Sayem Miah, PhD

Full Member

Research Program:

Cancer Biology

Faculty Rank:

Assistant Professor

Campus:

University of Arkansas for Medical Sciences

College:

College of Medicine

Department:

Biochemistry & Molecular Biology

Cancer Research Interest

Disease Site Focus: Breast, Prostate, Thoracic/ Lung
Research Focus Area: Carcinogenesis, Treatment
Type of Research: Basic
Research Interest Statement: My long term career goal is to establish an interdisciplinary research program to develop more effective therapeutics for the treatment of metastatic breast cancer, focusing on non-Receptor Protein Tyrosine kinase (nRTKs) and their potential as a therapeutic target to restore the anti-metastatic function of TGFβ/SMAD signaling in metastatic breast cancer. I want to undertake a `systems-wide` interrogation of nRTK mediated signaling networks using innovative proteomic and genomic technologies to decipher the switch of anti-metastatic TGFβ signaling to a metastatic-promoting factor, a long-standing biological paradox in the field of metastatic breast cancer.

NIGMS – 1P20GM152281
“Defining Breast Tumor Kinase-Dependent Dysregulation of TGF-beta/SMAD Signaling”
Principal Investigator
3/5/2024 – 12/31/2028

Alam J, Huda MN, Tackett AJ, Miah S. Oncogenic signaling-mediated regulation of chromatin during tumorigenesis. Cancer metastasis reviews. 2023. PMID: 37147457. PMCID: PMC10348982.
Acharya B, Miah S, Frett B. Targeting TGF-β: triumphs and challenges. Future medicinal chemistry. 2022. PMID: 35152715.
Chappell K, Tackett A, Manna K, [et al., including Miah S]. Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer. Molecular omics. 2021. PMID: 34142686. PMCID: PMC8504614.
Adams MK, Banks CAS, Thornton JL, [et al., including Miah S]. Differential Complex Formation via Paralogs in the Human Sin3 Protein Interaction Network. Molecular & cellular proteomics : MCP. 2020 19(9):1468-1484. PMID: 32467258. PMCID: PMC8143632.
Banks CAS, Zhang Y, Miah S, [et al.]. Integrative Modeling of a Sin3/HDAC Complex Sub-structure. Cell reports. 2020 31(2):107516. PMID: 32294434. PMCID: PMC7217224.