Edward TH Yeh, MD

Research Program: Cancer Therapeutics Faculty Rank: Professor, Chair of Department of Internal Medicine Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Internal Medicine

Cancer Research Interest

• Disease Site Focus: Breast, No Specific Disease Site
• Research Focus Area: Treatment, Diagnosis/ Prognosis
• Type of Research: Basic
• Research Interest Statement: I was the founding chair of the Department of Cardiology at the University of Texas MD Anderson Cancer Center for 16 years and established the field of Onco-cardiology (cardio-oncology). My laboratory discovered that Topoisomerase 2b (Top2b) is the molecular basis of anthracycline-induced cardiotoxicity. This discovery changed the 40 year old paradigm that anthracycline toxicity is due to ROS generation alone and provided new insight for prevention of doxorubicin induced heart failure. I trained leaders in the field and edited the textbook that defined the field of Onco-cardiology.

Contact Information

• Email Address: EYEH@UAMS.EDU
• Profiles Research Networking Software: View Profile

Active Grants

• Arkansas Research Alliance – NA
  “Arkansas Research Alliance Scholar Award”
  Principal Investigator
  07/01/21 – 06/30/24
• NIH/Nat. Heart, Lung & Blood Institute – 7R01HL151993
  “Prevention of Heart Failure induced by Doxorubicin with Early Administration of Dexrazoxane”
  Co-Investigator
  06/01/21 – 05/31/25

Publications

• Sheng ZF, Zhang H, Phaup JG, [et al., including Yeh ETH]. Corticotropin-releasing hormone neurons in the central nucleus of amygdala are required for chronic stress-induced hypertension. Cardiovascular research. 2023. PMID: 37041718. PMCID: PMC10325697.
• Wang C, Nistala R, Cao M, [et al., including Yeh ETH]. Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells. Cell reports. 2023 42(2):112105. PMID: 36807138. PMCID: PMC10432577.
• Zhang H, Sheng ZF, Wang J, [et al., including Yeh ETH]. Signaling pathways involved in NMDA-induced suppression of M-channels in corticotropin-releasing hormone neurons in central amygdala. Journal of neurochemistry. 2022. PMID: 35583089. PMCID: PMC10210974.
• Yang FM, Chang HM, Yeh ETH. Regulation of TLR4 signaling through the TRAF6/sNASP axis by reversible phosphorylation mediated by CK2 and PP4. Proceedings of the National Academy of Sciences of the United States of America. 2021 118(47). PMID: 34789577. PMCID: PMC8617457.
• Sheng ZF, Zhang H, Zheng P, [et al., including Yeh ETH]. Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension. Cardiovascular research. 2021. PMID: 33512443. PMCID: PMC8803073.
• Chang HM, Yeh ETH. SUMO: From Bench to Bedside. Physiological reviews. 2020 100(4):1599-1619. PMID: 32666886. PMCID: PMC7717128.
• Li J, Chang HM, Banchs J, [et al., including Yeh ETH]. Detection of subclinical cardiotoxicity in sarcoma patients receiving continuous doxorubicin infusion or pre-treatment with dexrazoxane before bolus doxorubicin. Cardio-oncology (London, England). 2020 6:1. PMID: 32154027. PMCID: PMC7048030.
• Yeh ETH, Ewer MS, Moslehi J, [et al.]. Mechanisms and clinical course of cardiovascular toxicity of cancer treatment I. Oncology. Seminars in oncology. 2019 46(6):397-402. PMID: 31753424.