Narasimhan Rajaram, PhD

Research Program: Cancer Biology Faculty Rank: Assistant Professor Campus: University of Arkansas (Fayetteville) College: College of Engineering Department: Biomedical Engineering

Cancer Research Interest

• Disease Site Focus: Breast, Head and Neck, Thoracic/ Lung
• Research Focus Area: Treatment, Diagnosis/ Prognosis, Detection
• Type of Research: Basic, Population Sciences
• Research Interest Statement: Optical spectroscopy, multiphoton microscopy, point-of-care technologies, radiation resistance, monitoring and predicting response to therapy, field cancerization, early detection, tumor metabolism, hypoxia, breast cancer, head and neck cancer, lung cancer

Contact Information

• Email Address: nrajaram@uark.edu
• Profiles Research Networking Software: View Profile

Active Grants

• NIH/Nat. Cancer Institute – 1R01CA238025
  “Determination of Functional and Molecular Biomarkers of Treatment Resistance with Multimodal Optical Spectroscopy”
  Principal Investigator
  08/13/19 – 07/31/24

Publications

• Jenkins SV, Shah S, Jamshidi-Parsian A, [et al., including Rajaram N]. Acquired Radiation Resistance Induces Thiol-dependent Cisplatin Cross-resistance. Radiation research. 2024 201(2):174-187. PMID: 38329819. PMCID: PMC10993299.
• Sharma M, Brown AW, Powell NM, [et al., including Rajaram N]. Racial and skin color mediated disparities in pulse oximetry in infants and young children. Paediatric respiratory reviews. 2024. PMID: 38233229.
• Rodriguez Troncoso J, Marium Mim U, Ivers JD, [et al., including Rajaram N]. Evaluating differences in optical properties of indolent and aggressive murine breast tumors using quantitative diffuse reflectance spectroscopy. Biomedical optics express. 2023 14(12):6114-6126. PMID: 38420330. PMCID: PMC10898562.
• Jules A, Means D, Troncoso JR, [et al., including Rajaram N]. Diffuse Reflectance Spectroscopy of Changes in Tumor Microenvironment in Response to Different Doses of Radiation. Radiation research. 2022. PMID: 36240754. PMCID: PMC9798304.
• Bess SN, Greening GJ, Rajaram N, Muldoon TJ. Macrophage-targeted anti-CCL2 immunotherapy enhances tumor sensitivity to 5-fluorouracil in a Balb/c-CT26 murine colon carcinoma model measured using diffuse reflectance spectroscopy. BMC immunology. 2022 23(1):20. PMID: 35461243. PMCID: PMC9035255.
• Paidi SK, Troncoso JR, Harper MG, [et al., including Rajaram N]. Raman spectroscopy reveals phenotype switches in breast cancer metastasis. Theranostics. 2022 12(12):5351-5363. PMID: 35910801. PMCID: PMC9330538.
• Paidi SK, Rajaram N, Raj P, [et al.]. Raman and quantitative phase imaging allow morpho-molecular recognition of malignancy and stages of B-cell acute lymphoblastic leukemia. Biosensors & bioelectronics. 2021 190:113403. PMID: 34130086. PMCID: PMC8492164.
• Paidi SK, Troncoso JR, Raj P, [et al., including Rajaram N]. Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy. Cancer research. 2021. PMID: 34645610. PMCID: PMC8841097.
• Troncoso JR, Diaz PM, Lee DE, [et al., including Rajaram N]. Longitudinal monitoring of tumor response to immune checkpoint inhibitors using noninvasive diffuse reflectance spectroscopy. Biomedical optics express. 2021 12(7):3982-3991. PMID: 34457393. PMCID: PMC8367250.
• Vohra N, Chavez T, Troncoso JR, [et al., including Rajaram N]. Mammary tumors in Sprague Dawley rats induced by N-ethyl-N-nitrosourea for evaluating terahertz imaging of breast cancer. Journal of medical imaging (Bellingham, Wash.). 2021 8(2):023504. PMID: 33928181. PMCID: PMC8071784.
• Paidi SK, Rajaram N, Shah V, [et al.]. Coarse Raman and optical diffraction tomographic imaging enable label-free phenotyping of isogenic breast cancer cells of varying metastatic potential. Biosensors & bioelectronics. 2021 175:112863. PMID: 33272866. PMCID: PMC7847362.
• Yuan Y, Rajaram N, Raj P, [et al.]. Furin-Mediated Self-Assembly of Olsalazine Nanoparticles for Targeted Raman Imaging of Tumors. Angewandte Chemie (International ed. in English). 2021 60(8):3923-3927. PMID: 33325142. PMCID: PMC7902394.
• Dadgar S, Greene E, Dhamad A, [et al., including Rajaram N]. Diffuse reflectance spectroscopy reveals heat stress-induced changes in hemoglobin concentration in chicken breast. Scientific reports. 2021 11(1):3649. PMID: 33574480. PMCID: PMC7878772.
• Lee DE, Brown JL, Rosa-Caldwell ME, [et al., including Rajaram N]. Cancer-induced Cardiac Atrophy Adversely Affects Myocardial Redox State and Mitochondrial Oxidative Characteristics. JCSM rapid communications. 2021 4(1):3-15. PMID: 33693448. PMCID: PMC7939061.
• Dadgar S, Troncoso JR, Siegel ER, [et al., including Rajaram N]. Spectroscopic investigation of radiation-induced reoxygenation in radiation-resistant tumors. Neoplasia (New York, N.Y.). 2020 23(1):49-57. PMID: 33220616. PMCID: PMC7683290.
• Mundo AI, Greening GJ, Fahr MJ, [et al., including Rajaram N]. Diffuse reflectance spectroscopy to monitor murine colorectal tumor progression and therapeutic response (Erratum). Journal of biomedical optics. 2020 25(4):1. PMID: 32323510. PMCID: PMC7174893.
• Mundo AI, Greening GJ, Fahr MJ, [et al., including Rajaram N]. Diffuse reflectance spectroscopy to monitor murine colorectal tumor progression and therapeutic response. Journal of biomedical optics. 2020 25(3):1-16. PMID: 32141266. PMCID: PMC7058691.
• Lee DE, Perry RA Jr, Brown JL, [et al., including Rajaram N]. Mitochondrial mRNA translation initiation contributes to oxidative metabolism in the myocardia of aged, obese mice. Experimental gerontology. 2019 121:62-70. PMID: 30928679.