Rupak Pathak, PhD

Research Program: Cancer Therapeutics Faculty Rank: Assistant Professor Campus: University of Arkansas for Medical Sciences College: College of Pharmacy Department: Pharmaceutical Sciences

Cancer Research Interest

• Disease Site Focus: GI
• Research Focus Area: Treatment
• Type of Research: Basic
• Research Interest Statement: Understanding the mechanisms of therapeutic radiation-induced normal tissue toxicity and its mitigation. Radio-sensitization of tumor using pharmacologic and genetic approaches. Platelet-leukocyte or platelet, endothelial cell interaction in modifying tumor radiation response.

Contact Information

• Email Address: RPATHAK@UAMS.EDU
• Profiles Research Networking Software: View Profile

Active Grants

• NIH/Nat. Inst. of Allergy & Infectious Diseases – 1U01AI170039
  “Platelets in radiation-induced immune dysregulation”
  Principal Investigator
  07/25/22 – 05/31/27
• National Aeronautics & Space Administration – 80NSSC21M0323
  “Preventing immune system dysregulation during deep-space missions by Tocofexol, a modified isomer of vitamin E - AA request”
  Principal Investigator
  08/15/21 – 08/14/24
• NIH/Nat. Inst. of Allergy & Infectious Diseases – 2U19AI067773
  “Development of a fast and sensitive biodosimetry assay using molecular cytogenetics.”
  Principal Investigator
  05/01/21 – 07/31/24

Publications

• Jain SM, Nagainallur Ravichandran S, Murali Kumar M, [et al., including Pathak R]. Understanding the molecular mechanism responsible for developing therapeutic radiation-induced radioresistance of rectal cancer and improving the clinical outcomes of radiotherapy - A review. Cancer biology & therapy. 2024 25(1):2317999. PMID: 38445632. PMCID: PMC10936619.
• Binz RL, Burns K, Pathak R. Protocol for preparation and staining of chromosomes isolated from mouse and human tissues for conventional and molecular cytogenetic analysis. STAR protocols. 2024 5(1):102897. PMID: 38373079. PMCID: PMC10884542.
• Shrum SA, Nukala U, Shrimali S, [et al., including Pathak R]. Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects. Antioxidants (Basel, Switzerland). 2023 12(11). PMID: 38001840. PMCID: PMC10668991.
• Larrey EK, Pathak R. Radiation-Induced Intestinal Normal Tissue Toxicity: Implications for Altered Proteome Profile. Genes. 2022 13(11). PMID: 36360243. PMCID: PMC9689954.
• Ewing LE, Pathak R, Landes RD, [et al.]. Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese. International journal of radiation biology. 2022:1-12. PMID: 35939319. PMCID: PMC9929030.
• Binz RL, Pathak R. Molecular Cytogenetics Reveals Mosaicism in Human Umbilical Vein Endothelial Cells. Genes. 2022 13(6). PMID: 35741774. PMCID: PMC9222953.
• Poudel H, Sanford K, Szwedo PK, [et al., including Pathak R]. Synthetic Matrices for Intestinal Organoid Culture: Implications for Better Performance. ACS omega. 2022 7(1):38-47. PMID: 35036676. PMCID: PMC8756583.
• Richardson KK, Ling W, Krager K, [et al., including Pathak R]. Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice. International journal of molecular sciences. 2022 23(2). PMID: 35054859. PMCID: PMC8775597.
• Ewing LE, Biju PG, Pathak R, [et al.]. Methods for induction and assessment of intestinal permeability in rodent models of radiation injury. Methods in cell biology. 2022 168:235-247. PMID: 35366985. PMCID: PMC9808921.
• Simmons P, Trujillo M, McElroy T, [et al., including Pathak R]. Evaluating the effects of low-dose simulated galactic cosmic rays on murine hippocampal-dependent cognitive performance. Frontiers in neuroscience. 2022 16:908632. PMID: 36561122. PMCID: PMC9765097.
• Corken A, Ghosh SP, Du R, [et al., including Pathak R]. Platelet glycoprotein Ibα provides radiation protection. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2021 167:143-148. PMID: 34971661. PMCID: PMC8934272.
• Nemec-Bakk AS, Sridharan V, Landes RD, [et al., including Pathak R]. Mitigation of late cardiovascular effects of oxygen ion radiation by γ-tocotrienol in a mouse model. Life sciences in space research. 2021 31:43-50. PMID: 34689949. PMCID: PMC8548672.
• Jun SR, Boerma M, Udaondo Z, [et al., including Pathak R]. Plasma Metabolomics in a Nonhuman Primate Model of Abdominal Radiation Exposure. Metabolites. 2021 11(8). PMID: 34436481. PMCID: PMC8398377.
• Wang J, Garg S, Landes RD, [et al., including Pathak R]. Differential Recovery of Small Intestinal Segments after Partial-Body Irradiation in Non-Human Primates. Radiation research. 2021. PMID: 34043805. PMCID: PMC8440418.
• Binz RL, Sadhukhan R, Miousse IR, [et al., including Pathak R]. Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells. International journal of molecular sciences. 2021 22(5). PMID: 33673497. PMCID: PMC7956689.
• Sadhukhan R, Majumdar D, Garg S, [et al., including Pathak R]. Simultaneous exposure to chronic irradiation and simulated microgravity differentially alters immune cell phenotype in mouse thymus and spleen. Life sciences in space research. 2021 28:66-73. PMID: 33612181. PMCID: PMC7900614.
• Ewing LE, Skinner CM, Pathak R, [et al.]. Dietary Methionine Supplementation Exacerbates Gastrointestinal Toxicity in a Mouse Model of Abdominal Irradiation. International journal of radiation oncology, biology, physics. 2020. PMID: 33002540. PMCID: PMC7855316.
• Sadhukhan R, Leung JWC, Garg S, [et al., including Pathak R]. Fractionated radiation suppresses Kruppel-like factor 2 pathway to a greater extent than by single exposure to the same total dose. Scientific reports. 2020 10(1):7734. PMID: 32382091. PMCID: PMC7206069.
• Miousse IR, Ewing LE, Skinner CM, [et al., including Pathak R]. Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome. American journal of physiology. Gastrointestinal and liver physiology. 2020 318(3):G439-G450. PMID: 31961718. PMCID: PMC7099489.
• Binz RL, Boerma M, Tian E, [et al., including Pathak R]. Identification of novel breakpoints for locus- and region-specific translocations in 293 cells by molecular cytogenetics before and after irradiation. Scientific reports. 2019 9(1):10554. PMID: 31332273. PMCID: PMC6646394.