Zhiqiang Qin, MD, PhD

Research Program: Cancer Biology Faculty Rank: Associate Professor Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Pathology

Cancer Research Interest

• Disease Site Focus: Brain, Leukemia/ Lymphoma, Thoracic/ Lung
• Research Focus Area: Treatment, Carcinogenesis
• Type of Research: Basic
• Research Interest Statement: My research interest focuses on using Kaposi's sarcoma-related herpesvirus (KSHV) as a model pathogen to study the mechanisms of viral oncogenesis and identify the key viral and/or host factors that contribute to the pathogenesis of this oncogenic virus. My group has established KSHV+ primary effusion lymphoma (PEL) and Kaposi's sarcoma (KS) xenograft models, which can be widely used in identifying the oncogenic role of host/viral factors in PEL or KS progression in vivo and test novel therapeutic agents against these virus-associated malignancies. My group is interested in understanding how the interaction of KSHV and other co-infected pathogens such as periodontal bacteria, opportunistic pathogens, HPV, can contribute to this oncogenic virus pathogenesis. My lab also does some anticancer research on common tumors, such as lung cancer and brain tumors.

Contact Information

• Email Address: ZQIN@UAMS.EDU
• Profiles Research Networking Software: View Profile

Active Grants

• US Department of Defense – HT94252310083
  “Development of O'PROTACs-based Novel EIF4G1 Degrad”
  Principal Investigator
  01/15/23 – 01/14/24

Publications

• Chen J, Song J, Plaisance-Bonstaff K, [et al., including Qin Z]. Role of Histamine and Related Signaling in Kaposi's Sarcoma-Associated Herpesvirus Pathogenesis and Oncogenesis. Viruses. 2023 15(4). PMID: 37112991. PMCID: PMC10142667.
• Chen J, Wang Z, Phuc T, [et al., including Qin Z]. Oncolytic strategy using new bifunctional HDACs/BRD4 inhibitors against virus-associated lymphomas. PLoS pathogens. 2023 19(1):e1011089. PMID: 36638143. PMCID: PMC9879403.
• Chen J, Song J, Dai L, [et al., including Qin Z]. SARS-CoV-2 infection and lytic reactivation of herpesviruses: A potential threat in the postpandemic era?. Journal of medical virology. 2022. PMID: 35819034. PMCID: PMC9350099.
• Benson LN, Liu Y, Wang X, [et al., including Qin Z]. The IFN?-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension. Circulation research. 2022 130(10):1550-1564. PMID: 35430873. PMCID: PMC9106883.
• Chen J, Barrett L, Lin Z, [et al., including Qin Z]. Identification of natural compounds tubercidin and lycorine HCl against small-cell lung cancer and BCAT1 as a therapeutic target. Journal of cellular and molecular medicine. 2022. PMID: 35318805. PMCID: PMC9077304.
• Chen J, Dai L, Kendrick S, [et al., including Qin Z]. The anti-COVID-19 Drug Remdesivir Promotes Oncogenic Herpesviruses Reactivation through Regulation of Intracellular Signaling Pathways. Antimicrobial agents and chemotherapy. 2022:aac0239521. PMID: 35041508. PMCID: PMC8923226.
• Dai L, Lu YC, Chen J, [et al., including Qin Z]. Oral Shedding of an Oncogenic Virus Alters the Oral Microbiome in HIV+ Patients. Frontiers in microbiology. 2022 13:882520. PMID: 35516440. PMCID: PMC9063630.
• Chen J, Song J, James J, [et al., including Qin Z]. Activation of IL1 signaling molecules by Kaposi's sarcoma-associated herpesvirus. Frontiers in cellular and infection microbiology. 2022 12:1049624. PMID: 36457850. PMCID: PMC9705745.
• Chen J, Dai L, Barrett L, [et al., including Qin Z]. SARS-CoV-2 proteins and anti-COVID-19 drugs induce lytic reactivation of an oncogenic virus. Communications biology. 2021 4(1):682. PMID: 34083759. PMCID: PMC8175744.
• Del Valle L, Dai L, Lin HY, [et al., including Qin Z]. Role of EIF4G1 network in non-small cell lung cancers (NSCLC) cell survival and disease progression. Journal of cellular and molecular medicine. 2021. PMID: 33539648. PMCID: PMC7957206.
• Barrett L, Dai L, Wang S, Qin Z. Kaposi's sarcoma-associated herpesvirus and extracellular vesicles. Journal of medical virology. 2021. PMID: 33415746.
• Liang Z, Qin Z, Riker AI, Xi Y. CRISPR/Cas9 ablating viral microRNA promotes lytic reactivation of Kaposi's sarcoma-associated herpesvirus. Biochemical and biophysical research communications. 2020 533(4):1400-1405. PMID: 33092788. PMCID: PMC7813130.
• Chen J, Dai L, Barrett L, [et al., including Qin Z]. SARS-CoV-2 proteins and anti-COVID-19 drugs induce lytic reactivation of an oncogenic virus. bioRxiv : the preprint server for biology. 2020. PMID: 33024968. PMCID: PMC7536871.
• Zhao M, Nanbo A, Becnel D, [et al., including Qin Z]. Ubiquitin Modification of the Epstein-Barr Virus Immediate Early Transactivator Zta. Journal of virology. 2020. PMID: 32847852. PMCID: PMC7592219.
• Dai L, Jung BG, Chen J, [et al., including Qin Z]. The potential impacts of early secreted antigenic target of 6 kDa (ESAT-6) of Mycobacterium tuberculosis on KSHV-infected cells. Journal of medical virology. 2020. PMID: 32648938. PMCID: PMC7796979.
• Chen J, Goyal N, Dai L, [et al., including Qin Z]. Developing new ceramide analogs and identifying novel sphingolipid controlled genes against a virus-associated lymphoma. Blood. 2020. PMID: 32518949. PMCID: PMC7645984.
• Chen J, Lin Z, Barrett L, [et al., including Qin Z]. Identification of new therapeutic targets and natural compounds against diffuse intrinsic pontine glioma (DIPG). Bioorganic chemistry. 2020 99:103847. PMID: 32311581. PMCID: PMC7260728.
• Dai L, Chen J, Lin Z, [et al., including Qin Z]. Targeting Sphingosine Kinase by ABC294640 against Diffuse Intrinsic Pontine Glioma (DIPG). Journal of Cancer. 2020 11(16):4683-4690.
• Dai L, Forrest J, Barrett L, [et al., including Qin Z]. Porphyromonas gingivalis coinfects with KSHV in oral cavities of HIV+ patients and induces viral lytic reactivation. Journal of medical virology. 2020. PMID: 32436999. PMCID: PMC7679274.
• Dai L, Forrest J, Qiao J, [et al., including Qin Z]. Kaposi Sarcoma-Associated Herpesvirus and Staphylococcus aureus Coinfection in Oral Cavities of HIV-Positive Patients: A Unique Niche for Oncogenic Virus Lytic Reactivation. The Journal of infectious diseases. 2020 221(8):1331-1341. PMID: 31111897. PMCID: PMC7325796.
• Dai L, Chen J, Lin Z, [et al., including Qin Z]. Targeting Sphingosine Kinase by ABC294640 against Diffuse Intrinsic Pontine Glioma (DIPG). Journal of Cancer. 2020 11(16):4683-4691. PMID: 32626514. PMCID: PMC7330698.
• Barrett L, Chen J, Dai L, [et al., including Qin Z]. Role of Interleukin-1 Family Members and Signaling Pathways in KSHV Pathogenesis. Frontiers in cellular and infection microbiology. 2020 10:587929. PMID: 33194830. PMCID: PMC7662392.
• Gilreath C, Boerma M, Qin Z, [et al.]. The Hypoxic Microenvironment of Breast Cancer Cells Promotes Resistance in Radiation Therapy. Frontiers in oncology. 2020 10:629422. PMID: 33680952. PMCID: PMC7930560.
• Chen J, Forrest J, post s, [et al., including Qin Z]. Mechanistic Insights into Chemoresistance Mediated by Oncogenic Viruses in Lymphomas. Viruses. 2019 11(12). PMID: 31888174. PMCID: PMC6950054.
• Chen J, Dai L, Goldstein A, [et al., including Qin Z]. Identification of new antiviral agents against Kaposi's sarcoma-associated herpesvirus (KSHV) by high-throughput drug screening reveals the role of histamine-related signaling in promoting viral lytic reactivation. PLoS pathogens. 2019 15(12):e1008156. PMID: 31790497. PMCID: PMC6907871.
• Chen J, Del Valle L, Lin HY, [et al., including Qin Z]. Expression of PD-1 and PD-Ls in Kaposi's sarcoma and regulation by oncogenic herpesvirus lytic reactivation. Virology. 2019 536:16-19. PMID: 31394407. PMCID: PMC6733645.
• Chen J, Forrest J, post s, [et al., including Qin Z]. Transactivation of human endogenous retroviruses by tumor viruses and their functions in virus-associated malignancies. Oncogenesis. 2019 8(1):6. PMID: 30643113. PMCID: PMC6331641.
• Xu W, Forrest J, post s, [et al., including Qin Z]. Distinct systemic microbiome and microbial translocation are associated with plasma level of anti-CD4 autoantibody in HIV infection. Scientific reports. 2018 8(1):12863. PMID: 30150778. PMCID: PMC6110826.
• Dai L, Del Valle L, Miley W, [et al., including Qin Z]. Transactivation of human endogenous retrovirus K (HERV-K) by KSHV promotes Kaposi's sarcoma development. Oncogene. 2018 37(33):4534-4545. PMID: 29743595. PMCID: PMC6195842.
• Qiao J, Cao Y, Zabaleta J, [et al., including Qin Z]. Regulation of Virus-Associated Lymphoma Growth and Gene Expression by Bacterial Quorum-Sensing Molecules. Journal of virology. 2018 92(14). PMID: 29743366. PMCID: PMC6026753.
• Dai L, Smith CD, Foroozesh M, [et al., including Qin Z]. The sphingosine kinase 2 inhibitor ABC294640 displays anti-non-small cell lung cancer activities in vitro and in vivo. International journal of cancer. 2018 142(10):2153-2162. PMID: 29277894. PMCID: PMC5867242.
• Dai L, Chen J, Cao Y, [et al., including Qin Z]. Ribonucleotide Reductase Inhibitor 3-AP Induces Oncogenic Virus Infected Cell Death and Represses Tumor Growth. Journal of Cancer. 2018 9(23):4503-4509. PMID: 30519356. PMCID: PMC6277659.
• Dai L, Zhao M, Jiang W, [et al., including Qin Z]. KSHV co-infection, a new co-factor for HPV-related cervical carcinogenesis?. American journal of cancer research. 2018 8(11):2176-2184. PMID: 30555737. PMCID: PMC6291645.
• Dai L, Qiao J, Del Valle L, Qin Z. KSHV co-infection regulates HPV16+ cervical cancer cells pathogenesis in vitro and in vivo. American journal of cancer research. 2018 8(4):708-714. PMID: 29736315. PMCID: PMC5934560.
• Dai L, Bai A, Smith CD, [et al., including Qin Z]. ABC294640, A Novel Sphingosine Kinase 2 Inhibitor, Induces Oncogenic Virus-Infected Cell Autophagic Death and Represses Tumor Growth. Molecular cancer therapeutics. 2017 16(12):2724-2734. PMID: 28939554. PMCID: PMC5716930.
• Luo Z, Zhou Z, Ogunrinde E, [et al., including Qin Z]. The effect of plasma auto-IgGs on CD4+ T cell apoptosis and recovery in HIV-infected patients under antiretroviral therapy. Journal of leukocyte biology. 2017 102(6):1481-1486. PMID: 29030391. PMCID: PMC6608058.
• Dai L, Lin Z, Jiang W, [et al., including Qin Z]. Lipids, lipid metabolism and Kaposi's sarcoma-associated herpesvirus pathogenesis. Virologica Sinica. 2017 32(5):369-375. PMID: 29019168. PMCID: PMC5869022.
• Chin J, Sinha S, Nalaparaju A, [et al., including Qin Z]. Pseudomonas aeruginosa Psl exopolysaccharide interacts with the antimicrobial peptide LG21. Water. 2017 9(9):681.
• Dai L, Lin Z, Qiao J, [et al., including Qin Z]. Ribonucleotide reductase represents a novel therapeutic target in primary effusion lymphoma. Oncogene. 2017 36(35):5068-5074. PMID: 28459467. PMCID: PMC5578886.
• Dai L, Lin Z, Cao Y, [et al., including Qin Z]. Targeting EIF4F complex in non-small cell lung cancer cells. Oncotarget. 2017 8(33):55731-55735. PMID: 28903455. PMCID: PMC5589694.
• Bai L, Feng T, Yang L, [et al., including Qin Z]. Retrospective analysis of risk factors associated with Kawasaki disease in China. Oncotarget. 2017 8(33):54357-54363. PMID: 28903347. PMCID: PMC5589586.
• Dai L, Cao Y, Jiang W, [et al., including Qin Z]. KSHV co-infection down-regulates HPV16 E6 and E7 from cervical cancer cells. Oncotarget. 2017 8(22):35792-35803. PMID: 28415759. PMCID: PMC5482618.
• Lam BQ, Dai L, Li L, [et al., including Qin Z]. Molecular mechanisms of activating c-MET in KSHV+ primary effusion lymphoma. Oncotarget. 2017 8(11):18373-18380. PMID: 28407694. PMCID: PMC5392335.
• Bonsignore L, Passelli K, Pelzer C, [et al., including Qin Z]. A role for MALT1 activity in Kaposi's sarcoma-associated herpes virus latency and growth of primary effusion lymphoma. Leukemia. 2017 31(3):614-624. PMID: 27538487. PMCID: PMC5339436.
• Cao Y, Qiao J, Lin Z, [et al., including Qin Z]. Up-regulation of tumor suppressor genes by exogenous dhC16-Cer contributes to its anti-cancer activity in primary effusion lymphoma. Oncotarget. 2017 8(9):15220-15229. PMID: 28146424. PMCID: PMC5362481.
• Qin Z, Lin WT, Zhu S, Franco AT. Imaging the motility and chemotaxis machineries in Helicobacter pylori by cryo-electron tomography. Journal of bacteriology. 2017 199(3):e00695-16. PMID: 27849173. PMCID: PMC5237115.
• Lam BQ, Dai L, Qin Z. The role of HGF/c-MET signaling pathway in lymphoma. Journal of hematology & oncology. 2016 9(1):135. PMID: 27923392. PMCID: PMC5141645.
• Dai L, Bai L, Lin Z, [et al., including Qin Z]. Transcriptomic analysis of KSHV-infected primary oral fibroblasts: The role of interferon-induced genes in the latency of oncogenic virus. Oncotarget. 2016 7(30):47052-47060. PMID: 27363016. PMCID: PMC5216923.