Isabelle Racine Miousse, PhD

Research Program: Cancer Biology Faculty Rank: Assistant Professor Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Biochemistry & Molecular Biology

Cancer Research Interest

• Disease Site Focus: Cutaneous/Melanoma
• Research Focus Area: Treatment
• Type of Research: Basic
• Research Interest Statement: I specialize in epigenetics, with a focus on how environmental factors linked to cancer affect DNA and histone methylation. My project investigates how the supply and metabolism of the essential amino acid and methyl donor methionine modulates cancer susceptibility and development. My expertise covers the absorption, processing, and utilization of methyl groups, as well as epigenetic changes associated with cancer. My current project studies the mechanism behind methionine dependence in cancer, and the application of dietary methionine restriction to the treatment of metastatic melanoma.

Contact Information

• Email Address: IRACINEMIOUSSE@UAMS.EDU
• Profiles Research Networking Software: View Profile

Active Grants

• NIH/Nat. Inst. of General Medical Sciences – 1P20GM139768
  “Methionine restriction as an adjuvant therapy in melanoma”
  Principal Investigator
  4/1/2021 – 2/28/2026

Recent Publications

• Ferdous KU, Tesfay MZ, Cios A, [et al., including Miousse IR]. Enhancing Neoadjuvant Virotherapy's Effectiveness by Targeting Stroma to Improve Resectability in Pancreatic Cancer. Biomedicines. 2024 12(7). PMID: 39062169. PMCID: PMC11275208.
• Garg S, Miousse IR. Rescue of Methionine Dependence by Cobalamin in a Human Colorectal Cancer Cell Line. Nutrients. 2024 16(7). PMID: 38613029. PMCID: PMC11013648.
• Garg TK, Garg S, Miousse IR, [et al.]. Modulation of Hematopoietic Injury by a Promising Radioprotector, Gamma-Tocotrienol, in Rhesus Macaques Exposed to Partial-Body Radiation. Radiation research. 2023. PMID: 38059553.
• Miousse IR, Hale RB, Alsbrook S, [et al.]. Climate Change and New Challenges for Rural Communities: Particulate Matter Matters. Sustainability. 2023 15(23). PMID: 39119507. PMCID: PMC11307925.
• Morehead LC, Koss B, Fil D, [et al., including Miousse IR]. Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma. Molecular immunology. 2023 163:188-195. PMID: 37837954. PMCID: PMC10792541.
• Garg S, Morehead LC, Bird JT, [et al., including Miousse IR]. Characterization of methionine dependence in melanoma cells. Molecular omics. 2023. PMID: 37782107. PMCID: PMC10903584.
• Morehead LC, Garg S, Wallis KF, [et al., including Miousse IR]. Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model. Cancers. 2023 15(18). PMID: 37760436. PMCID: PMC10526448.
• Nemec-Bakk AS, Sridharan V, Seawright JW, [et al., including Miousse IR]. Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model. Life sciences in space research. 2023 37:78-87. PMID: 37087182. PMCID: PMC10122719.
• Garg TK, Garg S, Miousse IR, [et al.]. Gamma-Tocotrienol Modulates Total-Body Irradiation-Induced Hematopoietic Injury in a Nonhuman Primate Model. International journal of molecular sciences. 2022 23(24). PMID: 36555814. PMCID: PMC9784560.
• Clement K, McGill MR, Miousse IR, [et al.]. Methylsulfonylmethane Serves as a Donor of Methyl Groups for Methylation of DNA in Human Liver HepaRG Cells. Journal of dietary supplements. 2022:1-13. PMID: 36469606. PMCID: PMC10239780.
• Garg S, Garg TK, Miousse IR, [et al.]. Effects of Gamma-Tocotrienol on Partial-Body Irradiation-Induced Intestinal Injury in a Nonhuman Primate Model. Antioxidants (Basel, Switzerland). 2022 11(10). PMID: 36290618. PMCID: PMC9598988.
• Garg S, Garg TK, Wise SY, [et al., including Miousse IR]. Effects of Gamma-Tocotrienol on Intestinal Injury in a GI-Specific Acute Radiation Syndrome Model in Nonhuman Primate. International journal of molecular sciences. 2022 23(9). PMID: 35563033. PMCID: PMC9100017.
• Ronis MJJ, Gomez-Acevedo H, Shankar K, [et al., including Miousse I]. Soy Formula Is Not Estrogenic and Does Not Result in Reproductive Toxicity in Male Piglets: Results from a Controlled Feeding Study. Nutrients. 2022 14(5). PMID: 35268101. PMCID: PMC8912539.
• Jun SR, Boerma M, Udaondo Z, [et al., including Miousse IR]. Plasma Metabolomics in a Nonhuman Primate Model of Abdominal Radiation Exposure. Metabolites. 2021 11(8). PMID: 34436481. PMCID: PMC8398377.
• Binz RL, Sadhukhan R, Miousse IR, [et al.]. Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells. International journal of molecular sciences. 2021 22(5). PMID: 33673497. PMCID: PMC7956689.
• Wallis KF, Morehead LC, Bird JT, [et al., including Miousse IR]. Differences in cell death in methionine versus cysteine depletion. Environmental and molecular mutagenesis. 2021. PMID: 33615565. PMCID: PMC8130902.
• Miousse IR, Tobacyk J, Quick CM, [et al.]. Reply to Flugge: the anti-metastatic potential of methionine restriction in melanoma. Carcinogenesis. 2020 41(3):390-391. PMID: 31140558. PMCID: PMC7221500.
• Wallis KF, Melnyk SB, Miousse IR. Sex-Specific Effects of Dietary Methionine Restriction on the Intestinal Microbiome. Nutrients. 2020 12(3). PMID: 32187981. PMCID: PMC7146121.
• Miousse IR, Ewing LE, Skinner CM, [et al.]. Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome. American journal of physiology. Gastrointestinal and liver physiology. 2020 318(3):G439-G450. PMID: 31961718. PMCID: PMC7099489.