Ganesh Narayanasamy, PhD

Research Program: Cancer Therapeutics Faculty Rank: Associate Professor Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Radiation Oncology Physics

Cancer Research Interest

• Disease Site Focus: Brain, GI, GU, Thoracic/ Lung, Head and Neck
• Research Focus Area: Treatment, Informatics, Detection, Diagnosis/ Prognosis
• Type of Research: Clinical
• Research Interest Statement: Dr. Narayanasamy’s research interests include dosimetric studies in radiation therapy, assessment of new and existing technologies in radiation therapy, and study of radiation biology. He currently pursues a series of radiation studies on lung tumors while minimizing radiation toxicity to normal tissue from using a specialized treatment technique, Stereotactic body radiation therapy (SBRT). Dosimetric comparison between treatment planning systems has been my special research interest. While Eclipse Varian TPS has set benchmarks for industry standards, Raystation TPS provides “Robust Optimization” and “Multi-criteria optimization” features that reduces the integral dose for a given prescription dose (Rx). Brainlab Elements have provided fast and reliable way to treat multiple brain tumors using a single isocenter with substantial savings in treatment time. Patient discomfort and possible patient motion during treatment are also minimized.In addition, Dr. Narayanasamy has recently commissioned a small-animal irradiator facility at the UAMS College of Pharmacy Department of Pharmaceutical Sciences with Cesium-137 source. Irradiation using this low dose rate device on small animals with hind-limb suspension mimics zero gravity environment. I have been involved in a multitude of small animal studies that take place in the small animal conformal radiation treatment and imaging device that has the unique capability to perform spatially fractionated (grid) treatments and cone-beam CT guided image guided radiotherapy (IGRT) in Radiation Oncology department.

Contact Information

• Email Address: GANESH@UAMS.EDU
• Profiles Research Networking Software: View Profile

Active Grants

• Brainlab AG – AWD00055415
  “Retrospective dosimetric comparison of 4pi treatment geometry with VMAT based radiation therapy of brain tumor (IRB 261309)”
  Principal Investigator
  4/13/2021 – 4/13/2031

Recent Publications

• Frometa-Castillo T, Pyakuryal A, Narayanasamy G, Sio T. The effective normal tissue non-complication probability (E0): a probabilistic methodology in the representation of the stochastic health safety effects of low levels of ionizing radiation on the human tissues or organs. International journal of radiation biology. 2025:1-5. PMID: 39898896.
• Boria AJ, Narayanasamy G, Bimali M, [et al.]. Cleaning the dose falloff with low modulation in SBRT lung plans. Biomedical physics & engineering express. 2023 9(4). PMID: 37140156.
• Petragallo R, Bertram P, Halvorsen P, [et al., including Narayanasamy G]. Development and multi-institutional validation of a convolutional neural network to detect vertebral body mis-alignments in 2D x-ray setup images. Medical physics. 2023. PMID: 36908243.
• Hammers J, Lindsay D, Narayanasamy G, [et al.]. Evaluation of the clinical impact of the differences between planned and delivered dose in prostate cancer radiotherapy based on CT-on-rails IGRT and patient-reported outcome scores. Journal of applied clinical medical physics. 2023 24(1):e13780. PMID: 36087039. PMCID: PMC9859987.
• Nissen C, Ying J, Newkirk M, [et al., including Narayanasamy G]. An Analysis of Risk Factors for Radiation Necrosis Following Cranial Radiation. Cureus. 2022 14(9):e29268. PMID: 36133504. PMCID: PMC9482441.
• Frometa-Castillo T, Pyakuryal A, Narayanasamy G, [et al.]. The use of the normal tissue non-complication probability (NTCP0) in the safety evaluations as a new alternative of assessing the side-effects of the radiation oncology treatments. International journal of radiation biology. 2022:1-7. PMID: 35930494.
• Shrestha N, Narayanasamy G, Kalantari F, [et al.]. A phantom-based study and clinical implementation of brainlab's treatment planning system for radiosurgical treatments of arteriovenous malformations. Biomedical physics & engineering express. 2022. PMID: 35856850.
• Deshazer G, Narayanasamy G, Bimali M, [et al.]. A dosimetric comparative analysis of Brainlab elements and Eclipse RapidArc for spine SBRT treatment planning. Biomedical physics & engineering express. 2022 8(2). PMID: 35086071.
• Frometa-Castillo T, Pyakuryal A, Narayanasamy G, [et al.]. The use of the normal tissue non-complication probability (NTCP0) methodology as a new alternative of assessing side-effects in brachytherapy treatments. Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology. 2022 27(4):602-609. PMID: 36196423. PMCID: PMC9521694.
• Manavalan M, Durai M, Narayanasamy G, [et al.]. Output factor measurements with multiple detectors in CyberKnife(®) Robotic Radiosurgery System. Journal of cancer research and therapeutics. 2021 17(4):870-874. PMID: 34528534.
• Sadhukhan R, Majumdar D, Garg S, [et al., including Narayanasamy G]. Simultaneous exposure to chronic irradiation and simulated microgravity differentially alters immune cell phenotype in mouse thymus and spleen. Life sciences in space research. 2021 28:66-73. PMID: 33612181. PMCID: PMC7900614.
• Desai D, Narayanasamy G, Bimali M, [et al.]. Cleaning the dose falloff in lung SBRT plan. Journal of applied clinical medical physics. 2020. PMID: 33285036. PMCID: PMC7856511.
• Johnsrud AJ, Jenkins SV, Jamshidi-Parsian A, [et al., including Narayanasamy G]. Evidence for Early Stage Anti-Tumor Immunity Elicited by Spatially Fractionated Radiotherapy-Immunotherapy Combinations. Radiation research. 2020 194(6):688-697. PMID: 33348372. PMCID: PMC8008989.
• Veluvolu M, Patel M, Narayanasamy G, Kim T. Definitive single fraction stereotactic ablative radiotherapy for inoperable early-stage breast cancer: A case report. Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology. 2020 25(5):760-764. PMID: 32742200. PMCID: PMC7387738.