Igor Koturbash, MD, PhD

Research Program: Cancer Therapeutics Faculty Rank: Associate Professor Campus: University of Arkansas for Medical Sciences College: College of Public Health Department: Environmental & Occupational Health

Cancer Research Interest

• Disease Site Focus: GI, Leukemia/ Lymphoma
• Research Focus Area: Health Disparities, Prevention, Treatment, Carcinogenesis
• Type of Research: Basic
• Research Interest Statement: Being both MD and PhD, Igor has a long lasting interest in diet and dietary supplements and their impact on human health. The major focus of his research is safety, efficacy and mechanisms of action of dietary supplements and understanding how diet and dietary supplements can modulate tissue response to cancer therapy. Igor has published 90+ peer-reviewed articles and book chapters and his research has received uninterrupted extramural funding from various sources since the beginning of his independent career. In 2018, he has initiated the development of the Center for Dietary Supplements Research (CDSR) at his home university (UAMS). The mission of the Center is to provide regulatory agencies, industry and the public with credible information, assessments, expert opinions, and risk communications as well as professional and educational services relating to the efficacy and safety of dietary supplements.

Contact Information

• Email Address: IKOTURBASH@UAMS.EDU
• Profiles Research Networking Software: View Profile

Recent Publications

• Koturbash I, Yeager RP, Mitchell CA, [et al.]. Botanical-induced toxicity: Liver injury and botanical-drug interactions. A report on a society of Toxicology Annual Meeting symposium. Regulatory toxicology and pharmacology : RTP. 2024 153:105708. PMID: 39304112. PMCID: PMC11556352.
• Roe AL, Krzykwa J, Calderón AI, [et al., including Koturbash I]. Developing a Screening Strategy to Identify Hepatotoxicity and Drug Interaction Potential of Botanicals. Journal of dietary supplements. 2024:1-31. PMID: 39450425.
• Wallace TC, Koturbash I. DSHEA 1994 - Celebrating 30 Years of Dietary Supplement Regulation in the United States. Journal of dietary supplements. 2024:1-8. PMID: 39449550.
• Ewing LE, Harpenau RJ, Skinner CM, [et al., including Koturbash I]. Inter-strain variability in responses to a single administration of the cannabidiol-rich cannabis extract in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024 192:114909. PMID: 39128689. PMCID: PMC11381146.
• Gurley BJ, Koturbash I. Phenibut: A drug with one too many "buts". Basic & clinical pharmacology & toxicology. 2024. PMID: 39197876. PMCID: PMC11583343.
• Ewing LE, Skinner CM, McGill MR, [et al., including Koturbash I]. Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract. Drug and chemical toxicology. 2024:1-8. PMID: 39155655.
• Mattes MD, Koturbash I, Leung CN, [et al.]. A Phase I Trial of a Methionine Restricted Diet with Concurrent Radiation Therapy. Nutrition and cancer. 2024:1-6. PMID: 38591931. PMCID: PMC11407292.
• Layman AJ, Alsbrook SM, Koturbash IK, McGill MR. Natural Products That Protect Against Acetaminophen Hepatotoxicity: A Call for Increased Rigor in Preclinical Studies of Dietary Supplements. Journal of dietary supplements. 2024:1-18. PMID: 38562009. PMCID: PMC11442681.
• Afshari N, Koturbash I, Boerma M, [et al.]. A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment. International journal of molecular sciences. 2024 25(2). PMID: 38256089. PMCID: PMC10816679.
• Franks AM, Teeter BS, Davis P, [et al., including Koturbash I]. First-year evaluation of a campus-wide, cross-disciplinary scholarly writing development program supported by a center for biomedical research excellence (COBRE). PloS one. 2024 19(10):e0312322. PMID: 39471171. PMCID: PMC11521313.
• Miousse IR, Hale RB, Alsbrook S, [et al., including Koturbash I]. Climate Change and New Challenges for Rural Communities: Particulate Matter Matters. Sustainability. 2023 15(23). PMID: 39119507. PMCID: PMC11307925.
• Nemec-Bakk AS, Sridharan V, Seawright JW, [et al., including Koturbash I]. Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model. Life sciences in space research. 2023 37:78-87. PMID: 37087182. PMCID: PMC10122719.
• Clement K, McGill MR, Miousse IR, [et al., including Koturbash I]. Methylsulfonylmethane Serves as a Donor of Methyl Groups for Methylation of DNA in Human Liver HepaRG Cells. Journal of dietary supplements. 2022:1-13. PMID: 36469606. PMCID: PMC10239780.
• Gurley BJ, McGill MR, Koturbash I. Hepatotoxicity due to herbal dietary supplements: Past, present and the future. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022 169:113445. PMID: 36183923. PMCID: PMC11404749.
• Norton JC, Politis MD, Bimali M, [et al., including Koturbash I]. Analysis of COVID-19 Pandemic on Supplement Usage and Its Combination with Self-Medication within the State of Arkansas. Journal of dietary supplements. 2022:1-28. PMID: 36178162. PMCID: PMC10033323.
• Ewing LE, Pathak R, Landes RD, [et al., including Koturbash I]. Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese. International journal of radiation biology. 2022:1-12. PMID: 35939319. PMCID: PMC9929030.
• Ewing LE, Biju PG, Pathak R, [et al., including Koturbash I]. Methods for induction and assessment of intestinal permeability in rodent models of radiation injury. Methods in cell biology. 2022 168:235-247. PMID: 35366985. PMCID: PMC9808921.
• Binz RL, Sadhukhan R, Miousse IR, [et al., including Koturbash I]. Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells. International journal of molecular sciences. 2021 22(5). PMID: 33673497. PMCID: PMC7956689.
• Boerma M, Koturbash I. Manned space travel: from a race between nations to a race against the environmental stressors beyond earth. Journal of environmental science and health. Part C, Toxicology and carcinogenesis. 2021 39(2):109-112. PMID: 33902390.
• Kutanzi KR, Ewing LE, Skinner CM, [et al., including Koturbash I]. Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration. International journal of molecular sciences. 2020 21(20). PMID: 33096940. PMCID: PMC7656295.
• Ewing LE, Skinner CM, Pathak R, [et al., including Koturbash I]. Dietary Methionine Supplementation Exacerbates Gastrointestinal Toxicity in a Mouse Model of Abdominal Irradiation. International journal of radiation oncology, biology, physics. 2020. PMID: 33002540. PMCID: PMC7855316.
• Miousse IR, Tobacyk J, Quick CM, [et al., including Koturbash I]. Reply to Flugge: the anti-metastatic potential of methionine restriction in melanoma. Carcinogenesis. 2020 41(3):390-391. PMID: 31140558. PMCID: PMC7221500.
• Miousse IR, Ewing LE, Skinner CM, [et al., including Koturbash I]. Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome. American journal of physiology. Gastrointestinal and liver physiology. 2020 318(3):G439-G450. PMID: 31961718. PMCID: PMC7099489.
• Koturbash I, MacKay D. Cannabidiol and Other Cannabinoids: From Toxicology and Pharmacology to the Development of a Regulatory Pathway. Journal of dietary supplements. 2020 17(5):487-492. PMID: 32715797.
• Walker LA, Koturbash I, Kingston R, [et al.]. Cannabidiol (CBD) in Dietary Supplements: Perspectives on Science, Safety, and Potential Regulatory Approaches. Journal of dietary supplements. 2020 17(5):493-502. PMID: 32543246.
• Skinner CM, Nookaew I, Ewing LE, [et al., including Koturbash I]. Potential Probiotic or Trigger of Gut Inflammation - The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract. Journal of dietary supplements. 2020 17(5):543-560. PMID: 32400224. PMCID: PMC7470626.