Kyle Patrick Quinn, PhD

Research Program: Cancer Biology Faculty Rank: Associate Professor Campus: University of Arkansas (Fayetteville) College: College of Engineering Department: Biomedical Engineering

Cancer Research Interest

• Disease Site Focus: No Specific Disease Site
• Research Focus Area: Detection, Informatics, Diagnosis/ Prognosis, Carcinogenesis, Treatment, Health Disparities
• Type of Research: Basic, Clinical
• Research Keywords: cancer metabolism, dermatology, optical imaging
• Research Interest Statement: My overall research interests are in developing and utilizing non-invasive quantitative optical methods to characterize the spatiotemporal patterns of disease progression and tissue repair processes. My research lab is currently utilizing label-free multiphoton microscopy to obtain high-resolution 3D images of cell metabolism and extracellular matrix organization. We also develop and implement a variety of advanced image analysis techniques to characterize the organization of the extracellular matrix, inter-cellular arrangement and morphology, as well as subcellular organelle distributions within cells. We are interested in applying these imaging and analysis techniques to various collaborative cancer research projects.

Contact Information

• Email Address: kpquinn@uark.edu

Publications

• Sander EA, Quinn KP. Special Issue: Honoring the Editorial Accomplishments of Beth Winkelstein and Victor Barocas. Journal of biomechanical engineering. 2023 145(3). PMID: 36661079.
• Woessner AE, Quinn KP. Improved segmentation of collagen second harmonic generation images with a deep learning convolutional neural network. Journal of biophotonics. 2022 15(12):e202200191. PMID: 36087040. PMCID: PMC9789175.
• Blair MJ, Quinn KP. Single shot quantitative polarized light imaging system for rapid planar biaxial testing of soft tissues. Frontiers in bioengineering and biotechnology. 2022 10:1010307. PMID: 36213065. PMCID: PMC9532628.
• Witt N, Woessner A, Quinn K, Sander E. Multiscale Computational Model Predicts Mouse Skin Kinematics Under Tensile Loading. Journal of biomechanical engineering. 2021. PMID: 34729595. PMCID: PMC8719047.
• Paskal W, Kopka M, Stachura A, [et al., including Quinn KP]. Single Dose of N-Acetylcysteine in Local Anesthesia Increases Expression of HIF1?, MAPK1, TGF?1 and Growth Factors in Rat Wound Healing. International journal of molecular sciences. 2021 22(16). PMID: 34445365. PMCID: PMC8395485.
• Paskal W, Paskal AM, Pietruski P, [et al., including Quinn KP]. N-Acetylcysteine Added to Local Anesthesia Reduces Scar Area and Width in Early Wound Healing-An Animal Model Study. International journal of molecular sciences. 2021 22(14). PMID: 34299175. PMCID: PMC8307704.
• Jones JD, Rodriguez MR, Quinn KP. Automated Extraction of Skin Wound Healing Biomarkers From In Vivo Label-Free Multiphoton Microscopy Using Convolutional Neural Networks. Lasers in surgery and medicine. 2021. PMID: 33442889. PMCID: PMC8275674.
• Tandon I, Quinn KP, Balachandran K. Label-Free Multiphoton Microscopy for the Detection and Monitoring of Calcific Aortic Valve Disease. Frontiers in cardiovascular medicine. 2021 8:688513. PMID: 34179147. PMCID: PMC8226007.
• Liu Z, Meng J, Quinn KP, Georgakoudi I. Tissue Imaging and Quantification Relying on Endogenous Contrast. Advances in experimental medicine and biology. 2021 3233:257-288. PMID: 34053031.
• Seyed Jafari SM, Blank F, Ramser HE, [et al., including Quinn KP]. Efficacy of Combined in-vivo Electroporation-Mediated Gene Transfer of VEGF, HGF, and IL-10 on Skin Flap Survival, Monitored by Label-Free Optical Imaging: A Feasibility Study. Frontiers in surgery. 2021 8:639661. PMID: 33834037. PMCID: PMC8021947.
• Woessner AE, Jones JD, Witt NJ, [et al., including Quinn KP]. Three-Dimensional Quantification of Collagen Microstructure During Tensile Mechanical Loading of Skin. Frontiers in bioengineering and biotechnology. 2021 9:642866. PMID: 33748088. PMCID: PMC7966723.
• Tandon I, Johns S, Woessner A, [et al., including Quinn KP]. Label-free optical biomarkers detect early calcific aortic valve disease in a wild-type mouse model. BMC cardiovascular disorders. 2020 20(1):521. PMID: 33308143. PMCID: PMC7731510.
• Jones JD, Quinn KP. Automated Quantitative Analysis of Wound Histology Using Deep-Learning Neural Networks. The Journal of investigative dermatology. 2020. PMID: 33121938. PMCID: PMC8068577.
• Kim CS, Ding X, Allmeroth K, [et al., including Quinn KP]. Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle. Cell metabolism. 2020 32(4):629-642.e8. PMID: 32905798.
• Tandon I, Kolenc OI, Cross D, [et al., including Quinn KP]. Label-free metabolic biomarkers for assessing valve interstitial cell calcific progression. Scientific reports. 2020 10(1):10317. PMID: 32587322. PMCID: PMC7316720.
• Blair MJ, Jones JD, Woessner AE, Quinn KP. Skin Structure-Function Relationships and the Wound Healing Response to Intrinsic Aging. Advances in wound care. 2020 9(3):127-143. PMID: 31993254. PMCID: PMC6985772.
• Jones JD, Ramser HE, Woessner AE, [et al., including Quinn KP]. Quantifying Age-Related Changes in Skin Wound Metabolism Using In Vivo Multiphoton Microscopy. Advances in wound care. 2020 9(3):90-102. PMID: 31993251. PMCID: PMC6985773.
• Woessner AE, McGee JD, Jones JD, Quinn KP. Characterizing differences in the collagen fiber organization of skin wounds using quantitative polarized light imaging. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 2019 27(6):711-714. PMID: 31418977. PMCID: PMC7000211.
• Prieto SP, Reed CL, James HM, [et al., including Quinn KP]. Differences in colonic crypt morphology of spontaneous and colitis-associated murine models via second harmonic generation imaging to quantify colon cancer development. BMC cancer. 2019 19(1):428. PMID: 31072353. PMCID: PMC6507102.
• Kolenc OI, Quinn KP. Evaluating Cell Metabolism Through Autofluorescence Imaging of NAD(P)H and FAD. Antioxidants & redox signaling. 2019 30(6):875-889. PMID: 29268621. PMCID: PMC6352511.
• Li X, Saeidi N, Villiger M, [et al., including Quinn KP]. Rejuvenation of aged rat skin with pulsed electric fields. Journal of tissue engineering and regenerative medicine. 2018 12(12):2309-2318. PMID: 30353675.
• Vargas I, Alhallak K, Kolenc OI, [et al., including Quinn KP]. Rapid quantification of mitochondrial fractal dimension in individual cells. Biomedical optics express. 2018 9(11):5269-5279. PMID: 30460127. PMCID: PMC6238904.
• Liu Z, Speroni L, Quinn KP, [et al.]. 3D organizational mapping of collagen fibers elucidates matrix remodeling in a hormone-sensitive 3D breast tissue model. Biomaterials. 2018 179:96-108. PMID: 29980078. PMCID: PMC6176712.
• Lee DE, Alhallak K, Jenkins SV, [et al., including Quinn KP]. A Radiosensitizing Inhibitor of HIF-1 alters the Optical Redox State of Human Lung Cancer Cells In Vitro. Scientific reports. 2018 8(1):8815. PMID: 29891977. PMCID: PMC5995847.
• Liu Z, Pouli D, Alonzo CA, [et al., including Quinn KP]. Mapping metabolic changes by noninvasive, multiparametric, high-resolution imaging using endogenous contrast. Science advances. 2018 4(3):eaap9302. PMID: 29536043. PMCID: PMC5846284.
• Jones JD, Ramser HE, Woessner AE, Quinn KP. In vivo multiphoton microscopy detects longitudinal metabolic changes associated with delayed skin wound healing. Communications biology. 2018 1:198. PMID: 30480099. PMCID: PMC6242983.
• Golberg A, Villiger M, Felix Broelsch G, [et al., including Quinn KP]. Skin regeneration with all accessory organs following ablation with irreversible electroporation. Journal of tissue engineering and regenerative medicine. 2018 12(1):98-113. PMID: 27976527. PMCID: PMC5555830.
• Roberts K, Schluns J, Walker A, [et al., including Quinn KP]. Cell derived extracellular matrix fibers synthesized using sacrificial hollow fiber membranes. Biomedical materials (Bristol, England). 2017 13(1):015023. PMID: 28855424. PMCID: PMC5769927.
• Baugh LM, Liu Z, Quinn KP, [et al.]. Non-destructive two-photon excited fluorescence imaging identifies early nodules in calcific aortic-valve disease. Nature biomedical engineering. 2017 1(11):914-924. PMID: 29456878. PMCID: PMC5811202.
• Alhallak K, Jenkins SV, Lee DE, [et al., including Quinn KP]. Optical imaging of radiation-induced metabolic changes in radiation-sensitive and resistant cancer cells. Journal of biomedical optics. 2017 22(6):60502. PMID: 28622395. PMCID: PMC5499259.
• Stuntz E, Gong Y, Sood D, [et al., including Quinn KP]. Endogenous Two-Photon Excited Fluorescence Imaging Characterizes Neuron and Astrocyte Metabolic Responses to Manganese Toxicity. Scientific reports. 2017 7(1):1041. PMID: 28432298. PMCID: PMC5430620.
• Liu Z, Pouli D, Sood D, [et al., including Quinn KP]. Automated quantification of three-dimensional organization of fiber-like structures in biological tissues. Biomaterials. 2017 116:34-47. PMID: 27914265. PMCID: PMC5210183.
• Pouli D, Balu M, Alonzo CA, [et al., including Quinn KP]. Imaging mitochondrial dynamics in human skin reveals depth-dependent hypoxia and malignant potential for diagnosis. Science translational medicine. 2016 8(367):367ra169. PMID: 27903865. PMCID: PMC5176339.
• Quinn KP, Sullivan KE, Liu Z, [et al.]. Optical metrics of the extracellular matrix predict compositional and mechanical changes after myocardial infarction. Scientific reports. 2016 6:35823. PMID: 27819334. PMCID: PMC5098140.
• Alhallak K, Rebello LG, Muldoon TJ, [et al., including Quinn KP]. Optical redox ratio identifies metastatic potential-dependent changes in breast cancer cell metabolism. Biomedical optics express. 2016 7(11):4364-4374. PMID: 27895979. PMCID: PMC5119579.
• Golberg A, Villiger M, Khan S, [et al., including Quinn KP]. Preventing Scars after Injury with Partial Irreversible Electroporation. The Journal of investigative dermatology. 2016 136(11):2297-2304. PMID: 27393126. PMCID: PMC5516938.
• Yildirim M, Quinn KP, Kobler JB, [et al.]. Quantitative differentiation of normal and scarred tissues using second-harmonic generation microscopy. Scanning. 2016 38(6):684-693. PMID: 27111090. PMCID: PMC6050009.
• Lam NT, Muldoon TJ, Quinn KP, [et al.]. Valve interstitial cell contractile strength and metabolic state are dependent on its shape. Integrative biology : quantitative biosciences from nano to macro. 2016 8(10):1079-1089. PMID: 27713997. PMCID: PMC5096585.