melanoma, MHC-I, resveratrol, immune checkpoint inhibition
Type of Research:
Research Interest Statement:
My research project is focused on the potential of resveratrol as an adjuvant to immune checkpoint blockade treatment for metastatic melanoma. Despite the substantial improvements in survival that immune checkpoint blockade has lent to melanoma treatment, only about half of all patients respond to it. One contributory factor to the success of immune checkpoint blockade is expression of MHC-I on tumor cells. MHC-I allows T-cells to recognize tumor cells as ?foreign? so that they can be targeted and destroyed by the immune system. However, MHC-I expression is often downregulated in cancer cells. My preliminary research has indicated that resveratrol can potentiate MHC-I expression on cancer cells, with the mechanism being not well-defined. My goal is to explore the possibility of resveratrol as an immunostimulatory compound for the treatment of metastatic melanoma.