Jesus Delgado-Calle, PhD

Full Member

Research Program:

Cancer Biology

Faculty Rank:

Associate Professor

Campus:

University of Arkansas for Medical Sciences

College:

College of Medicine

Department:

Physiology & Cell Biology

Cancer Research Interest

Research Interest Statement: My research focuses on understanding the mechanisms by which cancer myeloma (MM) cells alter the biology of other cells in the tumor/bone marrow microenvironment, in particular osteocytes, with the final goal of identifying targetable factors for the treatment of cancer that grows in bone. My expertise is on osteocyte biology and pathophysiology, with experience in ex vivo and in vitro models to study osteocyte-tumor biology, and characterization of tumor growth and bone remodeling in animal models of MM-induced bone disease using genetic and pharmacologic approaches. Current projects in my laboratory investigate the effects of osteocyte-derived factors (i.e. Sclerostin) and Notch signaling communication in the tumor niche on MM growth, disease relapse, and bone disease. I also maintain an international collaboration with PharmaMar (Spain) to test the effects of Aplidin, a novel anti-tumor drug, on bone cells and MM growth. Moreover, I collaborate in studies examining the role of osteocytes in cancer-induced bone pain and muscle weakness.

American Association for Cancer Research – AWD00056331
“AACR-John Kincade Scholarship Fund Scholar-in-Training Award - Sabol”
Principal Investigator
4/12/2025 – 3/31/2026
NIH/Nat. Cancer Institute – 2R01CA209882
“Contribution of osteocytes to the musculoskeletal effects of Multiple Myeloma”
Principal Investigator
7/1/2023 – 6/30/2028