case reports in women's health. 2021 31:e00329. PMID: 34041000. PMCID: PMC8144653.
• Esagian SM, Kakos CD, Giorgakis E, [et al., including Burdine L]. Adjuvant Transarterial Chemoembolization Following Curative-Intent Hepatectomy Versus Hepatectomy Alone for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Cancers. 2021 13(12). PMID: 34203692. PMCID: PMC8232114.
• Giorgakis E, Khorsandi SE, Mathur AK, [et al., including Burdine L]. Comparable graft survival is achievable with the usage of donation after circulatory death liver grafts from donors at or above 70 years of age: A long-term UK national analysis. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2021 21(6):2200-2210. PMID: 33222386.
• Giorgakis E, Zehtaban SP, Stevens AE, [et al., including Burdine L]. COVID-19 in solid organ transplant recipients. Transplant infectious disease : an official journal of the Transplantation Society. 2021 23(1):e13419. PMID: 32667723. PMCID: PMC7404365.
• Harrison DK, Tackett A, Waldrip ZJ, [et al., including Burdine L]. DNA-PKcs Inhibition Extends Allogeneic Skin Graft Survival. Transplantation. 2020. PMID: 32890138. PMCID: PMC7902289.
• Kakadia S, Trotta H, Kurczek L, [et al., including Burdine L]. Early Outcomes of Ruxolitinib in the Treatment of Steroid Refractory Graft-versus-host Disease on Liver Transplant Recipients. Transplantation. 2020 104(8):e247. PMID: 32732859.