Marie Schluterman Burdine, PhD

Full Member

Research Program:

Cancer Biology

Faculty Rank:

Assistant Professor

Campus:

University of Arkansas for Medical Sciences

College:

College of Medicine

Department:

Surgery Leadership

Cancer Research Interest

Disease Site Focus: GI
Research Focus Area: Treatment, Diagnosis/ Prognosis
Type of Research: Basic
Research Interest Statement: My research focuses understanding the role of the DNA damage repair kinase DNA-PKcs in T cell immunity and how inhibitors alter T cell response to tumor antigens particularly hepatocellular carcinoma and pancreatic cancer.

Waldrip ZJ, Acharya B, Armstrong D, [et al., including Burdine MS]. Discovery of the DNA-PKcs inhibitor DA-143 which exhibits enhanced solubility relative to NU7441. Scientific reports. 2024 14(1):19999. PMID: 39198533. PMCID: PMC11358143.
Azevedo-Pouly AC, Appell LE, Burdine L, [et al., including Burdine MS]. Chemical inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4(+) helper and CD8(+) effector T cells. Immunology and cell biology. 2023. PMID: 37149747. PMCID: PMC10527493.
Fletchinger T, Jensen HK, Wells A, [et al., including Burdine M]. Impact of Prolonged Cold Ischemia Time on One Year Kidney Transplant Outcomes. Transplantation proceedings. 2022 54(8):2170-2173. PMID: 36180253.
Waldrip ZJ, Burdine L, Harrison DK, [et al., including Burdine MS]. DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells. The Journal of biological chemistry. 2021:101209. PMID: 34562454. PMCID: PMC8551498.
Harrison DK, Tackett A, Waldrip ZJ, [et al., including Burdine MS]. DNA-PKcs Inhibition Extends Allogeneic Skin Graft Survival. Transplantation. 2020. PMID: 32890138. PMCID: PMC7902289.