Research Focus Area:
Detection, Informatics, Diagnosis/ Prognosis, Carcinogenesis, Treatment, Health Disparities
cancer metabolism, dermatology, optical imaging
Type of Research:
Research Interest Statement:
My overall research interests are in developing and utilizing non-invasive quantitative optical methods to characterize the spatiotemporal patterns of disease progression and tissue repair processes. My research lab is currently utilizing label-free multiphoton microscopy to obtain high-resolution 3D images of cell metabolism and extracellular matrix organization. We also develop and implement a variety of advanced image analysis techniques to characterize the organization of the extracellular matrix, inter-cellular arrangement and morphology, as well as subcellular organelle distributions within cells. We are interested in applying these imaging and analysis techniques to various collaborative cancer research projects.
Jones JD, Rodriguez MR, Quinn KP. Automated Extraction of Skin Wound Healing Biomarkers From In Vivo Label-Free Multiphoton Microscopy Using Convolutional Neural Networks. Lasers in surgery and medicine. 2021. PMID: 33442889.
Tandon I, Johns S, Woessner A, [et al., including Quinn KP]. Label-free optical biomarkers detect early calcific aortic valve disease in a wild-type mouse model. BMC cardiovascular disorders. 2020 20(1):521. PMID: 33308143. PMCID: PMC7731510.
Jones JD, Quinn KP. Automated Quantitative Analysis of Wound Histology Using Deep-Learning Neural Networks. The Journal of investigative dermatology. 2020. PMID: 33121938.
Kim CS, Ding X, Allmeroth K, [et al., including Quinn KP]. Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle. Cell metabolism. 2020 32(4):629-642.e8. PMID: 32905798.
Tandon I, Kolenc OI, Cross D, [et al., including Quinn KP]. Label-free metabolic biomarkers for assessing valve interstitial cell calcific progression. Scientific reports. 2020 10(1):10317. PMID: 32587322. PMCID: PMC7316720.
Blair MJ, Jones JD, Woessner AE, Quinn KP. Skin Structure-Function Relationships and the Wound Healing Response to Intrinsic Aging. Advances in wound care. 2020 9(3):127-143. PMID: 31993254. PMCID: PMC6985772.
Jones JD, Ramser HE, Woessner AE, [et al., including Quinn KP]. Quantifying Age-Related Changes in Skin Wound Metabolism Using In Vivo Multiphoton Microscopy. Advances in wound care. 2020 9(3):90-102. PMID: 31993251. PMCID: PMC6985773.
Woessner AE, McGee JD, Jones JD, Quinn KP. Characterizing differences in the collagen fiber organization of skin wounds using quantitative polarized light imaging. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 2019 27(6):711-714. PMID: 31418977. PMCID: PMC7000211.
Prieto SP, Reed CL, James HM, [et al., including Quinn KP]. Differences in colonic crypt morphology of spontaneous and colitis-associated murine models via second harmonic generation imaging to quantify colon cancer development. BMC cancer. 2019 19(1):428. PMID: 31072353. PMCID: PMC6507102.
Kolenc OI, Quinn KP. Evaluating Cell Metabolism Through Autofluorescence Imaging of NAD(P)H and FAD. Antioxidants & redox signaling. 2019 30(6):875-889. PMID: 29268621. PMCID: PMC6352511.
Li X, Saeidi N, Villiger M, [et al., including Quinn KP]. Rejuvenation of aged rat skin with pulsed electric fields. Journal of tissue engineering and regenerative medicine. 2018 12(12):2309-2318. PMID: 30353675.
Vargas I, Alhallak K, Kolenc OI, [et al., including Quinn KP]. Rapid quantification of mitochondrial fractal dimension in individual cells. Biomedical optics express. 2018 9(11):5269-5279. PMID: 30460127. PMCID: PMC6238904.
Liu Z, Speroni L, Quinn KP, [et al.]. 3D organizational mapping of collagen fibers elucidates matrix remodeling in a hormone-sensitive 3D breast tissue model. Biomaterials. 2018 179:96-108. PMID: 29980078. PMCID: PMC6176712.
Lee DE, Alhallak K, Jenkins SV, [et al., including Quinn KP]. A Radiosensitizing Inhibitor of HIF-1 alters the Optical Redox State of Human Lung Cancer Cells In Vitro. Scientific reports. 2018 8(1):8815. PMID: 29891977. PMCID: PMC5995847.
Liu Z, Pouli D, Alonzo CA, [et al., including Quinn KP]. Mapping metabolic changes by noninvasive, multiparametric, high-resolution imaging using endogenous contrast. Science advances. 2018 4(3):eaap9302. PMID: 29536043. PMCID: PMC5846284.
Jones JD, Ramser HE, Woessner AE, Quinn KP. In vivo multiphoton microscopy detects longitudinal metabolic changes associated with delayed skin wound healing. Communications biology. 2018 1:198. PMID: 30480099. PMCID: PMC6242983.
Golberg A, Villiger M, Felix Broelsch G, [et al., including Quinn KP]. Skin regeneration with all accessory organs following ablation with irreversible electroporation. Journal of tissue engineering and regenerative medicine. 2018 12(1):98-113. PMID: 27976527. PMCID: PMC5555830.
Roberts K, Schluns J, Walker A, [et al., including Quinn KP]. Cell derived extracellular matrix fibers synthesized using sacrificial hollow fiber membranes. Biomedical materials (Bristol, England). 2017 13(1):015023. PMID: 28855424. PMCID: PMC5769927.
Baugh LM, Liu Z, Quinn KP, [et al.]. Non-destructive two-photon excited fluorescence imaging identifies early nodules in calcific aortic-valve disease. Nature biomedical engineering. 2017 1(11):914-924. PMID: 29456878. PMCID: PMC5811202.
Alhallak K, Jenkins SV, Lee DE, [et al., including Quinn KP]. Optical imaging of radiation-induced metabolic changes in radiation-sensitive and resistant cancer cells. Journal of biomedical optics. 2017 22(6):60502. PMID: 28622395. PMCID: PMC5499259.
Stuntz E, Gong Y, Sood D, [et al., including Quinn KP]. Endogenous Two-Photon Excited Fluorescence Imaging Characterizes Neuron and Astrocyte Metabolic Responses to Manganese Toxicity. Scientific reports. 2017 7(1):1041. PMID: 28432298. PMCID: PMC5430620.
Liu Z, Pouli D, Sood D, [et al., including Quinn KP]. Automated quantification of three-dimensional organization of fiber-like structures in biological tissues. Biomaterials. 2017 116:34-47. PMID: 27914265. PMCID: PMC5210183.
Pouli D, Balu M, Alonzo CA, [et al., including Quinn KP]. Imaging mitochondrial dynamics in human skin reveals depth-dependent hypoxia and malignant potential for diagnosis. Science translational medicine. 2016 8(367):367ra169. PMID: 27903865. PMCID: PMC5176339.
Quinn KP, Sullivan KE, Liu Z, [et al.]. Optical metrics of the extracellular matrix predict compositional and mechanical changes after myocardial infarction. Scientific reports. 2016 6:35823. PMID: 27819334. PMCID: PMC5098140.
Alhallak K, Rebello LG, Muldoon TJ, [et al., including Quinn KP]. Optical redox ratio identifies metastatic potential-dependent changes in breast cancer cell metabolism. Biomedical optics express. 2016 7(11):4364-4374. PMID: 27895979. PMCID: PMC5119579.
Yildirim M, Quinn KP, Kobler JB, [et al.]. Quantitative differentiation of normal and scarred tissues using second-harmonic generation microscopy. Scanning. 2016 38(6):684-693. PMID: 27111090. PMCID: PMC6050009.
Golberg A, Villiger M, Khan S, [et al., including Quinn KP]. Preventing Scars after Injury with Partial Irreversible Electroporation. The Journal of investigative dermatology. 2016 136(11):2297-2304. PMID: 27393126. PMCID: PMC5516938.
Lam NT, Muldoon TJ, Quinn KP, [et al.]. Valve interstitial cell contractile strength and metabolic state are dependent on its shape. Integrative biology : quantitative biosciences from nano to macro. 2016 8(10):1079-1089. PMID: 27713997. PMCID: PMC5096585.
Abbott RD, Borowsky FE, Quinn KP, [et al.]. Non-invasive Assessments of Adipose Tissue Metabolism In Vitro. Annals of biomedical engineering. 2016 44(3):725-32. PMID: 26399988. PMCID: PMC4792664.
Quinn KP, Leal EC, Tellechea A, [et al.]. Diabetic Wounds Exhibit Distinct Microstructural and Metabolic Heterogeneity through Label-Free Multiphoton Microscopy. The Journal of investigative dermatology. 2016 136(1):342-344. PMID: 26763462. PMCID: PMC4731029.
Bellas E, Rollins A, Moreau JE, [et al., including Quinn KP]. Equine model for soft-tissue regeneration. Journal of biomedical materials research. Part B, Applied biomaterials. 2015 103(6):1217-1227. PMID: 25350377. PMCID: PMC4868549.
Golberg A, Khan S, Belov V, [et al., including Quinn KP]. Skin rejuvenation with non-invasive pulsed electric fields. Scientific reports. 2015 5:10187. PMID: 25965851. PMCID: PMC4428072.
Xylas J, Varone A, Quinn KP, [et al.]. Noninvasive assessment of mitochondrial organization in three-dimensional tissues reveals changes associated with cancer development. International journal of cancer. 2015 136(2):322-32. PMID: 24862444. PMCID: PMC4837461.
Quinn KP, Golberg A, Broelsch GF, [et al.]. An automated image processing method to quantify collagen fibre organization within cutaneous scar tissue. Experimental dermatology. 2015 24(1):78-80. PMID: 25256009. PMCID: PMC4289465.
Özkucur N, Quinn KP, Pang JC, [et al.]. Membrane potential depolarization causes alterations in neuron arrangement and connectivity in cocultures. Brain and behavior. 2015 5(1):24-38. PMID: 25722947. PMCID: PMC4321392.