Narasimhan Rajaram, PhD

Research Program: Cancer Biology Faculty Rank: Assistant Professor Campus: University of Arkansas (Fayetteville) College: College of Engineering Department: Biomedical Engineering

Cancer Research Interest

• Disease Site Focus: Breast, Head and Neck, Thoracic/ Lung
• Research Focus Area: Treatment, Diagnosis/ Prognosis, Detection
• Type of Research: Basic, Population Sciences
• Research Interest Statement: Optical spectroscopy, multiphoton microscopy, point-of-care technologies, radiation resistance, monitoring and predicting response to therapy, field cancerization, early detection, tumor metabolism, hypoxia, breast cancer, head and neck cancer, lung cancer

Contact Information

• Email Address: nrajaram@uark.edu
• Profiles Research Networking Software: View Profile

Active Grants

• NIH/Nat. Cancer Institute – 1R01CA238025
  “Determination of Functional and Molecular Biomarkers of Treatment Resistance with Multimodal Optical Spectroscopy”
  Principal Investigator
  08/13/19 – 07/31/24

Publications

• Jules A, Means D, Troncoso JR, [et al., including Rajaram N]. Diffuse Reflectance Spectroscopy of Changes in Tumor Microenvironment in Response to Different Doses of Radiation. Radiation research. 2022. PMID: 36240754. PMCID: PMC9798304.
• Bess SN, Greening GJ, Rajaram N, Muldoon TJ. Macrophage-targeted anti-CCL2 immunotherapy enhances tumor sensitivity to 5-fluorouracil in a Balb/c-CT26 murine colon carcinoma model measured using diffuse reflectance spectroscopy. BMC immunology. 2022 23(1):20. PMID: 35461243. PMCID: PMC9035255.
• Paidi SK, Troncoso JR, Harper MG, [et al., including Rajaram N]. Raman spectroscopy reveals phenotype switches in breast cancer metastasis. Theranostics. 2022 12(12):5351-5363. PMID: 35910801. PMCID: PMC9330538.
• Paidi SK, Rajaram N, Raj P, [et al.]. Raman and quantitative phase imaging allow morpho-molecular recognition of malignancy and stages of B-cell acute lymphoblastic leukemia. Biosensors & bioelectronics. 2021 190:113403. PMID: 34130086. PMCID: PMC8492164.
• Paidi SK, Troncoso JR, Raj P, [et al., including Rajaram N]. Raman spectroscopy and machine learning reveals early tumor microenvironmental changes induced by immunotherapy. Cancer research. 2021. PMID: 34645610. PMCID: PMC8841097.
• Troncoso JR, Diaz PM, Lee DE, [et al., including Rajaram N]. Longitudinal monitoring of tumor response to immune checkpoint inhibitors using noninvasive diffuse reflectance spectroscopy. Biomedical optics express. 2021 12(7):3982-3991. PMID: 34457393. PMCID: PMC8367250.
• Vohra N, Chavez T, Troncoso JR, [et al., including Rajaram N]. Mammary tumors in Sprague Dawley rats induced by N-ethyl-N-nitrosourea for evaluating terahertz imaging of breast cancer. Journal of medical imaging (Bellingham, Wash.). 2021 8(2):023504. PMID: 33928181. PMCID: PMC8071784.
• Paidi SK, Rajaram N, Shah V, [et al.]. Coarse Raman and optical diffraction tomographic imaging enable label-free phenotyping of isogenic breast cancer cells of varying metastatic potential. Biosensors & bioelectronics. 2021 175:112863. PMID: 33272866. PMCID: PMC7847362.
• Yuan Y, Rajaram N, Raj P, [et al.]. Furin-Mediated Self-Assembly of Olsalazine Nanoparticles for Targeted Raman Imaging of Tumors. Angewandte Chemie (International ed. in English). 2021 60(8):3923-3927. PMID: 33325142. PMCID: PMC7902394.
• Dadgar S, Greene E, Dhamad A, [et al., including Rajaram N]. Diffuse reflectance spectroscopy reveals heat stress-induced changes in hemoglobin concentration in chicken breast. Scientific reports. 2021 11(1):3649. PMID: 33574480. PMCID: PMC7878772.
• Lee DE, Brown JL, Rosa-Caldwell ME, [et al., including Rajaram N]. Cancer-induced Cardiac Atrophy Adversely Affects Myocardial Redox State and Mitochondrial Oxidative Characteristics. JCSM rapid communications. 2021 4(1):3-15. PMID: 33693448. PMCID: PMC7939061.
• Dadgar S, Troncoso JR, Siegel ER, [et al., including Rajaram N]. Spectroscopic investigation of radiation-induced reoxygenation in radiation-resistant tumors. Neoplasia (New York, N.Y.). 2020 23(1):49-57. PMID: 33220616. PMCID: PMC7683290.
• Mundo AI, Greening GJ, Fahr MJ, [et al., including Rajaram N]. Diffuse reflectance spectroscopy to monitor murine colorectal tumor progression and therapeutic response (Erratum). Journal of biomedical optics. 2020 25(4):1. PMID: 32323510. PMCID: PMC7174893.
• Mundo AI, Greening GJ, Fahr MJ, [et al., including Rajaram N]. Diffuse reflectance spectroscopy to monitor murine colorectal tumor progression and therapeutic response. Journal of biomedical optics. 2020 25(3):1-16. PMID: 32141266. PMCID: PMC7058691.
• Lee DE, Perry RA Jr, Brown JL, [et al., including Rajaram N]. Mitochondrial mRNA translation initiation contributes to oxidative metabolism in the myocardia of aged, obese mice. Experimental gerontology. 2019 121:62-70. PMID: 30928679.
• Paidi SK, Diaz PM, Dadgar S, [et al., including Rajaram N]. Label-Free Raman Spectroscopy Reveals Signatures of Radiation Resistance in the Tumor Microenvironment. Cancer research. 2019 79(8):2054-2064. PMID: 30819665. PMCID: PMC6467810.
• Dadgar S, Rajaram N. Optical Imaging Approaches to Investigating Radiation Resistance. Frontiers in oncology. 2019 9:1152. PMID: 31750246. PMCID: PMC6848224.
• Greene E, Flees J, Dadgar S, [et al., including Rajaram N]. Quantum Blue Reduces the Severity of Woody Breast Myopathy via Modulation of Oxygen Homeostasis-Related Genes in Broiler Chickens. Frontiers in physiology. 2019 10:1251. PMID: 31632293. PMCID: PMC6781743.
• Vargas I, Alhallak K, Kolenc OI, [et al., including Rajaram N]. Rapid quantification of mitochondrial fractal dimension in individual cells. Biomedical optics express. 2018 9(11):5269-5279. PMID: 30460127. PMCID: PMC6238904.
• Vohra N, Bowman T, Diaz PM, [et al., including Rajaram N]. Pulsed Terahertz Reflection Imaging of tumors in a spontaneous model of breast cancer. Biomedical physics & engineering express. 2018 4(6). PMID: 31275612. PMCID: PMC6605103.
• Ravindranathan S, Nguyen KG, Kurtz SL, [et al., including Rajaram N]. Tumor-derived granulocyte colony-stimulating factor diminishes efficacy of breast tumor cell vaccines. Breast cancer research : BCR. 2018 20(1):126. PMID: 30348199. PMCID: PMC6198508.
• Diaz PM, Jenkins SV, Alhallak K, [et al., including Rajaram N]. Quantitative diffuse reflectance spectroscopy of short-term changes in tumor oxygenation after radiation in a matched model of radiation resistance. Biomedical optics express. 2018 9(8):3794-3804. PMID: 30338156. PMCID: PMC6191608.
• Greening G, Mundo A, Rajaram N, Muldoon TJ. Sampling depth of a diffuse reflectance spectroscopy probe for in-vivo physiological quantification of murine subcutaneous tumor allografts. Journal of biomedical optics. 2018 23(8):1-14. PMID: 30152204. PMCID: PMC8357195.
• Lee DE, Alhallak K, Jenkins SV, [et al., including Rajaram N]. A Radiosensitizing Inhibitor of HIF-1 alters the Optical Redox State of Human Lung Cancer Cells In Vitro. Scientific reports. 2018 8(1):8815. PMID: 29891977. PMCID: PMC5995847.
• Dadgar S, Troncoso JR, Rajaram N. Optical spectroscopic sensing of tumor hypoxia. Journal of biomedical optics. 2018 23(6):1-6. PMID: 29873205.
• Martinez AF, McCachren SS 3rd, Lee M, [et al., including Rajaram N]. Metaboloptics: Visualization of the tumor functional landscape via metabolic and vascular imaging. Scientific reports. 2018 8(1):4171. PMID: 29520098. PMCID: PMC5843602.
• Bowman T, Chavez T, Khan K, [et al., including Rajaram N]. Pulsed terahertz imaging of breast cancer in freshly excised murine tumors. Journal of biomedical optics. 2018 23(2):1-13. PMID: 29446263. PMCID: PMC5812433.
• Alhallak K, Jenkins SV, Lee DE, [et al., including Rajaram N]. Optical imaging of radiation-induced metabolic changes in radiation-sensitive and resistant cancer cells. Journal of biomedical optics. 2017 22(6):60502. PMID: 28622395. PMCID: PMC5499259.
• Alhallak K, Rebello LG, Muldoon TJ, [et al., including Rajaram N]. Optical redox ratio identifies metastatic potential-dependent changes in breast cancer cell metabolism. Biomedical optics express. 2016 7(11):4364-4374. PMID: 27895979. PMCID: PMC5119579.
• Greening GJ, Rajaram N, Muldoon TJ. Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis. Journal of visualized experiments : JoVE. 2016(116). PMID: 27805585. PMCID: PMC5092209.
• Lam NT, Muldoon TJ, Quinn KP, [et al., including Rajaram N]. Valve interstitial cell contractile strength and metabolic state are dependent on its shape. Integrative biology : quantitative biosciences from nano to macro. 2016 8(10):1079-1089. PMID: 27713997. PMCID: PMC5096585.