Disease Site Focus:
Brain, Breast, Gynecology, Leukemia/ Lymphoma
Research Focus Area:
Type of Research:
Research Interest Statement:
We study essential proteins involved in DNA repair processes. Using fragment-based and computer-aided drug designtechniques, we are developing small molecule inhibitors and chemical tool compounds of these essential proteins to provide agreater understanding of the mechanisms of DNA repair processes and of chemotherapeutic drug resistance. Obtain access to institute supported resources to facilitate research program. Meet additional investigators with common interest to development potential collaborations.
“Pharmacological Modulation of Poly (ADP-ribose) Metabolism”
09/01/18 – 08/31/22
NIH/Nat. Inst. of General Medical Sciences – 2R01GM047251
“Cellular Functions of Eukaryotic DNA Ligases”
08/01/18 – 07/31/22
Mery DE, Compadre AJ, Ordóñez PE, [et al., including Jones DE]. Analysis of Plant-Plant Interactions Reveals the Presence of Potent Antileukemic Compounds. Molecules (Basel, Switzerland). 2022 27(9). PMID: 35566279. PMCID: PMC9105371.
Ye Z, Xu S, Shi Y, [et al., including Jones DE]. GRB2 enforces homology-directed repair initiation by MRE11. Science advances. 2021 7(32). PMID: 34348893. PMCID: PMC8336959.
Nguyen MT, Moiani D, Ahmed Z, [et al., including Jones DE]. An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation. Progress in biophysics and molecular biology. 2021. PMID: 33675849.
Brosey CA, Houl JH, Katsonis P, [et al., including Jones DE]. Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Progress in biophysics and molecular biology. 2021. PMID: 33636189. PMCID: PMC7901392.
Moiani D, Link TM, Brosey CA, [et al., including Jones DE]. An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2. Methods in enzymology. 2021 661:407-431. PMID: 34776222. PMCID: PMC8474023.
Ordóñez PE, Mery DE, Sharma KK, [et al., including Jones DE]. Synthesis, Crystallography, and Anti-Leukemic Activity of the Amino Adducts of Dehydroleucodine. Molecules (Basel, Switzerland). 2020 25(20). PMID: 33092263. PMCID: PMC7588005.
Houl JH, Ye Z, Brosey CA, [et al., including Jones DE]. Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death. Nature communications. 2019 10(1):5654. PMID: 31827085. PMCID: PMC6906431.
Howes TRL, Sallmyr A, Brooks R, [et al., including Jones DE]. Erratum to. DNA repair. 2018 61:99. PMID: 29273192.
Howes TRL, Sallmyr A, Brooks R, [et al., including Jones DE]. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. DNA repair. 2017 60:29-39. PMID: 29078112. PMCID: PMC5881949.
Ordóñez PE, Sharma KK, Bystrom LM, [et al., including Jones DE]. Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells. Journal of natural products. 2016 79(4):691-6. PMID: 27057812.