Nukhet Aykin-Burns, PhD

Associate Member

Research Program:

Cancer Therapeutics

Faculty Rank:

Associate Professor

Campus:

University of Arkansas for Medical Sciences

College:

College of Pharmacy

Department:

Radiation Health

Cancer Research Interest

Disease Site Focus: Breast, Cutaneous/Melanoma, GI
Research Focus Area: Prevention, Treatment
Type of Research: Basic
Research Interest Statement: My research mainly focuses on the effects of cellular bioenergetics, mitochondrial dysfunction, and redox homeostasis in chemo/radiotherapy-induced normal tissue injuries in order to develop countermeasures to mitigate cancer therapy side effects.

Contact Information

Email Address: NAYKINBURNS@UAMS.EDU
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Active Grants

NIH/Nat. Cancer Institute – 1R37CA282349
“Ryanodine Receptors as Therapeutic Targets to Prevent Doxorubicin-Induced Lymphatic Dysfunction”
Co-Investigator
8/10/2023 – 7/31/2028
NIH/Nat. Cancer Institute – 1R01CA258673
“MnBuOE as a Novel Chemosensitizer for Breast Cancer and Neuroprotector”
Co-Investigator
8/1/2021 – 7/31/2025

Recent Publications

Richardson KK, Adam GO, Ling W, [et al., including Aykin-Burns N]. Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice. Molecular metabolism. 2024 88:102012. PMID: 39154858. PMCID: PMC11399565.
Shrum SA, Nukala U, Shrimali S, [et al., including Aykin-Burns N]. Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects. Antioxidants (Basel, Switzerland). 2023 12(11). PMID: 38001840. PMCID: PMC10668991.
McGill MR, Kaufman YJ, LoBianco FV, [et al., including Aykin-Burns N]. The role of cytochrome P450 3A4-mediated metabolism in sorafenib and lapatinib hepatotoxicity. Livers. 2023 3(2):310-321. PMID: 38037613. PMCID: PMC10688230.
Allen AR, Jones A', LoBianco FV, [et al., including Aykin-Burns N]. Effect of Sirt3 on hippocampal MnSOD activity, mitochondrial function, physiology, and cognition in an aged murine model. Behavioural brain research. 2023 444:114335. PMID: 36804441. PMCID: PMC10081808.
Wang X, Shao L, Richardson KK, [et al., including Aykin-Burns N]. Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice. The Journal of biological chemistry. 2022 299(2):102841. PMID: 36574841. PMCID: PMC9867982.
Trujillo M, Odle AK, Aykin-Burns N, Allen AR. Chemotherapy induced oxidative stress in the ovary: drug-dependent mechanisms and potential interventions†. Biology of reproduction. 2022. PMID: 36539327. PMCID: PMC10106837.
Das BK, Wang L, Fujiwara T, [et al., including Aykin-Burns N]. Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton. eLife. 2022 11. PMID: 35758636. PMCID: PMC9352353.
Richardson KK, Ling W, Krager K, [et al., including Aykin-Burns N]. Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice. International journal of molecular sciences. 2022 23(2). PMID: 35054859. PMCID: PMC8775597.
LoBianco FV, Krager KJ, Johnson E, [et al., including Aykin-Burns N]. Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells. Frontiers in toxicology. 2022 4:936149. PMID: 36591540. PMCID: PMC9795200.
Kim HN, Richardson KK, Krager KJ, [et al., including Aykin-Burns N]. Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice. International journal of molecular sciences. 2021 22(21). PMID: 34769141. PMCID: PMC8583929.
McDonald JT, Enguita FJ, Taylor D, [et al., including Aykin-Burns N]. Role of miR-2392 in driving SARS-CoV-2 infection. Cell reports. 2021:109839. PMID: 34624208. PMCID: PMC8481092.
Ling W, Krager K, Richardson KK, [et al., including Aykin-Burns N]. Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency. JCI insight. 2021. PMID: 33878033. PMCID: PMC8262324.
Sridharan V, Johnson KA, Landes RD, [et al., including Aykin-Burns N]. Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin. PloS one. 2021 16(5):e0252142. PMID: 34029348. PMCID: PMC8143413.
Koss B, Boerma M, Shields BD, [et al., including Aykin-Burns N]. Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion. Cancer research. 2020. PMID: 33004350. PMCID: PMC7642172.
Kim HN, Ponte F, Nookaew I, [et al., including Aykin-Burns N]. Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors. Scientific reports. 2020 10(1):11933. PMID: 32686739. PMCID: PMC7371870.
Tascioglu Aliyev A, LoBianco F, Krager KJ, [et al., including Aykin-Burns N]. Assessment of Cellular Oxidation using a Subcellular Compartment-Specific Redox-Sensitive Green Fluorescent Protein. Journal of visualized experiments : JoVE. 2020(160). PMID: 32628158. PMCID: PMC7725482.
LoBianco FV, Krager KJ, Carter GS, [et al., including Aykin-Burns N]. The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury. Antioxidants (Basel, Switzerland). 2020 9(5). PMID: 32403251. PMCID: PMC7278565.