Aaron Joseph Storey, PhD

Research Program: Cancer Therapeutics Faculty Rank: Research Assistant Professor Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Biochemistry & Molecular Biology

Cancer Research Interest

• Disease Site Focus: Cutaneous/Melanoma, Multiple Myeloma
• Research Focus Area: Diagnosis/ Prognosis, Informatics
• Type of Research: Basic, Clinical
• Research Keywords: Proteomics, Biomarkers
• Research Interest Statement: I am interested in applying cutting edge proteomics techniques to facilitate biomarker studies for a variety of cancer types. The field of proteomics has rapidly matured in recent years, allowing for deep, high-throughput studies of clinical samples. My goal is to work with physician scientists and apply these techniques to solve current problems in today's clinical practice.

Contact Information

• Email Address: ASTOREY@UAMS.EDU
• Profiles Research Networking Software: View Profile

Active Grants

• NIH/National Institutes of Health – 2R44DK130702
  “Development of a Precision Medicine-based Diagnost”
  Principal Investigator
  09/15/22 – 05/31/24
• NIH/Nat. Heart, Lung & Blood Institute – 1R01HL162958
  “Impact of hemodynamics on efferocytosis”
  Co-Investigator
  04/01/22 – 03/31/27
• NIH/National Institutes of Health – 1R01HL162958
  “Impact of hemodynamics on efferocytosis”
  Co-Investigator
  04/01/22 – 03/31/27
• NIH/Nat. Inst. of General Medical Sciences – 1R01GM141040
  “Discovery and Characterization of Novel Sepsis”
  Co-Investigator
  09/10/21 – 08/31/25

Publications

• Garg S, Morehead LC, Bird JT, [et al., including Storey AJ]. Characterization of methionine dependence in melanoma cells. bioRxiv : the preprint server for biology. 2023. PMID: 37066392. PMCID: PMC10104025.
• Caza TN, Storey AJ, Hassen SI, [et al.]. Discovery of seven novel putative antigens in membranous nephropathy and membranous lupus nephritis identified by mass spectrometry. Kidney international. 2023. PMID: 36638888. PMCID: PMC9974866.
• Li D, Yu X, Kottur J, [et al., including Storey AJ]. Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic. Oncogene. 2022. PMID: 35525905. PMCID: PMC9189076.
• Morelle J, Caza T, Debiec H, [et al., including Storey A]. Cubilin and amnionless protein are novel target antigens in anti-brush border antibody disease. Kidney international. 2022. PMID: 35276203.
• Manral P, Caza TN, Storey AJ, [et al.]. The Alternative Pathway Is Necessary and Sufficient for Complement Activation by Anti-THSD7A Autoantibodies, Which Are Predominantly IgG4 in Membranous Nephropathy. Frontiers in immunology. 2022 13:952235. PMID: 35874690. PMCID: PMC9301376.
• Delgado M, Washam CL, Urbaniak A, [et al., including Storey AJ]. Phosphoproteomics Provides Novel Insights into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle. ACS omega. 2021 6(38):24949-24959. PMID: 34604676. PMCID: PMC8482483.
• Waldrip ZJ, Burdine L, Harrison DK, [et al., including Storey AJ]. DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells. The Journal of biological chemistry. 2021:101209. PMID: 34562454. PMCID: PMC8551498.
• Xu C, Meng F, Park KS, [et al., including Storey AJ]. A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells. Cell chemical biology. 2021. PMID: 34469831. PMCID: PMC8882712.
• Caza TN, Hassen SI, Kenan DJ, [et al., including Storey A]. Transforming Growth Factor Beta Receptor 3 (TGFBR3)-Associated Membranous Nephropathy. Kidney360. 2021 2(8):1275-1286. PMID: 35369660. PMCID: PMC8676385.
• Ahn JH, Davis ES, Daugird TA, [et al., including Storey AJ]. Phase separation drives aberrant chromatin looping and cancer development. Nature. 2021. PMID: 34163069. PMCID: PMC8647409.
• Chappell K, Graw S, Washam CL, [et al., including Storey AJ]. PTMViz: a tool for analyzing and visualizing histone post translational modification data. BMC bioinformatics. 2021 22(1):275. PMID: 34039258. PMCID: PMC8157737.
• Fan H, Guo Y, Tsai YH, [et al., including Storey AJ]. A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing. Nucleic acids research. 2021 49(8):4441-4455. PMID: 33823544. PMCID: PMC8096256.
• Al-Rabadi LF, Caza T, Trivin-Avillach C, [et al., including Storey A]. Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy. Journal of the American Society of Nephrology : JASN. 2021. PMID: 33952630. PMCID: PMC8425645.
• Xu C, Tsai YH, Galbo PM, [et al., including Storey AJ]. Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer. Nucleic acids research. 2021. PMID: 33849067. PMCID: PMC8136773.
• Li J, Galbo PM Jr, Gong W, [et al., including Storey AJ]. ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism. Nature communications. 2021 12(1):1045. PMID: 33594072. PMCID: PMC7886901.
• Caza TN, Hassen SI, Kuperman M, [et al., including Storey A]. Neural cell adhesion molecule 1 is a novel autoantigen in membranous lupus nephritis. Kidney international. 2020. PMID: 33045259. PMCID: PMC8032825.
• Koss B, Boerma M, Shields BD, [et al., including Storey AJ]. Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion. Cancer research. 2020. PMID: 33004350. PMCID: PMC7642172.
• Caza T, Hassen S, Dvanajscak Z, [et al., including Storey A]. NELL1 is a target antigen in malignancy-associated membranous nephropathy. Kidney international. 2020. PMID: 32828756. PMCID: PMC7895854.
• Storey AJ, Naceanceno KS, Lan RS, [et al.]. ProteoViz: a tool for the analysis and interactive visualization of phosphoproteomics data. Molecular omics. 2020. PMID: 32347222. PMCID: PMC7423749.
• Storey AJ, Hardman RE, Byrum SD, [et al.]. Accurate and Sensitive Quantitation of the Dynamic Heat Shock Proteome Using Tandem Mass Tags. Journal of proteome research. 2020 19(3):1183-1195. PMID: 32027144. PMCID: PMC7241437.
• Larsen CP, Sharma SG, Caza TN, [et al., including Storey AJ]. Serum amyloid P deposition is a sensitive and specific feature of membranous-like glomerulopathy with masked IgG kappa deposits. Kidney international. 2020 97(3):602-608. PMID: 32001064. PMCID: PMC7869973.
• Storey AJ, Wang HP, Protacio RU, [et al.]. Targeted Forward Genetics: Population-Scale Analyses of Allele Replacements Spanning Thousands of Base Pairs in Fission Yeast. G3 (Bethesda, Md.). 2019 9(12):4097-4106. PMID: 31597677. PMCID: PMC6893178.
• Ren Z, Ahn JH, Liu H, [et al., including Storey AJ]. PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation. Blood. 2019 134(14):1176-1189. PMID: 31383640. PMCID: PMC6776795.
• Chiang TC, Koss B, Su L, [et al., including Storey A]. Effect of Sulforaphane and 5-Aza-2'-Deoxycytidine on Melanoma Cell Growth. Medicines (Basel, Switzerland). 2019 6(3). PMID: 31252639. PMCID: PMC6789461.
• Shields BD, Koss B, Taylor EM, [et al., including Storey AJ]. Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma. Cancer research. 2019 79(6):1113-1123. PMID: 30674537. PMCID: PMC6420873.
• Storey AJ, Wang HP, Protacio RU, [et al.]. Chromatin-mediated regulators of meiotic recombination revealed by proteomics of a recombination hotspot. Epigenetics & chromatin. 2018 11(1):64. PMID: 30373637. PMCID: PMC6205778.
• Byrum SD, Loughran AJ, Beenken KE, [et al., including Storey AJ]. Label-Free Proteomic Approach to Characterize Protease-Dependent and -Independent Effects of sarA Inactivation on the Staphylococcus aureus Exoproteome. Journal of proteome research. 2018 17(10):3384-3395. PMID: 30209945. PMCID: PMC6209314.
• Kriss CL, Gregory-Lott E, Storey AJ, [et al.]. In Vivo Metabolic Tracing Demonstrates the Site-Specific Contribution of Hepatic Ethanol Metabolism to Histone Acetylation. Alcoholism, clinical and experimental research. 2018 42(10):1909-1923. PMID: 30030934. PMCID: PMC6208134.