Laura Elizabeth Ewing, PhD

Research Program: Cancer Biology Faculty Rank: Post-doctoral fellow Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Biochemistry & Molecular Biology

Cancer Research Interest

• Disease Site Focus: Gynecology
• Research Focus Area: Treatment, Informatics
• Type of Research: Basic
• Research Keywords: ovarian cancer, microbiome
• Research Interest Statement: My primary research interests are in evaluating the effects of the microbiome on the development, progression, and treatment of ovarian cancer. The microbiome can affect metabolism of therapeutics and alter both inflammatory and immune cell processes, which can in turn affect antibody-based therapies.

Contact Information

• Email Address: leewing@uams.edu

Recent Publications

• Ewing LE, Harpenau RJ, Skinner CM, [et al.]. Inter-strain variability in responses to a single administration of the cannabidiol-rich cannabis extract in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024 192:114909. PMID: 39128689. PMCID: PMC11381146.
• Ewing LE, Skinner CM, McGill MR, [et al.]. Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract. Drug and chemical toxicology. 2024:1-8. PMID: 39155655.
• Nemec-Bakk AS, Sridharan V, Seawright JW, [et al., including Ewing LE]. Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model. Life sciences in space research. 2023 37:78-87. PMID: 37087182. PMCID: PMC10122719.
• Ewing LE, Pathak R, Landes RD, [et al.]. Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese. International journal of radiation biology. 2022:1-12. PMID: 35939319. PMCID: PMC9929030.
• Ewing LE, Biju PG, Pathak R, [et al.]. Methods for induction and assessment of intestinal permeability in rodent models of radiation injury. Methods in cell biology. 2022 168:235-247. PMID: 35366985. PMCID: PMC9808921.
• Kutanzi KR, Ewing LE, Skinner CM, [et al.]. Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration. International journal of molecular sciences. 2020 21(20). PMID: 33096940. PMCID: PMC7656295.
• Ewing LE, Skinner CM, Pathak R, [et al.]. Dietary Methionine Supplementation Exacerbates Gastrointestinal Toxicity in a Mouse Model of Abdominal Irradiation. International journal of radiation oncology, biology, physics. 2020. PMID: 33002540. PMCID: PMC7855316.
• Hay CE, Ewing LE, Hambuchen MD, [et al.]. The Development and Characterization of an scFv-Fc Fusion-Based Gene Therapy to Reduce the Psychostimulant Effects of Methamphetamine Abuse. The Journal of pharmacology and experimental therapeutics. 2020 374(1):16-23. PMID: 32245884. PMCID: PMC7289050.
• Miousse IR, Ewing LE, Skinner CM, [et al.]. Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome. American journal of physiology. Gastrointestinal and liver physiology. 2020 318(3):G439-G450. PMID: 31961718. PMCID: PMC7099489.
• Skinner CM, Nookaew I, Ewing LE, [et al.]. Potential Probiotic or Trigger of Gut Inflammation - The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract. Journal of dietary supplements. 2020 17(5):543-560. PMID: 32400224. PMCID: PMC7470626.