Reza Hakkak, PhD

Research Program: Cancer Prevention and Population Sciences Faculty Rank: Professor Campus: University of Arkansas for Medical Sciences College: College of Health Professions Department: Dietetics & Nutrition

Cancer Research Interest

• Research Interest Statement: I have several years of experience on investigating the effects of different diets on breast and cancer prevention using animal models. For past 10 years, my lab has been focused on investigating the effects of obesity and different diets on breast cancer animal model with focus on gut microbiota.

Contact Information

• Email Address: Hakkakreza@uams.edu
• Profiles Research Networking Software: View Profile

Active Grants

• UAMS ACHRI Flow Through – GR034036
  “Obesity, Gut Microbiota and Non-Alcoholic Fatty Liver Protection in Adolescents and Adults by Soy Protein Diet”
  Principal Investigator
  04/01/20 – 03/31/23

Publications

• Melnyk S, Hakkak R. Metabolic Status of Lean and Obese Zucker Rats Based on Untargeted and Targeted Metabolomics Analysis of Serum. Biomedicines. 2022 10(1). PMID: 35052832. PMCID: PMC8773868.
• Robeson MS 2nd, Manna K, Randolph C, [et al., including Hakkak R]. Short-Term Metformin Treatment Enriches Bacteroides dorei in an Obese Liver Steatosis Zucker Rat Model. Frontiers in microbiology. 2022 13:834776. PMID: 35432282. PMCID: PMC9006818.
• Kozaczek M, Kong B, Bottje W, Hakkak R. Hepatic Proteomics Analysis of Nonalcoholic Fatty Liver Disease Obese Rat Model After Short- and Long-Term Soy Protein Isolate Feeding. Journal of medicinal food. 2021. PMID: 34883038.
• Hakkak R, Rose S, Spray B, [et al.]. Effects of obesity and 10 weeks metformin treatment on liver steatosis. Biomedical reports. 2021 14(6):49. PMID: 33859820. PMCID: PMC8042663.
• Kozaczek M, Bottje W, Kong B, [et al., including Hakkak R]. A Comparison of Short- and Long-Term Soy Protein Isolate Intake and Its Ability to Reduce Liver Steatosis in Obese Zucker Rats Through Modifications of Genes Involved in Inflammation and Lipid Transport. Journal of medicinal food. 2021. PMID: 33751907.
• Kozaczek M, Bottje W, Albataineh D, Hakkak R. Effects of Short- and Long-Term Soy Protein Feeding on Hepatic Cytochrome P450 Expression in Obese Nonalcoholic Fatty Liver Disease Rat Model. Frontiers in nutrition. 2021 8:699620. PMID: 34262928. PMCID: PMC8273275.
• Zeng H, Larson KJ, Cheng WH, [et al., including Hakkak R]. Advanced liver steatosis accompanies an increase in hepatic inflammation, colonic, secondary bile acids and Lactobacillaceae/Lachnospiraceae bacteria in C57BL/6 mice fed a high-fat diet. The Journal of nutritional biochemistry. 2020 78:108336. PMID: 32004929.
• Kozaczek M, Bottje W, Kong B, [et al., including Hakkak R]. Long-Term Soy Protein Isolate Consumption Reduces Liver Steatosis Through Changes in Global Transcriptomics in Obese Zucker Rats. Frontiers in nutrition. 2020 7:607970. PMID: 33363197. PMCID: PMC7759473.
• Rochester E, Wickman BE, Bell A, [et al., including Hakkak R]. Correction: A diet containing high- versus low-daidzein does not affect bone density and osteogenic gene expression in the obese Zucker rat model. Food & function. 2019 10(12):8309. PMID: 31691687.
• Kozaczek M, Bottje W, Greene E, [et al., including Hakkak R]. Comparison of liver gene expression by RNAseq and PCR analysis after 8 weeks of feeding soy protein isolate- or casein-based diets in an obese liver steatosis rat model. Food & function. 2019 10(12):8218-8229. PMID: 31701992.
• Rochester E, Wickman BE, Bell A, [et al., including Hakkak R]. A diet containing high- versus low-daidzein does not affect bone density and osteogenic gene expression in the obese Zucker rat model. Food & function. 2019 10(10):6851-6857. PMID: 31580380. PMCID: PMC7151643.
• Hakkak R, Gauss CH, Bell A, Korourian S. Short-Term Soy Protein Isolate Feeding Prevents Liver Steatosis and Reduces Serum ALT and AST Levels in Obese Female Zucker Rats. Biomedicines. 2018 6(2). PMID: 29757972. PMCID: PMC6027420.
• Melnyk S, Korourian S, Levy JW, [et al., including Hakkak R]. Effects of Obesity on Pro-Oxidative Conditions and DNA Damage in Liver of DMBA-Induced Mammary Carcinogenesis Models. Metabolites. 2017 7(2). PMID: 28594380. PMCID: PMC5487997.
• Bell A, Korourian S, Zeng H, [et al., including Hakkak R]. A diet containing a high- versus low-daidzein level does not protect against liver steatosis in the obese Zucker rat model. Food & function. 2017 8(3):1293-1298. PMID: 28244519.
• Hakkak R, Bell A, Korourian S. Dehydroepiandrosterone (DHEA) Feeding Protects Liver Steatosis in Obese Breast Cancer Rat Model. Scientia pharmaceutica. 2017 85(1). PMID: 28335515. PMCID: PMC5388150.
• Zeng H, Taussig DP, Cheng WH, [et al., including Hakkak R]. Butyrate Inhibits Cancerous HCT116 Colon Cell Proliferation but to a Lesser Extent in Noncancerous NCM460 Colon Cells. Nutrients. 2017 9(1). PMID: 28045428. PMCID: PMC5295069.
• Hakkak R, Korourian S, Foley SL, Erickson BD. Assessment of gut microbiota populations in lean and obese Zucker rats. PloS one. 2017 12(7):e0181451. PMID: 28704522. PMCID: PMC5509373.
• Jousheghany F, Phelps J, Crook T, Hakkak R. Relationship between level of HbA1C and breast cancer. BBA clinical. 2016 6:45-48. PMID: 27957429. PMCID: PMC5144103.
• Hakkak R, Zeng H, Dhakal IB, Korourian S. Short- and Long-Term Soy Diet Versus Casein Protects Liver Steatosis Independent of the Arginine Content. Journal of medicinal food. 2015 18(11):1274-80. PMID: 26186426.