Research Interest Statement:
My current tobacco research agenda extends in three directions. The primary direction is on the stress-smoking relationship. Tobacco addiction disproportionately affects individuals with mood disorders, and smokers may use tobacco to temporarily reduce stress, anxiety, and depressed mood- albeit tobacco withdrawal may exacerbate negative mood. This year, I have received funding from NIDA to study the stress-smoking relationship as it pertains to short- and long-term quit outcomes.The second direction of my research agenda is on the effects of nicotine and tobacco addiction on neuroeconomic decision making. This decision making seeks to maximize the likelihood of obtaining a reward while minimizing the costs of obtaining it, which requires appropriate sensitivity to rewards and their costs. I've found that smokers? brain response to money reward is diminished by tobacco withdrawal, which may relate to why withdrawal symptoms decrease the motivation to remain abstinent. The third and newest direction of my research agenda is on the effects of ketamine on tobacco addiction. Ketamine is a glutamate NMDA receptor antagonist that is frequently used as a general anesthetic. A single sub-anesthetic dose rapidly (within 24 hours) reduces depression symptoms. A small number of studies have indicated that sub-anesthetic doses of ketamine also disrupt drug use behavior in individuals with substance use disorders. I am conducting a preliminary study on the effects of ketamine on tobacco use and smoking latency among non-treatment seeking cigarette smokers.
Addicott MA, Pearson JM, Schechter JC, [et al.]. Attention-deficit/hyperactivity disorder and the explore/exploit trade-off. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2020. PMID: 33040092.
Kinard JL, Mosner MG, Greene RK, [et al., including Addicott M]. Neural Mechanisms of Social and Nonsocial Reward Prediction Errors in Adolescents with Autism Spectrum Disorder. Autism research : official journal of the International Society for Autism Research. 2020 13(5):715-728. PMID: 32043748.
Addicott MA, Wardle MC, Selig JP. Effort-based decision making varies by smoking status. Psychopharmacology. 2020 237(4):1081-1090. PMID: 31900525. PMCID: PMC7125005.
Addicott MA, Schechter JC, Sapyta JJ, [et al.]. Methylphenidate increases willingness to perform effort in adults with ADHD. Pharmacology, biochemistry, and behavior. 2019 183:14-21. PMID: 31226260. PMCID: PMC6628703.
Addicott MA, Sweitzer MM, McClernon FJ. The Effects of Nicotine and Tobacco Use on Brain Reward Function: Interaction With Nicotine Dependence Severity. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2019 21(6):764-771. PMID: 29584917. PMCID: PMC6784410.
Addicott MA, Luber B, Nguyen D, [et al.]. Low- and High-Frequency Repetitive Transcranial Magnetic Stimulation Effects on Resting-State Functional Connectivity Between the Postcentral Gyrus and the Insula. Brain connectivity. 2019 9(4):322-328. PMID: 30773890. PMCID: PMC6533779.
Mosner MG, McLaurin RE, Kinard JL, [et al., including Addicott MA]. Neural Mechanisms of Reward Prediction Error in Autism Spectrum Disorder. Autism research and treatment. 2019 2019:5469191. PMID: 31354993. PMCID: PMC6634058.
Addicott MA, Daughters SB, Strauman TJ, Appelbaum LG. Distress tolerance to auditory feedback and functional connectivity with the auditory cortex. Psychiatry research. Neuroimaging. 2018 282:1-10. PMID: 30384144. PMCID: PMC6289788.
Sweitzer MM, Kollins SH, Kozink RV, [et al., including Addicott MA]. ADHD, Smoking Withdrawal, and Inhibitory Control: Results of a Neuroimaging Study with Methylphenidate Challenge. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2018 43(4):851-858. PMID: 29052617. PMCID: PMC5809794.
Meade CS, Addicott M, Hobkirk AL, [et al.]. Cocaine and HIV are independently associated with neural activation in response to gain and loss valuation during economic risky choice. Addiction biology. 2018 23(2):796-809. PMID: 28682013. PMCID: PMC6706251.
Lee HS, Addicott M, Martin LE, [et al.]. Implicit Attitudes and Smoking Behavior in a Smoking Cessation Induction Trial. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2017 20(1):58-66. PMID: 27679606. PMCID: PMC5896513.
Addicott MA, Pearson JM, Sweitzer MM, [et al.]. A Primer on Foraging and the Explore/Exploit Trade-Off for Psychiatry Research. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2017 42(10):1931-1939. PMID: 28553839. PMCID: PMC5561336.
Oliver JA, Evans DE, Addicott MA, [et al.]. Nicotine Withdrawal Induces Neural Deficits in Reward Processing. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2017 19(6):686-693. PMID: 28371807.
Addicott MA, Oliver JA, Joseph McClernon F. Nicotine increases anterior insula activation to expected and unexpected outcomes among nonsmokers. Psychopharmacology. 2017 234(7):1145-1154. PMID: 28190083. PMCID: PMC5986178.
Sweitzer MM, Geier CF, Addicott MA, [et al.]. Smoking Abstinence-Induced Changes in Resting State Functional Connectivity with Ventral Striatum Predict Lapse During a Quit Attempt. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2016 41(10):2521-9. PMID: 27091382. PMCID: PMC4987851.
McClernon FJ, Froeliger B, Rose JE, [et al., including Addicott MA]. The effects of nicotine and non-nicotine smoking factors on working memory and associated brain function. Addiction biology. 2016 21(4):954-61. PMID: 25904425. PMCID: PMC4618271.
McClernon FJ, Conklin CA, Kozink RV, [et al., including Addicott MA]. Hippocampal and Insular Response to Smoking-Related Environments: Neuroimaging Evidence for Drug-Context Effects in Nicotine Dependence. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2016 41(3):877-85. PMID: 26179147. PMCID: PMC4707833.
Addicott MA, Pearson JM, Kaiser N, [et al.]. Suboptimal foraging behavior: a new perspective on gambling. Behavioral neuroscience. 2015 129(5):656-665. PMID: 26191945. PMCID: PMC4586367.
Addicott MA, Sweitzer MM, Froeliger B, [et al.]. Increased Functional Connectivity in an Insula-Based Network is Associated with Improved Smoking Cessation Outcomes. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2015 40(11):2648-56. PMID: 25895453. PMCID: PMC4569957.