Shuk-Mei Ho, PhD

Full Member

Research Program:

Cancer Prevention and Population Sciences

Faculty Rank:

Professor

Campus:

University of Arkansas for Medical Sciences

College:

College of Medicine

Department:

Pharmacology & Toxicology

Cancer Research Interest

Disease Site Focus: No Specific Disease Site
Research Focus Area: Prevention
Type of Research: Population Sciences

Contact Information

Email Address: SHUKMEIHO@UAMS.EDU
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Active Grants

Central Office of the Veterans Administration (VA) – 1I01BX005395
“Metal-Induced Cell-Level Changes in Prostate Epithelium and Cancer Risk”
Principal Investigator
07/01/21 – 06/30/25

Publications

McDermott A, Kim K, Kasper S, [et al., including Ho SM]. The androgen receptor inhibits transcription of GPER1 by preventing Sp1 and Sp3 from binding to the promoters in prostate cancer cells. Oncotarget. 2022 13:46-60. PMID: 35018219. PMCID: PMC8741193.
Ho SM, Rao R, Ouyang B, [et al.]. Three-Generation Study of Male Rats Gestationally Exposed to High Butterfat and Bisphenol A: Impaired Spermatogenesis, Penetrance with Reduced Severity. Nutrients. 2021 13(10). PMID: 34684636. PMCID: PMC8541510.
Padala KP, Padala PR, Leung YK, [et al., including Ho SM]. Untangling the Complex Interactions of Open Burn Pit Exposure and Health Outcomes: Response to Brumage et al. The primary care companion for CNS disorders. 2021 23(2). PMID: 34000124.
Joshi NR, Kohan-Ghadr HR, Roqueiro DS, [et al., including Ho SM]. Genetic and epigenetic changes in the eutopic endometrium of women with endometriosis: association with decreased endometrial ?v?3 integrin expression. Molecular human reproduction. 2021. PMID: 33693877.
Leung YK, Biesiada J, Govindarajah V, [et al., including Ho SM]. Low-Dose Bisphenol A in a Rat Model of Endometrial Cancer: A CLARITY-BPA Study. Environmental health perspectives. 2020 128(12):127005. PMID: 33296240. PMCID: PMC7725436.
Padala KP, Padala PR, Leung YK, [et al., including Ho SM]. Open Burn Pit Exposure and Concern About the COVID-19 Pandemic. The primary care companion for CNS disorders. 2020 22(6). PMID: 33166097.
Heindel JJ, Belcher S, Flaws JA, [et al., including Ho SM]. Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies. Reproductive toxicology (Elmsford, N.Y.). 2020. PMID: 32682780. PMCID: PMC7365109.
Wongsurawat T, Jenjaroenpun P, De Loose A, [et al., including Ho SM]. A novel Cas9-targeted long-read assay for simultaneous detection of IDH1/2 mutations and clinically relevant MGMT methylation in fresh biopsies of diffuse glioma. Acta neuropathologica communications. 2020 8(1):87. PMID: 32563269. PMCID: PMC7305623.
Liu X, Zhang E, Kopras EJ, [et al., including Ho SM]. Estrogen activates pyruvate kinase M2 and increases the growth of TSC2-deficient cells. PloS one. 2020 15(2):e0228894. PMID: 32078667. PMCID: PMC7032738.
Khanal T, Leung YK, Jiang W, [et al., including Ho SM]. NR2E3 is a key component in p53 activation by regulating a long noncoding RNA DINO in acute liver injuries. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 33(7):8335-8348. PMID: 30991008. PMCID: PMC6593879.
Xie C, Leung YK, Chen A, [et al., including Ho SM]. Differential methylation values in differential methylation analysis. Bioinformatics (Oxford, England). 2019 35(7):1094-1097. PMID: 30184051. PMCID: PMC6449748.
Kim S, Xu X, Zhang Y, [et al., including Ho SM]. Metal concentrations in pregnant women and neonates from informal electronic waste recycling. Journal of exposure science & environmental epidemiology. 2019 29(3):406-415. PMID: 30111780. PMCID: PMC6377357.
Dworatzek E, Mahmoodzadeh S, Schriever C, [et al., including Ho SM]. Sex-specific regulation of collagen I and III expression by 17?-Estradiol in cardiac fibroblasts: role of estrogen receptors. Cardiovascular research. 2019 115(2):315-327. PMID: 30016401. PMCID: PMC6933535.
Leung YK, Chan QK, Ng CF, [et al., including Ho SM]. Correction: Hsa-miRNA-765 as a Key Mediator for Inhibiting Growth, Migration and Invasion in Fulvestrant-Treated Prostate Cancer. PloS one. 2019 14(3):e0214184. PMID: 30883603. PMCID: PMC6422296.
Choi H, Dostal M, Pastorkova A, [et al., including Ho SM]. Greater susceptibility of girls to airborne Benzo[a]pyrene for obesity-associated childhood asthma. Environment international. 2018 121(Pt 1):308-316. PMID: 30237028.
Leung YK, Ouyang B, Niu L, [et al., including Ho SM]. Identification of sex-specific DNA methylation changes driven by specific chemicals in cord blood in a Faroese birth cohort. Epigenetics. 2018 13(3):290-300. PMID: 29560787. PMCID: PMC5997167.
Zhang Y, Xu X, Chen A, [et al., including Ho SM]. Maternal urinary cadmium levels during pregnancy associated with risk of sex-dependent birth outcomes from an e-waste pollution site in China. Reproductive toxicology (Elmsford, N.Y.). 2018 75:49-55. PMID: 29154917.
Cheong A, Howald EC, Ellersieck MR, [et al., including Ho SM]. Gene expression and DNA methylation changes in the hypothalamus and hippocampus of adult rats developmentally exposed to bisphenol A or ethinyl estradiol: a CLARITY-BPA consortium study. Epigenetics. 2018 13(7):704-720. PMID: 30001178. PMCID: PMC6224219.
Khanal T, Choi K, Leung YK, [et al., including Ho SM]. Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer. Scientific reports. 2017 7(1):10662. PMID: 28878246. PMCID: PMC5587550.
Prins GS, Ye SH, Birch L, [et al., including Ho SM]. Prostate Cancer Risk and DNA Methylation Signatures in Aging Rats following Developmental BPA Exposure: A Dose-Response Analysis. Environmental health perspectives. 2017 125(7):077007. PMID: 28728135. PMCID: PMC5744650.
Chen T, Lu L, Xu C, [et al., including Ho SM]. Inhibition Role of Atherogenic Diet on Ethyl Carbamate Induced Lung Tumorigenesis in C57BL/6J Mice. Scientific reports. 2017 7(1):4723. PMID: 28680122. PMCID: PMC5498653.
Leung YK, Govindarajah V, Cheong A, [et al., including Ho SM]. Gestational high-fat diet and bisphenol A exposure heightens mammary cancer risk. Endocrine-related cancer. 2017 24(7):365-378. PMID: 28487351. PMCID: PMC5488396.
Sharma M, Zhang X, Zhang S, [et al., including Ho SM]. Inhibition of endocytic lipid antigen presentation by common lipophilic environmental pollutants. Scientific reports. 2017 7(1):2085. PMID: 28522830. PMCID: PMC5437007.
Ho SM, Cheong A, Adgent MA, [et al.]. Environmental factors, epigenetics, and developmental origin of reproductive disorders. Reproductive toxicology (Elmsford, N.Y.). 2017 68:85-104. PMID: 27421580. PMCID: PMC5233640.
Tarapore P, Hennessy M, Song D, [et al., including Ho SM]. High butter-fat diet and bisphenol A additively impair male rat spermatogenesis. Reproductive toxicology (Elmsford, N.Y.). 2017 68:191-199. PMID: 27658648. PMCID: PMC5357593.
Smithrud DB, Powers L, Lunn J, [et al., including Ho SM]. Ca2+ Selective Host Rotaxane Is Highly Toxic Against Prostate Cancer Cells. ACS medicinal chemistry letters. 2017 8(2):163-167. PMID: 28197305. PMCID: PMC5304289.
Zhou Z, Kennell C, Leung YK, [et al., including Ho S]. Calcium phosphate-polymer hybrid nanoparticles for enhanced triple negative breast cancer treatment via co-delivery of paclitaxel and miR-221/222 inhibitors. Nanomedicine : nanotechnology, biology, and medicine. 2017 13(2):403-410. PMID: 27520723.
Ho SM, Rao R, To S, [et al.]. Bisphenol A and its analogues disrupt centrosome cycle and microtubule dynamics in prostate cancer. Endocrine-related cancer. 2017 24(2):83-96. PMID: 27998958. PMCID: PMC5226663.
Xu Z, Taylor JA, Leung YK, [et al., including Ho SM]. oxBS-MLE: an efficient method to estimate 5-methylcytosine and 5-hydroxymethylcytosine in paired bisulfite and oxidative bisulfite treated DNA. Bioinformatics (Oxford, England). 2016 32(23):3667-3669. PMID: 27522082. PMCID: PMC5181539.
Tarapore P, Hennessy M, Song D, [et al., including Ho SM]. Data on spermatogenesis in rat males gestationally exposed to bisphenol A and high fat diets. Data in brief. 2016 9:812-817. PMID: 27872877. PMCID: PMC5107686.
Miller M, Bailey B, Govindarajah V, [et al., including Ho SM]. A community survey on knowledge of the impact of environmental and epigenetic factors on health and disease. Perspectives in public health. 2016 136(6):345-352. PMID: 26941233. PMCID: PMC5367049.
Ehrlich S, Lambers D, Baccarelli A, [et al., including Ho SM]. Endocrine Disruptors: A Potential Risk Factor for Gestational Diabetes Mellitus. American journal of perinatology. 2016 33(13):1313-1318. PMID: 27490770.
Seeberger J, Grandhi R, Kim SS, [et al., including Ho SM]. Special Report: E-Waste Management in the United States and Public Health Implications. Journal of environmental health. 2016 79(3):8-16. PMID: 29120130.
Cheong A, Zhang X, Cheung YY, [et al., including Ho SM]. DNA methylome changes by estradiol benzoate and bisphenol A links early-life environmental exposures to prostate cancer risk. Epigenetics. 2016 11(9):674-689. PMID: 27415467. PMCID: PMC5048723.
Yekeen TA, Xu X, Zhang Y, [et al., including Ho SM]. Assessment of health risk of trace metal pollution in surface soil and road dust from e-waste recycling area in China. Environmental science and pollution research international. 2016 23(17):17511-24. PMID: 27230155. PMCID: PMC5316230.
Liu R, Xu X, Zhang Y, [et al., including Ho SM]. Thyroid Hormone Status in Umbilical Cord Serum Is Positively Associated with Male Anogenital Distance. The Journal of clinical endocrinology and metabolism. 2016 101(9):3378-85. PMID: 27383112. PMCID: PMC5010576.
Wang Q, Trevino LS, Wong RL, [et al., including Ho SM]. Reprogramming of the Epigenome by MLL1 Links Early-Life Environmental Exposures to Prostate Cancer Risk. Molecular endocrinology (Baltimore, Md.). 2016 30(8):856-71. PMID: 27219490. PMCID: PMC4965842.
Rizzardi AE, Zhang X, Vogel RI, [et al., including Ho SM]. Quantitative comparison and reproducibility of pathologist scoring and digital image analysis of estrogen receptor ?2 immunohistochemistry in prostate cancer. Diagnostic pathology. 2016 11(1):63. PMID: 27401406. PMCID: PMC4940862.
Schade GR, Holt SK, Zhang X, [et al., including Ho SM]. Prostate Cancer Expression Profiles of Cytoplasmic ER?1 and Nuclear ER?2 are Associated with Poor Outcomes following Radical Prostatectomy. The Journal of urology. 2016 195(6):1760-6. PMID: 26804755. PMCID: PMC4871721.