Reza Hakkak, PhD

Research Program: Cancer Prevention and Population Sciences Faculty Rank: Professor Campus: University of Arkansas for Medical Sciences College: College of Health Professions Department: College of Health Profession

Cancer Research Interest

• Research Interest Statement: I have several years of experience on investigating the effects of different diets on breast and cancer prevention using animal models. For past 10 years, my lab has been focused on investigating the effects of obesity and different diets on breast cancer animal model with focus on gut microbiota.

Contact Information

• Email Address: RHAKKAK@UAMS.EDU
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Recent Publications

• Li W, Hakkak R. Soy Protein Concentrate Diets Inversely Affect LPS-Binding Protein Expression in Colon and Liver, Reduce Liver Inflammation, and Increase Fecal LPS Excretion in Obese Zucker Rats. Nutrients. 2024 16(7). PMID: 38613016. PMCID: PMC11013665.
• Li W, Spray B, Børsheim E, [et al., including Hakkak R]. Long-Term Feeding Soy Protein Concentrates Protect Against Hepatic Steatosis Independent of Isoflavone Levels. Journal of medicinal food. 2023 26(12):911-918. PMID: 37971778.
• Melnyk S, Hakkak R. Effect of Metformin Treatment on Serum Metabolic Profile Changes in Lean and Obese Zucker Rat Model for Fatty Liver Disease. Biomolecules. 2023 13(8). PMID: 37627299. PMCID: PMC10452862.
• Li W, Twaddle NC, Spray B, [et al., including Hakkak R]. Feeding Soy Protein Concentrates with Low and High Isoflavones Alters 9 and 18 Weeks Serum Isoflavones and Inflammatory Protein Levels in Lean and Obese Zucker Rats. Journal of medicinal food. 2023. PMID: 36720082.
• Li W, Hakkak R. Feeding soy protein concentrates with low or high isoflavone decreases liver inflammation by reducing lipopolysaccharide translocation. Frontiers in nutrition. 2023 10:1278158. PMID: 38075211. PMCID: PMC10699199.
• Melnyk S, Hakkak R. Metabolic Status of Lean and Obese Zucker Rats Based on Untargeted and Targeted Metabolomics Analysis of Serum. Biomedicines. 2022 10(1). PMID: 35052832. PMCID: PMC8773868.
• Robeson MS 2nd, Manna K, Randolph C, [et al., including Hakkak R]. Short-Term Metformin Treatment Enriches Bacteroides dorei in an Obese Liver Steatosis Zucker Rat Model. Frontiers in microbiology. 2022 13:834776. PMID: 35432282. PMCID: PMC9006818.
• Hakkak R, Spray B, Børsheim E, Korourian S. Diet Containing Soy Protein Concentrate With Low and High Isoflavones for 9 Weeks Protects Against Non-alcoholic Fatty Liver Steatosis Using Obese Zucker Rats. Frontiers in nutrition. 2022 9:913571. PMID: 35811988. PMCID: PMC9258741.
• Kozaczek M, Kong B, Bottje W, Hakkak R. Hepatic Proteomics Analysis of Nonalcoholic Fatty Liver Disease Obese Rat Model After Short- and Long-Term Soy Protein Isolate Feeding. Journal of medicinal food. 2021. PMID: 34883038.
• Hakkak R, Rose S, Spray B, [et al.]. Effects of obesity and 10 weeks metformin treatment on liver steatosis. Biomedical reports. 2021 14(6):49. PMID: 33859820. PMCID: PMC8042663.
• Kozaczek M, Bottje W, Kong B, [et al., including Hakkak R]. A Comparison of Short- and Long-Term Soy Protein Isolate Intake and Its Ability to Reduce Liver Steatosis in Obese Zucker Rats Through Modifications of Genes Involved in Inflammation and Lipid Transport. Journal of medicinal food. 2021. PMID: 33751907.
• Kozaczek M, Bottje W, Albataineh D, Hakkak R. Effects of Short- and Long-Term Soy Protein Feeding on Hepatic Cytochrome P450 Expression in Obese Nonalcoholic Fatty Liver Disease Rat Model. Frontiers in nutrition. 2021 8:699620. PMID: 34262928. PMCID: PMC8273275.
• Zeng H, Larson KJ, Cheng WH, [et al., including Hakkak R]. Advanced liver steatosis accompanies an increase in hepatic inflammation, colonic, secondary bile acids and Lactobacillaceae/Lachnospiraceae bacteria in C57BL/6 mice fed a high-fat diet. The Journal of nutritional biochemistry. 2020 78:108336. PMID: 32004929.
• Kozaczek M, Bottje W, Kong B, [et al., including Hakkak R]. Long-Term Soy Protein Isolate Consumption Reduces Liver Steatosis Through Changes in Global Transcriptomics in Obese Zucker Rats. Frontiers in nutrition. 2020 7:607970. PMID: 33363197. PMCID: PMC7759473.
• Kozaczek M, Bottje W, Greene E, [et al., including Hakkak R]. Comparison of liver gene expression by RNAseq and PCR analysis after 8 weeks of feeding soy protein isolate- or casein-based diets in an obese liver steatosis rat model. Food & function. 2019 10(12):8218-8229. PMID: 31701992.
• Rochester E, Wickman BE, Bell A, [et al., including Hakkak R]. Correction: A diet containing high- versus low-daidzein does not affect bone density and osteogenic gene expression in the obese Zucker rat model. Food & function. 2019 10(12):8309. PMID: 31691687.