Kyle Patrick Quinn, PhD

Research Program: Cancer Biology Faculty Rank: Associate Professor Campus: University of Arkansas (Fayetteville) College: College of Engineering Department: Biomedical Engineering

Cancer Research Interest

• Disease Site Focus: No Specific Disease Site
• Research Focus Area: Detection, Informatics, Diagnosis/ Prognosis, Carcinogenesis, Treatment, Health Disparities
• Type of Research: Basic, Clinical
• Research Keywords: cancer metabolism, dermatology, optical imaging
• Research Interest Statement: My overall research interests are in developing and utilizing non-invasive quantitative optical methods to characterize the spatiotemporal patterns of disease progression and tissue repair processes. My research lab is currently utilizing label-free multiphoton microscopy to obtain high-resolution 3D images of cell metabolism and extracellular matrix organization. We also develop and implement a variety of advanced image analysis techniques to characterize the organization of the extracellular matrix, inter-cellular arrangement and morphology, as well as subcellular organelle distributions within cells. We are interested in applying these imaging and analysis techniques to various collaborative cancer research projects.

Contact Information

• Email Address: kpquinn@uark.edu

Recent Publications

• Lewis M, David G, Jacobs D, [et al., including Quinn KP]. Neuro-regenerative behavior of adipose-derived stem cells in aligned collagen I hydrogels. Materials today. Bio. 2023 22:100762. PMID: 37600354. PMCID: PMC10433000.
• Georgakoudi I, Quinn KP. Label-Free Optical Metabolic Imaging in Cells and Tissues. Annual review of biomedical engineering. 2023. PMID: 37104650. PMCID: PMC10733979.
• Sander EA, Quinn KP. Special Issue: Honoring the Editorial Accomplishments of Beth Winkelstein and Victor Barocas. Journal of biomechanical engineering. 2023 145(3). PMID: 36661079.
• Woessner AE, Quinn KP. Improved segmentation of collagen second harmonic generation images with a deep learning convolutional neural network. Journal of biophotonics. 2022 15(12):e202200191. PMID: 36087040. PMCID: PMC9789175.
• Blair MJ, Quinn KP. Single shot quantitative polarized light imaging system for rapid planar biaxial testing of soft tissues. Frontiers in bioengineering and biotechnology. 2022 10:1010307. PMID: 36213065. PMCID: PMC9532628.
• Witt N, Woessner A, Quinn K, Sander E. Multiscale Computational Model Predicts Mouse Skin Kinematics Under Tensile Loading. Journal of biomechanical engineering. 2021. PMID: 34729595. PMCID: PMC8719047.
• Paskal W, Kopka M, Stachura A, [et al., including Quinn KP]. Single Dose of N-Acetylcysteine in Local Anesthesia Increases Expression of HIF1α, MAPK1, TGFβ1 and Growth Factors in Rat Wound Healing. International journal of molecular sciences. 2021 22(16). PMID: 34445365. PMCID: PMC8395485.
• Paskal W, Paskal AM, Pietruski P, [et al., including Quinn KP]. N-Acetylcysteine Added to Local Anesthesia Reduces Scar Area and Width in Early Wound Healing-An Animal Model Study. International journal of molecular sciences. 2021 22(14). PMID: 34299175. PMCID: PMC8307704.
• Jones JD, Rodriguez MR, Quinn KP. Automated Extraction of Skin Wound Healing Biomarkers From In Vivo Label-Free Multiphoton Microscopy Using Convolutional Neural Networks. Lasers in surgery and medicine. 2021. PMID: 33442889. PMCID: PMC8275674.
• Tandon I, Quinn KP, Balachandran K. Label-Free Multiphoton Microscopy for the Detection and Monitoring of Calcific Aortic Valve Disease. Frontiers in cardiovascular medicine. 2021 8:688513. PMID: 34179147. PMCID: PMC8226007.
• Woessner AE, Jones JD, Witt NJ, [et al., including Quinn KP]. Three-Dimensional Quantification of Collagen Microstructure During Tensile Mechanical Loading of Skin. Frontiers in bioengineering and biotechnology. 2021 9:642866. PMID: 33748088. PMCID: PMC7966723.
• Liu Z, Meng J, Quinn KP, Georgakoudi I. Tissue Imaging and Quantification Relying on Endogenous Contrast. Advances in experimental medicine and biology. 2021 3233:257-288. PMID: 34053031.
• Seyed Jafari SM, Blank F, Ramser HE, [et al., including Quinn KP]. Efficacy of Combined in-vivo Electroporation-Mediated Gene Transfer of VEGF, HGF, and IL-10 on Skin Flap Survival, Monitored by Label-Free Optical Imaging: A Feasibility Study. Frontiers in surgery. 2021 8:639661. PMID: 33834037. PMCID: PMC8021947.
• Tandon I, Johns S, Woessner A, [et al., including Quinn KP]. Label-free optical biomarkers detect early calcific aortic valve disease in a wild-type mouse model. BMC cardiovascular disorders. 2020 20(1):521. PMID: 33308143. PMCID: PMC7731510.
• Jones JD, Quinn KP. Automated Quantitative Analysis of Wound Histology Using Deep-Learning Neural Networks. The Journal of investigative dermatology. 2020. PMID: 33121938. PMCID: PMC8068577.
• Kim CS, Ding X, Allmeroth K, [et al., including Quinn KP]. Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle. Cell metabolism. 2020 32(4):629-642.e8. PMID: 32905798.
• Tandon I, Kolenc OI, Cross D, [et al., including Quinn KP]. Label-free metabolic biomarkers for assessing valve interstitial cell calcific progression. Scientific reports. 2020 10(1):10317. PMID: 32587322. PMCID: PMC7316720.
• Blair MJ, Jones JD, Woessner AE, Quinn KP. Skin Structure-Function Relationships and the Wound Healing Response to Intrinsic Aging. Advances in wound care. 2020 9(3):127-143. PMID: 31993254. PMCID: PMC6985772.
• Jones JD, Ramser HE, Woessner AE, [et al., including Quinn KP]. Quantifying Age-Related Changes in Skin Wound Metabolism Using In Vivo Multiphoton Microscopy. Advances in wound care. 2020 9(3):90-102. PMID: 31993251. PMCID: PMC6985773.