Hui-Ming Chang, MD, MPH

Research Program: Cancer Therapeutics Faculty Rank: Professor Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Pharmacology & Toxicology

Cancer Research Interest

• Disease Site Focus: Breast, No Specific Disease Site
• Research Focus Area: Treatment, Prevention, Health Disparities
• Type of Research: Clinical, Basic
• Research Interest Statement: My current interest is to conduct clinical trials on onco-cardiology (cardio-oncology). I have translated bench results from our animal studies to clinical trials. This NIH-funded project titled

Contact Information

• Email Address: HCHANG@UAMS.EDU
• Profiles Research Networking Software: View Profile

Open Clinical Trials

• “Prevention of Heart Failure induced by Doxorubicin with Early Administration of Dexrazoxane (PHOENIX 1)” (NCT03930680)

Active Grants

• NIH/Nat. Heart, Lung & Blood Institute – 7R01HL151993
  “Prevention of Heart Failure induced by Doxorubicin with Early Administration of Dexrazoxane”
  Principal Investigator
  6/1/2021 – 5/31/2025

Recent Publications

• Chang HM, Hsu JY, Ahn C, Yeh ETH. Prevention of Heart Failure Induced by Doxorubicin with Early Administration of Dexrazoxane (PHOENIX Study): dose response and time course of dexrazoxane-induced degradation of topoisomerase 2b. Cardio-oncology (London, England). 2025 11(1):42. PMID: 40317097. PMCID: PMC12046681.
• Sheng ZF, Zhang H, Phaup JG, [et al., including Chang HM]. Corticotropin-releasing hormone neurons in the central nucleus of amygdala are required for chronic stress-induced hypertension. Cardiovascular research. 2023. PMID: 37041718. PMCID: PMC10325697.
• Wang C, Nistala R, Cao M, [et al., including Chang HM]. Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells. Cell reports. 2023 42(2):112105. PMID: 36807138. PMCID: PMC10432577.
• Zhang H, Sheng ZF, Wang J, [et al., including Chang HM]. Signaling pathways involved in NMDA-induced suppression of M-channels in corticotropin-releasing hormone neurons in central amygdala. Journal of neurochemistry. 2022. PMID: 35583089. PMCID: PMC10210974.
• Yang FM, Chang HM, Yeh ETH. Regulation of TLR4 signaling through the TRAF6/sNASP axis by reversible phosphorylation mediated by CK2 and PP4. Proceedings of the National Academy of Sciences of the United States of America. 2021 118(47). PMID: 34789577. PMCID: PMC8617457.
• Sheng ZF, Zhang H, Zheng P, [et al., including Chang HM]. Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension. Cardiovascular research. 2021. PMID: 33512443. PMCID: PMC8803073.
• Chang HM, Yeh ETH. SUMO: From Bench to Bedside. Physiological reviews. 2020 100(4):1599-1619. PMID: 32666886. PMCID: PMC7717128.