Shuk-Mei Ho, PhD

Research Program: Cancer Prevention and Population Sciences Faculty Rank: Professor Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Pharmacology & Toxicology

Cancer Research Interest

• Disease Site Focus: No Specific Disease Site
• Research Focus Area: Prevention
• Type of Research: Population Sciences

Contact Information

• Email Address: SHUKMEIHO@UAMS.EDU
• Profiles Research Networking Software: View Profile

Active Grants

• NIH/Nat. Inst. of General Medical Sciences – 1T32GM150536
  “Training in Systems Pharmacology and Toxicology (T-SPaT)”
  Co-Investigator
  7/1/2023 – 6/30/2028
• Central Office of the Veterans Administration (VA) – 1IK6BX006182
  “BLRD Research Career Scientist Award”
  Principal Investigator
  10/1/2022 – 9/30/2027
• National Science Foundation – Contract # AWD30000-260
  “RII Track-2 FEC: Facilitating Ubiquitous Technology Utilizing Resilient Eco-friendly Sensors (FUTURE Sensors)”
  Principal Investigator
  8/1/2022 – 7/31/2028
• Central Office of the Veterans Administration (VA) – 1I01BX005395
  “Metal-Induced Cell-Level Changes in Prostate Epithelium and Cancer Risk”
  Principal Investigator
  7/1/2021 – 6/30/2025

Recent Publications

• Puvvula J, Song LC, Zalewska KJ, [et al., including Ho SM]. Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns. Metabolomics : Official journal of the Metabolomic Society. 2025 21(1):20. PMID: 39863779. PMCID: PMC11762426.
• Leung YK, Lee SG, Wang J, [et al., including Ho SM]. The Loss of an Orphan Nuclear Receptor NR2E3 Augments Wnt/β-catenin Signaling via Epigenetic Dysregulation that Enhances Sp1-β catenin-p300 Interactions in Hepatocellular Carcinoma. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024 11(29):e2308539. PMID: 38790135. PMCID: PMC11304255.
• Cortes-Ramirez SA, Ho SM, Leung YK. Endocrine-Disrupting Chemicals: A Looming Threat to Current and Future Generations. International journal of molecular sciences. 2024 25(15). PMID: 39125790. PMCID: PMC11311772.
• Ananthakrishnan AN, Gerasimidis K, Ho SM, [et al.]. Challenges in IBD Research 2024: Environmental Triggers. Inflammatory bowel diseases. 2024 30(Supplement_2):S19-S29. PMID: 38778624.
• Puvvula J, Braun JM, DeFranco EA, [et al., including Ho SM]. Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells. Epigenetics communications. 2024 4(1):4. PMID: 38962689. PMCID: PMC11217138.
• Puvvula J, Manz KE, Braun JM, [et al., including Ho SM]. Maternal and newborn metabolomic changes associated with urinary polycyclic aromatic hydrocarbon metabolite concentrations at delivery: an untargeted approach. Metabolomics : Official journal of the Metabolomic Society. 2023 20(1):6. PMID: 38095785.
• Tu SM, Chen JZ, Singh SR, [et al., including Ho SM]. Stem Cell Theory of Cancer: Clinical Implications of Epigenomic versus Genomic Biomarkers in Cancer Care. Cancers. 2023 15(23). PMID: 38067237. PMCID: PMC10705798.
• McDermott A, Kim K, Kasper S, [et al., including Ho SM]. The androgen receptor inhibits transcription of GPER1 by preventing Sp1 and Sp3 from binding to the promoters in prostate cancer cells. Oncotarget. 2022 13:46-60. PMID: 35018219. PMCID: PMC8741193.
• Ho SM, Rao R, Ouyang B, [et al.]. Three-Generation Study of Male Rats Gestationally Exposed to High Butterfat and Bisphenol A: Impaired Spermatogenesis, Penetrance with Reduced Severity. Nutrients. 2021 13(10). PMID: 34684636. PMCID: PMC8541510.
• Padala KP, Padala PR, Leung YK, [et al., including Ho SM]. Untangling the Complex Interactions of Open Burn Pit Exposure and Health Outcomes: Response to Brumage et al. The primary care companion for CNS disorders. 2021 23(2). PMID: 34000124.
• Joshi NR, Kohan-Ghadr HR, Roqueiro DS, [et al., including Ho SM]. Genetic and epigenetic changes in the eutopic endometrium of women with endometriosis: association with decreased endometrial αvβ3 integrin expression. Molecular human reproduction. 2021. PMID: 33693877. PMCID: PMC8178932.
• Leung YK, Biesiada J, Govindarajah V, [et al., including Ho SM]. Low-Dose Bisphenol A in a Rat Model of Endometrial Cancer: A CLARITY-BPA Study. Environmental health perspectives. 2020 128(12):127005. PMID: 33296240. PMCID: PMC7725436.
• Padala KP, Padala PR, Leung YK, [et al., including Ho SM]. Open Burn Pit Exposure and Concern About the COVID-19 Pandemic. The primary care companion for CNS disorders. 2020 22(6). PMID: 33166097.
• Heindel JJ, Belcher S, Flaws JA, [et al., including Ho SM]. Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies. Reproductive toxicology (Elmsford, N.Y.). 2020. PMID: 32682780. PMCID: PMC7365109.
• Wongsurawat T, Jenjaroenpun P, De Loose A, [et al., including Ho SM]. A novel Cas9-targeted long-read assay for simultaneous detection of IDH1/2 mutations and clinically relevant MGMT methylation in fresh biopsies of diffuse glioma. Acta neuropathologica communications. 2020 8(1):87. PMID: 32563269. PMCID: PMC7305623.