Isabelle Racine Miousse, PhD

Research Program: Cancer Biology Faculty Rank: Assistant Professor Campus: University of Arkansas for Medical Sciences College: College of Medicine Department: Biochemistry & Molecular Biology

Cancer Research Interest

• Disease Site Focus: Cutaneous/Melanoma
• Research Focus Area: Treatment
• Type of Research: Basic
• Research Interest Statement: I specialize in epigenetics, with a focus on how environmental factors linked to cancer affect DNA and histone methylation. My project investigates how the supply and metabolism of the essential amino acid and methyl donor methionine modulates cancer susceptibility and development. My expertise covers the absorption, processing, and utilization of methyl groups, as well as epigenetic changes associated with cancer. My current project studies the mechanism behind methionine dependence in cancer, and the application of dietary methionine restriction to the treatment of metastatic melanoma.

Contact Information

• Email Address: IRACINEMIOUSSE@UAMS.EDU
• Profiles Research Networking Software: View Profile

Active Grants

• NIH/Nat. Inst. of General Medical Sciences – 1P20GM139768
  “Methionine restriction as an adjuvant therapy ”
  Principal Investigator
  04/01/21 – 02/28/26

Publications

• Nemec-Bakk AS, Sridharan V, Seawright JW, [et al., including Miousse IR]. Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model. Life sciences in space research. 2023 37:78-87. PMID: 37087182. PMCID: PMC10122719.
• Morehead LC, Garg S, Wallis KF, [et al., including Miousse IR]. Increased response to immune checkpoint inhibitors with dietary methionine restriction. bioRxiv : the preprint server for biology. 2023. PMID: 37066240. PMCID: PMC10104076.
• Garg S, Morehead LC, Bird JT, [et al., including Miousse IR]. Characterization of methionine dependence in melanoma cells. bioRxiv : the preprint server for biology. 2023. PMID: 37066392. PMCID: PMC10104025.
• Garg TK, Garg S, Miousse IR, [et al.]. Gamma-Tocotrienol Modulates Total-Body Irradiation-Induced Hematopoietic Injury in a Nonhuman Primate Model. International journal of molecular sciences. 2022 23(24). PMID: 36555814. PMCID: PMC9784560.
• Clement K, McGill MR, Miousse IR, [et al.]. Methylsulfonylmethane Serves as a Donor of Methyl Groups for Methylation of DNA in Human Liver HepaRG Cells. Journal of dietary supplements. 2022:1-13. PMID: 36469606. PMCID: PMC10239780.
• Garg S, Garg TK, Miousse IR, [et al.]. Effects of Gamma-Tocotrienol on Partial-Body Irradiation-Induced Intestinal Injury in a Nonhuman Primate Model. Antioxidants (Basel, Switzerland). 2022 11(10). PMID: 36290618. PMCID: PMC9598988.
• Garg S, Garg TK, Wise SY, [et al., including Miousse IR]. Effects of Gamma-Tocotrienol on Intestinal Injury in a GI-Specific Acute Radiation Syndrome Model in Nonhuman Primate. International journal of molecular sciences. 2022 23(9). PMID: 35563033. PMCID: PMC9100017.
• Ronis MJJ, Gomez-Acevedo H, Shankar K, [et al., including Miousse I]. Soy Formula Is Not Estrogenic and Does Not Result in Reproductive Toxicity in Male Piglets: Results from a Controlled Feeding Study. Nutrients. 2022 14(5). PMID: 35268101. PMCID: PMC8912539.
• Jun SR, Boerma M, Udaondo Z, [et al., including Miousse IR]. Plasma Metabolomics in a Nonhuman Primate Model of Abdominal Radiation Exposure. Metabolites. 2021 11(8). PMID: 34436481. PMCID: PMC8398377.
• Binz RL, Sadhukhan R, Miousse IR, [et al.]. Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells. International journal of molecular sciences. 2021 22(5). PMID: 33673497. PMCID: PMC7956689.
• Wallis KF, Morehead LC, Bird JT, [et al., including Miousse IR]. Differences in cell death in methionine versus cysteine depletion. Environmental and molecular mutagenesis. 2021. PMID: 33615565. PMCID: PMC8130902.
• Miousse IR, Tobacyk J, Quick CM, [et al.]. Reply to Flugge: the anti-metastatic potential of methionine restriction in melanoma. Carcinogenesis. 2020 41(3):390-391. PMID: 31140558. PMCID: PMC7221500.
• Wallis KF, Melnyk SB, Miousse IR. Sex-Specific Effects of Dietary Methionine Restriction on the Intestinal Microbiome. Nutrients. 2020 12(3). PMID: 32187981. PMCID: PMC7146121.
• Miousse IR, Ewing LE, Skinner CM, [et al.]. Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome. American journal of physiology. Gastrointestinal and liver physiology. 2020 318(3):G439-G450. PMID: 31961718. PMCID: PMC7099489.
• Miousse IR, Skinner CM, Sridharan V, [et al.]. Changes in one-carbon metabolism and DNA methylation in the hearts of mice exposed to space environment-relevant doses of oxygen ions (16O). Life sciences in space research. 2019 22:8-15. PMID: 31421852. PMCID: PMC6703167.
• Gurley BJ, Miousse IR, Nookaew I, [et al.]. Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F? Mice. Nutrients. 2019 11(4). PMID: 30987244. PMCID: PMC6521095.
• Seawright JW, Sridharan V, Landes RD, [et al., including Miousse IR]. Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice. Life sciences in space research. 2019 20:72-84. PMID: 30797436. PMCID: PMC6391741.
• Ewing LE, Miousse IR, Pathak R, [et al.]. NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity. International journal of radiation biology. 2018:1-21. PMID: 30561233. PMCID: PMC6581619.
• Skinner CM, Miousse IR, Ewing LE, [et al.]. Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE Pro? (New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2018 122:21-32. PMID: 30282009. PMCID: PMC6219625.
• Miousse IR, Tobacyk J, Quick CM, [et al.]. Modulation of dietary methionine intake elicits potent, yet distinct, anticancer effects on primary versus metastatic tumors. Carcinogenesis. 2018 39(9):1117-1126. PMID: 29939201. PMCID: PMC6148987.
• Miousse IR, Ewing LE, Kutanzi KR, [et al.]. DNA Methylation in Radiation-Induced Carcinogenesis: Experimental Evidence and Clinical Perspectives. Critical reviews in oncogenesis. 2018 23(1-2):1-11. PMID: 29953365. PMCID: PMC6369919.
• Lin H, Ewing LE, Koturbash I, [et al., including Miousse IR]. MicroRNAs as biomarkers for liver injury: Current knowledge, challenges and future prospects. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2017 110:229-239. PMID: 29042291. PMCID: PMC6693868.
• Miousse IR, Skinner CM, Lin H, [et al.]. Safety assessment of the dietary supplement OxyELITE? Pro (New Formula) in inbred and outbred mouse strains. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2017 109(Pt 1):194-209. PMID: 28843594. PMCID: PMC6756457.
• Miousse IR, Murphy LA, Lin H, [et al.]. Dose-response analysis of epigenetic, metabolic, and apical endpoints after short-term exposure to experimental hepatotoxicants. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2017 109(Pt 1):690-702. PMID: 28495587. PMCID: PMC5656539.
• Miousse IR, Chang J, Shao L, [et al.]. Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation. International journal of molecular sciences. 2017 18(7). PMID: 28677663. PMCID: PMC5535921.
• Miousse IR, Tobacyk J, Melnyk S, [et al.]. One-carbon metabolism and ionizing radiation: a multifaceted interaction. Biomolecular concepts. 2017 8(2):83-92. PMID: 28574375. PMCID: PMC6693336.
• Miousse IR, Kutanzi KR, Koturbash I. Effects of ionizing radiation on DNA methylation: from experimental biology to clinical applications. International journal of radiation biology. 2017 93(5):457-469. PMID: 28134023. PMCID: PMC5411327.
• Miousse IR, Pathak R, Garg S, [et al.]. Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology. Genes & nutrition. 2017 12:22. PMID: 28904640. PMCID: PMC5588631.
• Miousse IR, Koturbash I, Chalbot MC, [et al.]. Analysis of the Ambient Particulate Matter-induced Chromosomal Aberrations Using an In Vitro System. Journal of visualized experiments : JoVE. 2016(118). PMID: 28060322. PMCID: PMC5226431.
• Kutanzi KR, Lumen A, Koturbash I, Miousse IR. Pediatric Exposures to Ionizing Radiation: Carcinogenic Considerations. International journal of environmental research and public health. 2016 13(11). PMID: 27801855. PMCID: PMC5129267.
• Prior S, Miousse IR, Nzabarushimana E, [et al.]. Densely ionizing radiation affects DNA methylation of selective LINE-1 elements. Environmental research. 2016 150:470-481. PMID: 27419368. PMCID: PMC5003736.