Nukhet Aykin-Burns, PhD

Research Program: DNA Damage and Host Response Faculty Rank: Associate Professor Campus: University of Arkansas for Medical Sciences College: College of Pharmacy Department: Pharmaceutical Sciences

Cancer Research Interest

• Disease Site Focus: Breast, Cutaneous/Melanoma, GI
• Research Focus Area: Prevention, Treatment
• Type of Research: Basic
• Research Interest Statement: My research mainly focuses on the effects of cellular bioenergetics, mitochondrial dysfunction, and redox homeostasis in chemo/radiotherapy-induced normal tissue injuries in order to develop countermeasures to mitigate cancer therapy side effects.

Contact Information

• Email Address: NAykinburns@uams.edu
• Profiles Research Networking Software: View Profile

Active Grants

• NIH/Nat. Cancer Institute – 1R01CA258673
  “MnBuOE as a Novel Chemosensitizer for Breast Cance”
  Co-Investigator
  08/01/21 – 07/31/25

Publications

• Richardson KK, Ling W, Krager K, [et al., including Aykin-Burns N]. Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice. International journal of molecular sciences. 2022 23(2). PMID: 35054859. PMCID: PMC8775597.
• Kim HN, Richardson KK, Krager KJ, [et al., including Aykin-Burns N]. Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice. International journal of molecular sciences. 2021 22(21). PMID: 34769141. PMCID: PMC8583929.
• McDonald JT, Enguita FJ, Taylor D, [et al., including Aykin-Burns N]. Role of miR-2392 in driving SARS-CoV-2 infection. Cell reports. 2021:109839. PMID: 34624208. PMCID: PMC8481092.
• McDonald JT, Enguita FJ, Taylor D, [et al., including Aykin-Burns N]. The Great Deceiver: miR-2392's Hidden Role in Driving SARS-CoV-2 Infection. bioRxiv : the preprint server for biology. 2021. PMID: 33948587. PMCID: PMC8095194.
• Ling W, Krager K, Richardson KK, [et al., including Aykin-Burns N]. Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency. JCI insight. 2021. PMID: 33878033.
• Sridharan V, Johnson KA, Landes RD, [et al., including Aykin-Burns N]. Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin. PloS one. 2021 16(5):e0252142. PMID: 34029348. PMCID: PMC8143413.
• Koss B, Boerma M, Shields BD, [et al., including Aykin-Burns N]. Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion. Cancer research. 2020. PMID: 33004350.
• Kim HN, Ponte F, Nookaew I, [et al., including Aykin-Burns N]. Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors. Scientific reports. 2020 10(1):11933. PMID: 32686739. PMCID: PMC7371870.
• Tascioglu Aliyev A, LoBianco F, Krager KJ, [et al., including Aykin-Burns N]. Assessment of Cellular Oxidation using a Subcellular Compartment-Specific Redox-Sensitive Green Fluorescent Protein. Journal of visualized experiments : JoVE. 2020(160). PMID: 32628158.
• LoBianco FV, Krager KJ, Carter GS, [et al., including Aykin-Burns N]. The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury. Antioxidants (Basel, Switzerland). 2020 9(5). PMID: 32403251. PMCID: PMC7278565.
• Aykin-Burns N, Pathak R, Boerma M, [et al.]. Utilization of Vitamin E Analogs to Protect Normal Tissues While Enhancing Antitumor Effects. Seminars in radiation oncology. 2019 29(1):55-61. PMID: 30573184. PMCID: PMC6309800.
• Alam S, Carter GS, Krager KJ, [et al., including Aykin-Burns N]. PCB11 Metabolite, 3,3'-Dichlorobiphenyl-4-ol, Exposure Alters the Expression of Genes Governing Fatty Acid Metabolism in the Absence of Functional Sirtuin 3: Examining the Contribution of MnSOD. Antioxidants (Basel, Switzerland). 2018 7(9). PMID: 30223548. PMCID: PMC6162768.
• Wang L, Fang B, Fujiwara T, [et al., including Aykin-Burns N]. Deletion of ferroportin in murine myeloid cells increases iron accumulation and stimulates osteoclastogenesis in vitro and in vivo. The Journal of biological chemistry. 2018 293(24):9248-9264. PMID: 29724825. PMCID: PMC6005439.
• Nukala U, Thakkar S, Krager KJ, [et al., including Aykin-Burns N]. Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans). Antioxidants (Basel, Switzerland). 2018 7(2). PMID: 29473853. PMCID: PMC5836023.
• Banerjee S, Melnyk SB, Krager KJ, [et al., including Aykin-Burns N]. Trifluoperazine inhibits acetaminophen-induced hepatotoxicity and hepatic reactive nitrogen formation in mice and in freshly isolated hepatocytes. Toxicology reports. 2017 4:134-142. PMID: 28503408. PMCID: PMC5426116.
• Banerjee S, Aykin-Burns N, Krager KJ, [et al.]. Loss of C/EBP? enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction. Free radical biology & medicine. 2016 99:296-307. PMID: 27554969. PMCID: PMC5673253.
• Pathak R, Wang J, Garg S, [et al., including Aykin-Burns N]. Recombinant Thrombomodulin (Solulin) Ameliorates Early Intestinal Radiation Toxicity in a Preclinical Rat Model. Radiation research. 2016 186(2):112-20. PMID: 27459702. PMCID: PMC4995594.
• Chang J, Wang Y, Shao L, [et al., including Aykin-Burns N]. Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nature medicine. 2016 22(1):78-83. PMID: 26657143. PMCID: PMC4762215.
• Banerjee S, Melnyk SB, Krager KJ, [et al., including Aykin-Burns N]. The neuronal nitric oxide synthase inhibitor NANT blocks acetaminophen toxicity and protein nitration in freshly isolated hepatocytes. Free radical biology & medicine. 2015 89:750-7. PMID: 26454079. PMCID: PMC5012542.
• Miousse IR, Chalbot MC, Pathak R, [et al., including Aykin-Burns N]. In Vitro Toxicity and Epigenotoxicity of Different Types of Ambient Particulate Matter. Toxicological sciences : an official journal of the Society of Toxicology. 2015 148(2):473-87. PMID: 26342214. PMCID: PMC5009441.