Lu Dai, MD

Research Program: Cancer Biology Faculty Rank: Associate staff scientist Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Pathology

Cancer Research Interest

• Disease Site Focus: Leukemia/ Lymphoma, Breast
• Research Focus Area: Treatment
• Type of Research: Basic
• Research Interest Statement: My major interest is to identify cancer stem cells (CSCs) in different type of cancers, explore molecule mechanisms of CSCs in cancer progression and develop new strategies against CSCs.

Contact Information

• Email Address: LDAI@UAMS.EDU
• Profiles Research Networking Software: View Profile

Active Grants

• US Department of Defense – HT94252310083
  “Development of O'PROTACs-based Novel EIF4G1 Degraders for Treatment of Non-small Cell Lung Cancer ”
  Co-Investigator
  01/15/23 – 07/14/24
• NIH/Nat. Inst. of Dental & Craniofacial Research – 1R03DE031978
  “Targeting ILlRAP in virus-associated malignancies”
  Principal Investigator
  05/01/22 – 04/30/25

Publications

• Dai L, Fan J, Qin Z. Development of human endogenous retrovirus type K- related treatments for human diseases. Journal of medical virology. 2024 96(3):e29532. PMID: 38497450.
• Chen J, Fan J, Lin Z, [et al., including Dai L]. Human endogenous retrovirus type K encoded Np9 oncoprotein induces DNA damage response. Journal of medical virology. 2024 96(3):e29534. PMID: 38501356.
• Dai L, Qin Z. Role of lymphatic endothelium specific hyaluronan receptor 1 in virus infection and associated diseases. Journal of medical virology. 2024 96(2):e29457. PMID: 38318772. PMCID: PMC10868962.
• Dai L, Wilson LG, Nakagawa M, Qin Z. Coinfections with additional oncoviruses in HPV+ individuals: Status, function and potential clinical implications. Journal of medical virology. 2024 96(1):e29363. PMID: 38178584. PMCID: PMC10783544.
• Dai L, Goyal N, Liu J, [et al.]. Developing new ceramide analogs against non-small cell lung cancer (NSCLC). American journal of cancer research. 2024 14(1):86-96. PMID: 38323290. PMCID: PMC10839310.
• Chen J, Lin Z, Song J, [et al., including Dai L]. Echinomycin as a promising therapeutic agent against KSHV-related malignancies. Journal of hematology & oncology. 2023 16(1):48. PMID: 37143124. PMCID: PMC10161613.
• Chen J, Song J, Plaisance-Bonstaff K, [et al., including Dai L]. Role of Histamine and Related Signaling in Kaposi's Sarcoma-Associated Herpesvirus Pathogenesis and Oncogenesis. Viruses. 2023 15(4). PMID: 37112991. PMCID: PMC10142667.
• Chen J, Wang Z, Phuc T, [et al., including Dai L]. Oncolytic strategy using new bifunctional HDACs/BRD4 inhibitors against virus-associated lymphomas. PLoS pathogens. 2023 19(1):e1011089. PMID: 36638143. PMCID: PMC9879403.
• Chen J, Song J, Dai L, [et al.]. SARS-CoV-2 infection and lytic reactivation of herpesviruses: A potential threat in the postpandemic era?. Journal of medical virology. 2022. PMID: 35819034. PMCID: PMC9350099.
• Chen J, Barrett L, Lin Z, [et al., including Dai L]. Identification of natural compounds tubercidin and lycorine HCl against small-cell lung cancer and BCAT1 as a therapeutic target. Journal of cellular and molecular medicine. 2022. PMID: 35318805. PMCID: PMC9077304.
• Chen J, Dai L, Kendrick S, [et al.]. The Anti-COVID-19 Drug Remdesivir Promotes Oncogenic Herpesvirus Reactivation through Regulation of Intracellular Signaling Pathways. Antimicrobial agents and chemotherapy. 2022:aac0239521. PMID: 35041508. PMCID: PMC8923226.
• Chen J, Song J, James J, [et al., including Dai L]. Activation of IL1 signaling molecules by Kaposi's sarcoma-associated herpesvirus. Frontiers in cellular and infection microbiology. 2022 12:1049624. PMID: 36457850. PMCID: PMC9705745.
• Dai L, Lu YC, Chen J, [et al.]. Oral Shedding of an Oncogenic Virus Alters the Oral Microbiome in HIV+ Patients. Frontiers in microbiology. 2022 13:882520. PMID: 35516440. PMCID: PMC9063630.
• Chen J, Dai L, Barrett L, [et al.]. SARS-CoV-2 proteins and anti-COVID-19 drugs induce lytic reactivation of an oncogenic virus. Communications biology. 2021 4(1):682. PMID: 34083759. PMCID: PMC8175744.
• Del Valle L, Dai L, Lin HY, [et al.]. Role of EIF4G1 network in non-small cell lung cancers (NSCLC) cell survival and disease progression. Journal of cellular and molecular medicine. 2021. PMID: 33539648. PMCID: PMC7957206.
• Barrett L, Dai L, Wang S, Qin Z. Kaposi's sarcoma-associated herpesvirus and extracellular vesicles. Journal of medical virology. 2021. PMID: 33415746.
• Dai L, Jung BG, Chen J, [et al.]. The potential impacts of early secreted antigenic target of 6 kDa of Mycobacterium tuberculosis on KSHV-infected cells. Journal of medical virology. 2020. PMID: 32648938. PMCID: PMC7796979.
• Chen J, Goyal N, Dai L, [et al.]. Developing new ceramide analogs and identifying novel sphingolipid-controlled genes against a virus-associated lymphoma. Blood. 2020. PMID: 32518949. PMCID: PMC7645984.
• Chen J, Lin Z, Barrett L, [et al., including Dai L]. Identification of new therapeutic targets and natural compounds against diffuse intrinsic pontine glioma (DIPG). Bioorganic chemistry. 2020 99:103847. PMID: 32311581. PMCID: PMC7260728.
• Dai L, Forrest J, Barrett L, [et al.]. Porphyromonas gingivalis coinfects with KSHV in oral cavities of HIV+ patients and induces viral lytic reactivation. Journal of medical virology. 2020. PMID: 32436999. PMCID: PMC7679274.
• Dai L, Forrest J, Qiao J, [et al.]. Kaposi Sarcoma-Associated Herpesvirus and Staphylococcus aureus Coinfection in Oral Cavities of HIV-Positive Patients: A Unique Niche for Oncogenic Virus Lytic Reactivation. The Journal of infectious diseases. 2020 221(8):1331-1341. PMID: 31111897. PMCID: PMC7325796.
• Dai L, Chen J, Lin Z, [et al.]. Targeting Sphingosine Kinase by ABC294640 against Diffuse Intrinsic Pontine Glioma (DIPG). Journal of Cancer. 2020 11(16):4683-4691. PMID: 32626514. PMCID: PMC7330698.
• Barrett L, Chen J, Dai L, [et al.]. Role of Interleukin-1 Family Members and Signaling Pathways in KSHV Pathogenesis. Frontiers in cellular and infection microbiology. 2020 10:587929. PMID: 33194830. PMCID: PMC7662392.
• Chen J, Dai L, Goldstein A, [et al.]. Identification of new antiviral agents against Kaposi's sarcoma-associated herpesvirus (KSHV) by high-throughput drug screening reveals the role of histamine-related signaling in promoting viral lytic reactivation. PLoS pathogens. 2019 15(12):e1008156. PMID: 31790497. PMCID: PMC6907871.