Rupak Pathak, PhD

Research Program: Cancer Therapeutics Faculty Rank: Assistant Professor Campus: University of Arkansas for Medical Sciences College: College of Pharmacy Department: Pharmaceutical Sciences

Cancer Research Interest

• Disease Site Focus: GI
• Research Focus Area: Treatment
• Type of Research: Basic
• Research Interest Statement: Understanding the mechanisms of therapeutic radiation-induced normal tissue toxicity and its mitigation. Radio-sensitization of tumor using pharmacologic and genetic approaches. Platelet-leukocyte or platelet, endothelial cell interaction in modifying tumor radiation response.

Contact Information

• Email Address: RPATHAK@UAMS.EDU
• Profiles Research Networking Software: View Profile

Active Grants

• NIH/Nat. Inst. of Allergy & Infectious Diseases – 1U01AI170039
  “Platelets in radiation-induced immune dysregulatio”
  Principal Investigator
  07/25/22 – 05/31/27
• National Aeronautics & Space Administration – 80NSSC21M0323
  “Preventing immune system dysregulation during deep”
  Principal Investigator
  08/15/21 – 08/14/24
• NIH/Nat. Inst. of Allergy & Infectious Diseases – 2U19AI067773
  “Development of a fast and sensitive biodosimetry a”
  Principal Investigator
  05/01/21 – 07/31/23

Publications

• Larrey EK, Pathak R. Radiation-Induced Intestinal Normal Tissue Toxicity: Implications for Altered Proteome Profile. Genes. 2022 13(11). PMID: 36360243. PMCID: PMC9689954.
• Ewing LE, Pathak R, Landes RD, [et al.]. Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese. International journal of radiation biology. 2022:1-12. PMID: 35939319. PMCID: PMC9929030.
• Binz RL, Pathak R. Molecular Cytogenetics Reveals Mosaicism in Human Umbilical Vein Endothelial Cells. Genes. 2022 13(6). PMID: 35741774. PMCID: PMC9222953.
• Poudel H, Sanford K, Szwedo PK, [et al., including Pathak R]. Synthetic Matrices for Intestinal Organoid Culture: Implications for Better Performance. ACS omega. 2022 7(1):38-47. PMID: 35036676. PMCID: PMC8756583.
• Richardson KK, Ling W, Krager K, [et al., including Pathak R]. Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice. International journal of molecular sciences. 2022 23(2). PMID: 35054859. PMCID: PMC8775597.
• Ewing LE, Biju PG, Pathak R, [et al.]. Methods for induction and assessment of intestinal permeability in rodent models of radiation injury. Methods in cell biology. 2022 168:235-247. PMID: 35366985. PMCID: PMC9808921.
• Simmons P, Trujillo M, McElroy T, [et al., including Pathak R]. Evaluating the effects of low-dose simulated galactic cosmic rays on murine hippocampal-dependent cognitive performance. Frontiers in neuroscience. 2022 16:908632. PMID: 36561122. PMCID: PMC9765097.
• Corken A, Ghosh SP, Du R, [et al., including Pathak R]. Platelet glycoprotein Ib? provides radiation protection. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2021 167:143-148. PMID: 34971661. PMCID: PMC8934272.
• Nemec-Bakk AS, Sridharan V, Landes RD, [et al., including Pathak R]. Mitigation of late cardiovascular effects of oxygen ion radiation by ?-tocotrienol in a mouse model. Life sciences in space research. 2021 31:43-50. PMID: 34689949. PMCID: PMC8548672.
• Jun SR, Boerma M, Udaondo Z, [et al., including Pathak R]. Plasma Metabolomics in a Nonhuman Primate Model of Abdominal Radiation Exposure. Metabolites. 2021 11(8). PMID: 34436481. PMCID: PMC8398377.
• Wang J, Garg S, Landes RD, [et al., including Pathak R]. Differential Recovery of Small Intestinal Segments after Partial-Body Irradiation in Non-Human Primates. Radiation research. 2021. PMID: 34043805. PMCID: PMC8440418.
• Binz RL, Sadhukhan R, Miousse IR, [et al., including Pathak R]. Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells. International journal of molecular sciences. 2021 22(5). PMID: 33673497. PMCID: PMC7956689.
• Sadhukhan R, Majumdar D, Garg S, [et al., including Pathak R]. Simultaneous exposure to chronic irradiation and simulated microgravity differentially alters immune cell phenotype in mouse thymus and spleen. Life sciences in space research. 2021 28:66-73. PMID: 33612181. PMCID: PMC7900614.
• Ewing LE, Skinner CM, Pathak R, [et al.]. Dietary Methionine Supplementation Exacerbates Gastrointestinal Toxicity in a Mouse Model of Abdominal Irradiation. International journal of radiation oncology, biology, physics. 2020. PMID: 33002540. PMCID: PMC7855316.
• Sadhukhan R, Leung JWC, Garg S, [et al., including Pathak R]. Fractionated radiation suppresses Kruppel-like factor 2 pathway to a greater extent than by single exposure to the same total dose. Scientific reports. 2020 10(1):7734. PMID: 32382091. PMCID: PMC7206069.
• Miousse IR, Ewing LE, Skinner CM, [et al., including Pathak R]. Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome. American journal of physiology. Gastrointestinal and liver physiology. 2020 318(3):G439-G450. PMID: 31961718. PMCID: PMC7099489.
• Binz RL, Boerma M, Tian E, [et al., including Pathak R]. Identification of novel breakpoints for locus- and region-specific translocations in 293 cells by molecular cytogenetics before and after irradiation. Scientific reports. 2019 9(1):10554. PMID: 31332273. PMCID: PMC6646394.
• Pathak R, Shah SK, Hauer-Jensen M. Therapeutic potential of natural plant products and their metabolites in preventing radiation enteropathy resulting from abdominal or pelvic irradiation. International journal of radiation biology. 2019 95(4):493-505. PMID: 30526224. PMCID: PMC6461490.
• Garg S, Boerma M, Sadhukhan R, [et al., including Pathak R]. Gamma-Tocotrienol Protects the Intestine from Radiation Potentially by Accelerating Mesenchymal Immune Cell Recovery. Antioxidants (Basel, Switzerland). 2019 8(3). PMID: 30845647. PMCID: PMC6466604.
• Pathak R, Kumar VP, Hauer-Jensen M, Ghosh SP. Enhanced Survival in Mice Exposed to Ionizing Radiation by Combination of Gamma-Tocotrienol and Simvastatin. Military medicine. 2019 184(Suppl 1):644-651. PMID: 30901461.
• Aykin-Burns N, Pathak R, Boerma M, [et al.]. Utilization of Vitamin E Analogs to Protect Normal Tissues While Enhancing Antitumor Effects. Seminars in radiation oncology. 2019 29(1):55-61. PMID: 30573184. PMCID: PMC6309800.
• Ewing LE, Miousse IR, Pathak R, [et al.]. NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity. International journal of radiation biology. 2018:1-21. PMID: 30561233. PMCID: PMC6581619.
• Banerjee S, Shah SK, Melnyk SB, [et al., including Pathak R]. Cebpd Is Essential for Gamma-Tocotrienol Mediated Protection against Radiation-Induced Hematopoietic and Intestinal Injury. Antioxidants (Basel, Switzerland). 2018 7(4). PMID: 29642403. PMCID: PMC5946121.
• Chang J, Wang Y, Pathak R, [et al.]. Whole body proton irradiation causes acute damage to bone marrow hematopoietic progenitor and stem cells in mice. International journal of radiation biology. 2017 93(12):1312-1320. PMID: 28782442. PMCID: PMC6693495.
• Wang J, Pathak R, Garg S, Hauer-Jensen M. Fibrinogen deficiency suppresses the development of early and delayed radiation enteropathy. World journal of gastroenterology. 2017 23(26):4701-4711. PMID: 28765691. PMCID: PMC5514635.
• Miousse IR, Chang J, Shao L, [et al., including Pathak R]. Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation. International journal of molecular sciences. 2017 18(7). PMID: 28677663. PMCID: PMC5535921.
• Pathak R, Koturbash I, Hauer-Jensen M. Detection of Inter-chromosomal Stable Aberrations by Multiple Fluorescence In Situ Hybridization (mFISH) and Spectral Karyotyping (SKY) in Irradiated Mice. Journal of visualized experiments : JoVE. 2017(119). PMID: 28117817. PMCID: PMC5352253.
• Miousse IR, Pathak R, Garg S, [et al.]. Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology. Genes & nutrition. 2017 12:22. PMID: 28904640. PMCID: PMC5588631.
• Wang Y, Chang J, Li X, [et al., including Pathak R]. Low doses of oxygen ion irradiation cause long-term damage to bone marrow hematopoietic progenitor and stem cells in mice. PloS one. 2017 12(12):e0189466. PMID: 29232383. PMCID: PMC5726652.
• Miousse IR, Koturbash I, Chalbot MC, [et al., including Pathak R]. Analysis of the Ambient Particulate Matter-induced Chromosomal Aberrations Using an In Vitro System. Journal of visualized experiments : JoVE. 2016(118). PMID: 28060322. PMCID: PMC5226431.
• Pathak R, Ghosh SP, Zhou D, Hauer-Jensen M. The Vitamin E Analog Gamma-Tocotrienol (GT3) and Statins Synergistically Up-Regulate Endothelial Thrombomodulin (TM). International journal of molecular sciences. 2016 17(11). PMID: 27869747. PMCID: PMC5133932.
• Prior S, Miousse IR, Nzabarushimana E, [et al., including Pathak R]. Densely ionizing radiation affects DNA methylation of selective LINE-1 elements. Environmental research. 2016 150:470-481. PMID: 27419368. PMCID: PMC5003736.
• Pathak R, Bachri A, Ghosh SP, [et al.]. The Vitamin E Analog Gamma-Tocotrienol (GT3) Suppresses Radiation-Induced Cytogenetic Damage. Pharmaceutical research. 2016 33(9):2117-25. PMID: 27216753. PMCID: PMC4967083.
• Pathak R, Wang J, Garg S, [et al.]. Recombinant Thrombomodulin (Solulin) Ameliorates Early Intestinal Radiation Toxicity in a Preclinical Rat Model. Radiation research. 2016 186(2):112-20. PMID: 27459702. PMCID: PMC4995594.