Research Interest Statement:
My career goal is to use genomic medicine to advance our knowledge about transmissibility of infectious agents; and change the paradigm for infection prevention, specifically pertaining to patients with cancer. My studies are focused on using a next generation sequencing (NGS) approach to traditional transmission linkage science to determine patterns of acquisition of viral and bacterial infections in patients with hematologic malignancies. I believe that the tools of sequencing and metagenomics can be applied to provide direct pathogen level evidence for targeted and evidence based infection control measures both in infusion centers and oncology units.
James AE, Gulley T, Kothari A, [et al.]. Performance of the BinaxNOW coronavirus disease 2019 (COVID-19) Antigen Card test relative to the severe acute respiratory coronavirus virus 2 (SARS-CoV-2) real-time reverse transcriptase polymerase chain reaction (rRT-PCR) assay among symptomatic and asymptomatic healthcare employees. Infection control and hospital epidemiology. 2021:1-3. PMID: 33487197. PMCID: PMC7870908.
Vang KE, Krow-Lucal ER, James AE, [et al., including Kothari A]. Participation in Fraternity and Sorority Activities and the Spread of COVID-19 Among Residential University Communities - Arkansas, August 21-September 5, 2020. MMWR. Morbidity and mortality weekly report. 2021 70(1):20-23. PMID: 33411698.
Leffert J, Purushothaman R, Vilanilam GK, [et al., including Kothari A]. HIV-vacuolar myelopathy: an unusual early presentation in HIV. International journal of STD & AIDS. 2020:956462420933786. PMID: 33323068.
Ipe TS, Le T, Quinn B, [et al., including Kothari A]. Provision of COVID-19 Convalescent Plasma in a Resource-Constrained State. Transfusion. 2020. PMID: 32989778. PMCID: PMC7536906.
Udaondo Z, Jenjaroenpun P, Wongsurawat T, [et al., including Kothari A]. Two Cases of Vancomycin-Resistant Enterococcus faecium Bacteremia With Development of Daptomycin-Resistant Phenotype and its Detection Using Oxford Nanopore Sequencing. Open forum infectious diseases. 2020 7(6):ofaa180. PMID: 32550237. PMCID: PMC7291683.
Jenjaroenpun P, Wongsurawat T, Udaondo Z, [et al., including Kothari A]. Complete Genome Sequences of Four Isolates of Vancomycin-Resistant Enterococcus faecium with the vanA Gene and Two Daptomycin Resistance Mutations, Obtained from Two Inpatients with Prolonged Bacteremia. Microbiology resource announcements. 2020 9(6). PMID: 32029568. PMCID: PMC7005116.
Udaondo Z, Wongsurawat T, Jenjaroenpun P, [et al., including Kothari A]. Draft Genome Sequences of 48 Vancomycin-Resistant Enterococcus faecium Strains Isolated from Inpatients with Bacteremia and Urinary Tract Infection. Microbiology resource announcements. 2019 8(15). PMID: 30975810. PMCID: PMC6460033.
Mohan M, Susanibar-Adaniya S, Buros A, [et al., including Kothari A]. Bacteremias following autologous stem cell transplantation for multiple myeloma: Risk factors and outcomes. Transplant infectious disease : an official journal of the Transplantation Society. 2019 21(2):e13052. PMID: 30689291.
Johnsrud AJ, Johnsrud JJ, Susanibar SA, [et al., including Kothari A]. Infectious and immunological sequelae of daratumumab in multiple myeloma. British journal of haematology. 2019 185(1):187-189. PMID: 29974956.
Cabal A, Jun SR, Jenjaroenpun P, [et al., including Kothari A]. Genome-Based Comparison of Clostridioides difficile: Average Amino Acid Identity Analysis of Core Genomes. Microbial ecology. 2018 76(3):801-813. PMID: 29445826. PMCID: PMC6132499.
Delgado M, Kothari A, Hittelman WN, Chambers TC. Preparation of Primary Acute Lymphoblastic Leukemia Cells in Different Cell Cycle Phases by Centrifugal Elutriation. Journal of visualized experiments : JoVE. 2017(129). PMID: 29155772. PMCID: PMC5755350.
Kothari A, Caradine KD, Rico Crescencio JC, [et al.]. Cytomegalovirus appendicitis after hematopoietic stem cell transplantation. Transplant infectious disease : an official journal of the Transplantation Society. 2017 19(5). PMID: 28708253.
Mathur P, Hollowoa B, Lala N, [et al., including Kothari A]. Enterococcus raffinosus infection with atypical hemolytic uremic syndrome in a multiple myeloma patient after autologous stem cell transplant. Hematology reports. 2017 9(3):7094. PMID: 29071054. PMCID: PMC5641830.
Kothari A, Burgess MJ, Crescencio JCR, [et al.]. The role of next generation sequencing in infection prevention in human parainfluenza virus 3 infections in immunocompromised patients. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 2017 92:53-55. PMID: 28531552. PMCID: PMC5521260.
Kothari A, Shalin SC, Crescencio JC, Burgess MJ. Skin lesion in a patient with acute myeloid leukemia. Transplant infectious disease : an official journal of the Transplantation Society. 2017 19(1). PMID: 27862750.
Kothari A, Shalin SC, Rico Crescencio JC, Burgess MJ. Skin Lesion with Splenic Microabscesses in a Patient with Acute Myeloid Leukemia. The American journal of medicine. 2016 129(12):e325-e327. PMID: 27637597.
Mohan M, Fogel B, Eluvathingal T, [et al., including Kothari A]. Gastrointestinal histoplasmosis in a patient after autologous stem cell transplant for multiple myeloma. Transplant infectious disease : an official journal of the Transplantation Society. 2016 18(6):939-941. PMID: 27696648.
Chu R, Alford SE, Hart K, [et al., including Kothari A]. Mitotic arrest-induced phosphorylation of Mcl-1 revisited using two-dimensional gel electrophoresis and phosphoproteomics: nine phosphorylation sites identified. Oncotarget. 2016 7(48):78958-78970. PMID: 27738316. PMCID: PMC5346690.
Kothari A, Chambers TC. CDK1/2 toolbox in need of an upgrade. Cell cycle (Georgetown, Tex.). 2016 15(13):1663-4. PMID: 27104300. PMCID: PMC4957594.
Kothari A, Hittelman WN, Chambers TC. Cell Cycle-Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells. Cancer research. 2016 76(12):3553-61. PMID: 27197148. PMCID: PMC4911277.
Alford SE, Kothari A, Loeff FC, [et al.]. BH3 Inhibitor Sensitivity and Bcl-2 Dependence in Primary Acute Lymphoblastic Leukemia Cells. Cancer research. 2015 75(7):1366-75. PMID: 25649768. PMCID: PMC4383710.