Viji Mohan Seenivasan, PhD, MBA

Associate Member

Research Program:

Cancer Therapeutics

Faculty Rank:

Research Instructor

Campus:

University of Arkansas for Medical Sciences

College:

College of Pharmacy

Department:

Pharmaceutical Sciences

Contact Information

Email Address: VMOHANSEENIVASAN@UAMS.EDU
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Active Grants

National Aeronautics & Space Administration – 80NSSC21K0544
“LSU subcontract - NASA Human Exploration Research”
Co-Investigator
06/01/21 – 05/31/24

Publications

Nemec-Bakk AS, Sridharan V, Seawright JW, [et al.]. Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model. Life sciences in space research. 2023 37:78-87. PMID: 37087182. PMCID: PMC10122719.
Li Y, Bansal S, Sridharan V, [et al.]. Urinary Metabolomics for the Prediction of Radiation-Induced Cardiac Dysfunction. Metabolites. 2023 13(4). PMID: 37110184. PMCID: PMC10146652.
Nemec-Bakk AS, Sridharan V, Desai P, [et al.]. Effects of Simulated 5-Ion Galactic Cosmic Radiation on Function and Structure of the Mouse Heart. Life (Basel, Switzerland). 2023 13(3). PMID: 36983950. PMCID: PMC10057791.
Sridharan V, Krager KJ, Pawar SA, [et al.]. Effects of Whole and Partial Heart Irradiation on Collagen, Mast Cells, and Toll-like Receptor 4 in the Mouse Heart. Cancers. 2023 15(2). PMID: 36672353. PMCID: PMC9856613.
Nemec-Bakk AS, Sridharan V, Landes RD, [et al.]. Effects of low-dose oxygen ions on cardiac function and structure in female C57BL/6J mice. Life sciences in space research. 2022 32:105-112. PMID: 35065756. PMCID: PMC8803400.
Boerma M, Sridharan V, Krager KJ, Pawar SA. Small animal models of localized heart irradiation. Methods in cell biology. 2022 168:221-234. PMID: 35366984. PMCID: PMC9642084.
Dina Zita M, Phillips MB, Stuart JD, [et al., including Sridharan V]. The M2 Gene Is a Determinant of Reovirus-Induced Myocarditis. Journal of virology. 2021:JVI0187921. PMID: 34757847. PMCID: PMC8791294.
Nemec-Bakk AS, Sridharan V, Landes RD, [et al.]. Mitigation of late cardiovascular effects of oxygen ion radiation by ?-tocotrienol in a mouse model. Life sciences in space research. 2021 31:43-50. PMID: 34689949. PMCID: PMC8548672.
Swinton C, Kiffer F, McElroy T, [et al., including Sridharan V]. Effects of 16O charged-particle irradiation on cognition, hippocampal morphology and mutagenesis in female mice. Behavioural brain research. 2021 407:113257. PMID: 33794227.
Sridharan V, Johnson KA, Landes RD, [et al.]. Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin. PloS one. 2021 16(5):e0252142. PMID: 34029348. PMCID: PMC8143413.
Girgis M, Li Y, Jayatilake M, [et al., including Sridharan V]. Short-term metabolic disruptions in urine of mouse models following exposure to low doses of oxygen ion radiation. Journal of environmental science and health. Part C, Toxicology and carcinogenesis. 2021 39(2):234-249. PMID: 33902388. PMCID: PMC9757021.
Dissmore T, DeMarco AG, Jayatilake M, [et al., including Sridharan V]. Longitudinal metabolic alterations in plasma of rats exposed to low doses of high linear energy transfer radiation. Journal of environmental science and health. Part C, Toxicology and carcinogenesis. 2021 39(2):219-233. PMID: 33902389. PMCID: PMC9896584.
Van S, Pal S, Garner BR, [et al., including Sridharan V]. Dantrolene Prevents the Lymphostasis Caused by Doxorubicin in the Rat Mesenteric Circulation. Frontiers in pharmacology. 2021 12:727526. PMID: 34483938. PMCID: PMC8415554.
Mao XW, Nishiyama NC, Byrum SD, [et al., including Sridharan V]. Spaceflight induces oxidative damage to blood-brain barrier integrity in a mouse model. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020. PMID: 32981077. PMCID: PMC8191453.
Sridharan V, Seawright JW, Landes RD, [et al.]. Effects of single-dose protons or oxygen ions on function and structure of the cardiovascular system in male Long Evans rats. Life sciences in space research. 2020 26:62-68. PMID: 32718688. PMCID: PMC7387753.
Upadhyay M, Rajagopal M, Gill K, [et al., including Sridharan V]. Identification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model. Metabolites. 2020 10(6). PMID: 32560360. PMCID: PMC7345467.
Unger K, Li Y, Yeh C, [et al., including Sridharan V]. Plasma metabolite biomarkers predictive of radiation induced cardiotoxicity. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2020. PMID: 32360032. PMCID: PMC7572465.
Kiffer F, Alexander T, Anderson J, [et al., including Sridharan V]. Late Effects of 1H + 16O on Short-Term and Object Memory, Hippocampal Dendritic Morphology and Mutagenesis. Frontiers in behavioral neuroscience. 2020 14:96. PMID: 32670032. PMCID: PMC7332779.
Mao XW, Boerma M, Rodriguez D, [et al., including Sridharan V]. Combined Effects of Low-Dose Proton Radiation and Simulated Microgravity on the Mouse Retina and the Hematopoietic System. Radiation research. 2019 192(3):241-250. PMID: 30430917. PMCID: PMC6820356.
Miousse IR, Skinner CM, Sridharan V, [et al.]. Changes in one-carbon metabolism and DNA methylation in the hearts of mice exposed to space environment-relevant doses of oxygen ions (16O). Life sciences in space research. 2019 22:8-15. PMID: 31421852. PMCID: PMC6703167.
Mao XW, Nishiyama NC, Byrum SD, [et al., including Sridharan V]. Characterization of mouse ocular response to a 35-day spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations. Scientific reports. 2019 9(1):8215. PMID: 31160660. PMCID: PMC6547757.
Kiffer F, Alexander T, Anderson JE, [et al., including Sridharan V]. Late Effects of 16O-Particle Radiation on Female Social and Cognitive Behavior and Hippocampal Physiology. Radiation research. 2019 191(3):278-294. PMID: 30664396. PMCID: PMC7150605.
Seawright JW, Sridharan V, Landes RD, [et al.]. Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice. Life sciences in space research. 2019 20:72-84. PMID: 30797436. PMCID: PMC6391741.
Howe A, Kiffer F, Alexander TC, [et al., including Sridharan V]. Long-Term Changes in Cognition and Physiology after Low-Dose 16O Irradiation. International journal of molecular sciences. 2019 20(1). PMID: 30621014. PMCID: PMC6337104.
Skinner CM, Miousse IR, Ewing LE, [et al., including Sridharan V]. Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE Pro? (New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2018 122:21-32. PMID: 30282009. PMCID: PMC6219625.
Mao XW, Byrum S, Nishiyama NC, [et al., including Sridharan V]. Impact of Spaceflight and Artificial Gravity on the Mouse Retina: Biochemical and Proteomic Analysis. International journal of molecular sciences. 2018 19(9). PMID: 30154332. PMCID: PMC6165321.
Mao XW, Boerma M, Rodriguez D, [et al., including Sridharan V]. Acute Effect of Low-Dose Space Radiation on Mouse Retina and Retinal Endothelial Cells. Radiation research. 2018 190(1):45-52. PMID: 29741442. PMCID: PMC6820357.
Kiffer F, Howe AK, Carr H, [et al., including Sridharan V]. Late effects of 1H irradiation on hippocampal physiology. Life sciences in space research. 2018 17:51-62. PMID: 29753414. PMCID: PMC7063743.
Kiffer F, Carr H, Groves T, [et al., including Sridharan V]. Effects of 1H + 16O Charged Particle Irradiation on Short-Term Memory and Hippocampal Physiology in a Murine Model. Radiation research. 2018 189(1):53-63. PMID: 29136391. PMCID: PMC7077734.
Chang J, Wang Y, Pathak R, [et al., including Sridharan V]. Whole body proton irradiation causes acute damage to bone marrow hematopoietic progenitor and stem cells in mice. International journal of radiation biology. 2017 93(12):1312-1320. PMID: 28782442. PMCID: PMC6693495.
Casero D, Gill K, Sridharan V, [et al.]. Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome. Microbiome. 2017 5(1):105. PMID: 28821301. PMCID: PMC5563039.
Sridharan V, Seawright JW, Antonawich FJ, [et al.]. Late Administration of a Palladium Lipoic Acid Complex (POLY-MVA) Modifies Cardiac Mitochondria but Not Functional or Structural Manifestations of Radiation-Induced Heart Disease in a Rat Model. Radiation research. 2017 187(3):361-366. PMID: 28231026. PMCID: PMC5483333.
Wang Y, Chang J, Li X, [et al., including Sridharan V]. Low doses of oxygen ion irradiation cause long-term damage to bone marrow hematopoietic progenitor and stem cells in mice. PloS one. 2017 12(12):e0189466. PMID: 29232383. PMCID: PMC5726652.
Seawright JW, Samman Y, Sridharan V, [et al.]. Effects of low-dose rate ?-irradiation combined with simulated microgravity on markers of oxidative stress, DNA methylation potential, and remodeling in the mouse heart. PloS one. 2017 12(7):e0180594. PMID: 28678877. PMCID: PMC5498037.
Boerma M, Sridharan V, Mao XW, [et al.]. Effects of ionizing radiation on the heart. Mutation research. 2016 770(Pt B):319-327. PMID: 27919338. PMCID: PMC5144922.