Research Focus Area:
Treatment, Diagnosis/ Prognosis
Type of Research:
Research Interest Statement:
My research focuses understanding the role of the DNA damage repair kinase DNA-PKcs in T cell immunity and how inhibitors alter T cell response to tumor antigens particularly hepatocellular carcinoma and pancreatic cancer.
Waldrip ZJ, Burdine L, Harrison DK, [et al., including Burdine MS]. DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells. The Journal of biological chemistry. 2021:101209. PMID: 34562454.
Harrison DK, Tackett A, Waldrip ZJ, [et al., including Burdine MS]. DNA-PKcs Inhibition Extends Allogeneic Skin Graft Survival. Transplantation. 2020. PMID: 32890138.
Byrum SD, Burdine MS, Orr L, [et al.]. Time- and radiation-dose dependent changes in the plasma proteome after total body irradiation of non-human primates: Implications for biomarker selection. PloS one. 2017 12(3):e0174771. PMID: 28350824. PMCID: PMC5370149.
Heard ME, Besio R, Weis M, [et al., including Burdine MS]. Sc65-Null Mice Provide Evidence for a Novel Endoplasmic Reticulum Complex Regulating Collagen Lysyl Hydroxylation. PLoS genetics. 2016 12(4):e1006002. PMID: 27119146. PMCID: PMC4847768.
Byrum SD, Burdine MS, Orr L, [et al.]. A Quantitative Proteomic Analysis of Urine from Gamma-Irradiated Non-Human Primates. Journal of proteomics & bioinformatics. 2016 9(Suppl 10). PMID: 26962295. PMCID: PMC4780756.