Sayem Miah, PhD

Research Program: Cancer Biology Faculty Rank: Assistant Professor Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Biochemistry & Molecular Biology

Cancer Research Interest

• Disease Site Focus: Breast, Prostate, Thoracic/ Lung
• Research Focus Area: Carcinogenesis, Treatment
• Type of Research: Basic
• Research Interest Statement: My long term career goal is to establish an interdisciplinary research program to develop more effective therapeutics for the treatment of metastatic breast cancer, focusing on non-Receptor Protein Tyrosine kinase (nRTKs) and their potential as a therapeutic target to restore the anti-metastatic function of TGF?/SMAD signaling in metastatic breast cancer. I want to undertake a `systems-wide` interrogation of nRTK mediated signaling networks using innovative proteomic and genomic technologies to decipher the switch of anti-metastatic TGF? signaling to a metastatic-promoting factor, a long-standing biological paradox in the field of metastatic breast cancer.

Contact Information

• Email Address: MSMIAH@UAMS.EDU
• Profiles Research Networking Software: View Profile

Active Grants

• UAMS ACHRI Flow Through – GR037194
  “ACRI Miah GR037194”
  Principal Investigator
  10/01/22 – 06/30/23
• UAMS Internal Research Awards – KL22022
  “TRI KL2 Scholars award - Miah”
  Principal Investigator
  07/01/22 – 06/30/24

Publications

• Acharya B, Miah S, Frett B. Targeting TGF-?: triumphs and challenges. Future medicinal chemistry. 2022. PMID: 35152715.
• Chappell K, Tackett A, Manna K, [et al., including Miah S]. Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer. Molecular omics. 2021. PMID: 34142686. PMCID: PMC8504614.
• Adams MK, Banks CAS, Thornton JL, [et al., including Miah S]. Differential Complex Formation via Paralogs in the Human Sin3 Protein Interaction Network. Molecular & cellular proteomics : MCP. 2020 19(9):1468-1484. PMID: 32467258. PMCID: PMC8143632.
• Banks CAS, Zhang Y, Miah S, [et al.]. Integrative Modeling of a Sin3/HDAC Complex Sub-structure. Cell reports. 2020 31(2):107516. PMID: 32294434. PMCID: PMC7217224.
• Miah S, Banks CAS, Ogunbolude Y, [et al.]. BRK phosphorylates SMAD4 for proteasomal degradation and inhibits tumor suppressor FRK to control SNAIL, SLUG, and metastatic potential. Science advances. 2019 5(10):eaaw3113. PMID: 31681835. PMCID: PMC6810434.
• Miah S, Bagu E, Goel R, [et al.]. Estrogen receptor signaling regulates the expression of the breast tumor kinase in breast cancer cells. BMC cancer. 2019 19(1):78. PMID: 30651078. PMCID: PMC6335685.
• Adams MK, Banks CAS, Miah S, [et al.]. Purification and enzymatic assay of class I histone deacetylase enzymes. Methods in enzymology. 2019 626:23-40. PMID: 31606077. PMCID: PMC6839770.
• Banks CAS, Miah S, Adams MK, [et al.]. Differential HDAC1/2 network analysis reveals a role for prefoldin/CCT in HDAC1/2 complex assembly. Scientific reports. 2018 8(1):13712. PMID: 30209338. PMCID: PMC6135828.
• Banks CAS, Thornton JL, Eubanks CG, [et al., including Miah S]. A Structured Workflow for Mapping Human Sin3 Histone Deacetylase Complex Interactions Using Halo-MudPIT Affinity-Purification Mass Spectrometry. Molecular & cellular proteomics : MCP. 2018 17(7):1432-1447. PMID: 29599190. PMCID: PMC6030732.
• Ogunbolude Y, Dai C, Bagu ET, [et al., including Miah S]. FRK inhibits breast cancer cell migration and invasion by suppressing epithelial-mesenchymal transition. Oncotarget. 2017 8(68):113034-113065. PMID: 29348886. PMCID: PMC5762571.
• Bagu ET, Miah S, Dai C, [et al.]. Repression of Fyn-related kinase in breast cancer cells is associated with promoter site-specific CpG methylation. Oncotarget. 2017 8(7):11442-11459. PMID: 28077797. PMCID: PMC5355277.
• Miah S, Banks CA, Adams MK, [et al.]. Advancement of mass spectrometry-based proteomics technologies to explore triple negative breast cancer. Molecular bioSystems. 2016 13(1):42-55. PMID: 27891540. PMCID: PMC5173390.