Lu Dai, MD

Full Member

Research Program:

Cancer Biology

Faculty Rank:

Assistant Professor

Campus:

University of Arkansas for Medical Sciences

College:

College of Medicine

Department:

Pathology Research Faculty

Cancer Research Interest

Disease Site Focus: Leukemia/ Lymphoma, Breast
Research Focus Area: Treatment
Type of Research: Basic
Research Interest Statement: My major interest is to identify cancer stem cells (CSCs) in different type of cancers, explore molecule mechanisms of CSCs in cancer progression and develop new strategies against CSCs.

Contact Information

Email Address: LDAI@UAMS.EDU
Profiles Research Networking Software: View Profile

Active Grants

NIH/Nat. Inst. of Allergy & Infectious Diseases – 1R21AI186566
“Development of O’PROTACs-based degraders targeting an oncogenic viral protein”
Principal Investigator
11/15/2024 – 10/31/2026

Recent Publications

Dai L, Choudhary A, Fan J, [et al.]. Identification of RP-54745, an IL-1 Inhibitor Displaying Anticancer Activities for KSHV-Related Primary Effusion Lymphoma. Journal of medical virology. 2025 97(2):e70200. PMID: 39891599.
Fan J, Lin Z, Zhang H, [et al., including Dai L]. Infection of human induced pluripotent stem cells by an oncogenic herpesvirus. Frontiers in cellular and infection microbiology. 2025 15:1563440. PMID: 40182776. PMCID: PMC11966036.
Dai L, Del Valle L, Miley W, [et al.]. Correction: Transactivation of human endogenous retrovirus K (HERV-K) by KSHV promotes Kaposi's sarcoma development. Oncogene. 2024 43(30):2372. PMID: 38890430.
Dai L, Fan J, Qin Z. Development of human endogenous retrovirus type K- related treatments for human diseases. Journal of medical virology. 2024 96(3):e29532. PMID: 38497450.
Chen J, Fan J, Lin Z, [et al., including Dai L]. Human endogenous retrovirus type K encoded Np9 oncoprotein induces DNA damage response. Journal of medical virology. 2024 96(3):e29534. PMID: 38501356.
Dai L, Qin Z. Role of lymphatic endothelium specific hyaluronan receptor 1 in virus infection and associated diseases. Journal of medical virology. 2024 96(2):e29457. PMID: 38318772. PMCID: PMC10868962.
Dai L, Wilson LG, Nakagawa M, Qin Z. Coinfections with additional oncoviruses in HPV+ individuals: Status, function and potential clinical implications. Journal of medical virology. 2024 96(1):e29363. PMID: 38178584. PMCID: PMC10783544.
Dai L, Goyal N, Liu J, [et al.]. Developing new ceramide analogs against non-small cell lung cancer (NSCLC). American journal of cancer research. 2024 14(1):86-96. PMID: 38323290. PMCID: PMC10839310.
Chen J, Lin Z, Fan J, [et al., including Dai L]. Identification of new microtubule small-molecule inhibitors and microtubule-associated genes against triple negative breast cancer. American journal of cancer research. 2024 14(4):1545-1560. PMID: 38726264. PMCID: PMC11076258.
Chen J, Lin Z, Song J, [et al., including Dai L]. Echinomycin as a promising therapeutic agent against KSHV-related malignancies. Journal of hematology & oncology. 2023 16(1):48. PMID: 37143124. PMCID: PMC10161613.
Chen J, Song J, Plaisance-Bonstaff K, [et al., including Dai L]. Role of Histamine and Related Signaling in Kaposi's Sarcoma-Associated Herpesvirus Pathogenesis and Oncogenesis. Viruses. 2023 15(4). PMID: 37112991. PMCID: PMC10142667.
Chen J, Wang Z, Phuc T, [et al., including Dai L]. Oncolytic strategy using new bifunctional HDACs/BRD4 inhibitors against virus-associated lymphomas. PLoS pathogens. 2023 19(1):e1011089. PMID: 36638143. PMCID: PMC9879403.
Chen J, Song J, Dai L, [et al.]. SARS-CoV-2 infection and lytic reactivation of herpesviruses: A potential threat in the postpandemic era?. Journal of medical virology. 2022. PMID: 35819034. PMCID: PMC9350099.
Chen J, Barrett L, Lin Z, [et al., including Dai L]. Identification of natural compounds tubercidin and lycorine HCl against small-cell lung cancer and BCAT1 as a therapeutic target. Journal of cellular and molecular medicine. 2022. PMID: 35318805. PMCID: PMC9077304.
Chen J, Dai L, Kendrick S, [et al.]. The Anti-COVID-19 Drug Remdesivir Promotes Oncogenic Herpesvirus Reactivation through Regulation of Intracellular Signaling Pathways. Antimicrobial agents and chemotherapy. 2022:aac0239521. PMID: 35041508. PMCID: PMC8923226.
Dai L, Lu YC, Chen J, [et al.]. Oral Shedding of an Oncogenic Virus Alters the Oral Microbiome in HIV+ Patients. Frontiers in microbiology. 2022 13:882520. PMID: 35516440. PMCID: PMC9063630.
Chen J, Song J, James J, [et al., including Dai L]. Activation of IL1 signaling molecules by Kaposi's sarcoma-associated herpesvirus. Frontiers in cellular and infection microbiology. 2022 12:1049624. PMID: 36457850. PMCID: PMC9705745.
Chen J, Dai L, Barrett L, [et al.]. SARS-CoV-2 proteins and anti-COVID-19 drugs induce lytic reactivation of an oncogenic virus. Communications biology. 2021 4(1):682. PMID: 34083759. PMCID: PMC8175744.
Del Valle L, Dai L, Lin HY, [et al.]. Role of EIF4G1 network in non-small cell lung cancers (NSCLC) cell survival and disease progression. Journal of cellular and molecular medicine. 2021. PMID: 33539648. PMCID: PMC7957206.
Barrett L, Dai L, Wang S, Qin Z. Kaposi's sarcoma-associated herpesvirus and extracellular vesicles. Journal of medical virology. 2021. PMID: 33415746.
Dai L, Jung BG, Chen J, [et al.]. The potential impacts of early secreted antigenic target of 6 kDa of Mycobacterium tuberculosis on KSHV-infected cells. Journal of medical virology. 2020. PMID: 32648938. PMCID: PMC7796979.
Chen J, Goyal N, Dai L, [et al.]. Developing new ceramide analogs and identifying novel sphingolipid-controlled genes against a virus-associated lymphoma. Blood. 2020. PMID: 32518949. PMCID: PMC7645984.
Chen J, Lin Z, Barrett L, [et al., including Dai L]. Identification of new therapeutic targets and natural compounds against diffuse intrinsic pontine glioma (DIPG). Bioorganic chemistry. 2020 99:103847. PMID: 32311581. PMCID: PMC7260728.
Dai L, Forrest J, Barrett L, [et al.]. Porphyromonas gingivalis coinfects with KSHV in oral cavities of HIV+ patients and induces viral lytic reactivation. Journal of medical virology. 2020. PMID: 32436999. PMCID: PMC7679274.