Igor Koturbash, MD, PhD

Research Program: Cancer Therapeutics Faculty Rank: Associate Professor Campus: University of Arkansas for Medical Sciences College: College of Public Health Department: Environmental & Occupational Health

Cancer Research Interest

• Disease Site Focus: GI, Leukemia/ Lymphoma
• Research Focus Area: Health Disparities, Prevention, Treatment, Carcinogenesis
• Type of Research: Basic
• Research Interest Statement: Being both MD and PhD, Igor has a long lasting interest in diet and dietary supplements and their impact on human health. The major focus of his research is safety, efficacy and mechanisms of action of dietary supplements and understanding how diet and dietary supplements can modulate tissue response to cancer therapy. Igor has published 90+ peer-reviewed articles and book chapters and his research has received uninterrupted extramural funding from various sources since the beginning of his independent career. In 2018, he has initiated the development of the Center for Dietary Supplements Research (CDSR) at his home university (UAMS). The mission of the Center is to provide regulatory agencies, industry and the public with credible information, assessments, expert opinions, and risk communications as well as professional and educational services relating to the efficacy and safety of dietary supplements.

Contact Information

• Email Address: IKOTURBASH@UAMS.EDU
• Profiles Research Networking Software: View Profile

Active Grants

• NIH/National Center for Complementary and Integrative Health – 5R21AT011107
  “Ole Miss R21 subaward - In vitro screening/HDI”
  Principal Investigator
  01/01/22 – 07/31/23
• National Aeronautics & Space Administration – 80NSSC21K0544
  “LSU subcontract - NASA Human Exploration Research”
  Principal Investigator
  06/01/21 – 05/31/24

Publications

• Nemec-Bakk AS, Sridharan V, Seawright JW, [et al., including Koturbash I]. Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model. Life sciences in space research. 2023 37:78-87. PMID: 37087182. PMCID: PMC10122719.
• Clement K, McGill MR, Miousse IR, [et al., including Koturbash I]. Methylsulfonylmethane Serves as a Donor of Methyl Groups for Methylation of DNA in Human Liver HepaRG Cells. Journal of dietary supplements. 2022:1-13. PMID: 36469606. PMCID: PMC10239780.
• Gurley BJ, McGill MR, Koturbash I. Hepatotoxicity due to herbal dietary supplements: Past, present and the future. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022 169:113445. PMID: 36183923.
• Norton JC, Politis MD, Bimali M, [et al., including Koturbash I]. Analysis of COVID-19 Pandemic on Supplement Usage and Its Combination with Self-Medication within the State of Arkansas. Journal of dietary supplements. 2022:1-28. PMID: 36178162. PMCID: PMC10033323.
• Ewing LE, Pathak R, Landes RD, [et al., including Koturbash I]. Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese. International journal of radiation biology. 2022:1-12. PMID: 35939319. PMCID: PMC9929030.
• Ewing LE, Biju PG, Pathak R, [et al., including Koturbash I]. Methods for induction and assessment of intestinal permeability in rodent models of radiation injury. Methods in cell biology. 2022 168:235-247. PMID: 35366985. PMCID: PMC9808921.
• Binz RL, Sadhukhan R, Miousse IR, [et al., including Koturbash I]. Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells. International journal of molecular sciences. 2021 22(5). PMID: 33673497. PMCID: PMC7956689.
• Boerma M, Koturbash I. Manned space travel: from a race between nations to a race against the environmental stressors beyond earth. Journal of environmental science and health. Part C, Toxicology and carcinogenesis. 2021 39(2):109-112. PMID: 33902390.
• Kutanzi KR, Ewing LE, Skinner CM, [et al., including Koturbash I]. Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration. International journal of molecular sciences. 2020 21(20). PMID: 33096940. PMCID: PMC7656295.
• Ewing LE, Skinner CM, Pathak R, [et al., including Koturbash I]. Dietary Methionine Supplementation Exacerbates Gastrointestinal Toxicity in a Mouse Model of Abdominal Irradiation. International journal of radiation oncology, biology, physics. 2020. PMID: 33002540. PMCID: PMC7855316.
• Miousse IR, Tobacyk J, Quick CM, [et al., including Koturbash I]. Reply to Flugge: the anti-metastatic potential of methionine restriction in melanoma. Carcinogenesis. 2020 41(3):390-391. PMID: 31140558. PMCID: PMC7221500.
• Miousse IR, Ewing LE, Skinner CM, [et al., including Koturbash I]. Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome. American journal of physiology. Gastrointestinal and liver physiology. 2020 318(3):G439-G450. PMID: 31961718. PMCID: PMC7099489.
• Koturbash I, MacKay D. Cannabidiol and Other Cannabinoids: From Toxicology and Pharmacology to the Development of a Regulatory Pathway. Journal of dietary supplements. 2020 17(5):487-492. PMID: 32715797.
• Walker LA, Koturbash I, Kingston R, [et al.]. Cannabidiol (CBD) in Dietary Supplements: Perspectives on Science, Safety, and Potential Regulatory Approaches. Journal of dietary supplements. 2020 17(5):493-502. PMID: 32543246.
• Skinner CM, Nookaew I, Ewing LE, [et al., including Koturbash I]. Potential Probiotic or Trigger of Gut Inflammation - The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract. Journal of dietary supplements. 2020 17(5):543-560. PMID: 32400224. PMCID: PMC7470626.
• Miousse IR, Skinner CM, Sridharan V, [et al., including Koturbash I]. Changes in one-carbon metabolism and DNA methylation in the hearts of mice exposed to space environment-relevant doses of oxygen ions (16O). Life sciences in space research. 2019 22:8-15. PMID: 31421852. PMCID: PMC6703167.
• Ewing LE, McGill MR, Yee EU, [et al., including Koturbash I]. Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration. Molecules (Basel, Switzerland). 2019 24(12). PMID: 31212965. PMCID: PMC6630875.
• Ewing LE, Skinner CM, Quick CM, [et al., including Koturbash I]. Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model. Molecules (Basel, Switzerland). 2019 24(9). PMID: 31052254. PMCID: PMC6539990.
• Gurley BJ, Miousse IR, Nookaew I, [et al., including Koturbash I]. Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F? Mice. Nutrients. 2019 11(4). PMID: 30987244. PMCID: PMC6521095.
• Koturbash I, Griffin RJ. Harnessing epigenetics and metabolism to modulate tissue response to radiotherapy. International journal of radiation biology. 2019 95(4):379-381. PMID: 30856046. PMCID: PMC6818243.
• Seawright JW, Sridharan V, Landes RD, [et al., including Koturbash I]. Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice. Life sciences in space research. 2019 20:72-84. PMID: 30797436. PMCID: PMC6391741.
• Ewing LE, Miousse IR, Pathak R, [et al., including Koturbash I]. NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity. International journal of radiation biology. 2018:1-21. PMID: 30561233. PMCID: PMC6581619.
• Skinner CM, Miousse IR, Ewing LE, [et al., including Koturbash I]. Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE Pro? (New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2018 122:21-32. PMID: 30282009. PMCID: PMC6219625.
• Miousse IR, Tobacyk J, Quick CM, [et al., including Koturbash I]. Modulation of dietary methionine intake elicits potent, yet distinct, anticancer effects on primary versus metastatic tumors. Carcinogenesis. 2018 39(9):1117-1126. PMID: 29939201. PMCID: PMC6148987.
• Koturbash I. 2017 Michael Fry Award Lecture When DNA is Actually Not a Target: Radiation Epigenetics as a Tool to Understand and Control Cellular Response to Ionizing Radiation. Radiation research. 2018 190(1):5-11. PMID: 29697303. PMCID: PMC6036898.
• Herceg Z, Ghantous A, Wild CP, [et al., including Koturbash I]. Roadmap for investigating epigenome deregulation and environmental origins of cancer. International journal of cancer. 2018 142(5):874-882. PMID: 28836271. PMCID: PMC6027626.
• Miousse IR, Ewing LE, Kutanzi KR, [et al., including Koturbash I]. DNA Methylation in Radiation-Induced Carcinogenesis: Experimental Evidence and Clinical Perspectives. Critical reviews in oncogenesis. 2018 23(1-2):1-11. PMID: 29953365. PMCID: PMC6369919.
• Lin H, Ewing LE, Koturbash I, [et al.]. MicroRNAs as biomarkers for liver injury: Current knowledge, challenges and future prospects. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2017 110:229-239. PMID: 29042291. PMCID: PMC6693868.
• Miousse IR, Skinner CM, Lin H, [et al., including Koturbash I]. Safety assessment of the dietary supplement OxyELITE? Pro (New Formula) in inbred and outbred mouse strains. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2017 109(Pt 1):194-209. PMID: 28843594. PMCID: PMC6756457.
• Miousse IR, Murphy LA, Lin H, [et al., including Koturbash I]. Dose-response analysis of epigenetic, metabolic, and apical endpoints after short-term exposure to experimental hepatotoxicants. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2017 109(Pt 1):690-702. PMID: 28495587. PMCID: PMC5656539.
• Casero D, Gill K, Sridharan V, [et al., including Koturbash I]. Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome. Microbiome. 2017 5(1):105. PMID: 28821301. PMCID: PMC5563039.
• Miousse IR, Chang J, Shao L, [et al., including Koturbash I]. Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation. International journal of molecular sciences. 2017 18(7). PMID: 28677663. PMCID: PMC5535921.
• Miousse IR, Tobacyk J, Melnyk S, [et al., including Koturbash I]. One-carbon metabolism and ionizing radiation: a multifaceted interaction. Biomolecular concepts. 2017 8(2):83-92. PMID: 28574375. PMCID: PMC6693336.
• Miousse IR, Kutanzi KR, Koturbash I. Effects of ionizing radiation on DNA methylation: from experimental biology to clinical applications. International journal of radiation biology. 2017 93(5):457-469. PMID: 28134023. PMCID: PMC5411327.
• Koturbash I, Merrifield M, Kovalchuk O. Fractionated exposure to low doses of ionizing radiation results in accumulation of DNA damage in mouse spleen tissue and activation of apoptosis in a p53/Atm-independent manner. International journal of radiation biology. 2017 93(2):148-155. PMID: 27758128. PMCID: PMC6709590.
• Pathak R, Koturbash I, Hauer-Jensen M. Detection of Inter-chromosomal Stable Aberrations by Multiple Fluorescence In Situ Hybridization (mFISH) and Spectral Karyotyping (SKY) in Irradiated Mice. Journal of visualized experiments : JoVE. 2017(119). PMID: 28117817. PMCID: PMC5352253.
• Miousse IR, Pathak R, Garg S, [et al., including Koturbash I]. Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology. Genes & nutrition. 2017 12:22. PMID: 28904640. PMCID: PMC5588631.
• Seawright JW, Samman Y, Sridharan V, [et al., including Koturbash I]. Effects of low-dose rate ?-irradiation combined with simulated microgravity on markers of oxidative stress, DNA methylation potential, and remodeling in the mouse heart. PloS one. 2017 12(7):e0180594. PMID: 28678877. PMCID: PMC5498037.
• Koturbash I. LINE-1 in response to exposure to ionizing radiation. Mobile genetic elements. 2017 7(6):e1393491. PMID: 29209557. PMCID: PMC5706599.
• Miousse IR, Koturbash I, Chalbot MC, [et al.]. Analysis of the Ambient Particulate Matter-induced Chromosomal Aberrations Using an In Vitro System. Journal of visualized experiments : JoVE. 2016(118). PMID: 28060322. PMCID: PMC5226431.
• Koturbash I, Jadavji NM, Kutanzi K, [et al.]. Fractionated low-dose exposure to ionizing radiation leads to DNA damage, epigenetic dysregulation, and behavioral impairment. Environmental epigenetics. 2016 2(4):dvw025. PMID: 29492301. PMCID: PMC5804539.
• Kutanzi KR, Lumen A, Koturbash I, Miousse IR. Pediatric Exposures to Ionizing Radiation: Carcinogenic Considerations. International journal of environmental research and public health. 2016 13(11). PMID: 27801855. PMCID: PMC5129267.
• Boerma M, Sridharan V, Mao XW, [et al., including Koturbash I]. Effects of ionizing radiation on the heart. Mutation research. 2016 770(Pt B):319-327. PMID: 27919338. PMCID: PMC5144922.
• Prior S, Miousse IR, Nzabarushimana E, [et al., including Koturbash I]. Densely ionizing radiation affects DNA methylation of selective LINE-1 elements. Environmental research. 2016 150:470-481. PMID: 27419368. PMCID: PMC5003736.
• Pathak R, Bachri A, Ghosh SP, [et al., including Koturbash I]. The Vitamin E Analog Gamma-Tocotrienol (GT3) Suppresses Radiation-Induced Cytogenetic Damage. Pharmaceutical research. 2016 33(9):2117-25. PMID: 27216753. PMCID: PMC4967083.