Samir V Jenkins, PhD

Research Program: Cancer Therapeutics Faculty Rank: Research Instructor Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Radiation Oncology Radiation Biology

Cancer Research Interest

• Disease Site Focus: Head and Neck, Melanoma, Breast, Thoracic/ Lung
• Research Focus Area: Treatment, Detection, Carcinogenesis
• Type of Research: Basic
• Research Keywords: Nanomaterials, Microbiome, Radiation
• Research Interest Statement: My primary research interests involve the development of novel therapeutics and treatment regimens for various tumor types. My educational background is in nanomaterials, and as such developing effective targeting strategies and multimodal nanomaterial based therapies is one of my primary research strategies. Therapeutically, I am interested in the combination of photothermal heating, radiation therapy, and drug delivery in the context of nanomaterials. Additionally, I focus on the interplay between immune response and radiation treatment, photodynamic therapy, or dysbiosis.

Contact Information

• Email Address: SVJENKINS@UAMS.EDU
• Profiles Research Networking Software: View Profile

Active Grants

• Radiation Research Foundation – AWD00055996
  “Primary Tumor Effects of Combined Spatially Fractionated Radiotherapy and Immune Checkpoint Inhibitors ”
  Principal Investigator
  1/1/2024 – 12/31/2024

Recent Publications

• Jamshidi-Parsian A, Jenkins SV, Tran A, [et al.]. CB-839 induces reversible dormancy in lung tumor-cells. European journal of pharmacology. 2024 982:176912. PMID: 39159716.
• Jenkins SV, Johnsrud AJ, Dings RPM, Griffin RJ. Bystander Effects in Spatially Fractionated Radiation Therapy: From Molecule To Organism To Clinical Implications. Seminars in radiation oncology. 2024 34(3):284-291. PMID: 38880537. PMCID: PMC11185274.
• Jenkins SV, Shah S, Jamshidi-Parsian A, [et al.]. Acquired Radiation Resistance Induces Thiol-dependent Cisplatin Cross-resistance. Radiation research. 2024 201(2):174-187. PMID: 38329819. PMCID: PMC10993299.
• Jenkins SV, Jung S, Jamshidi-Parsian A, [et al.]. Morphological Effects and In Vitro Biological Mechanisms of Radiation-Induced Cell Killing by Gold Nanomaterials. ACS applied materials & interfaces. 2023. PMID: 38059477.
• Todorova VK, Byrum SD, Mackintosh SG, [et al., including Jenkins SV]. Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells. International journal of molecular sciences. 2023 24(17). PMID: 37685904. PMCID: PMC10487651.
• Kore RA, Jenkins SV, Jamshidi-Parsian A, [et al.]. Proteomic analysis of transcription factors involved in the alteration of ischemic mouse heart as modulated by MSC exosomes. Biochemistry and biophysics reports. 2023 34:101463. PMID: 37125076. PMCID: PMC10130341.
• Nowak-Sliwinska P, van Beijnum JR, Griffioen CJ, [et al., including Jenkins SV]. Proinflammatory activity of VEGF-targeted treatment through reversal of tumor endothelial cell anergy. Angiogenesis. 2022. PMID: 36459240. PMCID: PMC10119234.
• Vasicek TW, Guillermo S, Swofford DR, [et al., including Jenkins SV]. β-Glucosidase Immobilized on Magnetic Nanoparticles: Controlling Biomolecule Footprint and Particle Functional Group Density to Navigate the Activity-Stability Tradeoff. ACS applied bio materials. 2022 5(11):5347-5355. PMID: 36331934.
• Stolarz AJ, Chhetri BP, Borrelli MJ, [et al., including Jenkins SV]. Liposome Formulation for Tumor-Targeted Drug Delivery Using Radiation Therapy. International journal of molecular sciences. 2022 23(19). PMID: 36232973. PMCID: PMC9569741.
• Macchi S, Jalihal A, Hooshmand N, [et al., including Jenkins S]. Enhanced photothermal heating and combination therapy of NIR dye via conversion to self-assembled ionic nanomaterials. Journal of materials chemistry. B. 2022 10(5):806-816. PMID: 35043823. PMCID: PMC8928910.
• Jung S, Harris N, Niyonshuti II, [et al., including Jenkins SV]. Photothermal Response Induced by Nanocage-Coated Artificial Extracellular Matrix Promotes Neural Stem Cell Differentiation. Nanomaterials (Basel, Switzerland). 2021 11(5). PMID: 34064443. PMCID: PMC8147862.
• Jenkins SV, Alimohammadi M, Terry AS, [et al.]. Dysbiotic stress increases the sensitivity of the tumor vasculature to radiotherapy and c-Met inhibitors. Angiogenesis. 2021. PMID: 33629198. PMCID: PMC8295215.
• Johnsrud AJ, Jenkins SV, Jamshidi-Parsian A, [et al.]. Evidence for Early Stage Anti-Tumor Immunity Elicited by Spatially Fractionated Radiotherapy-Immunotherapy Combinations. Radiation research. 2020 194(6):688-697. PMID: 33348372. PMCID: PMC8008989.