Zhiqiang Qin, MD, PhD

Research Program: Cancer Therapeutics Faculty Rank: Associate Professor Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Pathology Research Faculty

Cancer Research Interest

• Disease Site Focus: Brain, Leukemia/ Lymphoma, Thoracic/ Lung
• Research Focus Area: Treatment, Carcinogenesis
• Type of Research: Basic
• Research Interest Statement: My research interest focuses on using Kaposi's sarcoma-related herpesvirus (KSHV) as a model pathogen to study the mechanisms of viral oncogenesis and identify the key viral and/or host factors that contribute to the pathogenesis of this oncogenic virus. My group has established KSHV+ primary effusion lymphoma (PEL) and Kaposi's sarcoma (KS) xenograft models, which can be widely used in identifying the oncogenic role of host/viral factors in PEL or KS progression in vivo and test novel therapeutic agents against these virus-associated malignancies. My group is interested in understanding how the interaction of KSHV and other co-infected pathogens such as periodontal bacteria, opportunistic pathogens, HPV, can contribute to this oncogenic virus pathogenesis. My lab also does some anticancer research on common tumors, such as lung cancer and brain tumors.

Contact Information

• Email Address: ZQIN@UAMS.EDU
• Profiles Research Networking Software: View Profile

Active Grants

• NIH/Nat. Inst. of Allergy & Infectious Diseases – 1R01AI181787
  “Defining KSHV LANA functions in viral pathogenesis and immune evasion”
  Co-Investigator
  7/1/2024 – 5/31/2029
• Arkansas Breast Cancer Research Program – AWD00055867
  “ABCRP Fy24 award - Zhiqiang Qin”
  Principal Investigator
  9/1/2023 – 8/31/2025

Recent Publications

• Dai L, Del Valle L, Miley W, [et al., including Qin Z]. Correction: Transactivation of human endogenous retrovirus K (HERV-K) by KSHV promotes Kaposi's sarcoma development. Oncogene. 2024 43(30):2372. PMID: 38890430.
• Fan J, Qin Z. Roles of Human Endogenous Retrovirus-K-Encoded Np9 in Human Diseases: A Small Protein with Big Functions. Viruses. 2024 16(4). PMID: 38675923. PMCID: PMC11054019.
• Dai L, Fan J, Qin Z. Development of human endogenous retrovirus type K- related treatments for human diseases. Journal of medical virology. 2024 96(3):e29532. PMID: 38497450.
• Chen J, Fan J, Lin Z, [et al., including Qin Z]. Human endogenous retrovirus type K encoded Np9 oncoprotein induces DNA damage response. Journal of medical virology. 2024 96(3):e29534. PMID: 38501356.
• Dai L, Qin Z. Role of lymphatic endothelium specific hyaluronan receptor 1 in virus infection and associated diseases. Journal of medical virology. 2024 96(2):e29457. PMID: 38318772. PMCID: PMC10868962.
• Benson LN, Deck KS, Mora CJ, [et al., including Qin Z]. P2X7-Mediated Antigen-Independent Activation of CD8(+) T Cells Promotes Salt-Sensitive Hypertension. Hypertension (Dallas, Tex. : 1979). 2024. PMID: 38193292. PMCID: PMC10922507.
• Dai L, Wilson LG, Nakagawa M, Qin Z. Coinfections with additional oncoviruses in HPV+ individuals: Status, function and potential clinical implications. Journal of medical virology. 2024 96(1):e29363. PMID: 38178584. PMCID: PMC10783544.
• Dai L, Goyal N, Liu J, [et al., including Qin Z]. Developing new ceramide analogs against non-small cell lung cancer (NSCLC). American journal of cancer research. 2024 14(1):86-96. PMID: 38323290. PMCID: PMC10839310.
• Chen J, Lin Z, Fan J, [et al., including Qin Z]. Identification of new microtubule small-molecule inhibitors and microtubule-associated genes against triple negative breast cancer. American journal of cancer research. 2024 14(4):1545-1560. PMID: 38726264. PMCID: PMC11076258.
• Chen J, Lin Z, Song J, [et al., including Qin Z]. Echinomycin as a promising therapeutic agent against KSHV-related malignancies. Journal of hematology & oncology. 2023 16(1):48. PMID: 37143124. PMCID: PMC10161613.
• Chen J, Song J, Plaisance-Bonstaff K, [et al., including Qin Z]. Role of Histamine and Related Signaling in Kaposi's Sarcoma-Associated Herpesvirus Pathogenesis and Oncogenesis. Viruses. 2023 15(4). PMID: 37112991. PMCID: PMC10142667.
• Chen J, Wang Z, Phuc T, [et al., including Qin Z]. Oncolytic strategy using new bifunctional HDACs/BRD4 inhibitors against virus-associated lymphomas. PLoS pathogens. 2023 19(1):e1011089. PMID: 36638143. PMCID: PMC9879403.
• Chen J, Song J, Dai L, [et al., including Qin Z]. SARS-CoV-2 infection and lytic reactivation of herpesviruses: A potential threat in the postpandemic era?. Journal of medical virology. 2022. PMID: 35819034. PMCID: PMC9350099.
• Benson LN, Liu Y, Wang X, [et al., including Qin Z]. The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension. Circulation research. 2022 130(10):1550-1564. PMID: 35430873. PMCID: PMC9106883.
• Chen J, Barrett L, Lin Z, [et al., including Qin Z]. Identification of natural compounds tubercidin and lycorine HCl against small-cell lung cancer and BCAT1 as a therapeutic target. Journal of cellular and molecular medicine. 2022. PMID: 35318805. PMCID: PMC9077304.
• Chen J, Dai L, Kendrick S, [et al., including Qin Z]. The Anti-COVID-19 Drug Remdesivir Promotes Oncogenic Herpesvirus Reactivation through Regulation of Intracellular Signaling Pathways. Antimicrobial agents and chemotherapy. 2022:aac0239521. PMID: 35041508. PMCID: PMC8923226.
• Dai L, Lu YC, Chen J, [et al., including Qin Z]. Oral Shedding of an Oncogenic Virus Alters the Oral Microbiome in HIV+ Patients. Frontiers in microbiology. 2022 13:882520. PMID: 35516440. PMCID: PMC9063630.
• Chen J, Song J, James J, [et al., including Qin Z]. Activation of IL1 signaling molecules by Kaposi's sarcoma-associated herpesvirus. Frontiers in cellular and infection microbiology. 2022 12:1049624. PMID: 36457850. PMCID: PMC9705745.
• Chen J, Dai L, Barrett L, [et al., including Qin Z]. SARS-CoV-2 proteins and anti-COVID-19 drugs induce lytic reactivation of an oncogenic virus. Communications biology. 2021 4(1):682. PMID: 34083759. PMCID: PMC8175744.
• Del Valle L, Dai L, Lin HY, [et al., including Qin Z]. Role of EIF4G1 network in non-small cell lung cancers (NSCLC) cell survival and disease progression. Journal of cellular and molecular medicine. 2021. PMID: 33539648. PMCID: PMC7957206.
• Barrett L, Dai L, Wang S, Qin Z. Kaposi's sarcoma-associated herpesvirus and extracellular vesicles. Journal of medical virology. 2021. PMID: 33415746.
• Liang Z, Qin Z, Riker AI, Xi Y. CRISPR/Cas9 ablating viral microRNA promotes lytic reactivation of Kaposi's sarcoma-associated herpesvirus. Biochemical and biophysical research communications. 2020 533(4):1400-1405. PMID: 33092788. PMCID: PMC7813130.
• Zhao M, Nanbo A, Becnel D, [et al., including Qin Z]. Ubiquitin Modification of the Epstein-Barr Virus Immediate Early Transactivator Zta. Journal of virology. 2020. PMID: 32847852. PMCID: PMC7592219.
• Dai L, Jung BG, Chen J, [et al., including Qin Z]. The potential impacts of early secreted antigenic target of 6 kDa of Mycobacterium tuberculosis on KSHV-infected cells. Journal of medical virology. 2020. PMID: 32648938. PMCID: PMC7796979.
• Chen J, Goyal N, Dai L, [et al., including Qin Z]. Developing new ceramide analogs and identifying novel sphingolipid-controlled genes against a virus-associated lymphoma. Blood. 2020. PMID: 32518949. PMCID: PMC7645984.
• Chen J, Lin Z, Barrett L, [et al., including Qin Z]. Identification of new therapeutic targets and natural compounds against diffuse intrinsic pontine glioma (DIPG). Bioorganic chemistry. 2020 99:103847. PMID: 32311581. PMCID: PMC7260728.
• Dai L, Chen J, Lin Z, [et al., including Qin Z]. Targeting Sphingosine Kinase by ABC294640 against Diffuse Intrinsic Pontine Glioma (DIPG). Journal of Cancer. 2020 11(16):4683-4690.
• Dai L, Forrest J, Barrett L, [et al., including Qin Z]. Porphyromonas gingivalis coinfects with KSHV in oral cavities of HIV+ patients and induces viral lytic reactivation. Journal of medical virology. 2020. PMID: 32436999. PMCID: PMC7679274.
• Dai L, Forrest J, Qiao J, [et al., including Qin Z]. Kaposi Sarcoma-Associated Herpesvirus and Staphylococcus aureus Coinfection in Oral Cavities of HIV-Positive Patients: A Unique Niche for Oncogenic Virus Lytic Reactivation. The Journal of infectious diseases. 2020 221(8):1331-1341. PMID: 31111897. PMCID: PMC7325796.
• Dai L, Chen J, Lin Z, [et al., including Qin Z]. Targeting Sphingosine Kinase by ABC294640 against Diffuse Intrinsic Pontine Glioma (DIPG). Journal of Cancer. 2020 11(16):4683-4691. PMID: 32626514. PMCID: PMC7330698.
• Barrett L, Chen J, Dai L, [et al., including Qin Z]. Role of Interleukin-1 Family Members and Signaling Pathways in KSHV Pathogenesis. Frontiers in cellular and infection microbiology. 2020 10:587929. PMID: 33194830. PMCID: PMC7662392.
• Gilreath C, Boerma M, Qin Z, [et al.]. The Hypoxic Microenvironment of Breast Cancer Cells Promotes Resistance in Radiation Therapy. Frontiers in oncology. 2020 10:629422. PMID: 33680952. PMCID: PMC7930560.
• Chen J, Forrest J, post s, [et al., including Qin Z]. Mechanistic Insights into Chemoresistance Mediated by Oncogenic Viruses in Lymphomas. Viruses. 2019 11(12). PMID: 31888174. PMCID: PMC6950054.