Edward TH Yeh, MD

Research Program: Cancer Therapeutics Faculty Rank: Professor, Chair of Department of Internal Medicine Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Internal Medicine

Cancer Research Interest

• Disease Site Focus: Breast, No Specific Disease Site
• Research Focus Area: Treatment, Diagnosis/ Prognosis
• Type of Research: Basic
• Research Interest Statement: I was the founding chair of the Department of Cardiology at the University of Texas MD Anderson Cancer Center for 16 years and established the field of Onco-cardiology (cardio-oncology). My laboratory discovered that Topoisomerase 2b (Top2b) is the molecular basis of anthracycline-induced cardiotoxicity. This discovery changed the 40 year old paradigm that anthracycline toxicity is due to ROS generation alone and provided new insight for prevention of doxorubicin induced heart failure. I trained leaders in the field and edited the textbook that defined the field of Onco-cardiology.

Contact Information

• Email Address: EYEH@UAMS.EDU
• Profiles Research Networking Software: View Profile

Active Grants

• University of Colorado – NA
  “RMIE 2022 in Aurora, Colorado September 8-10, 2022”
  Principal Investigator
  09/08/22 – 09/07/23
• Arkansas Research Alliance – NA
  “ARA Scholar”
  Principal Investigator
  07/01/21 – 06/30/24
• NIH/Nat. Heart, Lung & Blood Institute – 7R01HL151993
  “Prevention of Heart Failure induced by Doxorubicin”
  Co-Investigator
  06/01/21 – 05/31/25

Publications

• Sheng ZF, Zhang H, Phaup JG, [et al., including Yeh ETH]. Corticotropin-releasing hormone neurons in the central nucleus of amygdala are required for chronic stress-induced hypertension. Cardiovascular research. 2023. PMID: 37041718.
• Wang C, Nistala R, Cao M, [et al., including Yeh ETH]. Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells. Cell reports. 2023 42(2):112105. PMID: 36807138.
• Zhang H, Sheng ZF, Wang J, [et al., including Yeh ETH]. Signaling pathways involved in NMDA-induced suppression of M-channels in corticotropin-releasing hormone neurons in central amygdala. Journal of neurochemistry. 2022. PMID: 35583089. PMCID: PMC10210974.
• Yang FM, Chang HM, Yeh ETH. Regulation of TLR4 signaling through the TRAF6/sNASP axis by reversible phosphorylation mediated by CK2 and PP4. Proceedings of the National Academy of Sciences of the United States of America. 2021 118(47). PMID: 34789577. PMCID: PMC8617457.
• Sheng ZF, Zhang H, Zheng P, [et al., including Yeh ETH]. Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension. Cardiovascular research. 2021. PMID: 33512443. PMCID: PMC8803073.
• Chang HM, Yeh ETH. SUMO: From Bench to Bedside. Physiological reviews. 2020 100(4):1599-1619. PMID: 32666886. PMCID: PMC7717128.
• Li J, Chang HM, Banchs J, [et al., including Yeh ETH]. Detection of subclinical cardiotoxicity in sarcoma patients receiving continuous doxorubicin infusion or pre-treatment with dexrazoxane before bolus doxorubicin. Cardio-oncology (London, England). 2020 6:1. PMID: 32154027. PMCID: PMC7048030.
• Yeh ETH, Ewer MS, Moslehi J, [et al.]. Mechanisms and clinical course of cardiovascular toxicity of cancer treatment I. Oncology. Seminars in oncology. 2019 46(6):397-402. PMID: 31753424.
• Jiang L, Han X, Wang J, [et al., including Yeh ETH]. Correction: SHP-1 regulates hematopoietic stem cell quiescence by coordinating TGF-? signaling. The Journal of experimental medicine. 2018 215(8):2227. PMID: 30006358. PMCID: PMC6080911.
• Yang FM, Zuo Y, Zhou W, [et al., including Yeh ET]. sNASP inhibits TLR signaling to regulate immune response in sepsis. The Journal of clinical investigation. 2018 128(6):2459-2472. PMID: 29733298. PMCID: PMC5983344.
• Jiang L, Han X, Wang J, [et al., including Yeh ETH]. SHP-1 regulates hematopoietic stem cell quiescence by coordinating TGF-? signaling. The Journal of experimental medicine. 2018 215(5):1337-1347. PMID: 29669741. PMCID: PMC5940262.
• Lao Y, Yang K, Wang Z, [et al., including Yeh ETH]. DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages. The Journal of biological chemistry. 2018 293(11):3965-3980. PMID: 29352108. PMCID: PMC5857993.
• Li J, Lu D, Dou H, [et al., including Yeh ETH]. Publisher Correction: Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway. Nature communications. 2018 9(1):646. PMID: 29422621. PMCID: PMC5805736.
• Li J, Lu D, Dou H, [et al., including Yeh ETH]. Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway. Nature communications. 2018 9(1):143. PMID: 29321472. PMCID: PMC5762923.
• Chang HM, Okwuosa TM, Scarabelli T, [et al., including Yeh ETH]. Cardiovascular Complications of Cancer Therapy: Best Practices in Diagnosis, Prevention, and Management: Part 2. Journal of the American College of Cardiology. 2017 70(20):2552-2565. PMID: 29145955. PMCID: PMC5825188.
• Chang HM, Moudgil R, Scarabelli T, [et al., including Yeh ETH]. Cardiovascular Complications of Cancer Therapy: Best Practices in Diagnosis, Prevention, and Management: Part 1. Journal of the American College of Cardiology. 2017 70(20):2536-2551. PMID: 29145954. PMCID: PMC5825187.
• Wang R, Liu F, Zhao Y, [et al., including Yeh ETH]. Reversible regulation of ORC2 SUMOylation by PIAS4 and SENP2. Oncotarget. 2017 8(41):70142-70155. PMID: 29050267. PMCID: PMC5642542.
• Yeh ETH, Chang HM. Cancer and Clot: Between a Rock and a Hard Place. Journal of the American College of Cardiology. 2017 70(8):939-941. PMID: 28818203.
• Chang HM, Yeh ETH. Potential of Oncocardiology-Reply. JAMA cardiology. 2017 2(7):818. PMID: 28273313.
• Bawa-Khalfe T, Yeh E, Yang FM, [et al.]. SENP1 regulates PTEN stability to dictate prostate cancer development. Oncotarget. 2017 8(11):17651-17664. PMID: 27852060. PMCID: PMC5392276.
• Chang HM, Yeh E. Oncocardiology-Past, Present, and Future: A Review. JAMA cardiology. 2016 1(9):1066-1072. PMID: 27541948. PMCID: PMC5788289.
• Zhou Z, Wang M, Li J, [et al., including Yeh ET]. SUMOylation and SENP3 regulate STAT3 activation in head and neck cancer. Oncogene. 2016 35(45):5826-5838. PMID: 27181202. PMCID: PMC5116054.
• Abe J, Martin JF, Yeh ET. The Future of Onco-Cardiology: We Are Not Just "Side Effect Hunters". Circulation research. 2016 119(8):896-9. PMID: 27688305. PMCID: PMC5147506.
• Moudgil R, Yeh ET. Mechanisms of Cardiotoxicity of Cancer Chemotherapeutic Agents: Cardiomyopathy and Beyond. The Canadian journal of cardiology. 2016 32(7):863-870.e5. PMID: 27117975. PMCID: PMC4921299.